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of special interest. This is an excellent review which chronicles the recent expansion in small-molecule library development and solid-phase chemistry.
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Thompson LA, Ellman JA. Synthesis and applications of small molecule libraries. of special interest Chem Rev. 96:1996;555-600 This is an excellent review which chronicles the recent expansion in small-molecule library development and solid-phase chemistry.
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Krchnák V, Lebl M. Synthetic library techniques-subjective (biased and generic) thoughts and views. Mol Divers. 1:1996;193-216.
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Lebl M, Pátek M, Kocis P, Krchnák V, Hruby VJ, Salmon SE, Lam KS. Multiple release of equimolar amounts of peptides from a polymeric carrier using orthogonal linkage-cleavage chemistry. Int J Peptide Protein Res. 41:1993;201-211.
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Weinberger H, Lichte E, Griesinger C, Kutscher B. Small peptide libraries - combinatorial split-mix synthesis followed by combinatorial amino acid analysis of selected variants. Archiv der Pharmazie. 330:1997;109-111.
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Weinberger, H.1
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Demirev PA, Zubarev RA. Probing combinatorial library diversity by mass spectrometry. Anal Chem. 69:1997;2893-2900.
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Demirev, P.A.1
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0029841811
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Chu YH, Dunayeskiy YM, Kirby DP, Vouros P, Karger BL. Affinity capillary electrophoresis-mass spectrometry for screening combinatorial libraries. J Am Chem Soc. 118:1996;7827-7835.
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Chu, Y.H.1
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Kaur S, Meguire L, Tang DZ, Dollinger G, Huebner V. Affinity selection and mass spectrometry-based strategies to identify lead compounds in combinatorial libraries. J Prot Chem. 16:1997;505-511.
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Kaur, S.1
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10
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Lam K, Lebl M, Krchnák V. The 'one-bead-one-compound' combinatorial library method. Chem Rev. 97:1997;411-448.
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Lam, K.1
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12
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Infrared spectrum of a single resin bead for real-time monitoring of solid-phase reactions
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Yan B, Kumaravel G, Anjaria H, Wu A, Petter R, Jewell CF Jr, Wareing JR. Infrared spectrum of a single resin bead for real-time monitoring of solid-phase reactions. J Org Chem. 60:1995;5736-5738.
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Yan, B.1
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Wareing, J.R.7
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13
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0030066941
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Probing solid-phase reactions by monitoring the IR bands of compounds on a single 'flattened' resin bead
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of special interest. This article describes a routine and general method for analyzing reaction progress, in real-time, on solid-phase.
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Yan B, Kumaravel G. Probing solid-phase reactions by monitoring the IR bands of compounds on a single 'flattened' resin bead. of special interest Tetrahedron. 52:1996;843-848 This article describes a routine and general method for analyzing reaction progress, in real-time, on solid-phase.
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Tetrahedron
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Yan, B.1
Kumaravel, G.2
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14
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0000014238
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Progression of organic reactions on resin supports monitored by single bead FTIR microspectroscopy
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Yan B, Fell JB, Kumaravel G. Progression of organic reactions on resin supports monitored by single bead FTIR microspectroscopy. J Org Chem. 61:1996;7467-7472.
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J Org Chem
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Yan, B.1
Fell, J.B.2
Kumaravel, G.3
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15
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85030305419
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Tools for combinatorial chemistry
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I.M. Chaiken, Janda K.D. Washington DC: ACS Conference Proceeding Series
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Russell K, Cole DC, McLaren FM, Pivonka DE. Tools for combinatorial chemistry. Chaiken IM, Janda KD. Molecular Diversity and Combinatorial Chemistry Libraries and Drug Discovery. 1996;246-254 ACS Conference Proceeding Series, Washington DC.
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Molecular Diversity and Combinatorial Chemistry Libraries and Drug Discovery
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Russell, K.1
Cole, D.C.2
McLaren, F.M.3
Pivonka, D.E.4
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17
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0000055405
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Anderson RC, Jarema MA, Shapiro MJ, Stokes JP, Ziliox M. Analytical techniques in combinatorial chemistry: MAS CH correlation in solvent-swollen resin. J Org Chem. 60:1995;2650-2651.
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Anderson, R.C.1
Jarema, M.A.2
Shapiro, M.J.3
Stokes, J.P.4
Ziliox, M.5
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18
-
-
85030306900
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Magic-angle spinning NMR spectroscopy of polystyrene-bound organic molecules
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I.M. Chaiken, Janda K.D. Washington DC: ACS Conference Proceeding Series
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Dhalluin C, Pop I, Déprez B, Melnyk P, Tartar A, Lippins G. Magic-angle spinning NMR spectroscopy of polystyrene-bound organic molecules. Chaiken IM, Janda KD. Molecular Diversity and Combinatorial Chemistry Libraries and Drug Discovery. 1996;256-272 ACS Conference Proceeding Series, Washington DC.
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Molecular Diversity and Combinatorial Chemistry Libraries and Drug Discovery
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Dhalluin, C.1
Pop, I.2
Déprez, B.3
Melnyk, P.4
Tartar, A.5
Lippins, G.6
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19
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0030038838
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Approaches to combinatorial synthesis of heterocycles: A solid-phase synthesis of 1,4-dihydro-pyridines
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Gordeev MF, Patel DV, Gordon EM. Approaches to combinatorial synthesis of heterocycles: a solid-phase synthesis of 1,4-dihydro-pyridines. J Org Chem. 61:1996;924-928.
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Gordeev, M.F.1
Patel, D.V.2
Gordon, E.M.3
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20
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0030252750
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Houghten RA, Blondelee SE, Dooley CT, Dorner B, Eichler J, Ostresh JM. Libraries from libraries-generation and comparison of screening profiles. Mol Divers. 2:1996;41-45.
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Mol Divers
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Houghten, R.A.1
Blondelee, S.E.2
Dooley, C.T.3
Dorner, B.4
Eichler, J.5
Ostresh, J.M.6
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21
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0030184108
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Highly specific cross-reactive sequences recognized by an anti-hbsag antibody identified from a positional scanning synthetic combinatorial library
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Appel JR, Muller S, Benkirane N, Houghten RA, Pinilla C. Highly specific cross-reactive sequences recognized by an anti-hbsag antibody identified from a positional scanning synthetic combinatorial library. Peptide Res. 9:1996;174-182.
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Appel, J.R.1
Muller, S.2
Benkirane, N.3
Houghten, R.A.4
Pinilla, C.5
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22
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0010587872
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Indexed combinatorial libraries: Nonoligomeric chemical diversity for the discovery of novel enzyme inhibitors
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A.W. Czarnik, Wilson S.R. New York: John Wiley & Sons
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Pirrung MC, Chau JH-L, Chen J. Indexed combinatorial libraries: nonoligomeric chemical diversity for the discovery of novel enzyme inhibitors. Czarnik AW, Wilson SR. Combinatorial Chemistry: Synthesis and Application. 1997;191-206 John Wiley & Sons, New York.
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Combinatorial Chemistry: Synthesis and Application
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Pirrung, M.C.1
Chau Jh-L2
Chen, J.3
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23
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84989568285
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Synthetic methods for the implementation of encoded combinatorial libraries
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Nielsen J, Brenner S, Janda KD. Synthetic methods for the implementation of encoded combinatorial libraries. J Am Chem Soc. 115:1993;9812-9813.
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J Am Chem Soc
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Nielsen, J.1
Brenner, S.2
Janda, K.D.3
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24
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0029109073
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Youngquist RS, Fuentes GR, Lacey MP, Keough T. Generation and screening of combinatorial peptide libraries designed for rapid sequencing by mass spectroscopy. J Am Chem Soc. 117:1995;3900-3906.
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Youngquist, R.S.1
Fuentes, G.R.2
Lacey, M.P.3
Keough, T.4
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25
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0027362628
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Complex synthetic chemical libraries indexed with molecular tags
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Ohlmeyer MHJ, Swanson RN, Dillard LW, Reader JC, Asouline G, Kobayashi R, Wigler M, Still WC. Complex synthetic chemical libraries indexed with molecular tags. Proc Natl Acad Sci USA. 90:1993;10922-10926.
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Ohlmeyer, M.H.J.1
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Asouline, G.5
Kobayashi, R.6
Wigler, M.7
Still, W.C.8
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26
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80052130082
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Isotope or mass encoding of combinatorial libraries
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Geysen HM, Wagner CD, Bodnar WM, Markworth CJ, Parke GJ, Schoenen FJ, Wagner DS, Kinder DS. Isotope or mass encoding of combinatorial libraries. Chem Biol. 3:1996;679-688.
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Geysen, H.M.1
Wagner, C.D.2
Bodnar, W.M.3
Markworth, C.J.4
Parke, G.J.5
Schoenen, F.J.6
Wagner, D.S.7
Kinder, D.S.8
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27
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33748243831
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Int Ed Engl
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Nicolaou KC, Xiao X-Y, Parandoosh Z, Senyei A, Nova MP. Radiofrequency encoded combinatorial chemistry. Int Ed Engl Angew Chem. 34:1995;2289-2291.
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Nicolaou, K.C.1
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Nova, M.P.5
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28
-
-
18844442544
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Microchip encoded combinatorial libraries-generation of a spatially encoded library from a pool synthesis
-
of special interest. Radiofrequency encoding of beads may potentially solve most of the problems of library deconvolution. This article describes its application in the construction and analysis of a 64 membered library
-
Armstrong RW, Tempest PA, Cargill JF. Microchip encoded combinatorial libraries-generation of a spatially encoded library from a pool synthesis. of special interest Chimia. 50:1996;258-260 Radiofrequency encoding of beads may potentially solve most of the problems of library deconvolution. This article describes its application in the construction and analysis of a 64 membered library.
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Chimia
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, pp. 258-260
-
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Armstrong, R.W.1
Tempest, P.A.2
Cargill, J.F.3
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29
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0002211643
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Combinatorial synthesis exploiting mutiple-component condensations, microchip encoding, and resin capture
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A.W. Czarnik, Wilson S.R. New York: John Wiley & Sons
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Armstrong RW, Brown DS, Keating TA, Tempest PA. Combinatorial synthesis exploiting mutiple-component condensations, microchip encoding, and resin capture. Czarnik AW, Wilson SR. Combinatorial Chemistry: Synthesis and Application. 1997;177-180 John Wiley & Sons, New York.
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Combinatorial Chemistry: Synthesis and Application
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Armstrong, R.W.1
Brown, D.S.2
Keating, T.A.3
Tempest, P.A.4
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30
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0344035192
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Parallel organic synthesis using Parke-Davis Diversomer technology
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A.W. Czarnik, Wilson S.R. New York: John Wiley & Sons
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Hobbs Dewitt S, Czarnik AW. Parallel organic synthesis using Parke-Davis Diversomer technology. Czarnik AW, Wilson SR. Combinatorial Chemistry: Synthesis and Application. 1997;25-38 John Wiley & Sons, New York.
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Combinatorial Chemistry: Synthesis and Application
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Hobbs Dewitt, S.1
Czarnik, A.W.2
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31
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0030893775
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Synthesis and evaluation of a library of peptidomimetics based upon the β-turn
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Virgilio AA, Bray AA, Zhang W, Trinh L, Snyder M, Morrissey MM, Ellman JA. Synthesis and evaluation of a library of peptidomimetics based upon the β-turn. Tetrahedron. 53:1997;6635-6644.
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Tetrahedron
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Virgilio, A.A.1
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Zhang, W.3
Trinh, L.4
Snyder, M.5
Morrissey, M.M.6
Ellman, J.A.7
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32
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0028458878
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Maeji NJ, Valerio RM, Bray AM, Campbell RA, Geysen HM. Grafted supports used with the multipin method of peptide-synthesis. Reactive Polymers. 22:1994;203-212.
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Reactive Polymers
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Maeji, N.J.1
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Campbell, R.A.4
Geysen, H.M.5
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33
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0031098534
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Organic synthesis on soluble polymer supports: Liquid-phase methodology
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of special interest. This review describes the evolution of soluble-polymer supports in organic synthesis and combinatorial chemistry. As more limitations become apparant with solid-phase polymer supports, liquid-phase alternatives may offer a number of potential advantages.
-
Gravert DJ, Janda KD. Organic synthesis on soluble polymer supports: liquid-phase methodology. of special interest Chem Rev. 97:1997;489-509 This review describes the evolution of soluble-polymer supports in organic synthesis and combinatorial chemistry. As more limitations become apparant with solid-phase polymer supports, liquid-phase alternatives may offer a number of potential advantages.
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Chem Rev
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, pp. 489-509
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Gravert, D.J.1
Janda, K.D.2
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34
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0030252431
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Liquid-phase combinatorial synthesis: In search of small-molecule enzyme mimics
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Vandersteen A, Han H, Janda KD. Liquid-phase combinatorial synthesis: in search of small-molecule enzyme mimics. Mol Divers. 2:1996;89-96.
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Mol Divers
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Vandersteen, A.1
Han, H.2
Janda, K.D.3
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35
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0344035191
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Soluble polymer supports for liquid phase synthesis
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Geckeler KE. Soluble polymer supports for liquid phase synthesis. Biopolymers. 35:1995;32-79.
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Biopolymers
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Geckeler, K.E.1
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Bayer E, Mutter M. Liquid-phase synthesis of peptides. Nature. 237:1972;512-513.
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Nature
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Bayer, E.1
Mutter, M.2
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37
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0029074627
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Liquid-phase combinatorial synthesis
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of special interest. This article is the first to report a soluble-polymer supported combinatorial library and opens up a whole new area of combinatorial chemistry research.
-
Han H, Wolfe MM, Brenner S, Janda KD. Liquid-phase combinatorial synthesis. of special interest Proc Natl Acad Sci USA. 92:1995;6419-6423 This article is the first to report a soluble-polymer supported combinatorial library and opens up a whole new area of combinatorial chemistry research.
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Proc Natl Acad Sci USA
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, pp. 6419-6423
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Han, H.1
Wolfe, M.M.2
Brenner, S.3
Janda, K.D.4
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38
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Han H, Janda KD. Solution and liquid-phase synthesis of a new peptidomimetic. J Am Chem Soc. 118:1996;2539-2544.
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J Am Chem Soc
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Han, H.1
Janda, K.D.2
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39
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0002211643
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Combinatorial synthesis exploiting mutiple-component condensations, microchip encoding, and resin capture
-
A.W. Czarnik, Wilson S.R. New York: John Wiley & Sons
-
Armstrong RW, Brown DS, Keating TA, Tempest PA. Combinatorial synthesis exploiting mutiple-component condensations, microchip encoding, and resin capture. Czarnik AW, Wilson SR. Combinatorial Chemistry: Synthesis and Application. 1997;180-186 John Wiley & Sons, New York.
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Combinatorial Chemistry: Synthesis and Application
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Armstrong, R.W.1
Brown, D.S.2
Keating, T.A.3
Tempest, P.A.4
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40
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0029963887
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Postcondensation modifications of the Ugi four-component condensation products: 1-isocyano-cyclohexene as a convertible isocyanide. Mechanism of conversion, synthesis of diverse structures, and demonstration of resin capture
-
of special interest. This article is the seminal report outlining solution-based synthesis followed by solid-phase purification - resin-capture.
-
Keating TA, Armstrong RW. Postcondensation modifications of the Ugi four-component condensation products: 1-isocyano-cyclohexene as a convertible isocyanide. Mechanism of conversion, synthesis of diverse structures, and demonstration of resin capture. of special interest J Am Chem Soc. 118:1996;2574-2583 This article is the seminal report outlining solution-based synthesis followed by solid-phase purification - resin-capture.
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J Am Chem Soc
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, pp. 2574-2583
-
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Keating, T.A.1
Armstrong, R.W.2
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41
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0030062225
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Synthesis of tetrasubstituted ethylenes on solid support via resin capture
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Brown SD, Armstrong RW. Synthesis of tetrasubstituted ethylenes on solid support via resin capture. J Am Chem Soc. 118:1996;6331-6332.
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J Am Chem Soc
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Brown, S.D.1
Armstrong, R.W.2
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42
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1842713260
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Poly(ethylene glycol) (PEG) as a reagent support: The preparation and utility of a PEG-triarylphosphine conjugate in liquid-phase organic synthesis (LPOS)
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Wentworth P Jr, Vandersteen AM, Janda KD. Poly(ethylene glycol) (PEG) as a reagent support: the preparation and utility of a PEG-triarylphosphine conjugate in liquid-phase organic synthesis (LPOS). Chem Commun. 1997;759-760.
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Chem Commun
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Wentworth P., Jr.1
Vandersteen, A.M.2
Janda, K.D.3
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43
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Booth RJ, Hodges JC. Polymer-supported quenching reagents for parallel purification. J Am Chem Soc. 119:1997;4882-4886.
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J Am Chem Soc
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Booth, R.J.1
Hodges, J.C.2
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44
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0030952762
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Chemical library purification strategies based on principles of complementary molecular reactivity and molecular recognition
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of special interest. With the expansion in solution-based combinatorial synthesis new methods are required for purification of unwanted components of mixtures. This article describes an elegant approach utilizing resin-supported reagents to the these impurities via a range of methodologies.
-
Flynn DL, Crich JZ, Devraj RV, Hockerman SL, Parlow JJ, South MS, Woodward S. Chemical library purification strategies based on principles of complementary molecular reactivity and molecular recognition. of special interest J Am Chem Soc. 119:1997;4874-4881 With the expansion in solution-based combinatorial synthesis new methods are required for purification of unwanted components of mixtures. This article describes an elegant approach utilizing resin-supported reagents to the these impurities via a range of methodologies.
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(1997)
J Am Chem Soc
, vol.119
, pp. 4874-4881
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-
Flynn, D.L.1
Crich, J.Z.2
Devraj, R.V.3
Hockerman, S.L.4
Parlow, J.J.5
South, M.S.6
Woodward, S.7
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