High-performance liquid chromatographic assay for the simultaneous determination of tramadol and its metabolites in microsomal fractions of human liver

Journal of Chromatography B: Biomedical Applications

Volumn 686, Issue 2, 1996, Pages 221-227

  Paar, W D ^a   Frankus, P ^a   Dengler, H J ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Mono N demethyltramadol; O demethyltramadol; Tramadol

Indexed keywords

DRUG METABOLITE; NARCOTIC ANALGESIC AGENT; TRAMADOL;

ACCURACY; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DRUG DETERMINATION; DRUG METABOLISM; DRUG TISSUE LEVEL; EXPERIMENT; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIVER MICROSOME; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TECHNIQUE;

ANALGESICS, OPIOID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MICROSOMES, LIVER; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE; TRAMADOL;

EID: 0030588943     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(96)00236-8     Document Type: Article

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