Elevated endogenous cortisol reduces autonomic neuroendocrine and symptom responses to subsequent hypoglycemia

American Journal of Physiology - Endocrinology and Metabolism

Volumn 282, Issue 4 45-4, 2002, Pages

  McGregor, Veronica P ^a   Banarer, Salomon ^a   Cryer, Philip E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diabetes; Epinephrine; Glucagon; Hypoglycemia associated autonomic failure; Norepinephrine

Indexed keywords

3 HYDROXYBUTYRIC ACID; CORTICOTROPIN; GLUCAGON; GROWTH HORMONE; HYDROCORTISONE; INSULIN; LACTIC ACID; PANCREAS POLYPEPTIDE;

ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD LEVEL; CHOLINERGIC SYSTEM; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GLUCAGON BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; HYPOGLYCEMIA; LACTATE BLOOD LEVEL; MALE; NEUROENDOCRINE SYSTEM; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

EID: 0036084113     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00447.2001     Document Type: Article

References (34)

1. Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response and low α-cell glucose concentration
2. Hormone-fuel interrelationships during fasting
3. Restoration of hypoglycemia unawareness in patients with long duration insulin-dependent diabetes mellitus
4. Iatrogenic hypoglycemia as a cause of hypoglycemiaassociated autonomic failure in IDDM: A vicious cycle
5. Hypoglycemia-associated autonomic failure in diabetes
6. Hypoglycemia-associated autonomic failure in insulin dependent diabetes mellitus
7. Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM
8. Activation of brain type II corticosteroid receptor is not responsible for blunting of autonomic nervous system responses to subsequent hypoglycemia
9. Role of cortisol in the pathogenesis of deficient counterregulation after antecedent hypoglycemia in normal humans
10. Prevention of an increase in plasma cortisol during hypoglycemia preserves subsequent counterregulatory responses
11. Immunoassays for glucagon
12. Long-term recovery from unawareness, deficient counterregulation, and lack of cognitive dysfunction during hypoglycemia following institution of rational intensive insulin therapy in IDDM
13. Impact of nocturnal hypoglycemia on hypoglycemic cognitive dysfunction in type 1 diabetes mellitus
14. Plasma cortisol determination: Radioimmunoassay and competitive protein binding compared
15. Effects of antecedent prolonged exercise on subsequent counterregulatory responses to hypoglycemia
16. Regional pancreatic concentration and in-vitro secretion of canine pancreatic polypeptide, insulin, and glucagon
17. Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after one episode of hypoglycemia in nondiabetic humans
18. A new colorimetric method for the determination of free fatty acids with acyl-CoA synthase and acyl-CoA oxidase
19. Determination of free and total insulin and C-peptide in insulin-treated diabetics
20. Effect of ischemia on known substrates, and co-factors of the glycolyptic pathway of the brain
21. Limited impact of vigorous exercise on defenses against hypoglycemia: Relevance to hypoglycemia-associated autonomic failure
22. Antecedent corticosterone does not produce the blunted activation of the paraventricular nucleus of the hypothalamus associated with hypoglycemia-associated autonomic failure
23. Brief twice weekly episodes of hypoglycemia reduce detection of clinical hypoglycemia in type 1 diabetes mellitus
24. Enzymatic assay of glycerol, dihydroxyacetone, and glyceraldehyde
25. Intra-islet cell-cell interactions and insulin secretion
26. A sensitive double antibody radioimmunoassay for growth hormone in plasma
27. The glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms
28. Hypoglycemia-associated autonomic failure in advanced type 2 diabetes
29. External and internal standards in the single-isotope derivative (radioenzymatic) measurement of plasma norepinephrine and epinephrine
30. Autonomic mediation of glucagon secretion during hypoglycemia
31. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
32. Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes
33. Mechanisms of awareness of hypoglycemia: Perception of neurogenic (predomiantly cholinergic) rather than neuroglycopenic symptoms