Formaldehyde production by Tris buffer in peptide formulations at elevated temperature

Journal of Pharmaceutical Sciences

Volumn 90, Issue 8, 2001, Pages 1198-1203

  Song, Yuan ^a   Schowen, Richard L ^a   Borchardt, Ronald T ^a   Topp, Elizabeth M ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Formaldehyde; Peptide; Poly (vinylpyrrolidone); Tris buffer; Tyrosine

Indexed keywords

FORMALDEHYDE; PEPTIDE; POVIDONE; TROMETAMOL; TYROSINE;

ARTICLE; CHEMICAL REACTION; DEGRADATION; DRUG FORMULATION; DRUG STABILITY; TEMPERATURE SENSITIVITY;

EID: 0034888365     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.1073     Document Type: Article

References (7)

1. Effect of 'pH' on the rate of aspragine deamidation in polymeric formulations: 'pH'-rate profile
2. Chemical pathways of peptide degradation. II. Kinetics of deamidation of an asparaginyl residue in a model hexapeptide
3. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction
4. Reaction of formaldehyde with proteins VI. Cross-linking of amino groups with phenol, imidazole, or indole groups
5. Reaction of formaldehyde with proteins V. Cross-linking between amino and primary amide or guanidyl groups
6. Catalysis by poly-l-lysine of aminolysis of penicillin by Tris (hydroxymethyl) aminomethane
7. Oxidation of Tris to one-carbon compounds in a radical-producing model system, in microsomes, in hepatocytes and in rats