Fluoroquinolone resistance mutations in the parC, parE, and gyrA genes of clinical isolates of viridans group streptococci

Antimicrobial Agents and Chemotherapy

Volumn 42, Issue 11, 1998, Pages 2792-2798

  González, Irene ^a   Georgiou, Marios ^a,b   Alcaide, Fernando ^c   Balas, Delia ^a   Liñares, Josefina ^c   De La Campa, Adela G ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b UNIVERSITY OF GREENWICH   (United Kingdom)

^c HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CIPROFLOXACIN; CLINAFLOXACIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); ISOLEUCINE; PHENYLALANINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SERINE; SPARFLOXACIN;

ALPHA HEMOLYTIC STREPTOCOCCUS; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATION; CONTROLLED STUDY; DNA SEQUENCE; GENE MUTATION; GENETIC TRANSFORMATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STREPTOCOCCUS MITIS; STREPTOCOCCUS ORALIS; STREPTOCOCCUS PNEUMONIAE;

EID: 0344431236     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.11.2792     Document Type: Article

References (43)

1. Alcaide, F., J. Carratala, J. Liñares, F. Gudiol, and R. Martín. 1996. In vitro activities of eight macrolide antibiotics and RP-59500 (quinupristin-dalfopristin) against viridans group streptococci isolated from blood of neutropenic cancer patients. Antimicrob. Agents Chemother. 40:2117-2120.
2. Alcaide, F., J. Liñares, R. Pallarés, J. Carratala, M. A. Benítez, F. Gudiol, and R. Martín. 1995. In vitro activity of 22 β-lactam antibiotics against penicillin-resistant and penicillin-susceptible viridans group streptococci isolated from blood. Antimicrob. Agents Chemother. 39:2243-2247.
3. Balas, D., E. Férnandez-Moreira, and A. G. de la Campa. 1998. Molecular characterization of the gene encoding the DNA gyrase A subunit of Streptococcus pneumoniae. J. Bacteriol. 180:2854-2861.
4. Belland, R., S. Morrison, C. Ison, and W. Huang. 1994. Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates. Mol. Microbiol. 14:371-380.
5. Bochud, P. Y., P. H. Eggiman, T. H. Calandra, G. Van Melle, L. Saghafi, and P. Francioli. 1994. Bacteremia due to viridans streptococcus in neutropenic patients with cancer: clinical spectrum and risk factors. Clin. Infect. Dis. 18: 25-31.
6. Breines, D. M., S. Ouabdesselam, E. Y. Ng, J. Tankovic, S. Shah, C. J. Soussy, and D. C. Hooper. 1997. Quinolone resistance locus nfxD of Escherichia coli, is a mutant allele of the parE gene encoding a subunit of topoisomerase IV. Antimicrob. Agents Chemother. 41:175-179.
7. Bruckner, D. A., and P. Colonna. 1997. Nomenclature for aerobic and facultative bacteria. Clin. Infect. Dis. 25:1-10.
8. Carratala J., F. Alcaide, A. Fernández-Sevilla, X. Corbell, J. Liñares, and F. Gudiol. 1995. Bacteremia due to viridans streptococci that are highly resistant to penicillin: increase among neutropenic patients with cancer. Clin. Infect. Dis. 20:1169-1173.
9. Coykendal, A. L. 1989. Classification and identification of the viridans group streptococci. Clin. Microbiol. Rev. 2:315-328.
10. Facklam, R. R., and J. A. Washington II. 1991. Streptococcus and related catalase-negative gram-positive cocci, p. 238-257. In A. Balows, W. J. Hausler, Jr., K. L. Herrmann, H. D. Isenberg, and H. J. Shadomy (ed.), Manual of clinical microbiology, 5th ed. American Society for Microbiology Washington, D.C.
11. Ferrero, L., B. Cameron, B. Manse, D. Langeaux, J. Crouzet, A. Famechon, and F. Blanche. 1994. Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones. Mol. Microbiol. 13:641-653.
12. Gensberg, K., Y. F. Jin, and L. J. V. Piddock. 1995. A novel gyrB mutation in a fluoroquinolone-resistant clinical isolate of Salmonella typhimurium. FEMS Microbiol. Lett. 132:57-60.
13. Georgiou, M., R. Muñoz, F. Román, R. Cantón, R. Gómez-Lus, J. Campos, and A. G. de la Campa. 1996. Ciprofloxacin-resistant Haemophilus influenzae strains possess mutations in analogous positions of GyrA and ParC. Antimicrob. Agents Chemother. 40:1741-1744.
14. Hoshino, K., I. Kitamura, I. Morrissey, K. Sato, and H. Ikeda. 1994. Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition. Antimicrob. Agents Chemother. 38:2623-2627.
15. Ito, H., H. Yoshida, M. Bogaki-Shonai, T. Niga, H. Hattori, and S. Nakamura. 1994. Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureus. Antimicrob. Agents Chemother. 38: 2014-2023.
16. Janoir, C., V. Zeller, M.-D. Kitzis, N. J. Moreau, and L. Gutmann. 1996. High-level fluoroquinolone resistance in Streptococcus pneumoniae requires mutations in parC and gyrA. Antimicrob. Agents Chemother. 40:2760-2764.
17. Kato, J., Y. Nishima, R. Imamura, H. Niki, S. Higara, and H. Suzuki. 1990. New topoisomerase essential for chromosome segregation in E. coli. Cell 63: 393-404.
18. Khodursky, A. B., E. L. Zechiedrich, and N. R. Cozzarelli. 1995. Topoisomerase IV is a target of quinolones in Escherichia coli. Proc. Natl. Acad. Sci. USA 92:11801-11805.
19. Kikuchi, K., T. Enari, K. Totsuka, and K. Shimizu. 1995. Comparison of phenotypic characteristics, DNA-DNA hybridization results, and results with a commercial rapid biochemical and enzymatic reaction system for identification of viridans group streptococci. J. Clin. Microbiol 33:1215-1222.
20. Korten, V., W. M. Huang, and B. E. Murray. 1994. Analysis by PCR and direct sequencing of gyrA mutations associated with fluoroquinolone resistance in Enterococcus faecalis. Antimicrob. Agents Chemother. 38:2091-2094.
21. Liñares, J., F. Tubau, R. Pallarés, C. Ardanuy, R. Martín, R. Muñoz, and A. G. de la Campa. 1997. Program and abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, abstr. C3.
22. López, P., M. Espinosa, D. Stassi, and S. A. Lacks. 1982. Facilitation of plasmid transfer in Streptococcus pneumoniae by chromosomal homology. J. Bacteriol. 150:692-701.
23. Luttinger, A. 1995. The twisted life of DNA in the cell: bacterial DNA topoisomerases. Mol. Microbiol. 15:601-606.
24. Muñoz, R., M. Bustamante, and A. G. de la Campa. 1995. Ser-127-to-Leu substitution in the DNA gyrase B subunit of Streptococcus pneumoniae is implicated in novobiocin resistance. J. Bacteriol. 177:4166-4170.
25. Muñoz, R., and A. G. de la Campa. 1996. ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype. Antimicrob. Agents Chemother. 40:2252-2257.
26. Pan, X.-S., and L. M. Fisher. 1997. Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones. Antimicrob. Agents Chemother. 41:471-474.
27. Pan, X.-S., J. Ambler, S. Mehtar, and L. M. Fisher. 1996. Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 40:2321-2326.
28. Pan, X.-S., and L. M. Fisher. 1996. Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance. J. Bacteriol. 178:4060-4069.
29. Perichon, B., J. Tankovic, and P. Courvalin. 1997. Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 41:1166-1167.
30. Poulsen, K., and M. Kilian. 1998. Program and abstracts of the American Society for Microbiology Conference on Streptococcal Genetics, abstr. 2D-05.
31. Romero, A., R. López, and P. García. 1990. Sequence of the Streptococcus pneumoniae bacteriophage HB-3 amidase reveals high homology with the major host autolysin. J. Bacteriol. 172:5064-5070.
32. Ronda, C., J. L. García, and R. López. 1988. Characterization of genetic transformation in Streptococcus oralis NCTC 11427: expression of the pneumococcal amidase in S. oralis using a new shuttle vector. Mol. Gen. Genet. 215:53-57.
33. Ruoff, K. L. 1995. Streptococcus, p. 299-307. In P. R. Murray, E. J. Baron, M. A. Pfaller, F. C. Tenover, and R. H. Yolken (ed.), Manual of clinical microbiology, 6th ed. American Society for Microbiology, Washington, D.C.
34. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
35. Spratt, B. G. 1994. Resistance to antibiotics mediated by target alterations. Science 264:388-393.
36. Tankovic, J., B. Perichon, J. Duval, and P. Courvalin. 1996. Contribution of mutations in gyrA and parC genes to fluoroquinolone resistance of mutants of Streptococcus pneumoniae obtained in vivo and in vitro. Antimicrob. Agents Chemother. 40:2505-2510.
37. Tomasz, A. 1970. Cellular metabolism in genetic transformation of pneumococci: requirement for protein synthesis during induction of competence. J. Bacteriol. 101:860-871.
38. Vandamme, P., U. Torck, E. Falsen, B. Pot, H. Goosens, and K. Hersters. 1998. Whole-cell protein electrophoretic analysis of viridans streptococci: evidence for heterogeneity among Streptococcus mitis biovars. Int. J. Syst. Bacteriol. 48:117-125.
39. Venditti, M., P. Baiocchi, C. Barandimarte, P. Serra, G. Gentile, C. Girmenia, and P. Martino. 1989. Antimicrobial susceptibilities of Streptococcus species that cause septicemia in neutropenic patients. Antimicrobial. Agents Chemother. 33:580-582.
40. Wang, J. C. 1985. DNA topoisomerases. Annu. Rev. Biochem. 54:665-697.
41. Wilson, K. 1994. Preparation of genomic DNA from bacteria, p. 2.4.1. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology, vol. 1. J. Wiley & Sons, Inc., New York, N.Y.
42. Yoshida, H., M. Bogaki, M. Nakamura, L. M. Yamanaka, and S. Nakamura. 1991. Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli. Antimicrob. Agents Chemother. 35:1647-1650.
43. Yoshida, H., M. Bogaki, M. Nakamura, and S. Nakamura. 1990. Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. Antimicrob. Agents Chemother. 34:1271-1272.