Antecedent Adrenaline Attenuates the Responsiveness to but Not the Release of Counterregulatory Hormones during Subsequent Hypoglycemia

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 11, 2003, Pages 5462-5467

  De Galan, Bastiaan E ^a   Rietjens, Saskia J ^a   Tack, Cees J ^a   Van Der Werf, Sieberen P ^a   Sweep, C G J ^a   Lenders, Jacques W M ^a   Smits, Paul ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; HORMONE;

ADULT; ARTICLE; CARDIOVASCULAR RESPONSE; CLAMP; CLINICAL ARTICLE; CLINICAL FEATURE; COGNITION; CONTROLLED STUDY; FEMALE; HORMONE RELEASE; HUMAN; HYPERINSULINEMIA; HYPOGLYCEMIA; HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; PRIORITY JOURNAL; REACTION TIME; SYMPTOM;

ADRENERGIC AGONISTS; ADULT; AWARENESS; BLOOD GLUCOSE; DOWN-REGULATION; EPINEPHRINE; FEMALE; HUMANS; HYPERINSULINISM; HYPOGLYCEMIA; INSULIN; MALE; PERCEPTION;

EID: 0344442408     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030407     Document Type: Article

References (40)

1. Gerich JE, Mokan M, Veneman T, Korytkowski M, Mitrakou A 1991 Hypoglycemia unawareness. Endocr Rev 12:356-371
2. Mokan M, Mitrakou A, Veneman T, Ryan C, Korytkowski M, Cryer P, Gerich J 1994 Hypoglycemia unawareness in IDDM. Diabetes Care 17:1397-1403
3. Cryer PE 2002 Hypoglycaemia: the limiting factor in the glycaemic management of type I and type II diabetes. Diabetologia 45:937-948
4. Heller SR, Cryer PE 1991 Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in non-diabetic humans. Diabetes 40:223-226
5. Amiel SA, Pottinger RC, Archibald HR, Chusney G, Cunnah DT, Prior PF, Gale EA 1991 Effect of antecedent glucose control on cerebral function during hypoglycemia. Diabetes Care 14:109-118
6. Widom B, Simonson DC 1992 Intermittent hypoglycemia impairs glucose counterregulation. Diabetes 41:1597-1602
7. Boyle PJ, Kempers SF, O'Connor AM, Nagy RJ 1995 Brain glucose uptake and unawareness of hypoglycemia in patients with insulin-dependent diabetes mellitus. N Engl J Med 333-1726-1731
8. Segel SA, Fanelli CG, Dence CS, Markham J, Videen TO, Paramore DS, Powers WJ, Cryer PE 2001 Blood-to-brain glucose transport, cerebral glucose metabolism, and cerebral blood flow are not increased after hypoglycemia. Diabetes 50:1911-1917
9. Davis SN, Shavers C, Costa F, Mosqueda Garcia R 1996 Role of cortisol in the pathogenesis of deficient counterregulation after antecedent hypoglycemia in normal humans. J Clin Invest 98:680-691
10. McGregor VP, Banarer S, Cryer PE 2002 Elevated endogenous cortisol reduces autonomic neuroendocrine and symptom responses to subsequent hypoglycemia. Am J Physiol Endocrinol Metab 282:E770-E777
11. Galassetti P, Mann S, Tate D, Neill RA, Costa F, Wasserman DH, Davis SN 2001 Effects of antecedent prolonged exercise on subsequent counterregulatory responses to hypoglycemia. Am J Physiol Endocrinol Metab 280:E908-E917
12. McGregor VP, Greiwe JS, Banarer S, Cryer PE 2002 Limited impact of vigorous exercise on defenses against hypoglycemia: relevance to hypoglycemia-associated autonomie failure. Diabetes 51:1485-1492
13. Towler DA, Havlin CE, Craft S, Cryer P 1993 Mechanism of awareness of hypoglycemia. Perception of neurogenic (predominantly cholinergic) rather than neuroglycopenic symptoms. Diabetes 42:1791-1798
14. Berlin I, Grimaldi A, Landault C, Zoghbi F, Thervet F, Puech AJ, Legrand JC 1988 Lack of hypoglycemic symptoms and decreased β-adrenergic sensitivity in insulin-dependent diabetic patients. J Clin Endocrinol Metab 66:273-278
15. Trovik TS, Jaeger R, Jorde R, Sager G 1994 Reduced sensitivity to β-adrenoceptor stimulation and blockade in insulin dependent diabetic patients with hypoglycaemia unawareness. Br J Clin Pharmacol 38:427-432
16. Korytkowski MT, Mokan M, Veneman TF, Mitrakou A, Cryer PE, Gerich JE 1998 Reduced β-adrenergic sensitivity in patients with type 1 diabetes and hypoglycemia unawareness. Diabetes Care 21:1939-1943
17. Fritsche A, Stefan N, Haring H, Gerich J, Stumvoll M 2001 Avoidance of hypoglycemia restores hypoglycemia awareness by increasing beta-adrenergic sensitivity in type 1 diabetes. Ann Intern Med 134:729-736
18. Porta S, Epple A, Kvetnansky R, Leitner G, Emsenhuber W, Radkohl W 1995 Temporary increase of plasma epinephrine affects stress responses 24 h later. Physiol Behav 58:223-228
19. Konarska M, Stewart RE, McCarty R 1990 Habituation and sensitization of plasma catecholamine responses to chronic intermittent stress: effects of stressor intensity. Physiol Behav 47:647-652
20. Dishy V, Sofowora GG, Xie HG, Kim RB, Byrne DW, Stein CM, Wood AJ 2001 The effect of common polymorphisms of the β2-adrenergic receptor on agonist-mediated vascular desensitization. N Engl J Med 345:1030-1035
21. Stein M, Deegan R, Wood AJ 1993 Long-term exposure to β2-receptor agonist specifically desensitizes β-receptor-mediated venodilation. Clin Pharmacol Ther 54:187-193
22. Eysmann SB, Gervino E, Vatner DE, Katz SE, Decker L, Douglas PS 1996 Prolonged exercise alters β-adrenergic responsiveness in healthy sedentary humans. J Appl Physiol 80:616-622
23. Ensinger H, Weichel T, Lindner KH, Prengel A, Grunert A, Ahnefeld FW 1992 Relationship between arterial and peripheral venous catecholamine plasma catecholamine concentrations during infusion of noradrenaline and adrenaline in healthy volunteers. Eur J Clin Pharmacol 43:245-249
24. De Galan BE, Tack CJ, Lenders JW, Pasman JW, Elving LD, Russel FG, Lutterman JA, Smits P 2002 Theophylline improves hypoglycemia unawareness in type 1 diabetes. Diabetes 51:790-796
25. Maggs DG, MacDonald IA, Tattersall RB 1994 Thermoregulatory responses to hyperinsulinaemic hypoglycaemia and euglycaemia in IDDM. Diabetologia 37:689-696
26. Stinissen J, Willems PJ, Coetsier L, Hulsman WLL 1970 Manual of the Dutch edition of the WAIS. Amsterdam: Swets and Zeitlinger
27. Willemsen JJ, Ross HA, Jacobs MC, Lenders JW, Thien T, Swinkels LM, Benraad TJ 1995 Highly sensitive and specific HPLC with fluorometric detection for determination of plasma epinephrine and norepinephrine applied to kinetic studies in humans. Clin Chem 41:1455-1460
28. Chu CA, Sindelar DK, Neal DW, Allen EJ, Donahue EP, Cherrington AD 1997 Comparison of the direct and indirect effects of epinephrine on hepatic glucose production. J Clin Invest 99:1044-1056
29. Cryer PE 1994 Banting Lecture. Hypoglycemia: the limiting factor in the management of IDDM. Diabetes 43:1378-1389
30. Hoffman RP, Sinkey CA, Dopp JM, Phillips BG 2002 Systemic and local adrenergic regulation of muscle glucose utilization during hypoglycemia in healthy subjects. Diabetes 51:734-742
31. Polonsky K, Bergenstal R, Pons G, Schneider M, Jaspan J, Rubenstein A 1982 Relation of counterregulatory responses to hypoglycemia in type I diabetics. N Engl J Med 307:1106-1112
32. Fritsche A, Stumvoll M, Grub M, Sieslack S, Renn W, Schmulling RM, Haring HU, Gerich JE 1998 Effect of hypoglycemia on β-adrenergic sensitivity in normal and type 1 diabetic subjects. Diabetes Care 21:1505-1510
33. Trovik TS, Jaeger R, Jorde R, Sager G 1995 Reduced β-adrenergic sensitivity in healthy volunteers induced by hypoglycemia. Fundam Clin Pharmacol 9:181-186
34. Wilken J, Smith BD, Tola K, Mann M 1999 Anxiety and arousal: tests of a new six-system model. Int J Psychophysiol 33:197-207
35. Birnbaum S, Gobeske KT, Auerbach J, Taylor JR, Arnsten AF 1999 A role for norepinephrine in stress-induced cognitive deficits: α-1-adrenoceptor mediation in the prefrontal cortex. Biol Psychiatry 46:1266-1274
36. Heller SR, MacDonald IA 1996 The measurement of cognitive function during acute hypoglycaemia: experimental limitations and their effect on the study of hypoglycaemia unawareness. Diabet Med 13:607-615
37. Amiel SA 1998 Cognitive function testing in studies of acute hypoglycaemia: rights and wrongs? Diabetologia 41:713-719
38. Veneman T, Mitrakou A, Mokan M, Cryer P, Gerich J 1993 Induction of hypoglycemia unawareness by asymptomatic nocturnal hypoglycemia. Diabetes 42:1233-1237
39. Davis SN, Tate D 2001 Effects of morning hypoglycemia on neuroendocrine and metabolic responses to subsequent afternoon hypoglycemia in normal man. J Clin Endocrinol Metab 86:2043-2050
40. Davis SN, Mann S, Galassetti P, Neill RA, Tate D, Ertl AC, Costa F 2000 Effects of differing durations of antecedent hypoglycemia on counterregulatory responses to subsequent hypoglycemia in normal humans. Diabetes 49: 1897-1903