Quantitative correlation between susceptibility and OprJ production in NfxB mutants of Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 4, 1996, Pages 909-913

  Masuda, Nobuhisa ^a,b   Gotoh, Naomasa ^a   Ohya, Satoshi ^b   Nishino, Takeshi ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 [2 (2 AMINO 4 THIAZOLYL) 2 [(1 CARBOXYETHOXY)IMINO]ACETAMIDO] 3 [(1 ETHYL 4 PYRIDINIO)THIOMETHYL] 3 CEPHEM 4 CARBOXYLIC ACID; ANTIBIOTIC AGENT; AZTREONAM; BIAPENEM; CARBENICILLIN; CEFCLIDIN; CEFEPIME; CEFLUPRENAM; CEFOPERAZONE; CEFOSELIS; CEFOZOPRAN; CEFPIROME; CEFTAZIDIME; CHLORAMPHENICOL; COUMAMYCIN; ERYTHROMYCIN; GENTAMICIN; IMIPENEM; KANAMYCIN; LATAMOXEF; LENAPENEM; MEMBRANE PROTEIN; NOVOBIOCIN; OFLOXACIN; PANIPENEM; PIPERACILLIN; POLYMYXIN B; RIFAMPICIN; STREPTOMYCIN; SULBENICILLIN; TETRACYCLINE;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL MUTATION; BACTERIUM TRANSFORMATION; DRUG CONJUGATION; MEMBRANE BINDING; OPERON; PHENOTYPE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; QUANTITATIVE ASSAY; STRAIN DIFFERENCE;

EID: 0029986587     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.4.909     Document Type: Article

References (28)

1. Angus, B. L., A. M. Carey, D. A. Caron, A. M. B. Kropinski, and R. E. W. Hancock. 1982. Outer membrane permeability in Pseudomonas aeruginosa: comparison of a wild-type with an antibiotic-supersusceptible mutant. Antimicrob. Agents Chemother. 21:299-309.
2. Fu, K. P., B. D. Foleno, S. C. Lafredo, J. M. LoCoco, and D. M. Isaacson. 1993. In vitro and in vivo antibacterial activities of FK037, a novel patenteral broad-spectrum cephalosporin. Antimicrob. Agents Chemother. 37:301-307.
3. Fukuda, H., M. Hosaka, K. Hirai, and S. Iyobe. 1990. New norfloxacin resistance gene in Pseudomonas aeruginosa PAO. Antimicrob. Agents Chemother. 34:1757-1761.
4. Gotoh, N., N. Itoh, H. Tsujimoto, J. Yamagishi, Y. Oyamada, and T. Nishino. 1994. Isolation of OprM-deficient mutants of Pseudomonas aeruginosa by transposon insertion mutagenesis. evidence of involvement in multiple antibiotic resistance. FEMS Microbiol. Lett. 122:267-274.
5. Gotoh, N., and K. Poole. Unpublished data.
6. Gotoh, N., H. Tsujimoto, K. Poole, J. Yamagishi, and T. Nishino. 1995. The outer membrane protein OprM of Pseudomonas aeruginosa is encoded by oprK of the mexA-mexB-oprK multidrug resistance operon. Antimicrob. Agents Chemother. 39:2567-2569.
7. Hirai, K., S. Suzue, T. Irikura, S. Iyobe, and S. Mitsuhashi. 1987. Mutations producing resistance to norfloxacin in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 31:582-586.
8. Hosaka, M., N. Gotoh, and T. Nishino. 1995. Purification of a 54-kilodalton protein (OprJ) produced in NfxB mutants of Pseudomonas aerugmosa and production of a monoclonal antibody specific to OprJ. Antimicrob. Agents Chemother. 39:1731-1735.
9. Itoh, Y., L. Soldati, T. Leisinger, and D. Haas. 1988. Low- and intermediate-copy-number cloning vectors based on the Pseudomanas plasmid pVS1. Antonic van Leeuwenhock 54:567-573.
10. Iwahi, T., K. Okonogi, T. Yamazaki, S. Shiki, M. Kondo, A. Miyake, and A. Imada. 1992 In vitro and in vitro activities of SCE-2787, a new parenteral cephalosporin with a broad antibacterial spectrum. Antimicrob. Agents Chemother. 36:1358-1366.
11. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
12. Lewis, K. 1994 Multidrug resistance pumps in bacteria, variations on a theme. Trends Biochem Sci. 19:119-123.
13. Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual, p 366-367. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
14. Masuda, N., N. Gotoh, and T. Nishino. Unpublished data.
15. Masuda, N., and S. Ohya. 1992. Cross-resistance to meropenem, cephems. and quinolones in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 36:1847-1851.
16. Masuda, N., E. Sakagawa, and S. Ohya. 1995. Outer membrane proteins responsible for multiple drug resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother 39:645-649.
17. Matsumoto, H., S. Ohta, R. Kobayashi, and Y. Terawaki. 1978. Chromosomal location of genes participating in the degradation of purine in Pseudomonas aeruginosa. Mol. Gen. Genet. 167:165-176.
18. Matsumoto, H., and T. Tazaki. 1973. FP5 factor, an undescribed sex factor of Pseudomonas aeruginosa. Jpn. J. Microbiol. 17:409-417.
19. Nakagawa, S., T. Hashizume, K. Matsuda, M. Sanada, O. Okamoto, H. Fukatsu, and N. Tanaka. 1993. In vitro activity of a new carbapenem antibiotic, BO-2727, with potent antrpseudomonal activity. Antimicrob. Agents Chemother. 37:2756-2759.
20. Neu, H. C., G. Saha, and N. X. Chin. 1989. In vitro activity of ME1228, a new parenteral cephalosporin Antimicrob. Agents Chemother. 32:535-539.
21. Nikaido, H. 1985. Role of permeability barriers in resistance to β-lactam antibiotics. Pharmacol. Ther. 27:197-231.
22. Nikaido, H. 1994. Prevention of drug access to bacterial targets: permeability barriers and active efflux Science 264:382-388.
23. Okazaki, T., and K. Hirai. 1992. Cloning and nucleotide sequence of the Pseudomonas aeruginosa nfxB gene, conferring resistance to new quinolones. FEMS Microbiol. Lett. 97:197-202.
24. Okazaki, T., S. Iyobe, H. Hashimoto, and K. Hirai. 1991. Cloning and characterization of a DNA fragment that complements the nfxB mutation in Pseudomonas aeruginosa PAO. FEMS Microbiol. Lett. 79:31-36.
25. Poole, K., K. Krebes, C. McNally, and S. Neshat, 1993. Multiple antibiotic resistance in Pseudomonas aeruginosa; evidence for involvement of an efflux operon. J. Bacteriol. 175:7363-7372.
26. Relia, M., and D. Haas. 1982. Resistance of Pseudomonas aeruginosa PAO to nalidixic acid and tow levels of β-lactam antibiotics: mapping of chromosomal genes. Antimicrob Agents Chemother. 22:242-249.
27. Watanabe, N., R. Hiruma, and K. Katsu. 1992. In vitro evaluation of E1077, a new cephalosporin with a broad antibacterial spectrum. Antimicrob. Agents Chemother 36:589-597.
28. Yoshimura, F., and H. Nikaido. 1982. Permeability of Pseudomonas aeruginosa outer membrane to hydrophilic solutes. J Bacteriol. 152:636-642.