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Volumn 43, Issue 16, 2000, Pages 3111-3117

Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists

(15) Murugesan, N a Gu, Z a Stein, P D a Spergel, S a Mathur, A a Leith, L a Liu, E C K a Zhang, R a Bird, E a Waldron, T a Marino, A a Morrison, R A a Webb, M L a Moreland, S a Barrish, J C a

a BRISTOL MYERS SQUIBB (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIPHENYLSULFONAMIDE DERIVATIVE; BMS 193884; ENDOTHELIN A RECEPTOR ANTAGONIST; N (3,4 DIMETHYL 5 ISOXAZOLYL) 4' (2 OXAZOLYL)[1,1' BIPHENYL] 2 SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RABBIT; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD PRESSURE; CAROTID ARTERIES; DRUG EVALUATION, PRECLINICAL; HYPERTENSION; INJECTIONS, INTRAVENOUS; MACACA FASCICULARIS; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; OXAZOLES; RABBITS; RADIOLIGAND ASSAY; RATS; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0034632777 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm000105c Document Type: Article

Times cited : (37)

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