Safety and tolerability of the antioxidant OPC-14117 in HIV-associated cognitive impairment

Neurology

Volumn 49, Issue 1, 1997, Pages 142-146

  Kieburtz, Karl ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N (7 HYDROXY 2,2,4,6 TETRAMETHYL 1 INDANYL) 4 (3 METHOXYPHENYL) 1 PIPERAZINEACETAMIDE; UNCLASSIFIED DRUG;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMENTIA; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERANCE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0030789134     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.49.1.142     Document Type: Article

References (22)

1. Janssen RS, Cornblath DR, Epstein LG, et al. Nomenclature and research case definitions for neurological manifestations of human immunodeficiency virus type-1 (HIV-1 ) infection. Report of a Working Group of the American Academy of Neurology AIDS Task Force. Neurology 1991;41:778-785.
2. McArthur JC, Hoover DR, Bacellar H, et al. Dementia in AIDS patients: incidence and risk factors. Neurology 1993;43: 2245-2252.
3. Yarchoan R, Pluda JM, Thomas RV, et al. Long-term toxicity/ activity profile of 2́,3́-dideoxyinosine in AIDS and AIDS-related complex. Lancet 1990;336:526-529.
4. Yarchoan R, Berg G, Brouwers P, et al. Response of human-immunodeficiency-virus-associated neurological disease to 3́-azido-3́-deoxythymidine. Lancet 1987;1:132-135.
5. Schmitt FA, Bigley JWS, McKinnis R, et al. Neuropsychological outcome of zidovudine (AZT) treatment of patients with AIDS and AIDS-related complex. N Engl J Med 1988;319: 1573-1578.
6. Sidtis JJ, Gatsonis C, Price RW, et al. Zidovudine treatment of the AIDS dementia complex: results of a placebo-controlled trial. Ann Neurol 1993;33:343-349.
7. Epstein LG, Gendelman HE. Human immunodeficiency virus type 1 infection of the nervous system: pathogenetic mechanisms. Ann Neurol 1993;33:429-436.
8. Lipton SA, Gendelman HE. The dementia associated with the acquired immunodeficiency syndrome. N Engl J Med 1995; 332:934-940.
9. Coyle JT, Puttfarken P. Oxidative stress, glutamate and neurodegenerative disorders. Science 1993;262:698-700.
10. Huntington Study Group (F Marshall primary author). Safety and tolerability of the free-radical scavenger OPC-14117 in Huntington's disease [abstract]. Mov Disord 1996; 11(suppl 1): 59.
11. Dana Consortium on Therapy For HIV Dementia and Related Cognitive Disorders. Clinical Confirmation of the American Academy of Neurology Algorithm for HIV Associated Cognitive Motor Disorder. Neurology 1996;47:1247-1253.
12. Concha M, Selnes OA, McArthur J, et al. Normative data for a brief neuropsychologic test battery in a cohort of injecting drug users. Int J Addict 1995;30:823-841.
13. Selnes OA, Jacobson L, Machado AM, et al. Normative data for a brief neuropsychological screening battery. Percept Mot Skills 1991;73:539-550.
14. Karnofsky DA, Abelman WH, Carver LF, et al. The use of nitrogen mustards in the palliative treatment of carcinoma. Cancer 1948;1:634-656.
15. Rey A. L'examen psychologique dans les cas d'encephalopathie traumatique. Arch Psychologie 1941;28:286-340.
16. Wechsler D. Wechsler Adult Intelligence Scale Revised. New York, NY: The Psychological Corporation, 1981.
17. Klove H. Clinical neuropsychology. Med Clin North Am 1963; 46:1647-1658.
18. Katz S, Ford A, Moskowitz R, et al. Studies of illness in the aged: the index of ADL. JAMA 1963;183:914-919.
19. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969;9:179-186.
20. Stewart AL, Ware JE. Measuring function and well-being: The Medical Outcomes Study Approach. Durham, NC: Duke University Press, 1993.
21. Radloff LL. The CES-D: a self-report depression scale for research in the general population. Appl Psychol Meas 1977;1: 385-401.
22. Agresti A. Categorical data analysis. New York: Wiley, 1990.