IGF-I and MAP Kinase Involvement in the Stimulatory Effects of LNCaP Prostate Cancer Cell Conditioned Media on Cell Proliferation and Protein Synthesis in MC3T3-E1 Osteoblastic Cells

Journal of Cellular Biochemistry

Volumn 90, Issue 5, 2003, Pages 925-937

  Bhattacharyya, Rumi S ^a   Stern, Paula H ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Dept Molec Pharmacol/Biol Chem ^*  (United States)

Author keywords

IGF I; LNCaP cells; MAP kinase; Osteoblastic metastases; Prostate cancer

Indexed keywords

CARBON 14; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROLINE; SOMATOMEDIN; THYMIDINE DERIVATIVE; TRITIUM;

ANIMAL CELL; ARTICLE; CANCER CELL; CELL CULTURE; CELL LINE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MALE; MOLECULAR DYNAMICS; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIVISION; CULTURE MEDIA, CONDITIONED; ENZYME INHIBITORS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; OSTEOBLASTS; PROLINE; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION; THYMIDINE; TUMOR CELLS, CULTURED;

EID: 0345017075     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10726     Document Type: Article

References (52)

1. Amarnani S, Merriman HL, Linkhart TA, Baylink DJ, Mohan S. 1993. Autocrine regulators of MC3T3-E1 cell proliferation. J Bone Miner Res 8:157-165.
2. Arteaga CL, Osborne CK. 1989. Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor. Cancer Res 49:6237-6241.
3. Baier TG, Jenne EW, Blum W, Schonberg D, Hartmann KK. 1992. Influence of antibodies against IGF-I, insulin or their receptors on proliferation of human acute lymphoblastic leukemia cell lines. Leuk Res 16:807-814.
4. Canalis E. 1980. Effect of insulin like growth factor I on DNA and protein synthesis in cultured rat calvaria. J Clin Invest 66:709-719.
5. Canalis E, Lian JB. 1988. Effects of bone associated growth factors on DNA, collagen and osteocalcin synthesis in cultured fetal rat calvariae. Bone 9:243-246.
6. Canalis E, McCarthy T, Centrella M. 1988. Isolation of growth factors from adult bovine bone. Calcif Tissue Int 43:346-351.
7. Canalis E, Centrella M, Burch W, McCarthy TL. 1989. Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures. J Clin Invest 83:60-65.
8. Canalis E, Pash J, Gabbitas B, Rydziel S, Varghese S. 1993. Growth factors regulate the synthesis of insulin-like growth factor-I in bone cell cultures. Endocrinology 133:33-38.
9. Carlin BI, Andriole GL. 2000. The natural history, skeletal complications, and management of bone metastases in patients with prostate carcinoma. Cancer 88:2989-2994.
10. Centrella M, McCarthy TL, Canalis E. 1990. Receptors for insulin-like growth factors-I and -II in osteoblast-enriched cultures from fetal rat bone. Endocrinology 126:39-44.
11. Charhon SA, Chapuy MC, Delvin EE, Valentin-Opran A, Edouard CM, Meunier PJ. 1983. Histomorphometric analysis of sclerotic bone metastases from prostatic carcinoma with special reference to osteomalacia. Cancer 51:918-924.
12. Chihara K, Sugimoto T. 1997. The action of GH/IGF-I/IGFBP in osteoblasts and osteoclasts. Horm Res 48(Suppl 5):45-49.
13. Chirardo A. 1991. National Cancer Institute roundtable on prostate cancer: Future research directions. Cancer Res 51:2498-2505.
14. Conover CA. 1996. The role of insulin-like growth factors and binding proteins in bone cell biology. In: Bilezikian JP, Raisz LG, Rodan GA, editors. Principles of bone biology. San Diego: Academic Press. pp 607-618.
15. Culig Z, Hobisch A, Cronauer MV, Radmayr C, Trapman J, Hittmair A, Bartsch G, Klocker H. 1994. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res 54:5474-5478.
16. Djavan B, Waldert M, Seitz C, Marberger M. 2001. Insulin-like growth factors and prostate cancer. World J Urol 19:225-233.
17. Grant ES, Ross MB, Ballard S, Naylor A, Habib FK. 1998. The insulin-like growth factor type I receptor stimulates growth and suppresses apoptosis in prostatic stromal cells. J Clin Endocrinol Metab 83:3252-3257.
18. Grimberg A, Cohen P. 2000. Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J Cell Physiol 183:1-9.
19. Guise TA, Mundy GR. 1998. Cancer and bone. Endocr Rev 19(1):18-54.
20. Hellawell GO, Turner GD, Davies DR, Poulsom R, Brewster SF, Macaulay VM. 2002. Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease. Cancer Res 62:2942-2950.
21. Hipskind RA, Bilbe G. 1998. MAP kinase signaling cascades and gene expression in osteoblasts. Front Biosci 3:D804-D816.
22. Hock JM, Centrella M, Canalis E. 1989. Insulin-like growth factor I has independent effects on bone matrix formation and cell replication. Endocrinology 122:254-260.
23. Horoszewicz JS, Leong SS, Chu TM, Wajsman ZL, Friedman M, Papsiderso L, Kim J, Chai LS, Kakati S, Arya SK, Sandberg AA. 1980. The LNCaP cell line-A new model for studies on human prostatic carcinoma. Prog Clin Biol Res 37:115-132.
24. Huang BK, Golden LA, Tarjan G, Madison LD, Stern PH. 2000. Insulin-like growth factor production is essential for anabolic effects of thyroid hormone in osteoblasts. J Bone Miner Res 15:188-197.
25. Iwamura M, Sluss PM, Casamento JB, Cockett AT. 1993. Insulin-like growth factor I: Action and receptor characterization in human prostate cancer cell lines. Prostate 22:243-252.
26. Kawaguchi H, Pilbeam CC, Raisz LG. 1994. Anabolic effects of 3,3′,5-triiodothyronine and triiodothyroacetic acid in cultured neonatal mouse parietal bones. Endocrinology 135:971-976.
27. Keller ET, Zhang J, Cooper CR, Smith PC, McCauley LK, Pienta KJ, Taichman RS. 2001. Prostate carcinoma skeletal metastases: Cross-talk between tumor and bone. Cancer Metastasis Rev 20:333-349.
28. Kull FC, Jr., Jacobs S, Su YF, Svoboda ME, Van Wyk JJ, Cuatrecasas P. 1983. Monoclonal antibodies to receptors for insulin and somatomedin-C. J Biol Chem 258:6561-6566.
29. Lahm H, Amstad P, Wyniger J, Yilmaz A, Fischer JR, Schreyer M, Givel JC. 1994. Blockade of the insulin-like growth-factor-I receptor inhibits growth of human colorectal cancer cells: Evidence of a functional IGF-II-mediated autocrine loop. Int J Cancer 58:452-459.
30. Lakatos P, Caplice MD, Khanna V, Stern PH. 1993. Thyroid homrones increase insulin-like growth factor I content in the medium of rat bone tissue. J Bone Miner Res 8:1475-1481.
31. Linkhart TA, Mohan S, Baylink DJ. 1996. Growth factors for bone growth and repair: IGF, TGFβ, and BMP. Bone 19:1S-12S.
32. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275.
33. McCarthy TL, Centrella M, Canalis E. 1989a. Parathyroid hormone enhances the trancript and polypeptide levels of insulin-like growth factor I in osteoblast-enriched cultures from fetal rat bone. Endocrinology 124:1247-1253.
34. McCarthy TL, Centrella M, Canalis E. 1989b. Regulatory effects of insulin-like growth factors I and II on bone collagen synthesis in rat calvarial cultures. Endocrinology 124:301-309.
35. McCarthy TL, Ji C, Centrella M. 2000. Links among growth factors, hormones, and nuclear factors with essential roles in bone formation. Crit Rev Oral Biol Med 11:409-422.
36. Nemeth JA, Harb JF, Barroso U, He Z, Grignon DJ, Cher ML. 1999. Severe combined immunodeficient-hu model of human prostate cancer metastasis to human bone. Cancer Res 59:1987-1993.
37. Pfeilschifter J, Laukhuf F, Muller-Beckmann B, Blum WF, Pfister T, Ziegler R. 1995. Parathyroid hormone increases the concentration of insulin-like growth factor-I and transforming growth factor beta 1 in rat bone. J Clin Invest 96:767-774.
38. Pietrzkowski Z, Wernicke D, Porcu P, Jameson BA, Baserga R. 1992. Inhibition of cellular proliferation by peptide analogues of insulin-like growth factor 1. Cancer Res 52:6447-6451.
39. Pollak M, Beamer W, Zhang JC. 1998. Insulin-like growth factors and prostate cancer. Cancer Metastasis Rev 17:383-390.
40. Raile K, Hoflich A, Kessler U, Yang Y, Pfuender M, Blum WF, Kolb H, Schwarz HP, Kiess W. 1994. Human osteosarcoma (U-2 OS) cells express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptors and synthesize IGF-II: Autocrine growth stimulation by IGF-II via the IGF-I receptor. J Cell Physiol 159:531-541.
41. Ritchie CK, Andrews LR, Thomas KG, Tindall DJ, Fitzpatrick LA. 1997. The effects of growth factors associated with osteoblasts on prostate carcinoma proliferation and chemotaxis: Implications for the development of metastatic disease. Endocrinology 138:1145-1150.
42. Roodman GD. 2003. Role of stromal-derived cytokines and growth factors in bone metastasis. Cancer 97:733-738.
43. Rosol TJ. 2000. Pathogenesis of bone metastases: Role of tumor-related proteins. J Bone Miner Res 15:844-850.
44. Rubin J, Chung LW, Fan X, Zhu L, Murphy TC, Nanes MS, Rosen CJ. 2002. Bone microenvironment triggers IGF-I release from prostate carcinoma. J Bone Miner Res 17: S148.
45. Sanders JL, Stern PH. 1996. Expression and phorbol-ester induced down regulation of protein kinase C isozymes in osteoblasts. J Bone Miner Res 11:1862-1872.
46. Schmid C. 1995. Insulin-like growth factors. Cell Biol Int 19:445-457.
47. Schmid C, Rutishauser J, Schlapfer I, Froesch ER, Zapf J. 1991. Intact but not truncated insulin-like growth factor binding protein-3 (IGFBP-3) blocks IGF I-induced stimulation of osteoblasts: Control of IGF signalling to bone cells by IGFBP-3-specific proteolysis? Biochem Biophys Res Commun 179:579-585.
48. Sudo H, Kodama HA, Amagai Y, Yamamoto S, Kasai S. 1983. In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J Cell Biol 96:191-198.
49. Thrailkill KM, Siddhanti SR, Fowlkes JL, Quarles LD. 1995. Differentiation of MC3T3-E1 osteoblasts is associated with temporal changes in the expression of IGF-I and IGFBPs. Bone 17:307-313.
50. Turner CH. 1992. Functional determinants of bone structure: Beyond Wolffs law of bone transformation. Bone 13:403-409.
51. Wolk A, Mantzoros CS, Andersson SO, Bergstrom R, Signorello LB, Lagiou P, Adami HO, Trichopoulos D. 1998. Insulin-like growth factor 1 and prostate cancer risk: A population-based, case-control study. J Natl Cancer Inst 90:911-915.
52. Zhang J, Dai J, Qi Y, Lin DL, Smith P, Strayhorn C, Mizokami A, Fu Z, Westman J, Keller ET. 2001. Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone. J Clin Invest 157:539-543.