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Volumn 16, Issue 7, 2003, Pages 413-422

Incretins and Their Analogues as New Antidiabetic Drugs

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; CJC 1311; DIPEPTIDYL PEPTIDASE IV; EXENDIN 4; GASTRIC INHIBITORY POLYPEPTIDE; GASTROINTESTINAL HORMONE; GLUCAGON LIKE PEPTIDE 1; LIRAGLUTIDE; LY 307161; UNCLASSIFIED DRUG;

EID: 0344549608     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2003.16.7.829353     Document Type: Review
Times cited : (42)

References (119)
  • 1
    • 0018758893 scopus 로고
    • The incretin concept today
    • Creutzfeldt, W. The incretin concept today. Diabetologia 1979, 16: 75-85.
    • (1979) Diabetologia , vol.16 , pp. 75-85
    • Creutzfeldt, W.1
  • 2
    • 0026786570 scopus 로고
    • Gut hormones and diabetes mellitus
    • Creutzfeldt, W. and Nauck, M. Gut hormones and diabetes mellitus. Diabetes Metab Rev 1992, 8: 149-77.
    • (1992) Diabetes Metab Rev , vol.8 , pp. 149-177
    • Creutzfeldt, W.1    Nauck, M.2
  • 4
    • 0022389280 scopus 로고
    • Glucagon-like peptide I but not glucagon-like peptide 2 stimulates insulin release from isolated rat pancreatic islets
    • Schmidt, W.E., Siegel, E.G. and Creutzfeldt, W. Glucagon-like peptide I but not glucagon-like peptide 2 stimulates insulin release from isolated rat pancreatic islets. Diabetologia 1985, 28: 704-7.
    • (1985) Diabetologia , vol.28 , pp. 704-707
    • Schmidt, W.E.1    Siegel, E.G.2    Creutzfeldt, W.3
  • 5
    • 0023638829 scopus 로고
    • Glucagon-like peptide-I [7-36]: A physiological incretin in man
    • Kreymann, B., Williams, G., Ghatei, M.A. and Bloom, S.R. Glucagon-like peptide-I [7-36]: A physiological incretin in man. Lancet 1987, 2: 1300-4.
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 6
    • 0024424884 scopus 로고
    • Insulinotropic properties of synthetic gastric inhibitory peptide in man: Interactions with glucose, phenylalanine, and cholezystokinin-8
    • Nauck, M.A., Schmidt, W.E., Ebert, R. et al. Insulinotropic properties of synthetic gastric inhibitory peptide in man: Interactions with glucose, phenylalanine, and cholezystokinin-8. J Clin Endocrinol Metab 1989, 69: 654-62.
    • (1989) J Clin Endocrinol Metab , vol.69 , pp. 654-662
    • Nauck, M.A.1    Schmidt, W.E.2    Ebert, R.3
  • 7
    • 0027419106 scopus 로고
    • Additive insulino-tropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations
    • Nauck, M.A., Bartels, E., Ørskov, C., Ebert, R. and Creutzfeldt, W. Additive insulino-tropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations. J Clin Endocrinol Metab 1993, 76: 912-7.
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 912-917
    • Nauck, M.A.1    Bartels, E.2    Ørskov, C.3    Ebert, R.4    Creutzfeldt, W.5
  • 8
    • 0021983672 scopus 로고
    • Effects of intravenously infused porcine GIP on serum insulin, plasma C-peptide, and pancreatic polypeptide in non-insulin-dependent diabetes in the fasting state
    • Amland, P.F., Jorde, R., Aanderup, S., Burhol, P.G. and Giercksky, K.-E. Effects of intravenously infused porcine GIP on serum insulin, plasma C-peptide, and pancreatic polypeptide in non-insulin-dependent diabetes in the fasting state. Scand J Gastroenterol 1985, 20: 315-20.
    • (1985) Scand J Gastroenterol , vol.20 , pp. 315-320
    • Amland, P.F.1    Jorde, R.2    Aanderup, S.3    Burhol, P.G.4    Giercksky, K.-E.5
  • 9
    • 0023243048 scopus 로고
    • The effects of glucose-dependent insulinotropic polypeptide infused at physiological concentrations in normal subjects and type 2 (non-insulin-dependent) diabetic patients on glucose tolerance and B-cell secretion
    • Jones, I.R., Owens, D.R., Moody, A.J., Luzio, S.D., Morris, T. and Hayes, T.M. The effects of glucose-dependent insulinotropic polypeptide infused at physiological concentrations in normal subjects and type 2 (non-insulin-dependent) diabetic patients on glucose tolerance and B-cell secretion. Diabetologia 1987, 30: 707-12.
    • (1987) Diabetologia , vol.30 , pp. 707-712
    • Jones, I.R.1    Owens, D.R.2    Moody, A.J.3    Luzio, S.D.4    Morris, T.5    Hayes, T.M.6
  • 10
    • 0023179206 scopus 로고
    • Effect of porcine gastric inhibitory polypeptide on beta-cell function in type I and type II diabetes mellitus
    • Krarup, T., Saurbrey, N., Moody, A.J., Kühl, C. and Madsbad, S. Effect of porcine gastric inhibitory polypeptide on beta-cell function in type I and type II diabetes mellitus. Metabolism 1988, 36: 677-82.
    • (1988) Metabolism , vol.36 , pp. 677-682
    • Krarup, T.1    Saurbrey, N.2    Moody, A.J.3    Kühl, C.4    Madsbad, S.5
  • 11
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide I [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck, M.A., Heimesaat, M.M., Ørskov, C., Holst, J.J., Ebert, R. and Creutzfeldt, W. Preserved incretin activity of glucagon-like peptide I [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 1993, 91: 301-7.
    • (1993) J Clin Invest , vol.91 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Ørskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 12
    • 0035512742 scopus 로고    scopus 로고
    • Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes
    • Meier, J.J., Hücking, K., Holst, J.J., Deacon, C.F., Schmiegel, W.H. and Nauck, M.A. Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes, Diabetes 2001, 50: 2497-504.
    • (2001) Diabetes , vol.50 , pp. 2497-2504
    • Meier, J.J.1    Hücking, K.2    Holst, J.J.3    Deacon, C.F.4    Schmiegel, W.H.5    Nauck, M.A.6
  • 13
    • 0035041250 scopus 로고    scopus 로고
    • Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
    • Lynn, F.C., Pamir, N., Ng, E.H., McIntosh, C.H., Kieffer, T.J. and Pederson, R.A. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes 2001, 50: 1004-11.
    • (2001) Diabetes , vol.50 , pp. 1004-1011
    • Lynn, F.C.1    Pamir, N.2    Ng, E.H.3    McIntosh, C.H.4    Kieffer, T.J.5    Pederson, R.A.6
  • 14
    • 0023955686 scopus 로고
    • Immunoreactive gastric inhibitory polypeptide
    • Krarup, T. Immunoreactive gastric inhibitory polypeptide. Endocr Rev 1988, 9: 122-33.
    • (1988) Endocr Rev , vol.9 , pp. 122-133
    • Krarup, T.1
  • 15
    • 0024397993 scopus 로고
    • The glucose dependent insulinotropic polypeptide response to oral glucose and mixed meals is increased in patients with type 2 (non-insulin-dependent) diabetes mellitus
    • Jones, I.R., Owens, D.R., Luzio, S., Williams, S. and Hayes, T.M. The glucose dependent insulinotropic polypeptide response to oral glucose and mixed meals is increased in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1989, 32: 668-77.
    • (1989) Diabetologia , vol.32 , pp. 668-677
    • Jones, I.R.1    Owens, D.R.2    Luzio, S.3    Williams, S.4    Hayes, T.M.5
  • 16
    • 0020026919 scopus 로고
    • Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem
    • Lund, P.K., Goodman, R.H., Dee, P.C. and Habener, J.F. Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem. Proc Natl Acad Sci USA 1982, 79: 345-9.
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 345-349
    • Lund, P.K.1    Goodman, R.H.2    Dee, P.C.3    Habener, J.F.4
  • 17
    • 0020535282 scopus 로고
    • Exon duplication and divergence in the human preproglucagon gene
    • Bell, G.I., Sanchez-Pescador, R., Laybourn, P.J. and Najarian, R.C. Exon duplication and divergence in the human preproglucagon gene. Nature 1983, 304: 368-71.
    • (1983) Nature , vol.304 , pp. 368-371
    • Bell, G.I.1    Sanchez-Pescador, R.2    Laybourn, P.J.3    Najarian, R.C.4
  • 18
    • 0022971804 scopus 로고
    • Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas
    • Ørskov, C., Knuhtsen, S., Baldissera, F.G., Poulsen, S.S., Nielsen, O.V. and Holst, J.J. Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas. Endocrinology 1986, 119: 1467-75.
    • (1986) Endocrinology , vol.119 , pp. 1467-1475
    • Ørskov, C.1    Knuhtsen, S.2    Baldissera, F.G.3    Poulsen, S.S.4    Nielsen, O.V.5    Holst, J.J.6
  • 20
    • 0024359370 scopus 로고
    • Complete sequences of glucagon-like peptide-1 from human and pig small intestine
    • Ørskov, C., Bersani, M., Johnsen, A.H., Hojrup, P. and Holst, J.J. Complete sequences of glucagon-like peptide-1 from human and pig small intestine. J Biol Chem 1989, 264: 12826-9.
    • (1989) J Biol Chem , vol.264 , pp. 12826-12829
    • Ørskov, C.1    Bersani, M.2    Johnsen, A.H.3    Hojrup, P.4    Holst, J.J.5
  • 21
    • 0023104829 scopus 로고
    • Truncated glucagon-like peptide 1, an insulin-releasing hormone from the distal gut
    • Holst, J.J., Ørskov, C., Vagn-Nielsen, O. and Schwartz, T.W. Truncated glucagon-like peptide 1, an insulin-releasing hormone from the distal gut. FEBS Lett 1987, 211: 169-74.
    • (1987) FEBS Lett , vol.211 , pp. 169-174
    • Holst, J.J.1    Ørskov, C.2    Vagn-Nielsen, O.3    Schwartz, T.W.4
  • 22
    • 0023107555 scopus 로고
    • Insulinotropin: Glucagon-like peptide 1 (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
    • Mojsov, S., Weir. G.C. and Habener, J.F. Insulinotropin: Glucagon-like peptide 1 (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest 1987, 79: 616-9.
    • (1987) J Clin Invest , vol.79 , pp. 616-619
    • Mojsov, S.1    Weir, G.C.2    Habener, J.F.3
  • 23
    • 0022461548 scopus 로고
    • Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
    • Nauck, M.A., Homberger, E., Siegel, E.G. et al. Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab 1986, 63: 492-8.
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 492-498
    • Nauck, M.A.1    Homberger, E.2    Siegel, E.G.3
  • 24
    • 0023836241 scopus 로고
    • Incretin effect due to increased secretion and decreased clearance of insuIin in normal humans
    • Shuster, L.T., Go, V.L.W., Rizza, R.A., O'Brien, P.C. and Service, F.J. Incretin effect due to increased secretion and decreased clearance of insuIin in normal humans. Diabetes 1988, 37: 200-3.
    • (1988) Diabetes , vol.37 , pp. 200-203
    • Shuster, L.T.1    Go, V.L.W.2    Rizza, R.A.3    O'Brien, P.C.4    Service, F.J.5
  • 25
    • 0023758530 scopus 로고
    • Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach
    • Ørskov, C., Holst, J.J. and Nielsen, O.V. Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach. Endocrinology 1988, 123: 2009-13.
    • (1988) Endocrinology , vol.123 , pp. 2009-2013
    • Ørskov, C.1    Holst, J.J.2    Nielsen, O.V.3
  • 26
    • 0026542396 scopus 로고
    • Insulinotropic action of glucagon-like peptide 1 (7-37) it diabetic and non-diabetic subjects
    • Nathan, D.M., Schreiber, E., Fogel, H., Mojsov, S. and Habener, J.F. Insulinotropic action of glucagon-like peptide 1 (7-37) it diabetic and non-diabetic subjects. Diabetes Care 1992, 15: 270-6.
    • (1992) Diabetes Care , vol.15 , pp. 270-276
    • Nathan, D.M.1    Schreiber, E.2    Fogel, H.3    Mojsov, S.4    Habener, J.F.5
  • 27
    • 0029954211 scopus 로고    scopus 로고
    • Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients
    • Creutzfeldt, W.O., Kleine, N., Willms, B., Ørskov, C., Holst, J.J. and Nauck, M.A. Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients. Diabetes Care 1996, 19: 580-6.
    • (1996) Diabetes Care , vol.19 , pp. 580-586
    • Creutzfeldt, W.O.1    Kleine, N.2    Willms, B.3    Ørskov, C.4    Holst, J.J.5    Nauck, M.A.6
  • 28
    • 0027248866 scopus 로고    scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck, M.A., Kleine, N., Ørskov, C., Holst, J.J., Willms, B. and Creutzfeldt, W. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 741-4.
    • Diabetologia , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Ørskov, C.3    Holst, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 29
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes satiety and suppresses energy intake in humans
    • Flint, A., Raben, A., Astrup, A. and Holst, J.J. Glucagon-like peptide-1 promotes satiety and suppresses energy intake in humans. J Clin Invest 1998, 101: 515-20.
    • (1998) J Clin Invest , vol.101 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 30
    • 0001218043 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 is a physiologic regulator of food intake in humans
    • Gutzwiller, J.P., Göke, B., Drewe, J. et al. Glucagon-like peptide-1 is a physiologic regulator of food intake in humans. Gastroenterol 1997, 112(Suppl.): A1153.
    • (1997) Gastroenterol , vol.112 , Issue.SUPPL.
    • Gutzwiller, J.P.1    Göke, B.2    Drewe, J.3
  • 31
    • 0032976939 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients
    • Toft-Nielsen, M.-B., Madsbad, S. and Holst, J.J. Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients. Diabetes Care 1999, 22: 1137-43.
    • (1999) Diabetes Care , vol.22 , pp. 1137-1143
    • Toft-Nielsen, M.-B.1    Madsbad, S.2    Holst, J.J.3
  • 32
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
    • Zander, M., Madsbad, S., Madsen. J.L. and Holst, J.J. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study. Lancet 2002, 359: 824-30.
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 33
    • 0029903111 scopus 로고    scopus 로고
    • Glucagon-like peptide I receptors in the subfornicaI organ and the area postrema are accessible to circulating glucagon-like peptide 1
    • Ørskov, C., Poulsen, S.S., Moller, M. and Holst. J.J. Glucagon-like peptide I receptors in the subfornicaI organ and the area postrema are accessible to circulating glucagon-like peptide 1. Diabetes 1996, 45: 832-5.
    • (1996) Diabetes , vol.45 , pp. 832-835
    • Ørskov, C.1    Poulsen, S.S.2    Moller, M.3    Holst, J.J.4
  • 35
    • 0030068620 scopus 로고    scopus 로고
    • Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: Effects of erogenotis glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients
    • Willms B., Werner, J., Holst, J.J., Ørskov, C., Creutzfeldt, W. and Nauck, M.A. Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: Effects of erogenotis glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients. J Clin Endocrinol Metab 1996, 81: 327-32.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 327-332
    • Willms, B.1    Werner, J.2    Holst, J.J.3    Ørskov, C.4    Creutzfeldt, W.5    Nauck, M.A.6
  • 36
    • 0030667056 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans
    • Nauck, M.A., Niedereichholz, U., Ettler, R. et al. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol 1997, 273: E981-8.
    • (1997) Am J Physiol , vol.273
    • Nauck, M.A.1    Niedereichholz, U.2    Ettler, R.3
  • 37
    • 0033028297 scopus 로고    scopus 로고
    • Is glucagon-like peptide 1 an incretin hormone?
    • Nauck. M.A. Is glucagon-like peptide 1 an incretin hormone? Diabetologia 1999, 42: 373-9.
    • (1999) Diabetologia , vol.42 , pp. 373-379
    • Nauck, M.A.1
  • 38
    • 0029584116 scopus 로고
    • Regulation of islet hormone gene expression by incretin hormones
    • Fehmann, H.C., Gherzi, R. and Göke, B. Regulation of islet hormone gene expression by incretin hormones. Exp Clin Endocrinol Diabetes 1995, 103(Suppl. 2): 56-65.
    • (1995) Exp Clin Endocrinol Diabetes , vol.103 , Issue.SUPPL. 2 , pp. 56-65
    • Fehmann, H.C.1    Gherzi, R.2    Göke, B.3
  • 39
    • 0034522773 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
    • Perfetti, R., Zhou, J., Doyle, M.E. and Egan, J.M. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 2000, 141: 4600-5.
    • (2000) Endocrinology , vol.141 , pp. 4600-4605
    • Perfetti, R.1    Zhou, J.2    Doyle, M.E.3    Egan, J.M.4
  • 40
    • 0035046251 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism
    • Wang, X., Zhou, J., Doyle, M.E. and Egan, J.M. Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism. Endocrinology 2001, 142: 1820-7.
    • (2001) Endocrinology , vol.142 , pp. 1820-1827
    • Wang, X.1    Zhou, J.2    Doyle, M.E.3    Egan, J.M.4
  • 41
    • 0029907680 scopus 로고    scopus 로고
    • Effects of subcutaneous glucagon-like peptide I (GLP-1 [7-36 amide]) in patients with NIDDM
    • Nauck, M.A., Wollschläger, D., Wemer, J. et al. Effects of subcutaneous glucagon-like peptide I (GLP-1 [7-36 amide]) in patients with NIDDM. Diabetologia 1996, 39: 1546-53.
    • (1996) Diabetologia , vol.39 , pp. 1546-1553
    • Nauck, M.A.1    Wollschläger, D.2    Wemer, J.3
  • 42
    • 0031740718 scopus 로고    scopus 로고
    • Normalization of fasting glycaemia by intravenous GLP-1 ([7-36 amide] of [7-37]) in type 2-diabetic patient
    • Nauck, M.A., Weber, I., Bach, I. et al. Normalization of fasting glycaemia by intravenous GLP-1 ([7-36 amide] of [7-37]) in type 2-diabetic patient. Diabetic Med 1998, 15: 937-45.
    • (1998) Diabetic Med , vol.15 , pp. 937-945
    • Nauck, M.A.1    Weber, I.2    Bach, I.3
  • 43
    • 0031033531 scopus 로고    scopus 로고
    • Near-normalization of diurnal glucose concentrations by continuous administration of glucagon-like peptide 1 (GLP-1) in subjects with NIDDM
    • Rachman, J., Gribble, EM., Levy, J.C. and Turner, R.C. Near-normalization of diurnal glucose concentrations by continuous administration of glucagon-like peptide 1 (GLP-1) in subjects with NIDDM. Diabetologia 1997, 40: 205-11.
    • (1997) Diabetologia , vol.40 , pp. 205-211
    • Rachman, J.1    Gribble, E.M.2    Levy, J.C.3    Turner, R.C.4
  • 44
    • 0030983816 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for type 2-diabetes
    • Nauck, M.A., Holst, J.J., Willms, B. and Schmiegel, W. Glucagon-like peptide 1 (GLP-1) as a new therapeutic approach for type 2-diabetes. Exp Clin Endocrinol Diabetes 1997, 105: 187-95.
    • (1997) Exp Clin Endocrinol Diabetes , vol.105 , pp. 187-195
    • Nauck, M.A.1    Holst, J.J.2    Willms, B.3    Schmiegel, W.4
  • 45
    • 0002099506 scopus 로고    scopus 로고
    • GLP-1 secretion is decreased in NIDDM patients compared to matched control subjects with normal glucose tolerance
    • Toft-Nielsen, M., Damholt, M.B., Hilsted, L. et al. GLP-1 secretion is decreased in NIDDM patients compared to matched control subjects with normal glucose tolerance (abstract). Diabetologia 1999, Supplement A40.
    • (1999) Diabetologia , Issue.SUPPL.
    • Toft-Nielsen, M.1    Damholt, M.B.2    Hilsted, L.3
  • 46
    • 0034880655 scopus 로고    scopus 로고
    • Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients
    • Toft-Nielsen, M.B., Damholt, M.B., Madsbad, S. et al. Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. J Clin Endocrinol Metab 2001, 86: 3717-23.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3717-3723
    • Toft-Nielsen, M.B.1    Damholt, M.B.2    Madsbad, S.3
  • 47
    • 0001095690 scopus 로고    scopus 로고
    • Reduced postprandial concentrations of intact biologically active glucagon-like peptide I in type 2 diabetic patients
    • Vilsbøll, T., Krarup, T., Deacon, C.F., Madsbad, S. and Holst, J.J. Reduced postprandial concentrations of intact biologically active glucagon-like peptide I in type 2 diabetic patients. Diabetes 2001, 50: 609-13.
    • (2001) Diabetes , vol.50 , pp. 609-613
    • Vilsbøll, T.1    Krarup, T.2    Deacon, C.F.3    Madsbad, S.4    Holst, J.J.5
  • 48
    • 0029797540 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig
    • Deacon, C.F., Pridal, L., Klarskov, L., Olesen, M. and Holst, J.J. Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig. Am J Physiol 1996, 271: E458-64.
    • (1996) Am J Physiol , vol.271
    • Deacon, C.F.1    Pridal, L.2    Klarskov, L.3    Olesen, M.4    Holst, J.J.5
  • 49
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory, polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein, R., Gallwitz, B. and Schmidt, W.E. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory, polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 1993, 214: 829-35.
    • (1993) Eur J Biochem , vol.214 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 50
    • 0030607672 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor
    • Knudsen, L.B. and Pridal, L. Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur J Pharmacol 1996, 318: 429-35.
    • (1996) Eur J Pharmacol , vol.318 , pp. 429-435
    • Knudsen, L.B.1    Pridal, L.2
  • 51
    • 0344029860 scopus 로고    scopus 로고
    • GLP-1 [9-36 amide] neither affects insulin release nor antagonises the insulinotropic effects of GLP-1 [7-36 amide] (abstract)
    • Deacon, C.F., Hughes, T.E. and Holst, J.J. GLP-1 [9-36 amide] neither affects insulin release nor antagonises the insulinotropic effects of GLP-1 [7-36 amide] (abstract). Diabetologia 1999, 42: A198.
    • (1999) Diabetologia , vol.42
    • Deacon, C.F.1    Hughes, T.E.2    Holst, J.J.3
  • 52
    • 0028803336 scopus 로고
    • Both subcutaneously and intravenously administered glucagon-like peptide 1 are rapidly degraded from the NH2-terminus in type 2-diabetic patients and in healthy subjects
    • Deacon, C.F., Nauck, M.A., Toft-Nielsen, M., Pridal, L., Willms, B. and Holst, J.J. Both subcutaneously and intravenously administered glucagon-like peptide 1 are rapidly degraded from the NH2-terminus in type 2-diabetic patients and in healthy subjects. Diabetes 1995, 44: 1126-31.
    • (1995) Diabetes , vol.44 , pp. 1126-1131
    • Deacon, C.F.1    Nauck, M.A.2    Toft-Nielsen, M.3    Pridal, L.4    Willms, B.5    Holst, J.J.6
  • 53
    • 0028071448 scopus 로고
    • Subcutaneous injection of the incretin hormone glucagon-like peptide 1 abolishes postprandial glycemia in NIDDM
    • Gutniak, M.K., Linde, B., Holst, J.J. and Efendic, S. Subcutaneous injection of the incretin hormone glucagon-like peptide 1 abolishes postprandial glycemia in NIDDM. Diabetes Care 1994, 17: 1039-44.
    • (1994) Diabetes Care , vol.17 , pp. 1039-1044
    • Gutniak, M.K.1    Linde, B.2    Holst, J.J.3    Efendic, S.4
  • 54
    • 0029074964 scopus 로고
    • Pharmacokinetic, insulinotropic, and glucagonostatic properties of GLP-1 [7-36 amide] after subcutaneous injection in healthy volunteers. Dose-response-relationships
    • Ritzel, R., Ørskov, C., Holst, J.J. and Nauck, M.A. Pharmacokinetic, insulinotropic, and glucagonostatic properties of GLP-1 [7-36 amide] after subcutaneous injection in healthy volunteers. Dose-response-relationships. Diabetologia 1995, 38: 720-5.
    • (1995) Diabetologia , vol.38 , pp. 720-725
    • Ritzel, R.1    Ørskov, C.2    Holst, J.J.3    Nauck, M.A.4
  • 55
    • 0030613750 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and its potential in the treatment of non-insulin-dependent diabetes mellitus
    • Nauck, M.A., Holst, J.J. and Willms, B. Glucagon-like peptide 1 and its potential in the treatment of non-insulin-dependent diabetes mellitus. Horm Metab Res 1997, 29: 411-6.
    • (1997) Horm Metab Res , vol.29 , pp. 411-416
    • Nauck, M.A.1    Holst, J.J.2    Willms, B.3
  • 56
    • 0008972628 scopus 로고    scopus 로고
    • GLP-1 must be present continuously in order to obtain a good glycaemic control in NIDDM
    • Larsen, J. and Damsbo, P. GLP-1 must be present continuously in order to obtain a good glycaemic control in NIDDM (abstract), Diabetes 1997, 46(Suppl. 1): 186A.
    • (1997) Diabetes , vol.46 , Issue.SUPPL. 1
    • Larsen, J.1    Damsbo, P.2
  • 57
    • 0035829852 scopus 로고    scopus 로고
    • Intensive insulin therapy in critically ill patients
    • Van den Berghe, G., Wouters, P., Weekers, F. et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001, 345: 1359-67.
    • (2001) N Engl J Med , vol.345 , pp. 1359-1367
    • Van Den Berghe, G.1    Wouters, P.2    Weekers, F.3
  • 58
    • 0034108646 scopus 로고    scopus 로고
    • Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration
    • Knudsen, L.B., Nielsen, P.F., Huusfeldt, P.O. et al. Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration. J Med Chem 2000, 43: 1664-9.
    • (2000) J Med Chem , vol.43 , pp. 1664-1669
    • Knudsen, L.B.1    Nielsen, P.F.2    Huusfeldt, P.O.3
  • 59
    • 0029893636 scopus 로고    scopus 로고
    • GLP-1/GIP chimeric peptides define the structural requirement for specific ligand-receptor interaction of GLP-1
    • Gallwitz, B., Witt, M., Morys-Wortmann, C., Fölsch, U.R. and Schmidt, W.E. GLP-1/GIP chimeric peptides define the structural requirement for specific ligand-receptor interaction of GLP-1. Regul Pept 1996, 63:17-22.
    • (1996) Regul Pept , vol.63 , pp. 17-22
    • Gallwitz, B.1    Witt, M.2    Morys-Wortmann, C.3    Fölsch, U.R.4    Schmidt, W.E.5
  • 60
    • 0345323825 scopus 로고    scopus 로고
    • LY307161: A fully active, DPP-IV resistant analogue of GLP-1
    • Hoffman, J., Chou. J., Myers, S. and Williams, V. LY307161: A fully active, DPP-IV resistant analogue of GLP-1 (abstract). Diabetologia 2000, 43(Suppl. 1): A145.
    • (2000) Diabetologia , vol.43 , Issue.SUPPL. 1
    • Hoffman, J.1    Chou, J.2    Myers, S.3    Williams, V.4
  • 61
    • 0031782440 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity
    • Deacon, C.F., Knudsen, L.B., Madsen, K., Wiberg, EC., Jacobson, O. and Holst, J.J. Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity. Diabetologia 1998, 41: 271-8.
    • (1998) Diabetologia , vol.41 , pp. 271-278
    • Deacon, C.F.1    Knudsen, L.B.2    Madsen, K.3    Wiberg, E.C.4    Jacobson, O.5    Holst, J.J.6
  • 62
    • 0026775150 scopus 로고
    • Expression cloning of the pancreatic beta cell receptor for the glucoincretin hormone glucagon-like peptide 1
    • Thorens, B. Expression cloning of the pancreatic beta cell receptor for the glucoincretin hormone glucagon-like peptide 1. Proc Natl Acad Sci USA 1992, 89: 8641-5.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 8641-8645
    • Thorens, B.1
  • 63
    • 0027425034 scopus 로고
    • Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor
    • Thorens, B., Porret, A., Buhler, L., Deng, S.P., Morel, P. and Widmann, C. Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 1993, 42: 1678-82.
    • (1993) Diabetes , vol.42 , pp. 1678-1682
    • Thorens, B.1    Porret, A.2    Buhler, L.3    Deng, S.P.4    Morel, P.5    Widmann, C.6
  • 64
    • 0036189831 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
    • Aaersø, H., Jensen, L.B., Elbrønd, B., Rolan, P. and Zdravkovic, M. The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia 2002, 45: 195-202.
    • (2002) Diabetologia , vol.45 , pp. 195-202
    • Aaersø, H.1    Jensen, L.B.2    Elbrønd, B.3    Rolan, P.4    Zdravkovic, M.5
  • 65
    • 0036066641 scopus 로고    scopus 로고
    • Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes
    • Juhl, C.B., Hollingdal, M., Sturis, J. et al. Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes. Diabetes 2002, 51: 424-9.
    • (2002) Diabetes , vol.51 , pp. 424-429
    • Juhl, C.B.1    Hollingdal, M.2    Sturis, J.3
  • 66
    • 0038527035 scopus 로고    scopus 로고
    • The long-acting GLP-1 derivative, NN2211, a new agent for the treatment of type 2 diabetes
    • Matthews, D., Madsbad, S., Schmitz, O., Langendorf, K.W. and Jakobsen, G. The long-acting GLP-1 derivative, NN2211, a new agent for the treatment of type 2 diabetes (abstract). Diabetes 2002, 51 (Suppl, 2): A84.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 2
    • Matthews, D.1    Madsbad, S.2    Schmitz, O.3    Langendorf, K.W.4    Jakobsen, G.5
  • 67
    • 0027184119 scopus 로고
    • Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells
    • Göke, R., Fehmann, H.C., Linn, T et al. Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells. J Biol Chem 1993, 268: 19650-5.
    • (1993) J Biol Chem , vol.268 , pp. 19650-19655
    • Göke, R.1    Fehmann, H.C.2    Linn, T.3
  • 68
    • 0037593121 scopus 로고    scopus 로고
    • Subcutaneous injection of AC 2993 (synthetic exendin-4) lowered fasting glucose concentrations through suppression of glucagon and dose-dependent insulinotropism in patients with type 2 diabetes
    • Kim, D., Taylor, K., Bicsak, T. et al. Subcutaneous injection of AC 2993 (synthetic exendin-4) lowered fasting glucose concentrations through suppression of glucagon and dose-dependent insulinotropism in patients with type 2 diabetes (abstract). Diabetes 2002, 51(Suppl. 2): A104.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 2
    • Kim, D.1    Taylor, K.2    Bicsak, T.3
  • 69
    • 0012306247 scopus 로고    scopus 로고
    • AC 2993 (synthetic exendin-4) added to existing metformin (MET) and/or sulfonylurea (SFU) treatment improved glycemic control in patients with type 2 diabetes (DM2) during 28 days of treatment
    • Fineman, M.S., Bicsak, T., Shen, L. et al. AC 2993 (synthetic exendin-4) added to existing metformin (MET) and/or sulfonylurea (SFU) treatment improved glycemic control in patients with type 2 diabetes (DM2) during 28 days of treatment (abstract). Diabetes 2002, 51(Suppl. 2): A85.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 2
    • Fineman, M.S.1    Bicsak, T.2    Shen, L.3
  • 70
    • 0344892689 scopus 로고    scopus 로고
    • LY 307161 SR, a sustained release formulation of a GLP-1 analog, is suitable for once daily administration in patients with type 2 diabetes
    • Trautmann, M.E., Kapitza, C., Mace, K.F., Patterson, B., Hompesch, M. and Heise, T. LY 307161 SR, a sustained release formulation of a GLP-1 analog, is suitable for once daily administration in patients with type 2 diabetes (abstract). Diabetes 2002, 51(Suppl. 2): A135.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 2
    • Trautmann, M.E.1    Kapitza, C.2    Mace, K.F.3    Patterson, B.4    Hompesch, M.5    Heise, T.6
  • 71
    • 0002075995 scopus 로고    scopus 로고
    • Daily administration of LY307161 (GLP-1 analog) normalizes blood glucose on type 2 diabetes
    • Kapitza, C., Trautmann, M., Heise, T., Heinemann, L. and Patterson, B. Daily administration of LY307161 (GLP-1 analog) normalizes blood glucose on type 2 diabetes (abstract). Diabetes 2002, 51(Suppl. 2): A84.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 2
    • Kapitza, C.1    Trautmann, M.2    Heise, T.3    Heinemann, L.4    Patterson, B.5
  • 72
    • 0002043269 scopus 로고    scopus 로고
    • R CJC-1131, the novel long-acting GLP-1 analogue, delays gastric emptying and demonstrates safety and tolerability in preclinical testing
    • Lawrence, B., Wen, S.Y., Jette, L., Thibaudeau, K. and Castaigne, J.-R CJC-1131, the novel long-acting GLP-1 analogue, delays gastric emptying and demonstrates safety and tolerability in preclinical testing (abstract). Diabetes 2002, 51(Suppl. 2): A84.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 2
    • Lawrence, B.1    Wen, S.Y.2    Jette, L.3    Thibaudeau, K.4    Castaigne, J.5
  • 73
    • 0012980860 scopus 로고    scopus 로고
    • The long-acting GLP-1 agonist CJC 1131 exhibits high potency and extended pharmacokinetics in vivo
    • Bridon, D.P., Thibaudeau, K., L'Archeveque, B.P., Pham, K., Robitaille, M.F., Drucker, D.J. et al. The long-acting GLP-1 agonist CJC 1131 exhibits high potency and extended pharmacokinetics in vivo (abstract). Diabetes 2002, 51(Suppl. 2): A93.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 2
    • Bridon, D.P.1    Thibaudeau, K.2    L'Archeveque, B.P.3    Pham, K.4    Robitaille, M.F.5    Drucker, D.J.6
  • 74
    • 0010795476 scopus 로고    scopus 로고
    • Development and characterization of long-acting degradation resistant GLP-1-DAC compounds for the treatment of type 2 diabetes
    • Thibaudeau, K., Smith, D.C., Jette, L. et al. Development and characterization of long-acting degradation resistant GLP-1-DAC compounds for the treatment of type 2 diabetes (abstract). Diabetes 2002, 50(Suppl. 2): A116.
    • (2002) Diabetes , vol.50 , Issue.SUPPL. 2
    • Thibaudeau, K.1    Smith, D.C.2    Jette, L.3
  • 75
    • 0031916924 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition potentiates the insalinotropic effect of glucagon-like peptide 1 in the anesthetized pig
    • Deacon, C.F., Highes, T.E. and Holst, J.J. Dipeptidyl peptidase IV inhibition potentiates the insalinotropic effect of glucagon-like peptide 1 in the anesthetized pig. Diabetes 1998, 47: 764-9.
    • (1998) Diabetes , vol.47 , pp. 764-769
    • Deacon, C.F.1    Highes, T.E.2    Holst, J.J.3
  • 76
    • 0035403058 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of G1P and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs
    • Deacon, C.F., Danielsen, P., Klarskov, L., Olesen, M. and Holst, J.J. Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of G1P and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs. Diabetes 2001, 50: 1588-97.
    • (2001) Diabetes , vol.50 , pp. 1588-1597
    • Deacon, C.F.1    Danielsen, P.2    Klarskov, L.3    Olesen, M.4    Holst, J.J.5
  • 77
    • 0003073206 scopus 로고    scopus 로고
    • Treatment with a DPP-IV inhibitor, NVP-DPP728, increases prandial intact GLP-1 levels and reduces glucose exposure in humans
    • Rothenberg, P., Kalbag, J., Smith, H. et al. Treatment with a DPP-IV inhibitor, NVP-DPP728, increases prandial intact GLP-1 levels and reduces glucose exposure in humans (abstract). Diabetes 2000, 49(Suppl. 1): A39.
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Rothenberg, P.1    Kalbag, J.2    Smith, H.3
  • 78
    • 0035081369 scopus 로고    scopus 로고
    • No reactive hypoglycaemia in Type 2 diabetic patients after subcutaneous administration of GLP-1 and intravenous glucose
    • Vitsbøll, T., Krarup, T., Madsbad, S. and Holst, J.J. No reactive hypoglycaemia in Type 2 diabetic patients after subcutaneous administration of GLP-1 and intravenous glucose. Diabet Med 2001, 18: 144-9.
    • (2001) Diabet Med , vol.18 , pp. 144-149
    • Vitsbøll, T.1    Krarup, T.2    Madsbad, S.3    Holst, J.J.4
  • 79
    • 0036959991 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
    • Nauck, M.A., Heimesaat, M.M., Behle et al. Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. J Clin Endocrinol Metab 2002, 87: 1239-46.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1239-1246
    • Nauck, M.A.1    Heimesaat, M.M.2    Behle3
  • 80
    • 0000283169 scopus 로고    scopus 로고
    • Insulinotropic effect of exendin-4 in humans
    • Egan, J., Clocquet, A.R. and Elahi, D. Insulinotropic effect of exendin-4 in humans (abstract). Diabetologia 1999, 42(Suppl. 1): A41.
    • (1999) Diabetologia , vol.42 , Issue.SUPPL. 1
    • Egan, J.1    Clocquet, A.R.2    Elahi, D.3
  • 81
    • 0000181936 scopus 로고    scopus 로고
    • Dose-response for postprandial glucose-lowering effect of synthetic exendin-4 (AC2993) in subjects with type 2 diabetes
    • Fineman, M., Young, A., Gaines, E. and Prickett, K. Dose-response for postprandial glucose-lowering effect of synthetic exendin-4 (AC2993) in subjects with type 2 diabetes (abstract). Diabetes 2000, 49(Suppl. 1): A106.
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Fineman, M.1    Young, A.2    Gaines, E.3    Prickett, K.4
  • 82
    • 0038584690 scopus 로고    scopus 로고
    • Dose-response for inhibition of glucagon secretion and gastric emptying by synthetic exendin-4 (AC2993) in subjects with type 2 diabetes
    • Kolterman, O., Gottlieb, A., Prickett, K., Gaines, E. and Young, A. Dose-response for inhibition of glucagon secretion and gastric emptying by synthetic exendin-4 (AC2993) in subjects with type 2 diabetes (abstract). Diabetes 2000, 49(Suppl. 1): A114.
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Kolterman, O.1    Gottlieb, A.2    Prickett, K.3    Gaines, E.4    Young, A.5
  • 83
    • 26544432116 scopus 로고    scopus 로고
    • Measurements of satiety and fullness following a sustacal challenge in type 2 diabetic subjects administered synthetic exendin-4 (AC2993)
    • Young, A., Gottlieb, A., Fineman, M. and Kolterman, O. Measurements of satiety and fullness following a sustacal challenge in type 2 diabetic subjects administered synthetic exendin-4 (AC2993) (abstract). Diabetologia 1999, 42(Suppl. 1): A40.
    • (1999) Diabetologia , vol.42 , Issue.SUPPL. 1
    • Young, A.1    Gottlieb, A.2    Fineman, M.3    Kolterman, O.4
  • 84
    • 0002812851 scopus 로고    scopus 로고
    • AC2993 (synthetic exendin-4) lowered postprandial plasma glucose concentrations in people with type 2 diabetes
    • Kolterman, O., Fineman, M., Gottlieb, A., Petrella, E., Pricket, K. and Young, A. AC2993 (synthetic exendin-4) lowered postprandial plasma glucose concentrations in people with type 2 diabetes (abstract). Diabetologia 1999, 42(Suppl. 1): A41.
    • (1999) Diabetologia , vol.42 , Issue.SUPPL. 1
    • Kolterman, O.1    Fineman, M.2    Gottlieb, A.3    Petrella, E.4    Pricket, K.5    Young, A.6
  • 85
    • 1342265272 scopus 로고    scopus 로고
    • Subcutaneous exendin-4 improves daytime glucose exposure by reducing postprandial glucose increment in diet treated type 2 diabetic patients
    • Levy, J.C., Maksoud, H., Barrow, B.A. and Sutton, P.J. Subcutaneous exendin-4 improves daytime glucose exposure by reducing postprandial glucose increment in diet treated type 2 diabetic patients (abstract). Diabetes 2000, 49(Suppl. 1): A115.
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Levy, J.C.1    Maksoud, H.2    Barrow, B.A.3    Sutton, P.J.4
  • 86
    • 0344460918 scopus 로고    scopus 로고
    • Subcutaneous exendin-4 reduces basal glucose and postprandial glucose increment and improves beta cell function in sulphonylurea treated type 2 diabetic subjects
    • Maksoud, H., Barrow, B.A., Manley, S.E. and Levy, J.C. Subcutaneous exendin-4 reduces basal glucose and postprandial glucose increment and improves beta cell function in sulphonylurea treated type 2 diabetic subjects (abstract). Diabetes 2000. 49(Suppl. 1): A116.
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Maksoud, H.1    Barrow, B.A.2    Manley, S.E.3    Levy, J.C.4
  • 87
    • 0013028550 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of AC 2993 (synthetic exendin-4) provides sustained day-long glycemic control to patients with type 2 diabetes
    • Taylor, K., Kim, D., Bicsak, T. et al. Continuous subcutaneous infusion of AC 2993 (synthetic exendin-4) provides sustained day-long glycemic control to patients with type 2 diabetes (abstract). Diabetes 2002, 51(Suppl. 2): A85.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 2
    • Taylor, K.1    Kim, D.2    Bicsak, T.3
  • 88
    • 0000181936 scopus 로고    scopus 로고
    • Effect of five-day dosing of synthetic exendin-4 (AC2993) in people with type 2 diabetes
    • Buse, J., Fineman, M., Gottlieb, A., Gaines, E. and Kolterman, O. Effect of five-day dosing of synthetic exendin-4 (AC2993) in people with type 2 diabetes (abstract). Diabetes 2000, 49(Suppl. 1).
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Buse, J.1    Fineman, M.2    Gottlieb, A.3    Gaines, E.4    Kolterman, O.5
  • 89
    • 0002444399 scopus 로고    scopus 로고
    • Single dose treatment of patients by the DPIV inhibitor P32/98
    • Demuth, H.-U., Hoffmann, T., Glund, K. et al. Single dose treatment of patients by the DPIV inhibitor P32/98 (abstract). Diabetes 2000, 49(Suppl. 1): A102.
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Demuth, H.-U.1    Hoffmann, T.2    Glund, K.3
  • 90
    • 0036583164 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes
    • Åhren, B., Simonsson, E., Larsson, H. et al. Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes. Diabetes Care 2002, 25: 869-75.
    • (2002) Diabetes Care , vol.25 , pp. 869-875
    • Åhren, B.1    Simonsson, E.2    Larsson, H.3
  • 91
    • 0012254681 scopus 로고    scopus 로고
    • The GLP-1 analogue, NN2211, inhibits free fatty acid-induced opoptosis in primary rat beta-cells
    • Bregenholdt, S., Møldrup, A., Blume, N., Bjerre Knudsen, L. and Petersen, J.S. The GLP-1 analogue, NN2211, inhibits free fatty acid-induced opoptosis in primary rat beta-cells (abstract). Diabetologia 2001, 44(Suppl. 1): A19.
    • (2001) Diabetologia , vol.44 , Issue.SUPPL. 1
    • Bregenholdt, S.1    Møldrup, A.2    Blume, N.3    Bjerre Knudsen, L.4    Petersen, J.S.5
  • 92
    • 0002604912 scopus 로고    scopus 로고
    • The GLP-1 derivative NN2211 inhibits cytokine-induced apoptosis in primary rat beta-cells
    • Bregenholdt, S., Moldrup, A.B., Knudsen, L. and Petersen, J.S. The GLP-1 derivative NN2211 inhibits cytokine-induced apoptosis in primary rat beta-cells (abstracts). Diabetes 2001, 50(Suppl. 1): A31.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Bregenholdt, S.1    Moldrup, A.B.2    Knudsen, L.3    Petersen, J.S.4
  • 93
    • 0003046870 scopus 로고    scopus 로고
    • Efficacy of the long-acting GLP-I derivative NN2211 in diabetic db/db mice
    • Rolin, B., Carr, R. and Knudsen, L.B. Efficacy of the long-acting GLP-I derivative NN2211 in diabetic db/db mice (abstract). Diabetes 2000, 49(Suppl. 1): A227.
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Rolin, B.1    Carr, R.2    Knudsen, L.B.3
  • 94
    • 0344892685 scopus 로고    scopus 로고
    • NN2211, a long-acting GLP-1 derivative, decreases blood glucose and stimulates beta-cell proliferation in db/db mice
    • Larsen, M.O., Gotfredsen, C.F., Rolin, B., Wilken, M. and Bjerre Knudsen, L. NN2211, a long-acting GLP-1 derivative, decreases blood glucose and stimulates beta-cell proliferation in db/db mice (abstract). Diabetologia 2001, 44(Suppl. 1): A197.
    • (2001) Diabetologia , vol.44 , Issue.SUPPL. 1
    • Larsen, M.O.1    Gotfredsen, C.F.2    Rolin, B.3    Wilken, M.4    Bjerre Knudsen, L.5
  • 95
    • 4244087058 scopus 로고    scopus 로고
    • NN2211, a GLP-1 derivative, has a long lasting blood glucose lowering effect in db/db mice: A comparison with exendin-4
    • Larsen, M.O., Rolin, B., Wilken, M., Carr, R.D. and Bjerre Knudsen, L. NN2211, a GLP-1 derivative, has a long lasting blood glucose lowering effect in db/db mice: A comparison with exendin-4 (abstract). Diabetes 2001. 50(Suppl. 1): A312.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Larsen, M.O.1    Rolin, B.2    Wilken, M.3    Carr, R.D.4    Bjerre Knudsen, L.5
  • 96
    • 0000948274 scopus 로고    scopus 로고
    • Systemic administration of the long-acting GLP-1 analogue, NN2211, induces lasting and reversible loss of body adiposity
    • Larsen, P.J., Tang-Christensen, M. and Knudsen, L.B. Systemic administration of the long-acting GLP-1 analogue, NN2211, induces lasting and reversible loss of body adiposity, (abstract). Diabetologia 2000, 43(Suppl. 1): A144.
    • (2000) Diabetologia , vol.43 , Issue.SUPPL. 1
    • Larsen, P.J.1    Tang-Christensen, M.2    Knudsen, L.B.3
  • 97
    • 0000184018 scopus 로고    scopus 로고
    • Long-acting GLP-1 derivative NN2211 markedly slows the development of diabetes in the male Zucker diabetic fatty rat
    • Sturis, J., Jappe, M.B., Knudsen, L.B. et al. Long-acting GLP-1 derivative NN2211 markedly slows the development of diabetes in the male Zucker diabetic fatty rat (abstract). Diabetes 2000, 49(Suppl. 1): A228.
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Sturis, J.1    Jappe, M.B.2    Knudsen, L.B.3
  • 98
    • 0010471727 scopus 로고    scopus 로고
    • NN2211, a protracted GLP-1 derivative, ameliorates glycaemia and reduces triglyceride levels in pre-diabetic ZDF rats
    • Rolin, B., Gotfredsen, C., Sturis, J. et al. NN2211, a protracted GLP-1 derivative, ameliorates glycaemia and reduces triglyceride levels in pre-diabetic ZDF rats (abstract). Diabetes 2001, 50(Suppl. 1): A312.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Rolin, B.1    Gotfredsen, C.2    Sturis, J.3
  • 99
    • 0006746234 scopus 로고    scopus 로고
    • Effect of the long-acting GLP-1 derivative NN2211 in 60% pancreatectomized rats
    • Rømer, J., Pedersen, K.E., Jørgensen, B. et al. Effect of the long-acting GLP-1 derivative NN2211 in 60% pancreatectomized rats (abstract). Diabetes 2001, 50(Suppl. 1): A312.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Rømer, J.1    Pedersen, K.E.2    Jørgensen, B.3
  • 100
    • 0002962342 scopus 로고    scopus 로고
    • Glucose lowering effect of the protracted GLP-1 derivative, NN2211, in the beta cell reduced minipig
    • Ribel, U., Hvidt, M., Larsen, M.Ø., Rolin, B., Wilken, M. and Knudsen, L.B. Glucose lowering effect of the protracted GLP-1 derivative, NN2211, in the beta cell reduced minipig (abstract). Diabetologia 2000, 43(Suppl. 1): A145,
    • (2000) Diabetologia , vol.43 , Issue.SUPPL. 1
    • Ribel, U.1    Hvidt, M.2    Larsen, M.Ø.3    Rolin, B.4    Wilken, M.5    Knudsen, L.B.6
  • 101
    • 0003303540 scopus 로고    scopus 로고
    • Sustained appetite suppression and weight loss in obese rhesus monkeys treated with a long-acting GLP-1 derivative, NN2211
    • Hansen, B.C., Bjenning, C. and Bjerrre Knudsen, L. Sustained appetite suppression and weight loss in obese rhesus monkeys treated with a long-acting GLP-1 derivative, NN2211 (abstract). Diabetologia 2001, 44(Suppl. 1): A196.
    • (2001) Diabetologia , vol.44 , Issue.SUPPL. 1
    • Hansen, B.C.1    Bjenning, C.2    Bjerrre Knudsen, L.3
  • 102
    • 0037570396 scopus 로고    scopus 로고
    • Effect of exendin-4 on glucagon secretion in lean and obese Zucker (ZDF) rats
    • Parkes, D., Gedulin, B., Smith, P. and Young, A. Effect of exendin-4 on glucagon secretion in lean and obese Zucker (ZDF) rats (abstracts). Diabetes 2001, 50(Suppl. 1): A313.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Parkes, D.1    Gedulin, B.2    Smith, P.3    Young, A.4
  • 103
    • 0013015375 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) or exendin-4 administration enhances regeneration of the beta-cell mass in streptozotocin-treated newborn rats
    • Tourrel, C., Bailbe, D., Meile, M.-J., Kergoat, M. and Portha, B. Glucagon-like peptide-1 (GLP-1) or exendin-4 administration enhances regeneration of the beta-cell mass in streptozotocin-treated newborn rats (abstract). Diabetes 2000, 49(Suppl. 1): A257.
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Tourrel, C.1    Bailbe, D.2    Meile, M.-J.3    Kergoat, M.4    Portha, B.5
  • 104
    • 26544458103 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) of exendin-4 treatment limited to the pre-diabetic period limits the progression to overt NIDDM in the adult GK rat
    • Tourrel, C., Bailbe, D., Meile, M.-J., Kergoat, M. and Portha, B. Glucagon-like peptide-1 (GLP-1) of exendin-4 treatment limited to the pre-diabetic period limits the progression to overt NIDDM in the adult GK rat (abstract). Diabetes 2001, 50(Suppl. 1): A3339.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Tourrel, C.1    Bailbe, D.2    Meile, M.-J.3    Kergoat, M.4    Portha, B.5
  • 105
    • 0006416240 scopus 로고    scopus 로고
    • Increased beta-cell mass as mechanism of ameliorated glucose tolerance after exendin-4 treatment in diabetic pancreatectomized rats
    • Bonner-Weir, S. Increased beta-cell mass as mechanism of ameliorated glucose tolerance after exendin-4 treatment in diabetic pancreatectomized rats (abstract). Diabetes 1999, 48(Suppl. 1): A20.
    • (1999) Diabetes , vol.48 , Issue.SUPPL. 1
    • Bonner-Weir, S.1
  • 106
    • 26544448814 scopus 로고    scopus 로고
    • Acute and chronic effects of exendin-4 on glycaemic control and food intake in diabetic mice
    • Nolan, A.L., Sennitt, M.V., Whittle, E.B., Stocker, C.J. and Cawthorne, M.A. Acute and chronic effects of exendin-4 on glycaemic control and food intake in diabetic mice (abstract). Diabetologia 2000, 43(Suppl. 1): A148.
    • (2000) Diabetologia , vol.43 , Issue.SUPPL. 1
    • Nolan, A.L.1    Sennitt, M.V.2    Whittle, E.B.3    Stocker, C.J.4    Cawthorne, M.A.5
  • 107
    • 26544441777 scopus 로고    scopus 로고
    • Continuous infusion of exendin-4 lowered HbA1c at least as effectively as twice daily injections in diabetic Zucker fatty (ZDF) rats
    • Bhasvar, S., Jodka, C., Smith, P., Gedulin, B. and Young, A. Continuous infusion of exendin-4 lowered HbA1c at least as effectively as twice daily injections in diabetic Zucker fatty (ZDF) rats (abstract). Diabetologia 2001, 44(Suppl. 1): A198.
    • (2001) Diabetologia , vol.44 , Issue.SUPPL. 1
    • Bhasvar, S.1    Jodka, C.2    Smith, P.3    Gedulin, B.4    Young, A.5
  • 108
    • 26544447683 scopus 로고    scopus 로고
    • Exendin-4 injections ameliorated progression of fasting hyperglycemia and elevation of HbA1c in diabetic fatty Zucker (ZDF) rats
    • Smith, P., Young, A. and Gedulin, B. Exendin-4 injections ameliorated progression of fasting hyperglycemia and elevation of HbA1c in diabetic fatty Zucker (ZDF) rats (abstract). Diabetes 2001, 50(Suppl. 1): A197.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Smith, P.1    Young, A.2    Gedulin, B.3
  • 109
    • 26544446079 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition promotes differentiation of new beta cells in 60% pancreatectomized rats
    • Ribel, U., Bentsen, E., Rømer. J., Jørgensen, B., Rothe, R, Pedersen, K.E. et al. Dipeptidyl peptidase IV inhibition promotes differentiation of new beta cells in 60% pancreatectomized rats (abstract). Diabetologia 2001, 44(Suppl. 1): A 192.
    • (2001) Diabetologia , vol.44 , Issue.SUPPL. 1
    • Ribel, U.1    Bentsen, E.2    Rømer, J.3    Jørgensen, B.4    Rothe, R.5    Pedersen, K.E.6
  • 110
    • 0142172906 scopus 로고    scopus 로고
    • Dosage of a dipeptidyl peptidase IV (DP IV) inhibitor and timing of its administration to improve glucose tolerance in rats
    • Freyse, E.-J., Knospe, S., Glund, K. and Demuth, H.U. Dosage of a dipeptidyl peptidase IV (DP IV) inhibitor and timing of its administration to improve glucose tolerance in rats (abstract). Diabetes 1999, 48(Suppl. 1): A355.
    • (1999) Diabetes , vol.48 , Issue.SUPPL. 1
    • Freyse, E.-J.1    Knospe, S.2    Glund, K.3    Demuth, H.U.4
  • 111
    • 26544441106 scopus 로고    scopus 로고
    • Prodrugs of DP IV inhibitors strongly improved incretin-mediated glucose tolerance
    • Demuth, H.-U., Freyse, E.-J., Ber, S., Heinke. P., McIntosh, C.C.H. and Pederson, R.A. Prodrugs of DP IV inhibitors strongly improved incretin-mediated glucose tolerance (abstract). Diabetes 2000, 49(Suppl. 1): A228.
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Demuth, H.-U.1    Freyse, E.-J.2    Ber, S.3    Heinke, P.4    McIntosh, C.C.H.5    Pederson, R.A.6
  • 112
    • 0345323800 scopus 로고    scopus 로고
    • Metabolic effects of subchronic oral application of the DPPIV-inhibitor P32/98 and a P32/98 prodrug in diabetic Zucker rats (fa/fa)
    • Freyse, E.-J., Berg, S., Glund, K., Heinke, P. and Demuth. H.-U. Metabolic effects of subchronic oral application of the DPPIV-inhibitor P32/98 and a P32/98 prodrug in diabetic Zucker rats (fa/fa) (abstract). Diabetes 2001, 50(Suppl. 1).
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Freyse, E.-J.1    Berg, S.2    Glund, K.3    Heinke, P.4    Demuth, H.-U.5
  • 113
    • 0345853864 scopus 로고    scopus 로고
    • The dipeptidyl peptidase inhibitor P32/98 improves glucose tolerance in diabetic ZDF rats
    • Stocker, C., Wargent, E., Subramaniam, A., Demuth, H.-U., Sennitt, M. and Cawthome, M.A. The dipeptidyl peptidase inhibitor P32/98 improves glucose tolerance in diabetic ZDF rats (abstract). Diabetes 2001, 50(Suppl. 1): A522.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Stocker, C.1    Wargent, E.2    Subramaniam, A.3    Demuth, H.-U.4    Sennitt, M.5    Cawthome, M.A.6
  • 114
    • 0009604428 scopus 로고    scopus 로고
    • Long-term DP inhibitor (P32/98) treatment causes sustained improvements in glucose tolerance, insulin sensitivity, and hyperinsulinemia in fa/fa Zucker rats
    • Pospisislik, J.A., Stafford, S., Demuth, H.-U., McIntosh, C.H.S. and Pederson, R.A. Long-term DP IV inhibitor (P32/98) treatment causes sustained improvements in glucose tolerance, insulin sensitivity, and hyperinsulinemia in fa/fa Zucker rats (abstract). Diabetes 2001, 50(Suppl. 1): A311.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Pospisislik, J.A.1    Stafford, S.2    Demuth, H.-U.3    McIntosh, C.H.S.4    Pederson IV, R.A.5
  • 115
    • 26544438769 scopus 로고    scopus 로고
    • Sustained improvement of glucose tolerance by DPP-IV inhibition after chronic treatment with NVP-DPP728
    • Balkan, B., Kwasnik, L., Battle, B. and Li., X. Sustained improvement of glucose tolerance by DPP-IV inhibition after chronic treatment with NVP-DPP728 (abstract). Diabetologia 1999, 42(Suppl. 1): A41.
    • (1999) Diabetologia , vol.42 , Issue.SUPPL. 1
    • Balkan, B.1    Kwasnik, L.2    Battle, B.3    Li, X.4
  • 116
    • 26544469537 scopus 로고    scopus 로고
    • GLP-I secretion and beneficial effects of DPP-IV inhibition are increased by insulin resistant rats
    • Balkan, B., Li, X. and Kwasnik, L. GLP-I secretion and beneficial effects of DPP-IV inhibition are increased by insulin resistant rats (abstract). Diabetologia 2000, 43(Suppl. 1): A148.
    • (2000) Diabetologia , vol.43 , Issue.SUPPL. 1
    • Balkan, B.1    Li, X.2    Kwasnik, L.3
  • 117
    • 26544453593 scopus 로고    scopus 로고
    • Lack of dipeptidyl peptidase IV (DPP-IV) activitv prevents the development of impaired glucose tolerance in rats fed a high fat diet
    • Mitani, H., Takimoto, M., Balkan, B., Hughes, T. and Kimura, M. Lack of dipeptidyl peptidase IV (DPP-IV) activitv prevents the development of impaired glucose tolerance in rats fed a high fat diet (abstract). Diabetes 2000, 49(Suppl. 1): A286.
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Mitani, H.1    Takimoto, M.2    Balkan, B.3    Hughes, T.4    Kimura, M.5
  • 118
    • 0345323795 scopus 로고    scopus 로고
    • Six week treatment with a DPP-IV inhibitor, NVP-DPP728, prevents metabolic deterioration in overfed cynomolgus monkeys
    • Dunning, B.E., Deacon, R., Paladini, S. and Hughes, T. Six week treatment with a DPP-IV inhibitor, NVP-DPP728, prevents metabolic deterioration in overfed cynomolgus monkeys (abstract). Diabetes 2000, 49(Suppl. 1).
    • (2000) Diabetes , vol.49 , Issue.SUPPL. 1
    • Dunning, B.E.1    Deacon, R.2    Paladini, S.3    Hughes, T.4
  • 119
    • 0345323799 scopus 로고    scopus 로고
    • CD26 knockout mice have improved glucose tolerance and elevated levels of intact incretin hormones
    • Elm, T., Ribel, U., Bentsen, E., Due, A.-L., Deacon, C.F., Wagtman, N. et al. CD26 knockout mice have improved glucose tolerance and elevated levels of intact incretin hormones (abstract). Diabetologia 2001, 44(Suppl. 1).
    • (2001) Diabetologia , vol.44 , Issue.SUPPL. 1
    • Elm, T.1    Ribel, U.2    Bentsen, E.3    Due, A.-L.4    Deacon, C.F.5    Wagtman, N.6


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