Protein kinase C in the developing kidney: Isoform expression and effects of ceramide and PKC inhibitors

Kidney International

Volumn 52, Issue 4, 1997, Pages 901-910

  Serlachius, Eva ^b   Svennilson, Johan ^b   Schalling, Martin ^b   Aperia, Anita ^a  

^a ST GÖRAN S HOSPITAL   (Sweden)

^b NONE

Author keywords

Apoptosis; DNA synthesis; Fetal kidney; Growth; Kidney development; Metanephrie mesenchyme; Nephrogenesis; Protein kinase C

Indexed keywords

PROTEIN KINASE C INHIBITOR; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; DISEASE ASSOCIATION; ENZYME INHIBITION; FETUS; GENE EXPRESSION; KIDNEY DEVELOPMENT; KIDNEY PROXIMAL TUBULE; NEPHRON; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0030752645     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1997.411     Document Type: Article

References (38)

1. SAXÉN L: Organogenesis of the kidney. Cambridge, Cambridge University Press, 1987
2. KOSEKI C: Cell death programmed in uninduced metanephric mesenchymal cells. Pediatr Nephrol 7:609-611, 1993
3. MUMBY MC, WALTER G: Protein serine/threonine phosphatases: Structure, regulation, and functions in cell growth. Physiol Rev 73:673-699, 1993
4. NISHIZUKA Y: Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607-614, 1992
5. MISCHAK H, PIERCE JH, GOODNIGHT JA, KAZANIETZ MG, BLUMBERG PM, MUSHINSKI JF: Phorhol esther-induced myeloid differentitation is mediated by protein kinase C-α and -δ and not by protein kinase C-βII, -∈, -ζ and η. J Biol Chem 268:20110-20115, 1993
6. SZALLASI Z, KOSA K, SMITH CB, DLUGOSZ AA, WILLIAMS EK, YUSPA SH, BLUMBERG PM: Differential regulation by anti-tumor-promoting 12-deoxyphorbol-13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes. Mol Pharmacol 47:258-265. 1995
7. HOUSEY GM, JOHNSON MD, HSIAO WL, O'BRIAN CA, MURPHY JM, KIRSHMEIER P, WEINSTEIN IB: Overproduction of protein kinase C causes disordered growth control in rat fibroblasts. Cell 52:343-345, 1988
8. DONG L, STEVENS NS JL, FABBRO D, JAKEN S: Regulation of protein kinase C isozymes in kidney regeneration. Cancer Res 53:4542-4549, 1993
9. MISCHAK H, GOODNIGHT J, KOLCH W, MARTINY-BARON G, SCHAECHTLES C, KAZANIETZ MG, BLUMBERG PM, PIERCE JH, MUSHINSKI JF: Overexpression of protein kinase C-δ and -∈ in N1H 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem 268:6090-6096, 1993
10. BERRA E, DÍAZ-MECO MT, DOMÍNGUEZ I, MUNICIO MM, SANZ L, LOZANO J, CHAPKIN RS, MOSCAT J: Protein kinase ζ isoform is critical for mitogenic signal transduction. Cell 74:555-563, 1994
11. ÖSTLUND E, MENDEZ CF, JAKOBSSON G, FRYCKSTEDT J, MEISTER B, APERIA A: Expression of protein kinase C isoforms in renal tissue. Kidney Int 47:766-773, 1995
12. AKIMOTO K, MIZUNO K, OSADA S-I, HIRAI S-I, TANUMA S-I SUZUKI K, OHNO S: A new member of the third class in the protein kinase C family. PKCA, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells. J Biol Chem 269:12677-12683, 1994
13. MIDDLETON JP, KHAN WA, COLLINSWORTH G, HANNUN YA, MEDFORD RM: Heterogenity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem 268: 15958-15964, 1993
14. + -ATPase is an effector protein for protein kinase C in renal proximal tubular cells. Am J Physiol 261:F679-F687, 1989
15. HORIE S, MOE O, TYLER MILLER R, ALPERN RJ: Long-term activation of protein kinase C causes chronic Na/H antiporter stimulation in cultured proximal tubule cells. J Clin Invest 89:365-372, 1992
16. HANNUN YA, OBEID LM: Ceramide: An intracellular signal for apoptosis. TIBS 20:73-77, 1995
17. TOULLEC D, PIANETTI P, COSTE H, BELLEVERGUE P, GRAND-PERRET T, AJAKANE M, BAUDET V, BOISSIN P, BOURSIER E, LORIOLLE F, DUHAMEL L, CHARON D, KIRILOVSKY J: The bisindolylmalcimide GF 109203X is A potent and selective inhibitor of protein kinase C. J Biol Chem 266:15771-15781, 1991
18. WILKINSON SE, PARKER PJ, NIXON JS: Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J 294:335-337, 1993
19. KOBAYASHI E, NAKANO H, MORIMOTO M, TAMAOKI T: Calphostin C (UNC-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 159:548-553, 1989
20. ONO Y, FUJI T, IGARASHI K, KIKKAWA U, OGITA K, NISHIZUKA Y: Nucleotide sequences of cDNAs for α and γ subspecies of rat brain protein kinase C. Nucl Acids Res 16:5199-5200, 1988
21. ONO Y, FUJI T, OGITA K, KIKKAWA U, IGARSHI K, NISHIZUKA Y: The structure, expression and properties of additional members of the protein kinase C family. J Biol Chem 263:6927-6932, 1988
22. ONO Y, FUJI T, OGITA K, KIKKAWA U, IGARSHI K, NISHIZUKA Y: Protein kinase C ζ subspecies from rat brain: Its structure, expression, and properties. Proc Natl Acad Sci USA 86:3099-3103, 1989
23. OSADA S-I. MIZUNO K, SAIDO TC, AKITA Y, SUZUKI K, KUROKI T, OHNO S: A phorbol ester receptor/protein kinase, NPKCη, a new member of the protein kinase C family predominantly expressed in lung and skin. J Biol Chem 265:22434-22440, 1990
24. SVENNILSON J, DURBEEJ M, CELSI G, LAESTADIUS Å, DA CRUZ E SILVA EF, EKBLOM P, APERIA A: Evidence for a role of protein phosphatases 1 and 2A during early nephrogenesis. Kidney Int 48:103-110, 1995
25. RICHTER A, SANIFORD KK, EVANS VJ: Influence of oxygen and culture media on plating efficiency of some mammalian tissue cells. J Natl Cancer Inst 49:1705-1712, 1972
26. LARSSON SH, APERIA A, LECHENE C: Studies on final differentiation of rat renal proximal tubular cells in culture. Am J Physiol 251:C455-C464, 1986
27. LARSSON SH, FUKUDA Y, KÖLARE S, APERIA A: Proliferation and intracellular pH in cultured proximal tubular cells. Am J Physiol 258:F697-F704, 1990
28. COMPTON MM: A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome. Cancer Metastasis Rev 11:105-119, 1992
29. DUKE RC, CHERVENAK R, COHEN JJ: Endogenous endonuclease-inuced DNA fragmentation: An early event in cell-mediated cytolysis. Proc Natl Acad Sci USA 80:6361-6365, 1983
30. BRUNS RF, MILLLR FD, MERRIMAN RL, HOWBERT JJ, HEATH WF, KOBAYASHI E, TAKAHASHI I, TAMAOKI T, NAKANO H: Inhibition of protein kinase C by calphostin C is light-dependent, Biochem Biophys Res Commun 176:288-293, 1991
31. LUCAS M, SÁNCHEZ-MAGALET V, SANZ A, SOLANO F: Protein kinase C activation promotes cell survival in mature lymphocytes prone to apoptosis. Biochem Pharmacol 47:667-672, 1994
32. ILLERA VA, PERANDONES CE, STUNZ LL, DA, MOWER JR, ASHMAN RF: Apoptosis in splenic B lymphocytes. J Immnunol 151:2965-2973, 1993
33. CUVILLIER O, PIRIANOV G, KLEUSER B, VANEK PG, COSO OA, GUTKIND JS, SPIEGEL S: Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381:800-803, 1996
34. PUSHKAREVA M, OBEID LM, HANNUN YA: Ceramide: An endogenous regulator of apoptosis and growth suppression, Immnunol Today 16: 294-297, 1995
35. JONES MJ, MURRAY AW: Evidence that ceramide selectively inhibits protein kinase C-α translocation and modulates bradykinin activation of phospholipase D. J Biol Chem 270:5007-5013, 1995
36. LEE J, HANNUN YA, OBEID LM: Ceramide inactivates protein kinase C alpha. J Biol Chem 272:13169-13174, 1996
37. CELSI G, JAKOBSSON B, APERIA A: Influence of age on compensatory renal growth in rats. Pediatr Res 20:347-350, 1986
38. 2+ -independent isoform of protein kinase C in epithelial tissues, in association with epithelial differentiation. Cell Growth Differentiation 4:167-175, 1993