Specificity of brain tumor capillaries and novel drug delivery system

Annals of Cancer Research and Therapy

Volumn 6, Issue 1, 1997, Pages 39-44

  Ikezaki, Kiyonobu ^a   Inamura, Takanori ^b   Samoto, Ken ^b   Koga, Hiromichi ^b   Matsukado, Koichiro ^b   Shono, Tadahisa ^b   Yokoyama, Nobuhiko ^b   Fukui, Masashi ^b   Black, Keith L ^c   Kuwano, Michihiko ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

angiogenesis; bradykinin; brain neoplasm; drug delivery; growth factor

Indexed keywords

EID: 0344528932     PISSN: 13446835     EISSN: None     Source Type: Journal    
DOI: 10.4993/acrt1992.6.39     Document Type: Article

References (47)

1. Joó F. Endothelial cells of the brain and other organ systems: some similarities and differences. Progress in Neurobiology, 48: 255-273, 1996.
2. Kaluza J. Selected histochemical and immunocytochemical markers of biological activity of brain blood vessels. Folia Neuropathol, 33 (4): 198-200, 1995.
3. Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC. Cellular localization of the multidrug resistance gene product in normal brain tissues. Proc Natl Acad Sci USA, 84: 7735-7738, 1987.
4. Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR, Bertino JR. Multidrug resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA, 86: 695-698, 1989.
5. Schinkel AH, Smit JJM, van Teilinger O, Beijnen JH, Wagenaar E, van Deemter L, Mol CAAM, van der Valk MA, Robanus-Maandag EC, te Riele HPJ, Berns AJM, Borst P. Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increase sensitivity to drugs. Cell, 77: 491-502, 1994.
6. Folkman J, Shing Y. Angiogenesis. J Biol Chem, 267: 10931-10934, 1992.
7. Risau W, Seulberger H. Angiogenesis and differentiation of blood-brain barrier endothelium. In: Johansson BB, Owman Ch, Winder H, eds. Pathophysiology of the blood-brain barrier. Amsterdam: Elsevier, 3-9, 1990.
8. Kovacs Z, Ikezaki K, Samoto K, Inamura T, Fukui M. VEGF and fit. Expression time kinetics in rat brain infarct. Stroke, 27: 1865-1873, 1996.
9. Leung DW, Cachianes G, Kuang WJ, Goeddle D, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science, 146: 1306-1309, 1989.
10. Connolly DT, Heuvelman DM, Nelson R, Olander JV, Eppley BL, Delfindo JJ, Siegel RM, Leimgruber RM, Feder J. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest, 84: 1470-1478, 1989.
11. Plate KH, Breier G, Weich HA, Risau W. Vascular endothelial growth factor is a potent tumor angiogenesis factor in human gliomas in vivo. Nature, 359: 846-847, 1992.
12. Samoto K, Ikezaki K, Ono M, Shono T, Kohno K, Kuwano M, Fukui M. Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors. Cancer Res, 55: 1189-1193, 1995.
13. Ikezaki K, Samoto K, Inamura T, Shono T, Fukui M, Ono M, Kuwano M. Expression of vascular growth factor in human brain tumors in vivo. In: Nagai M, eds. Brain tumor research and therapy. Tokyo; Springer-Verlag, 237-235, 1996.
14. Tsai J-C, Goldman CK, Gillespie GY. Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF. J Neurosurg, 82: 864-873, 1995.
15. Hatva E, Kaipainen A, Mentula P, Jääskeläinen J, Paetau A, Haltia M, Alitalo K. Expression on endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors. Am J Pathol, 146: 368-378, 1995.
16. Plate KH, Breier G, Weich HA, Mennel HD, Risau W. Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int J Cancer, 59: 520-529, 1994.
17. Takano S, Yoshii Y, Rondo S, Suzuki H, Maruno T, Shirai S, Nose T. Concentration of vascular growth factor in the serum and tumor tissue of brain tumor patients. Cancer Res, 56: 2185-2190, 1996.
18. Sola F, Farao M, Ciomei M, Pastori A, Mongelli N, Grandi M. FCE27266, a sulfonic distamycin derivative, inhibits experimental and spontaneous lung and liver metastasis. Invasion Metastasis, 15: 222-231, 1995.
19. Saleh M, Stacker SA, Wilks AF. Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence. Cancer Res, 56: 393-401, 1996.
20. Farrell CL, Risau W. Normal and abnormal development of the blood-brain barrier. Microscopy Research and Technique, 27: 495-506, 1994.
21. Long DM. Capillary ultrastructure and the blood-brain barrier in human malignant tumors. J Neurosurg, 32: 127-144, 1970.
22. Hirano A, Matsui T. Vascular structures in brain tumors. Human Pathol, 6: 611-621, 1975.
23. Shibata S. Ultrastructure of blood-brain barrier in human brain tumors. No Shinkei Geka, 20: 1135-1147, 1992, (Japanese).
24. Ikezaki K, Baba T, Inamura T, Nomura T, Fukui M. Selective increase of vascular permeability in brain tumors by leukotriene C4: role of γ-GTP in capillary endothelial cells. Therapeutic Research, 13: 1453-1459, 1992, (Japanese).
25. Ikezaki K, Yokoyama N, Samoto K, Fukui M. Differential expression of P-glycoprotein on capillary endothelial cells in brain tumors with neuroepithelial origin. J Cereb Blood Flow Metab, 13 (Supplement 1): s28, 1993.
26. Henson JW, Cordon-Cardo C, Posner JB. P-glycoprotein expression in brain tumors. J Neuro-Oncol, 14: 37-43, 1992.
27. Wahl M, Unterberg A, Baethman A, Schilling L. Mediators of blood-brain barrier dysfunction and formation of vasogenic edema. J Cereb Blood Flow Metab, 8: 621-634, 1988.
28. Panther LA, Baumbach GL, Bigner DD, Piegoros D, Grooth-uis DR, Heistad DD. Vasoactive drugs produce selective changes in flow to experimental brain tumors. Ann Neurol, 118: 712-715, 1985.
29. Inoue T, Fukui M, Nishio S, Kitamura K, Nagara H. Hyperosmotic blood brain barrier disruption in brains of rats with an intracerebrally transplanted RG-C6 tumor. J Neurosurg, 66: 256-263, 1987.
30. Williams PC, Henner WD, Roman-Goldstein S, Dahlborg SA, Brummett BE, Tableman M, Dana BW, Neuwelt EA. Toxicity and efficacy of carboplatin and etoposide in conjunction with disruption of the blood-brain tumor barrier in the treatment of intracranial neoplasms. Neurosurgey, 37: 17-28, 1995.
31. Baba T, Fukui M, Sakata S, Tashima T, Takeshita I, Nakamura T, Inoue T. Selective enhancement of intratumoral blood flow in malignant gliomas: experimental study in rats by intracarotid administration of adenosine or adenosine triphosphate. Acta Neurochir, 101: 66-74, 1989.
32. Baba T, Fukui M, Takeshita I, Ichiya Y, Kuwabara Y, Hasuo K. Selective enhancement of intratumoral blood flow in malignant glioma using intraarterial adenosine triphosphate. J Neurosurg, 72: 907-911, 1990.
33. Nomura T, Ikezaki K, Natori Y, Fukui M. Altered response of histamine in brain tumor vessels: the selective increase of regional cerebral blood flow in transplanted rat brain tumor. J Neurosurg, 79: 722-728, 1993.
34. Nomura T, Ikezaki K, Matsukado K, Fukui M. Effects of prostacyclin analogue iloprost on the regional blood flow in transplanted rat brain tumour. Neurol Res, 15: 401-404, 1993.
35. Matsukado K, Ikezaki K, Nomura T, Fukui M. Effect of calcium antagonists on regional cerebral blood flow in transplanted rat brain tumors. J Neuro-Oncol, 27: 1-10, 1996.
36. Black KL, King WA, Ikezaki K. Selective opening of the blood-tumor barrier by intracarotid infusion of leukotriene C4. J Neurosurg, 72: 912-916, 1990.
37. Inamura T, Abe M, Ikezaki K, Fukui M. Leukotriene C4 contents, synthase and catabolic activity in human meningiomas. Neurol Res, 14: 405-410, 1992.
38. Inamura T, Nomura T, Ikezaki K, Fukui M, Pollinger G, Black KL. Intracarotid histamine infusion increases blood tumour permeability in RG2 glioma. Neurol Res, 16: 125-128, 1994.
39. Nomura T, Inamura T, Black KL. Intracarotid infusion of bradykinin selectively increases blood-tumor permeability in 9L and C6 brain tumors. Brain Res, 659: 62-66, 1994.
40. Inamura T, Black KL. Bradykinin selectively opens blood-brain barrier in tumors. J Cereb Blood Flow Metab, 14: 862-870, 1994.
41. Inamura T, Nomura T, Bartus RT, Black KL. Intracarotid infusion of RMP-7, a bradykinin analog: a method for selective drug delivery to brain tumors. J Neurosurg, 81: 752-758, 1994.
42. Koga H, Inamura T, Ikezaki K, Nomura T, Samoto K, Fukui M. Increased delivery of a new cisplatin analogue (254-S) in a rat brain tumor by an intracarotid infusion of bradykinin. Neurol Res, 18: 244-247, 1996.
43. Matsukado K, Inamura T, Nakano S, Fukui M, Bartus RT, Black KL. Enhanced tumor uptake of carboplatin and survival in glioma-bearing rats by intracarotid infusion of bradykinin analog, RMP-7. Neurosurgery, 39: 125-134, 1996.
44. Black KL, Cloughesy T, Huang SC, Pierre Gobin Y, Zhou Y, Grous J, Nelson G, Farahani K, Hoh CK, Phelps M. Intracarotid infusion of RMP-7, a bradykinin analog, and transport of gallium-68 ethylenediamine tetraacetic acid into human gliomas. J Neurosurg, 86: 603-609, 1997.
45. Elliott PJ, Hayward NJ, Huff MR, Nagle TL, Black KL, Bartus RT. Unlocking the blood-brain-barrier: a role of RMP-7 in brain tumor therapy. Exp Neurol, 141: 214-224, 1996.
46. Nakano S, Matsukado K, Black KL. Increased brain tumor microvessel permeability after intracarotid bradykinin infusion is mediated by nitric oxide. Cancer Res, 56: 4027-4031, 1996.
47. Van Bree JBMM, De Boer AG, Danhof M, Breimer DD. Drug transport across the blood-brain barrier. III. Mechanisms and methods to improve drug delivery to the central nervous system. Pharmacy World & Science, 15: 2-9, 1993.