Effect of OFQ injection into intracerebroventricular and preoptic area on blood pressure and heart rate in rats

Acta Physiologica Sinica

Volumn 51, Issue 5, 1999, Pages 580-584

  Zhang, XiuZhu Chong Bin ^b   Shu, He ^a   Liu, Jing ^a   Wang, Yue Yan ^a   Wang, Ying ^a   Liu, Hai Ying ^a  

^a Jinan Mil Med Sch Shangdong Prov   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Blood pressure; Heart rate; Naloxone; Orphanin FQ; Preoptic area

Indexed keywords

DELTA OPIATE RECEPTOR; DYNORPHIN A; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; NALOXONE; NOCICEPTIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; BRADYCARDIA; CONTROLLED STUDY; DRUG EFFECT; HEART RATE; HYPOTENSION; INJECTION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MEAN ARTERIAL PRESSURE; NONHUMAN; PREOPTIC AREA; RAT;

ANIMALS; BLOOD PRESSURE; DEPRESSION, CHEMICAL; FEMALE; HEART RATE; INJECTIONS, INTRAVENTRICULAR; MALE; OPIOID PEPTIDES; PREOPTIC AREA; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0344718485     PISSN: 03710874     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Mollereau C, Parmentier M, Mailleux P, et al. ORL1, a novel member of the opioid receptor family cloning, functional expression and localization. FEBS Let, 1994, 341: 33-38.
2. Reinscheid RK, Nothacker HP, Bourson A, et al. Orphanin FQ: A neuropeptide that activates an opioid-like G protein-coupled receptor. Science, 1995, 270: 792-794.
3. Meunier JC, Mollereau C, Toll L, et al. Isolation and structure of the endogenous agonist of opioid receptor like ORL1 receptor. Nature, 1995, 377: 532-535.
4. Grisel JE, Mogil JS, Hunter MA, et al. Orphanin FQ is an antiopioid peptide. 27th Meeting of the International Narcotics Research Conference. 1996 July, California, 1996.
5. Champion HC, Czapla MA, Kadowitz PJ. Nociceptin, an endogenous ligand for the ORL1 receptor, decreases cardiac output and total peripheral resistance in the rat. Peptides, 1997, 18 (5): 729-732.
6. Bolme P, Fuxe K, Agnati L, et al. Cardiovascular effects of morphine and opioid peptides following intracisternal administration in chloralose-anesthetized rats. Eur J Pharmacol, 1978, 48: 319-324.
7. Zhang XL, Zhu CB, Xu SF, et al. Effect of intrathecal or intracerebro-ventricular administration of OFQ on pain threshold and acupuncture analgesia in rats. Acta Physiol Sin, 1997, 49 (5): 575-580 (in Chinese with English Abstract).
8. Doi N, Dutia MB, Brown CH, et al. Inhibitory actions of nociceptin (orphanin FQ) on rat supraoptic nucleus oxytocin and vasopressin neurones in vitro. Adv Exp Med Biol. 1998, 449: 147-151.
9. Saito Y, Maruyama K, Saido TC, et al. Overexpression of a neuropeptide nociceptin/orphanin FQ precursor gene, N23K/N27K, induces neurite outgrowth in mouse NS20Y cells. J Neurosci Res, 1997, 48 (5): 397-406.
10. Yu TP, Xie CW. Orphanin FQ/nociceptin inhibits synaptic transmission and long-term potentiation in rat dentate gyrus through poetsynaptic mechanisms. J Neurophysiol, 1998, 80 (3): 1277-1284.
11. Taniguchi H, Yomota E, Nogi K, et al. The effect of nociceptin, an endogenous ligand for the ORL1 receptor, on rat colonic contraction and transit. Eur J Pharmacol, 1998, 353 (2-3): 265-271.
12. Bunzow JR, Saez C, Mortrud M, et al. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type. FEBS Lett, 1994, 347: 284-288.
13. Chu X, Xu N, Li P, et al. The nociceptin receptor-mediated inhibition of the rat rostral ventrolateral medulla neurons in vitro. Eur J Pharmacol, 1999, 364 (1): 49-53.