Some sodium, potassium and water changes in the elderly and their treatment

Nephrology Dialysis Transplantation

Volumn 11, Issue SUPPL. 9, 1996, Pages 9-17

  Andreucci, Vittorio E ^a,b   Russo, Domenico ^a   Cianciaruso, Bruno ^a   Andreucci, Michele ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Nuovo Policlinico   (Italy)

Author keywords

Demyelination; Diuretics; Hypernatraemia; Hyponatraemia; Potassium; Sodium

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; LOOP DIURETIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; SODIUM CHLORIDE;

ADULT; AGED; AGING; BLOOD VOLUME; BRAIN ATROPHY; BRAIN HEMORRHAGE; CONFERENCE PAPER; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DEATH; DEHYDRATION; DEMYELINATING DISEASE; DIURESIS; FLUID INTAKE; GLOMERULUS FILTRATION RATE; HUMAN; HYPERLIPIDEMIA; HYPERNATREMIA; HYPERTENSION; HYPONATREMIA; HYPOVOLEMIA; KIDNEY FAILURE; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MUSCLE MASS; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; SODIUM BLOOD LEVEL; SODIUM LOAD; SODIUM METABOLISM; THIRST; WATER LOSS; WATER METABOLISM; WATER RETENTION;

EID: 0030483025     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/11.supp9.9     Document Type: Conference Paper

References (113)

1. Lindeman RD. Renal physiology and pathophysiology of aging. In: Berlyne GM, Giovannetti S, eds. Glomerulonephritis in the Elderly. Basel: Karger. Contrib Nephrol 1992; 1-12
2. Forbes GB, Reina JC. Adult lean body mass declines with age: some longitudinal observations. Metabolism 1970; 19: 653-663
3. Edelman IS, Leibman J. Anatomy of body water and electrolytes. Am J Med 1959; 27: 256-260
4. Macías-Núñez JF. Special considerations in the management of fluid and electrolyte disturbances in the elderly. Int Yearbook Nephrol Dial Transpl 1996. Oxford: Oxford University Press (in press)
5. Cohn JE, Shock NW. Blood volume studies in middle aged and elderly males. Am J Med Sci 1949; 217: 388-391
6. Chien S, Usami S, Simmons RL. Blood volume and age: repeated measurements on normal men. J Appl Physiol 1966; 21: 583-588
7. Lindeman RD, Van Buren HC, Raisz LG. Osmolar renal concentrating ability in healthy young men and hospitalized patients without renal disease. N Engl J Med 1960; 262: 1396-1309
8. Dontas AS, Marketos S, Papanayioutou P. Mechanisms of renal tubular defects in old age. Postgr Med J 1972; 48: 295-303
9. Phillips PA et al. Reduced thirst after water deprivation in healthy elderly men. N Engl J Med 1984; 311: 753-759
10. Editorial: thirst and osmoregulation in the elderly. Lancet 1984; ii: 1017-1018
11. Hugonot R, Dubos G, Mathes G. Étude experimental des troubles de la soif du veillard. Rev Gériat 1978; 4: 179-191
12. Sica DA, Harford A. Sodium and water diserders in the elderly. In: Zawada ET Jr, Sica DA. Geriatric Nephrology and Urology. Littleton, MA: PSG, 1985: 127-156
13. Miller PD, Krebs RA, Neal BJ et al. Hypodipsia in geriatric patients. Am J Med 1982; 73: 354-357
14. Rowe JW, Minaker KL, Sparrow D et al. Age-related failure of volume-pressure-mediated vasopressin release. J Clin Endocrinol Metab 1982; 54: 661-664
15. Kirkland J, Lye M, Goddard et al. Plasma arginine vasopressin in dehydrated elderly patients. Clin Endocrinol 1984; 20: 451-456
16. Shannon RP, Minaker KL, Rowe JW. Aging and water balance in humans. Semin Nephrol 1984; 4: 346-353
17. Rowe JW, Shock NW, De Fronzo RA. The influence of age on the renal response to water deprivation in man. Nephron 1976; 17: 270-278
18. Kirkland JL, Lye M, Levy DW, Banerjee AK. Patterns of urine flow and electrolyte secretion in healthy elderly people. Br Med J 1983; 285: 1665-1667
19. Macias-Núñez JF, Iglesias CG, Roman AB et al. Renal handling of sodium in old people: a functional study. Age Ageing 1978; 7: 178-181
20. Takazakura E, Sawabu N, Handa A et al. Intrarenal vasculature changes with age and disease. Kidney Int 1972; 2: 224-230
21. Hollenberg NK, Adams DF, Solomon HS et al. Senescenze and the renal vasculature in normal man. Circ Res 1974; 34: 309-316
22. Kleeman CR. Water metabolism. In: Maxwell MH, Kleeman CR, eds. Clinical Disorders of Fluid and Electrolyte Balance. New York: McGraw-Hill, 1972: 697
23. Yamada T, Endo T, Ito K, Nagata H, Izumiyama T. Age-related changes in endocrine and renal function in patients with essential hypertension. J Am Geriatr Soc 1979; 27: 280-292
24. Hiraide K. Alterations in electrolytes with aging. Nihon Univ J Med 1981; 23: 21-31
25. Bengele HN, Mathias RS, Alexander EA. Impaired natriuresis after volume expansion in the aged rat. Renal Physiol 1981; 4; 22-29
26. Hackbarth H, Harrison DE. Changes with age in renal function and morphology in C57BL/6, CBA/HT6, and B6CBAFI mice. J Gerontol 1982; 37: 540-547
27. Myers J, Morgan T, Waga S, Manley K. The effect of sodium intake on blood pressure related to the age of the patients. Clin Exp Pharmacol Physiol 1982; 9: 287-289
28. Epstein M, Hollenberg NH. Age as a determinant of renal sodium conservation in normal man. J Lab Clin Med 1976; 87: 411-417
29. Meyer BR. Renal function in ageing. J Am Geriatr Soc 1989; 37: 791-800
30. Fish LC, Murphy DJ, Elahi D, Minaker KL. Renal sodium excretion in normal aging: decreased excretion rates lead to delayed sodium excretion in normal aging. J Geriatric Nephrol Urol 1994; 4: 145-151
31. Flood C, Gerondache C, Pincus G, Tait JF, Tait SAS, Willoughby S. The metabolism and secretion of aldosterone in elderly subjects. J Clin Invest 1967; 46: 960-966
32. Crane M, Harris JJ. Effect of aging on renin activity and aldosterone excretion. J Lab Clin Med 1976; 87: 947-959
33. Weidmann P et al. Interrelations between age and plasma renin, aldosterone and cortisol, urinary cathecholamines, and the sodium/volume state in normal man. Klin Wschr 1977; 55: 723-733
34. Haller BGD, Zust H, Shaw S, Gnadinger MP, Uehlinger DE, Weidmann P. Effects of posture and ageing on circulating atrial natriuretic peptide levels in man. J Hypertension 1978; 5: 551-556
35. Heim JM, Gottmann K, Weil J, Stron TM, Gerzer R. Effects of a bolus of atrial natriuretic factor in youg and elderly volunteers. Eur J Clin Invest 1989; 19: 265-271
36. Fulöp T, Wörum I, Csöngor J, Foris G, Leóvey A. Body composition in elderly people. Gerontology 1985; 31: 6-14
37. Naylor GJ. The relationship between age and sodium metabolism in human erythrocytes. Gerontologia 1970; 16: 217-222
38. Nagaki J, Teraoka M. Age and sex differences of sodium and potassium concentration in red blood cells. Clin Chim Acta 1976; 66: 453-455
39. Cumberbatch M, Morgan DB. Relations between sodium transport and sodium concentration in human erythrocytes in health and disease. Clin Sci 1981; 60: 555-564
40. Cox JR, Shalaby WA. Potassium changes with age. Gerontolgoy 1981; 27: 340-344
41. Ibrahim IK, Ritch AES, McLennan WJ, May T. Are potassium supplements for the elderly necessary? Age Ageing 1978; 7: 165-170
42. Roberts LB. The normal ranges, with statistical analysis for seventeen blood constituents. Clin Chim Acta 1967; 16: 69-78
43. Leask RG, Andrews GR, Caird FI. Normal values for sixteen blood constituents in the elderly. Age Ageing 1973; 2: 14-23
44. Solomon LR, Lye M. Hypernatraemia in the elderly patient. Gerontology 1990; 36: 171-179
45. Mahowald JM, Himmelstein DU. Hypernatremia in the elderly: relation to infection and mortality. J Am Geriatr Soc 1981; 29: 177-180
46. Himmelstein DU, Jones AA, Woolhandler S. Hypernatremic dehydration in nursing home patients. J Am Geriatr Soc 1983; 31: 466-471
47. Richardson RMA. Fluid and electrolyte disorders in the elderly. In: Oreopoulos DG, ed. Geriatric Nephrology. Boston, MA: Martinus Nijhoff, 1986: 27-36
48. Sterns RH, Thomas DJ, Herndon RM: Brain dehydration and neurologic deterioration after rapid correction of hyponatremia. Kidney Int 1989; 35: 69-75
49. Sterns RH: The Management of symptomatic hyponatremia. Semin Nephrol 1990; 10: 503-514
50. Sterns RH, Spital A: Disorders of water balance. In: Kokko JP, Tannen RL, eds. Fluids and Electrolytes. Philadelphia: Saunders, 1990: 139-194
51. Sterns RH. Central nervous system complications of severe hyponatremia. In: Andreucci VE and Leon G, Fine LG, eds. International Yearbook of Nephrology 1992. London: Springer-Verlag, 1992: 55-74
52. Ross EJ, Christie SBM: Hypernatremia. Medicine 1969; 48: 441-473
53. Solomon LR, Sangster G, Lye M. Hyponatremia in the elderly patient. Geriatr Nephrol Urol 1992; 2: 63-74
54. Roberts MM, Robinson AG, Hyponatremia in the elderly: diagnosis and management. Geriatric Nephrol Urol 1993; 3: 43-50
55. Kleinfeld M, Casimir M, Borra S. Hyponatremia as observed in a chronic disease facility. J Am Geriatr Soc 1979; 27: 156-161
56. Flear CT, Gill GV. Hyponatremia: mechanisms and management. Lancet 1981; ii: 26-31
57. Sunderam SG, Mankikar GD. Hyponatremia in the elderly Age Ageing 1983; 12: 77-80
58. Rothenberg DM, Berns AS, Ivankovich AD: Isotonic hyponatremia following transurethral prostate resection. J Clin Anesth 1990; 2: 48-49
59. Halperin ML, Goldstein MB, Bear RA, Josse RG. Diabetic comas. In: Arieff AI and De Fronzo RA, eds. Fluid and Electrolyte and Acid-base Disorders. New York: Churchill Livingstone, 1985: 933-968
60. Arieff AI, Llach F, Massry SG: Neurologic manifestations and morbidity of hyponatremia: correlation with brain water and electrolytes. Medicine 1976; 55: 121-129
61. Thurston JH, Hauhart RE, Nelson JS: Adaptive decreases in amino acids (taurine in particular) creatine, and electrolytes prevent cerebral edema in hyponatremic mice. Rapid correction (experimental model of central pontine myelinolysis) causes dehydration and shrinkage of brain. Metab Brain Dis 1987; 2: 233-241
62. Lien YH, Shapiro JI, Chan L: Effects of hypernatremia on organic brain osmoles. J Clin Invest 1990; 85: 1427
63. Cluitsman FHM, Meinders AE. Management of severe hyponatremia: rapid or slow correction? Am J Med 1990; 88: 161-166
64. Sterns RH. Severe symptomatic hyponatremia: treatment and outcome. Ann Intern Med 1987; 107: 656-664
65. Sterns RH, Riggs JE, Schochet SS Jr. Osmotic demyelination syndrome following correction of hyponatremia. N Engl J Med 1986; 314: 1535-1542
66. Tomlinson BE, Pierides AM, Braddley WG. Central pontine myelinolysis. Q J Med 1976; 45: 373-386
67. Kleinschmidt-DeMasters BK, Norenberg MD. Rapid correction of hyponatremia causes demyelination: relation to central pontine myelinolysis. Science 1981; 211: 1068-1070
68. Laureno R. Central pontine myelinolysis following rapid correction of hyponatremia. Ann Neurol 1983; 13: 232-242
69. Norenberg MD, Leslie KO, Robertson AS. Association between rise in serum sodium and central pontine myelinolysis. Ann Neurol 1983; 40: 66-69
70. Hazratji SMA, Kim RC, Lee SH, Marasigan AV. Evolution of pontine and extrapontine myelinolysis. J Comput Assist Tomogr 1983; 7: 356-361
71. DaCunha C, Bertorini TE, Lawrence J, Witherington ? Central pontine myelinolysis - a preventable condition. J Tenn Med Assoc 1986; 79: 469-472
72. Boon AP, Potter AE. Extensive extrapontine and central pontine myelinolysis associated with correction of profound hyponatremia. Neuropathol Appl Neurobiol 1987; 13: 1-9
73. Gerard E, Healy ME, Hesselink JR. MR demonstration of mesencephalic lesions in osmotic demyelination syndrome (central pontine myelinolysis). Neuroradiology 1987; 29: 582-584
74. Walker JV, Englander RN. Central pontine myelinolysis following rapid correction of hyponatremia in an alcoholic. Am J Kidney Dis 1988; 12: 531-533
75. Miller GM, Baker HL Jr, Okazaki H, Whisnant JP Central pontine myelinolysis and its imitators: MR findings. Radiology 1988; 168: 795-802
76. Laureno R, Karp BI. Pontine and extrapontine myelinolysis following rapid correction of hyponatremia. Lancet 1988; i: 1439-1441
77. Sterns RH. Neurologic deterioration following treatment for hyponatremia. Am J Kidney Dis 1989; 13: 434-437
78. Wright DG, Laureno R, Victor M. Pontine and extrapontine myelinolysis. Brain 1989; 102: 361-385
79. Clifford DB, Gado MH, Levy BK. Osmotic demyelination syndrome. Lack of pathologic and radiologic imaging correlation. Arch Neurol 1989; 46: 343-347
80. Brunner JE, Redmond JM, Haggar AM, Kruger MSN, Elias S. Central pontine myelinolysis and pontine lesions after rapid correction of hyponatremia: a prospective magnetic imaging study. Ann Neurol 1990; 27: 61-66
81. Berl T. Treating hyponatremia: damned if we do and damned if we don't. Kidney Int 1990; 37: 1006-1018
82. Abramow M, Cogan E. Clinical aspects and pathophysiology of diuretic-induced hyponatremia. Adv Nephrol 1984; 13: 1-28
83. Videbaek A, Ackermann PG. The potassium content of plasma red cells in various age groups. J Gerontol 1953; 8: 63-64
84. Dall JLC, Gardiner NS. Dietary intake of potassium by geriatric patients. Gerontol Clin 1971; 13: 119-124
85. Burini R, Da Silva CA, Ribeiro MAC, Campana AD. Concentracão de sodio e de potassio no soro e plasma de individuos normais. Influencia da idade, do sexo e do sistema de colheita do sangue sobre os resultados. Rev Hosp Clin Facul Med São Paulo 1973: 28: 9-14
86. Lowenthal DT. Vulnerability to hyperkalemia. J Geriatric Nephrol Urol 1994; 4: 121-125
87. Dali JLC, Paulose S, Fergusson JA. Potassium intake of elderly patients in hospital. Gerontol Clin 1971; 13: 114-118
88. Kromhout D, Broberg U, Carlmark B, Karlsson S, Nisell O, Reizenstein P. Potassium depletion and ageing. Comprehensive Therap 1977; 3: 32-37
89. Young VR. Protein and aminoacid catabolism and nutrition during human aging. In: Platt D, ed. Geriatrics. New York: Springer-Verlag, 1983: 393-416
90. Allen TN, Anderson EC, Langham WH. Total body potassium and gross body composition in relation to age. J Gerontol 1960; 15: 348-357
91. Molaschi M, Molaschi ES. Correlazione tra metabolismo del potassio, funzionalità renale ed invecchiamento nell'uomo. Giorn Gerontol 1974; 22: 241-250
92. Cohn SN, Vaswani A, Zanzi I, Aloia JF, Roginsky MS, Ellis HJ. Changes in body chemical composition with age measured by total body neutron activation. Metabolism 1976; 25: 85-96.
93. Rajagopalan B, Thomas GW, Beilin LJ, Ledingham JGG. Total body potassium falls with age. Clin Sci 1980; 59: 427s-429s
94. Lye M. Distribution of body potassium in healthy elderly subjects. Gerontology 1981; 27: 286
95. Davies L, Hastrop K, Bender AE. Potassium intake of the elderly. Mod Geriatr 1973; 4: 482-488
96. Abdulla M, Jagerstad M, Norden A, Thulin T, Svensson S. Nutrition and old age. Sodium. Scand J Gastroenterol 1979; 14: 138-142
97. Systolic Hypertension in the Elderly Program Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. J Am Med Assoc 1991; 265: 3255-3264
98. Systolic Hypertension in the Elderly Program Cooperative Research Group. Implications of the systolic hypertension in the elderly program. Hypertension 1993; 21: 335-343
99. Mann SJ. Systolic hypertension in the elderly. Pathophysiology and management. Arch Intern Med 1992; 152: 1977-1984
100. Monane M, Glynn RJ, Gurwitz JH, Bohn RL, Levin R, Avorn J. Trends in medication choices for hypertension in the elderly: the decline of the thiazides. Hypertension 1995; 25: 1045-1051
101. MRC Working Party. Medical Research Council trial of treatment of hypertension in older adults: principal results. Br Med J 1992; 304: 405-411
102. Andreasen F, Hansen V, Husted SE, Magensen CE, Pedersen EB. The influence of age on renal and extrarenal effects of furosemide. Br J Clin Pharmacol 1984; 18: 65-74
103. Beard K, Bulpitt C, Mascie-Taylor H, O'Malley K, Sever P, Webb S. Management of elderly patients with sustained hypertension. Br Med J 1992; 304: 412-416
104. Guidlines Subcommittee of the WHO/ISH Mild Hypertension Liaison Committee. 1993 Guidlines for the management of mild hypertension. Memorandum from a World Health Organization/ International Society of Hypertension Meeting. Hypertension 1993; 22: 392-403
105. Ramsay LE, Yeo WW, Jackson PR. Thiazide diuretics: first-line therapy for hypertension. Curr Sci 1992; 10 (Suppl 3): S29-S33.
106. Weber E. Clinical pharmacology of antihypertensive drug therapy. In: Rosenthal S., ed. Arterial Hypertension. London: Springer-Verlag, 1982: 446-463
107. Russo D, Gazzotti MR, Testa A: Torasemide, a new loop diuretic, in patients with chronic renal failure. Nephron 1990; 55: 141-145.
108. Andreucci VE, Russo D, Memoli B, Testa A, Rampino T, Gazzotti RM. Efficacy of i.v. torasemide in the treatment of acute and chronic high grade renal failure. Prog Pharmacol Clin Pharmacol 1990; 8: 229-238
109. Andreucci VE, Russo D. The use of loop diuretics in chronic renal failure: positive effects and drawbacks. In Progress in Pharmacology and Clinical Pharmacology. Stuttgart: Gustav Fischer Verlag, 1992: vol 9, 577-595
110. Russo D, Memoli B, Andreucci VE: The place of loop diuretics in the treatment of acute and chronic renal failure. Clin Nephrol 1992; 38: S69-S73
111. Russo D, Minutolo R, Andreucci VE: Role of loop diuretics in chronic renal failure. Cardiology 1994; 84: 162-170
112. Dunn CJ, Fitton A, Brogden RN. Torasemide: an update of its pharmacological properties and therapeutic efficacy. Drugs 1995; 49: 121-142
113. Reyes AJ, Chiesa PD, Santucci MR, Batista LB, Olhaberry JV, Mosler AL, Mignone AM, Leary WP, Queiruga G. Hydro- chlorothiazide versus a non-diuretic dose of torasemide as once-daily antihypertensive monopharmacotherapy in elderly patients. A randomized and double-blind study. In: Kruck F, Mutschler E and Knauf H, eds. Torasemide: clinical pharmacology and therapeutic applications. Progr. Pharmacol Clin Pharmacol 1990; 8: 183-209