메뉴 건너뛰기




Volumn 50, Issue 3, 1998, Pages 645-651

A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; ANTIRETROVIRUS AGENT; CD4 ANTIGEN; MONOAMINE OXIDASE B INHIBITOR; PLACEBO; SELEGILINE; THIOCTIC ACID;

EID: 0344813768     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.50.3.645     Document Type: Article
Times cited : (106)

References (52)
  • 1
    • 0021821256 scopus 로고
    • Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): Experience at UCSF and review of the literature
    • Levy RM, Bredesen DE, Rosenblum NL. Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. J Neurosurg 1985;62:475-495.
    • (1985) J Neurosurg , vol.62 , pp. 475-495
    • Levy, R.M.1    Bredesen, D.E.2    Rosenblum, N.L.3
  • 2
    • 0023491951 scopus 로고
    • Neurologic manifestations of AIDS
    • McArthur JC. Neurologic manifestations of AIDS. Medicine 1987;66:407-437.
    • (1987) Medicine , vol.66 , pp. 407-437
    • McArthur, J.C.1
  • 3
    • 0025822601 scopus 로고
    • Nomeclature and research case definitions for neurological manifestations of human immunodeficiency virus type-1 (HIV-1) infection. Report of a Working Group of the American Academy of Neurology AIDS Task Force
    • Janssen RS, Cornblath DR, Epstein LG, et al. Nomeclature and research case definitions for neurological manifestations of human immunodeficiency virus type-1 (HIV-1) infection. Report of a Working Group of the American Academy of Neurology AIDS Task Force. Neurology 1991;41:778-785.
    • (1991) Neurology , vol.41 , pp. 778-785
    • Janssen, R.S.1    Cornblath, D.R.2    Epstein, L.G.3
  • 4
    • 0027372880 scopus 로고
    • Dementia in AIDS patients: Incidence and risk factors
    • McArthur JC, Hoover DR, Bacellar H, et al. Dementia in AIDS patients: incidence and risk factors. Neurology 1993;43: 2245-2252.
    • (1993) Neurology , vol.43 , pp. 2245-2252
    • McArthur, J.C.1    Hoover, D.R.2    Bacellar, H.3
  • 5
    • 0027209445 scopus 로고
    • Presentation and course of AIDS dementia complex: Ten years of follow-up in Amsterdam, the Netherlands
    • Portegies P, Enting RH, Degans J, et al. Presentation and course of AIDS dementia complex: ten years of follow-up in Amsterdam, the Netherlands. AIDS 1993;7:669-675.
    • (1993) AIDS , vol.7 , pp. 669-675
    • Portegies, P.1    Enting, R.H.2    Degans, J.3
  • 6
    • 0022518134 scopus 로고
    • The AIDS dementia complex. I. Clinical features
    • Navia BA, Jordan BD, Price RW. The AIDS dementia complex. I. Clinical features. Ann Neurol 1986;19:517-524.
    • (1986) Ann Neurol , vol.19 , pp. 517-524
    • Navia, B.A.1    Jordan, B.D.2    Price, R.W.3
  • 9
    • 0023658119 scopus 로고
    • Response of human-immunodeficiency-virus-associated neurological disease to 3′-azido-3′-deoxythymidine
    • Yarchoan R, Berg G, Brouwers P, et al. Response of human-immunodeficiency-virus-associated neurological disease to 3′-azido-3′-deoxythymidine. Lancet 1987;1:132-135.
    • (1987) Lancet , vol.1 , pp. 132-135
    • Yarchoan, R.1    Berg, G.2    Brouwers, P.3
  • 10
    • 0024208050 scopus 로고
    • Neuropsychological outcome of zidovudine (AZT) treatment of patients with AIDS and AIDS-related complex
    • Schmitt FA, Bigley JWS, McKinnis R, et al. Neuropsychological outcome of zidovudine (AZT) treatment of patients with AIDS and AIDS-related complex. N Engl J Med 1988;319: 1573-1578.
    • (1988) N Engl J Med , vol.319 , pp. 1573-1578
    • Schmitt, F.A.1    Bigley, J.W.S.2    McKinnis, R.3
  • 11
    • 0027530999 scopus 로고
    • Zidovudine treatment of the AIDS dementia complex: Results of a placebo-controlled trial
    • Sidtis JJ, Gatsonis C, Price RW, et al. Zidovudine treatment of the AIDS dementia complex: results of a placebo-controlled trial. Ann Neurol 1993;33:343-349.
    • (1993) Ann Neurol , vol.33 , pp. 343-349
    • Sidtis, J.J.1    Gatsonis, C.2    Price, R.W.3
  • 12
    • 0025088422 scopus 로고
    • Long-term toxicity/ activity profile of 2′,3′-dideoxyinosine in AIDS and AIDS-related complex
    • Yarchoan R, Pluda JM, Thomas RV, et al. Long-term toxicity/ activity profile of 2′,3′-dideoxyinosine in AIDS and AIDS-related complex. Lancet 1990;336:526-529.
    • (1990) Lancet , vol.336 , pp. 526-529
    • Yarchoan, R.1    Pluda, J.M.2    Thomas, R.V.3
  • 13
    • 0027325328 scopus 로고
    • Human immunodeficiency virus type 1 infection of the nervous system: Pathogenetic mechanisms
    • Epstein LG, Gendelman HE. Human immunodeficiency virus type 1 infection of the nervous system: pathogenetic mechanisms. Ann Neurol 1993;33:429-436.
    • (1993) Ann Neurol , vol.33 , pp. 429-436
    • Epstein, L.G.1    Gendelman, H.E.2
  • 14
    • 0028909868 scopus 로고
    • The dementia associated with the acquired immunodeficiency syndrome
    • Lipton SA, Gendelman HE. The dementia associated with the acquired immunodeficiency syndrome. N Engl J Med 1995; 332:934-940.
    • (1995) N Engl J Med , vol.332 , pp. 934-940
    • Lipton, S.A.1    Gendelman, H.E.2
  • 15
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate and neurodegenerative disorders
    • Coyle JT, Puttfarken P. Oxidative stress, glutamate and neurodegenerative disorders. Science 1993;262:698-700.
    • (1993) Science , vol.262 , pp. 698-700
    • Coyle, J.T.1    Puttfarken, P.2
  • 16
    • 0029069563 scopus 로고
    • Apoptotic neurons in brains from pediatric patients with HIV-1 encephalitis and progressive encephalopathy
    • Gelbard HA, James H, Sharer LR, et al. Apoptotic neurons in brains from pediatric patients with HIV-1 encephalitis and progressive encephalopathy. Neuropathol Appl Neurobiol 1995;21:208-217.
    • (1995) Neuropathol Appl Neurobiol , vol.21 , pp. 208-217
    • Gelbard, H.A.1    James, H.2    Sharer, L.R.3
  • 18
    • 0027200694 scopus 로고
    • Rescue of axotomized immature rat facial motorneurons by R(-)-deprenyl: Stereospecificity and independence from monoamine oxidase inhibition
    • Ansari KS, Yu PH, Kruck TPA, Tatton WG. Rescue of axotomized immature rat facial motorneurons by R(-)-deprenyl: stereospecificity and independence from monoamine oxidase inhibition. J Neurosci 1993;13:4042-4053.
    • (1993) J Neurosci , vol.13 , pp. 4042-4053
    • Ansari, K.S.1    Yu, P.H.2    Kruck, T.P.A.3    Tatton, W.G.4
  • 19
    • 0027941312 scopus 로고
    • (-)Deprenyl reduced PC12 cell apoptosis by inducing new protein synthesis
    • Tatton WG, Ju WYH, Holland DP, Tai C, Kwan M. (-)Deprenyl reduced PC12 cell apoptosis by inducing new protein synthesis. J Neurochem 1994;63:1572-1575.
    • (1994) J Neurochem , vol.63 , pp. 1572-1575
    • Tatton, W.G.1    Ju, W.Y.H.2    Holland, D.P.3    Tai, C.4    Kwan, M.5
  • 20
    • 0027496801 scopus 로고
    • Selegiline can mediate neuronal rescue rather than neuronal protection
    • Tatton WG. Selegiline can mediate neuronal rescue rather than neuronal protection. Move Dis 1993;8:520-530.
    • (1993) Move Dis , vol.8 , pp. 520-530
    • Tatton, W.G.1
  • 21
    • 0029731378 scopus 로고    scopus 로고
    • Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration
    • Tatton WG, Chalmers-Redman RME. Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration. Neurology 1996;47(Suppl 3):S171-183.
    • (1996) Neurology , vol.47 , Issue.3 SUPPL.
    • Tatton, W.G.1    Chalmers-Redman, R.M.E.2
  • 22
    • 0026778866 scopus 로고
    • Dihydrolipoic acid - A universal antioxidant both in the membrane and in the aqueous phase
    • Kagan VE, Shvedova A, Serbinova E, et al. Dihydrolipoic acid - a universal antioxidant both in the membrane and in the aqueous phase. Biochem Pharmacol 1992;44:1637-1649.
    • (1992) Biochem Pharmacol , vol.44 , pp. 1637-1649
    • Kagan, V.E.1    Shvedova, A.2    Serbinova, E.3
  • 23
    • 0027495451 scopus 로고
    • Vitamin E and alpha-lipoate: Role in antioxidant recycling and activation of the NF-MB transcription factor
    • Packer L, Suzuki YJ. Vitamin E and alpha-lipoate: role in antioxidant recycling and activation of the NF-MB transcription factor. Mol Aspects Med 1993;14:229-239.
    • (1993) Mol Aspects Med , vol.14 , pp. 229-239
    • Packer, L.1    Suzuki, Y.J.2
  • 24
    • 84907132010 scopus 로고
    • Normative data for a brief neuropsychologic test battery in a cohort of injecting drug users
    • Concha M, Selnes OA, McArthur JC, et al. Normative data for a brief neuropsychologic test battery in a cohort of injecting drug users. Int J Addict 1995;30:823-841.
    • (1995) Int J Addict , vol.30 , pp. 823-841
    • Concha, M.1    Selnes, O.A.2    McArthur, J.C.3
  • 25
    • 0026234795 scopus 로고
    • Normative data for a brief neuropsychological screening battery
    • Selnes OA, Jacobson L, Machado AM, et al. Normative data for a brief neuropsychological screening battery. Percept Mot Skills 1991;73:539-550.
    • (1991) Percept Mot Skills , vol.73 , pp. 539-550
    • Selnes, O.A.1    Jacobson, L.2    Machado, A.M.3
  • 26
    • 84961250245 scopus 로고
    • The use of nitrogen mustards in the palliative treatment of carcinoma
    • Karnofsky DA, Abelman WH, Carver LF, et al. The use of nitrogen mustards in the palliative treatment of carcinoma. Cancer 1948;1:634-656.
    • (1948) Cancer , vol.1 , pp. 634-656
    • Karnofsky, D.A.1    Abelman, W.H.2    Carver, L.F.3
  • 27
    • 0000054945 scopus 로고
    • L'examen Psychologique dans les cas d'enchephalopathie traumatique
    • Rey A. L'examen Psychologique dans les cas d'enchephalopathie traumatique. Arch Psychol 1941;28:286-340.
    • (1941) Arch Psychol , vol.28 , pp. 286-340
    • Rey, A.1
  • 29
    • 75449146111 scopus 로고
    • Clinical neuropsychology
    • Klove H. Clinical neuropsychology. Med Clin North Am 1963; 46:1647-1658.
    • (1963) Med Clin North Am , vol.46 , pp. 1647-1658
    • Klove, H.1
  • 30
    • 0026044155 scopus 로고
    • Computerized and conventional neuropsychological assessment of HIV-1 infected homosexual men
    • Miller EN, Satz P, Visscher B. Computerized and conventional neuropsychological assessment of HIV-1 infected homosexual men. Neurology 1991;41:1608-1616.
    • (1991) Neurology , vol.41 , pp. 1608-1616
    • Miller, E.N.1    Satz, P.2    Visscher, B.3
  • 31
    • 1642572165 scopus 로고
    • Studies of illness in the aged: The index of ADL
    • Katz S, Ford A, Moskowit R, et al. Studies of illness in the aged: The index of ADL. JAMA 1963;183:914-919.
    • (1963) JAMA , vol.183 , pp. 914-919
    • Katz, S.1    Ford, A.2    Moskowit, R.3
  • 32
    • 0014579432 scopus 로고
    • Assessment of older people: Self-maintaining and instrumental activities of daily living
    • Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969;9:179-186.
    • (1969) Gerontologist , vol.9 , pp. 179-186
    • Lawton, M.P.1    Brody, E.M.2
  • 34
    • 84965520932 scopus 로고
    • The CES-D: A self-report depression scale for research in the general population
    • Radloff LL. The CES-D: a self-report depression scale for research in the general population. Appl Psychol Meas 1977;1: 385-401.
    • (1977) Appl Psychol Meas , vol.1 , pp. 385-401
    • Radloff, L.L.1
  • 37
    • 0023781683 scopus 로고
    • The AIDS dementia complex
    • Price RW, Brew BJ. The AIDS dementia complex. J Infect Dis 1988;158:1079-1083.
    • (1988) J Infect Dis , vol.158 , pp. 1079-1083
    • Price, R.W.1    Brew, B.J.2
  • 38
    • 0030789134 scopus 로고    scopus 로고
    • Safety and tolerability of the antioxidant OPC-14,117 in HIV associated cognitive impairment
    • The Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders. Safety and tolerability of the antioxidant OPC-14,117 in HIV associated cognitive impairment. Neurology 1997;49:142-146.
    • (1997) Neurology , vol.49 , pp. 142-146
  • 39
    • 0027530638 scopus 로고
    • Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease
    • The Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med 1993;328:176-183.
    • (1993) N Engl J Med , vol.328 , pp. 176-183
  • 40
    • 0025837108 scopus 로고
    • L-Deprenyl therapy improves verbal memory in amnesic Alzheimer's patients
    • Finali G, Piccirilli M, Oliano G, et al. L-Deprenyl therapy improves verbal memory in amnesic Alzheimer's patients. Clin Neuropharmacol 1991;14:523-536.
    • (1991) Clin Neuropharmacol , vol.14 , pp. 523-536
    • Finali, G.1    Piccirilli, M.2    Oliano, G.3
  • 41
    • 0030967165 scopus 로고    scopus 로고
    • A controlled trial of selegilene, alpha-tocopherol, or both as treatment for Alzheimer's disease
    • Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegilene, alpha-tocopherol, or both as treatment for Alzheimer's disease. N Engl J Med 1997;336:1216-1222.
    • (1997) N Engl J Med , vol.336 , pp. 1216-1222
    • Sano, M.1    Ernesto, C.2    Thomas, R.G.3
  • 42
    • 0028025072 scopus 로고
    • The effect of deprenyl and tocopherol on cognitive performance in early untreated Parkinson's disease
    • Parkinson Study Group
    • Kieburtz K, McDermott M, Como P, et al. The effect of deprenyl and tocopherol on cognitive performance in early untreated Parkinson's disease. Parkinson Study Group. Neurology 1994;44:1756-1759.
    • (1994) Neurology , vol.44 , pp. 1756-1759
    • Kieburtz, K.1    McDermott, M.2    Como, P.3
  • 43
    • 0018128143 scopus 로고
    • The possible mechanism of action of (-)deprenyl in Parkinson's disease
    • Knoll J. The possible mechanism of action of (-)deprenyl in Parkinson's disease. J Neural Transm 1978;43:177-198.
    • (1978) J Neural Transm , vol.43 , pp. 177-198
    • Knoll, J.1
  • 44
    • 0031020650 scopus 로고    scopus 로고
    • L-Deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro
    • Mytilineou C, Radcliffe P, Leonardi EK, et al. L-Deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro. J Neurochem 1997;68:33-39.
    • (1997) J Neurochem , vol.68 , pp. 33-39
    • Mytilineou, C.1    Radcliffe, P.2    Leonardi, E.K.3
  • 45
    • 0007298326 scopus 로고
    • (-)-Deprenyl reduces neuronal apoptosis by maintaining bcl-2 synthesis and mitochondrial membrane potential
    • Tatton W, Ju W, Wadia J, et al. (-)-Deprenyl reduces neuronal apoptosis by maintaining bcl-2 synthesis and mitochondrial membrane potential. Mov Dis 1994;9:4.
    • (1994) Mov Dis , vol.9 , pp. 4
    • Tatton, W.1    Ju, W.2    Wadia, J.3
  • 46
    • 0028343249 scopus 로고
    • The concept of astrocyte-kinetic drug in the treatment of neurodegenerative disease: Evidence for L-deprenyl-induced activation of reactive astrocytes
    • Biagini G, Frasoldati A, Fuxe K, et al. The concept of astrocyte-kinetic drug in the treatment of neurodegenerative disease: evidence for L-deprenyl-induced activation of reactive astrocytes. Neurochem Int 1994;25:17-22.
    • (1994) Neurochem Int , vol.25 , pp. 17-22
    • Biagini, G.1    Frasoldati, A.2    Fuxe, K.3
  • 47
    • 0028121120 scopus 로고
    • Increased CNTF gene expression in process-bearing astrocytes following injury is augmented by R(-)-deprenyl
    • Seniuk NA, Henderson JT, Tatton WG, Roder JC. Increased CNTF gene expression in process-bearing astrocytes following injury is augmented by R(-)-deprenyl. J Neurosci Res 1994; 37:278-286.
    • (1994) J Neurosci Res , vol.37 , pp. 278-286
    • Seniuk, N.A.1    Henderson, J.T.2    Tatton, W.G.3    Roder, J.C.4
  • 48
    • 0027517052 scopus 로고
    • Apparent antioxidant effect of L-deprenyl on hydroxyl radical formation and nigral injury elicited by MPP+ in vivo
    • Wu RM, Chiueh CC, Pert A, Murphy DL. Apparent antioxidant effect of L-deprenyl on hydroxyl radical formation and nigral injury elicited by MPP+ in vivo. Eur J Pharmacol 1993; 243:241-247.
    • (1993) Eur J Pharmacol , vol.243 , pp. 241-247
    • Wu, R.M.1    Chiueh, C.C.2    Pert, A.3    Murphy, D.L.4
  • 49
    • 0028182741 scopus 로고
    • Suppression of hydroxyl radical formation by MAO inhibitors: A novel possible neuro-protective mechanism in dopaminergic neurotoxicity
    • Chiueh CC, Huang SJ, Murphy DL. Suppression of hydroxyl radical formation by MAO inhibitors: a novel possible neuro-protective mechanism in dopaminergic neurotoxicity. J Neural Transm Suppl 1994;41:189-196.
    • (1994) J Neural Transm Suppl , vol.41 , pp. 189-196
    • Chiueh, C.C.1    Huang, S.J.2    Murphy, D.L.3
  • 50
    • 0028181102 scopus 로고
    • (-)L-Deprenyl increases activities of superoxide dismutase (SOD) in striatum of dog brain
    • Carrillo MC, Ivy GO, Milgram NW, et al. (-)L-Deprenyl increases activities of superoxide dismutase (SOD) in striatum of dog brain. Life Sci 1994;54:1483-1489.
    • (1994) Life Sci , vol.54 , pp. 1483-1489
    • Carrillo, M.C.1    Ivy, G.O.2    Milgram, N.W.3
  • 51
    • 0028971624 scopus 로고
    • Effect of MPTP and L-deprenyl on antioxidant enzymes and lipid peroxidation levels in mouse brain
    • Thiffault C, Aumont N, Quiron R, Poirier J. Effect of MPTP and L-deprenyl on antioxidant enzymes and lipid peroxidation levels in mouse brain. J Neurochem 1995;65:2725-2733.
    • (1995) J Neurochem , vol.65 , pp. 2725-2733
    • Thiffault, C.1    Aumont, N.2    Quiron, R.3    Poirier, J.4
  • 52
    • 0029670154 scopus 로고    scopus 로고
    • (-)Deprenyl and (-)L-phenyl-2-propylaminopentane, [(-)PPAP], act primarily as potent stimulants of action potential-transmitter release coupling in the catecholaminergic neurons
    • Knoll J, Miklya I, Knoll B, Marko R, Kelemen K. (-)Deprenyl and (-)L-phenyl-2-propylaminopentane, [(-)PPAP], act primarily as potent stimulants of action potential-transmitter release coupling in the catecholaminergic neurons. Life Sci 1996;58:817-827.
    • (1996) Life Sci , vol.58 , pp. 817-827
    • Knoll, J.1    Miklya, I.2    Knoll, B.3    Marko, R.4    Kelemen, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.