Nonpeptide endothelin receptor antagonists. X. Inhibition of endothelin- 1- and hypoxia-induced pulmonary pressor responses in the guinea pig by the endothelin receptor antagonist, SB 217242

Journal of Pharmacology and Experimental Therapeutics

Volumn 283, Issue 3, 1997, Pages 1130-1137

  Underwood, David C ^a   Bochnowicz, Steve ^a   Osborn, Ruth R ^a   Luttmann, Mark A ^a   Hay, Douglas W P ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; ENRASENTAN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GUINEA PIG; HYPOXIA; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION;

ANIMALS; ANOXIA; BLOOD PRESSURE; CARBOXYLIC ACIDS; ENDOTHELIN-1; GUINEA PIGS; INDANS; MALE; PULMONARY ARTERY; RECEPTORS, ENDOTHELIN;

EID: 0031470841     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. ADNOT, S., RAFFESTIN, B., EDDAHIBI, S., BRAQUET, P. AND CHABRIER, P-E.: Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J. Clin. Invest. 87: 155-162, 1991.
2. ALLEN, S. W., CHATFIELD, B. A., KOPPENHAFER, S. A., SCHAFFER, M. S., WOLFE, R. R. AND ABMAN, S. H.: Circulating immunoreactive endothelin-1 in children with pulmonary hypertension. Am. Rev. Respir. Dis. 148: 519-522, 1993.
3. ARAI, H., NAKAO, K., TAKAYA, K., HOSODA, K., OGAWA, Y., NAKANISHI, S. AND IMURA, H.: The human endothelin-B receptor gene: structural organization and chromosomal assignment. J. Biol. Chem. 268: 3463-3470, 1993.
4. ARAI, H., HORI, S., ARAMORI, I., OHKUBO, S. AND NAKANISHI, S.: Cloning and expression of a cDNA encoding an endothelin receptor. Nature 348: 730-732, 1990.
5. BOCHNOWICZ, S., OSBORN, R. R., HAY, D. W. P. AND UNDERWOOD, D. C.: Hypoxiainduced pulmonary hypertension in an optimized environment for the guinea pig. Lab. Anim. 31: 347-356, 1997.
6. BONVALLET, S. T., ZAMORA, M. R., HASUNUMA, K., SATO, K., HANASATO, N., ANDERSON, D., SATO, K. AND STELZNER, T. J.: BQ123, an ETA-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats. Am. J. Physiol. 266: H1327-H1331, 1994.
7. BRINK, C., GILLARD, V., ROUBERT, P., MENCIA-HUERTA, J. M., CHABRIER, P. E., BRAQUET, P. AND VERLEY, J.: Effects of specific binding sites of endothelin in lung preparations. Pulmon. Pharmacol. 4: 54-59, 1991.
8. CERNACEK, P. AND STEWART, D. J.: Immunoreactive endothelin in human plasma: marked elevations in patients in cardiogenic shock. Biochem. Biophys. Res. Commun. 161: 562-567, 1989.
9. CHEN, S. J., CHEN, Y. F., MENG, Q. C., DURAND, J., DICARLO, V. S. AND OPARIL, S.: Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension in rats. J. Appl. Physiol.. 79: 2122-2131, 1995.
10. CODY, R. J., HALAS, G. J., BINKLEY, P. F., CAPERS, Q. AND KELLEY, R.: Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure. Circulation 85: 504-509, 1992.
11. DICARLO, V. S., CHEN, S. J., MENG, Q. C., DURAND, J., YANO, M., CHEN, Y. F. AND OPARIL, S.: ETA-receptor antagonist prevents and reverses chronic hypoxiainduced pulmonary hypertension in rats. Am. J. Physiol. 269: L690-L697, 1995.
12. ELTON, S., OPARIL, S., TAYLOR, G. R., HICKS, P. H., YANG, R. H., JIN, H. AND CHEN, Y. F.: Normobaric hypoxia stimulates endothelin-1 gene expression in the rat. Am. J. Physiol. 263: R1260-R1264, 1992.
13. FÉLÉTOU, M., GIRARD, V. AND CANET, E.: Different involvement of nitric oxide in endothelium-dependent relaxation of porcine pulmonary artery and vein: Influence of hypoxia. J. Cardiovasc. Pharmacol. 25: 665-673, 1995.
14. FUKURODA, T., FUJIKAWA, T., OZAKI, S., ISHIKAWA, K., YANO, M. AND NISHIKIBE, M.: Clearance of circulating endothelin-1 by ETB receptors in rats. Biochem. Biophys. Res. Commun. 199: 1461-1465, 1994.
15. GIAID, A. AND SALEH, D.: Reduced expression of endothelial nitric oxide synthase in the lung of patients with pulmonary hypertension. N. Engl. J. Med. 333: 214-221, 1995.
16. GIAID, A., YANAGISAWA, M., LANGLEBEN, D., MICHEL, R. P., LEVY, R., SHENNIB, H., KIMURA, S., MASAKI, T., DUGUID, W. P. AND STEWART, D. J.: Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N. Engl. J. Med. 328: 1732-1739, 1993.
17. GOLIGORSKY, M. S., TSUKAHARA, H., MAGAZINE, H., ANDERSEN, T. T., MALIK, A. B. AND BAHOU, W. F.: Termination of endothelin signaling: role of nitric oxide. J. Cell. Physiol. 158: 485-494, 1994.
18. GROVER, R. F., VOGEL, J. H. K., AVERILL, K. H. AND BLOUNT, S. G.: Pulmonary hypertension. Individual and species variability relative to vascular reactivity. Am. Heart J. 66: 1-3, 1963.
19. HAY, D. W. P., HENRY, P. J. AND GOLDIE, R. G.: Endothelin and the respiratory system. Trends Pharmacol. Sci. 14: 29-32, 1993a.
20. HAY, D. W. P., HUBBARD, W. C., LUTTMANN, M. AND UNDEM, B. J.: Endothelin receptor subtypes in guinea-pig and human pulmonary tissues. Br. J. Pharmacol. 110: 1175-1183, 1993b.
21. HAY, D. W. P. AND GOLDIE, R. G.: Role of endothelin in pulmonary diseases. In Endothelin: Role of Health and Disease, ed. by A. Gulati. pp. 251-273, Harwood Academic, Amsterdam, 1995.
22. HOSODA, K., NAKAO, K., TAMURA, N., ARAI, H., OGAWA, Y., SUGA, S.-I., NAKANISHI, S. AND IMURA, H.: Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor. J. Biol. Chem. 267: 18797-18804, 1992.
23. INOUE, A., YANAGISAWA, M., KIMURA, S., KASUYA, Y., MIYAUCHIL, T., GOTO, K. AND MASAKI, T.: The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. U.S.A. 86: 2862-2867, 1989.
24. KIOWSKI, W., SÜTSCH, G., HUNZIKER, P., MÜLLER, P., KIM, J., OECHSLIN, E., SCHMITT, R., JONES, R. AND BERTEL, O.: Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure. Lancet 346: 732-736, 1995.
25. KOUREMBANAS, S., MCQUILLAN, L. P., LEUNG, G. K. AND FALLER, D. V.: Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J. Clin. Invest. 92: 99-104, 1993.
26. LI, H., CHEN, S. J., CHEN, Y. F., MENG, Q. C., OPARIL, S. AND ELTON, T. S.: Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia. J. Appl. Physiol. 77: 1451-1459, 1994a.
27. LI, H., ELTON, T. S., CHEN, Y. F. AND OPARIL, S.: Increased endothelin receptor gene expression in hypoxic rat lung. Am. J. Physiol. 10: L553-L560, 1994b.
28. MACNEE, W.: Pathophysiology of cor pulmonale in chronic obstructive pulmonary disease, state-of-the-art: Parts one and two. Am. J. Respir. Crit. Care Med. 150: 833-852, 1158-1168, 1994.
29. MARKEWITZ, B. A., KOHAN, D. E. AND MICHAEL, J. R.: Hypoxia decreases endothelin-1 synthesis by rat lung endothelial cells. Am. J. Physiol. 269: L215-L220, 1995.
30. MASAKI, T., YANAGISAWA, M. AND GOTO. K.: Physiology and pharmacology of endothelins. Med. Res. Rev. 12: 391-421, 1992.
31. MICHAEL, J. R. AND MARKEWITZ, B. A.: Endothelins and the lung. Am. J. Respir. Crit. Care Med. 154: 555-581, 1996.
32. OHLSTEIN, E. H., NAMBI, P., LAGO, A., HAY, D. W. P., BECK, G., FONG, K.-L., EDDY, E. P., SMITH, P., ELLENS, H. AND ELLIOTT, J. D.: Nonpeptide endothelin receptor antagonists. VI: Pharmacological characterization of SB 217242, a potent and highly bioavailable endothelin receptor antagonist. J. Pharmacol. Exp. Ther. 276: 609-615, 1996.
33. OPARIL, S., CHEN, S. J., MENG, Q. C., ELTON, T. S., YANO, M. AND CHEN, Y. F.: Endothelin-A receptor antagonist prevents acute hypoxia-induced pulmonary hypertension in the rat. Am. J. Physiol. 268: L95-L100, 1995.
34. RABINOVITCH, M., GAMBLE, W., NADAS, A. S., MIETTINEN, O. S. AND REID, L.: Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features. Am. J. Physiol. 236: H818-H827, 1979.
35. REID, L. M.: The pulmonary circulation: Remodeling in growth and disease. Am. Rev. Respir. Dis. 119: 531-546, 1979.
36. RYAN, U. S., ZHONG, R., HATES, B. A., VISNER, G. AND SAUTHER, M. L.: Regulation of endothelin-1 expression in normal and transfected endothelial cells. J. Cardiovasc. Pharmacol. 22: suppl. 8, S38-S41, 1993.
37. SAKURAI, T., YANAGISAWA, M. AND MASAKI, T.: Molecular characterization of endothelin receptors. Trends Pharmacol. Sci. 13: 103-108, 1990.
38. SATO, K., OKA, M., HASUNUMA, K., OHNISHI, M., SATO, K. AND KIRA, S.: Effects of separate and combined ETA and ETB blockade on ET-1-induced constriction in perfused rat lungs. Am. J. Physiol. 269: L668-L672, 1995.
39. STEWART, D. J., LEVY, R. D., CERNACEK, P. AND LANGLEBEN, D.: Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of diseases? Ann. Intern. Med. 114: 464-469, 1991.
40. THOMPSON, B. T., HASSOUN, P. M., KRADIN, R. L . AND HALES, C. A.: Acute and chronic hypoxic pulmonary hypertension in guinea pigs. Am. J. Physiol. 66: 920-928, 1989.
41. VAN ROSSUM, J. M.: Cumulative dose-response curves. II. Techniques for the making of dose-response curves in isolated organs and the evaluation of drug parameters. Arch. Int. Pharmacodyn. 143: 299-330, 1963.
42. WARNER, T. D., ELLIOT, J. D. AND OHLSTEIN, E. H.: California dreamin' 'bout endothelin: Emerging new therapeutics. Trends Pharmacol. Sci. 17: 177-204, 1996.
43. YANAGISAWA, M., KURIHARA, H., KIMURA, S., TOMOBE, Y., KOBAYASHI, M., MITSUI, Y., YAZAKI, Y., GOTO, K. AND MASAKI, T.: A novel vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411-415, 1988.
44. YOSHIBAYASHI, M., NISHIOKA, K., NAKAO, K., SAITO, Y., MATSUMURA, M., UEDA, T., TEMMA, S., SHIRAKAMI, G., IMURA, H. AND MIKAWA, H.: Plasma endothelin concentrations in patients with pulmonary hypertension associated with congenital heart defects. Circulation 84: 2280-2285, 1991.
45. ZAMORA, M. A., DEMPSEY, E. C., WALCHAK, S. J. AND STELZNER, T. J.: BQ123, an ETA receptor antagonist, inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 9: 429-433, 1993.
46. ZAPOL, W. M. AND SNIDER, M. T.: Pulmonary Hypertension in severe acute respiratory failure. N. Engl. J. Med. 296: 476-480, 1977.