Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase A

Current Eye Research

Volumn 27, Issue 5, 2003, Pages 269-278

  Calvin, Harold I ^a,b   Wu, Kaili ^a,c   Li, Wenjie ^a,d   Guo, Li ^a,c   Banerjee, Urmi ^a,e   Fu, S C Joseph ^a,b  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b INSTITUTE OF OPHTHALMOLOGY AND VISUAL SCIENCE   (United States)

^c SUN YAT SEN UNIVERSITY   (China)

^d SECOND MILITARY MEDICAL UNIVERSITY   (China)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Buthionine sulfoximine; Cataract; Cation transport; Mouse lens culture; Protein kinase inhibitors

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; ALPHA CRYSTALLIN; BETA CRYSTALLIN; BUTHIONINE SULFOXIMINE; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYTOSKELETON PROTEIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHOSPHORUS 32; POTASSIUM ION; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SODIUM ION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CATARACT; CATARACTOGENESIS; CONTROLLED STUDY; FEMALE; ISOTOPE LABELING; LENS; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; TISSUE CULTURE; TWO DIMENSIONAL GEL ELECTROPHORESIS;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ALPHA-CRYSTALLIN A CHAIN; ANIMALS; ANIMALS, NEWBORN; BUTHIONINE SULFOXIMINE; CALCIUM; CATARACT; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENZYME INHIBITORS; FEMALE; ISOQUINOLINES; LENS CORTEX, CRYSTALLINE; MALE; MICE; ORGAN CULTURE TECHNIQUES; PHOSPHORYLATION; POTASSIUM; PREGNANCY; PROTEIN KINASE C; SODIUM; SPECTROPHOTOMETRY, ATOMIC; SULFONAMIDES;

EID: 0344413046     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.27.5.269.17224     Document Type: Article

References (47)

1. Kinoshita JH. Mechanisms initiating cataract formation. Proctor Lecture. Invest Ophthalmol. 1974;13:713-724.
2. Duncan G, Bushell AR. Ion analyses of human cataractous lenses. Exp Eye Res. 1975;20:223-230.
3. Harding CV, Unakar NJ, Bagchi M, Chylack LT, Jr., Jampel RS, Bobrowski WF et al. Elemental and structural studies of the rat galactose cataract. Lens Eye Toxic Res. 1989;6: 477-501.
4. Calvin HI, von Hagen S, Hess JL, Patel SA, Fu SC. Lens GSH depletion and electrolyte changes preceding cataracts induced by buthionine sulfoximine in suckling mice. Exp Eye Res. 1992;54:621-626.
5. Takehana M. Hereditary cataract of the Nakano mouse. Exp Eye Res. 1990;50:671-676.
6. Kilic F, Trevithick JR. Modelling cortical cataractogenesis. XXIX. Calpain proteolysis of lens fodrin in cataract. Biochem Mol Biol Int. 1998;45:963-978.
7. Nakamura Y, Fukiage C, Shih M, Ma H, David LL, Azuma M et al. Contribution of calpain Lp82-induced proteolysis to experimental cataractogenesis in mice. Invest Ophthalmol Vis Sci. 2000;41:1460-1466.
8. Sanderson J, Marcantonio JM, Duncan G. Calcium ionophore induced proteolysis and cataract: Inhibition by cell permeable calpain antagonists. Biochem Biophys Res Commun. 1996;218:893-901.
9. Bhuyan KC, Bhuyan DK, Molecular mechanism of cataractogenesis: III. Toxic metabolites of oxygen as initiators of lipid peroxidation and cataract. Curr Eye Res. 1984;3: 67-81.
10. Li WC, Wang GM, Wang RR, Spector A. The redox active components H2O2 and N-acetyl-L-cysteine regulate expression of c-jun and c-fos in lens systems. Exp Eye Res. 1994;59:179-190.
11. Bantseev VL, Herbert KL, Trevithick JR, Sivak JG. Mitochondria of rat lenses: Distribution near and at the sutures. Curr Eye Res. 1999;19:506-516.
12. Oriowo OM, Cullen AP, Sivak JG. Impairment of eye lens cell physiology and optics by broadband ultraviolet A-ultraviolet B radiation. Photochem Photobiol. 2002;76: 361-367.
13. Worgul BV, Merriam GR, Szechter A, Srinivasan D. Lens epithelium and radiation cataract. I. Preliminary studies. Arch Ophthalmol. 1976;94:996-999.
14. Hightower K, McReady J. Mechanisms involved in cataract development following near-ultraviolet radiation of cultured lenses. Curr Eye Res. 2002;7:679-689.
15. Hales AM, Chamberlain CG, Murphy CR, McAvoy JW. Estrogen protects lenses against cataract induced by transforming growth factor-beta (TGFbeta). J Exp Med. 1997; 185:273-280.
16. Thomas GR, Duncan G, Sanderson J. Acetylcholine-induced membrane potential oscillations in the intact lens. Invest Ophthalmol Vis Sci. 1998;39:111-119.
17. Calvin HI, Zhu G, Wu J, Banerjee U, Fu JS. Progression of mouse buthionine sulfoximine cataracts in vitro is inhibited by thiols or ascorbate. Exp Eye Res. 1997;65:341-347.
18. Martensson J, Steinherz R, Jain A, Meister A. Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage. Proc Natl Acad Sci USA. 1989;86:8727-8731.
19. Martensson J, Meister A, Martensson J. Glutathione deficiency decreases tissue ascorbate levels in newborn rats: ascorbate spares glutathione and protects. Proc Natl Acad Sci USA. 1991;88:4656-4660.
20. Maitra I, Serbinova E, Trischler H, Packer L. Alpha-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats. Free Radic Biol Med. 1995;18: 823-829.
21. Engh RA, Girod A, Kinzel V, Huber R, Bossemeyer D. Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J Biol Chem. 1996;271:26157-26164.
22. Brewitt B, Clark JI. A new method for study of normal lens development in vitro using pulsatile delivery of PDGF or EGF in HL-1 serum-free medium. In Vitro Cell Dev Biol. 1990;26:305-314.
23. Li W, Calvin H, David L, Wu K, McCormack A, Zhu G et al. Altered patterns of phosphorylation in cultured mouse lenses during development of buthionine sulfoximine cataracts. Exp Eye Res. 2002;75:335-346.
24. Esen A. A simple method for quantitative, semiquantitative, and qualitative assay of protein. Anal Biochem. 1978;89: 264-273.
25. Courchesne PL, Patterson S. Identification of proteins by matrix-assisted laser desorption/ionization mass spectrometry using peptide and fragment ion masses. Methods Mol Biol. 1999;112:487-511.
26. Calvin HI, Patel SA, Zhang JP, Li MY, Fu SC. Progressive modifications of mouse lens crystallins in cataracts induced by buthionine sulfoximine. Exp Eye Res. 1992;54:611-619.
27. Calvin HI, Medvedovsky C, Worgul BV. Near-total glutathione depletion and age-specific cataracts induced by buthionine sulfoximine in mice. Science. 1986;233:553-555.
28. David LL, Calvin HI, Fu SC. Buthionine sulfoximine induced cataracts in mice contain insolubilized crystallins with calpain II cleavage sites. Exp Eye Res. 1994;59:501-504.
29. Kantorow M, Piatigorsky J. Phosphorylations of alpha A-and alpha B-crystallin. Int J Biol Macromol. 1998;22: 307-314.
30. Findik D, Song Q, Hidaka H, Lavin M. Protein kinase A inhibitors enhance radiation-induced apoptosis. J Cell Biochem. 1995;57:12-21.
31. +, Cl-cotransport in fetal nonpigmented ciliary epithelial cells. Invest Ophthalmol Vis Sci. 1996;37:1047-1057.
32. - cotransporter in cultured bovine corneal endothelial cells (CBCEC). Invest Ophthalmol Vis Sci. 1997;38:S1050.
33. - cotransport in human NPE cells: effects of multiple hormones. Invest Ophthalmol Vis Sci. 1998;39:1444-1452.
34. Yang H, Wang Z, Miyamoto Y, Reinach PS. Cell signaling pathways mediating epidermal growth factor stimulation of Na:K:2Cl cotransport activity in rabbit corneal epithelial cells. J Membr Biol. 2001;183:93-101.
35. Ueda Y, Duncan MK, David LL. Lens proteomics: The accumulation of crystallin modifications in the mouse lens with age. Invest Ophthalmol Vis Sci. 2002;43:205-215.
36. Nakamura M, Russell P, Carper DA, Inana G, Kinoshita JH. Alteration of a developmentally regulated, heat-stable polypeptide in the lens of the Philly mouse. Implications for cataract formation. J Biol Chem. 1988;263:19218-19221.
37. Reed NA, Castellini MA, Ma H, Shearer TR, Duncan MK. Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens. Exp Eye Res. 2003;76:433-443.
38. Diecke FP, Zhu Z, Kang F, Kuang K, Fischbarg J. Sodium, potassium, two chloride cotransport in corneal endothelium: Characterization and possible role in volume regulation and fluid transport. Invest Ophthalmol Vis Sci. 1998;39:104-110.
39. Alvarez LJ, Candia OA, Turner HC, Polikoff LA. Localization of a Na(+)-K(+)-2Cl(-) cotransporter in the rabbit lens. Exp Eye Res. 2001;73:669-680.
40. Haas M, Forbush B, III. The Na-K-Cl cotransporter of secretory epithelia. Annu Rev Physiol. 2000;62:515-534.
41. Aperia A, Eklof AC, Holtback U, Nowicki S, Sundelof M, Greengard P. The renal dopamine system. Adv Pharmacol. 1998;42:870-873.
42. Candia OA, Zamudio AC. Regional distribution of the Na(+) and K(+) currents around the crystalline lens of rabbit. Am J Physiol Cell Physiol. 2002;282:C252-C262.
43. Zhang JJ, Jacob TJ. Volume regulation in the bovine lens and cataract. The involvement of chloride channels. J Clin Invest. 1996;97:971-978.
44. Merriman-Smith BR, Young MA, Jacobs MD, Kistler J, Donaldson PJ. Molecular identification of P-glycoprotein: A role in lens circulation? Invest Ophthalmol Vis Sci. 2002;43:3008-3015.
45. Idriss HT, Hannun YA, Boulpaep E, Basavappa S. Regulation of volume-activated chloride channels by P-glycoprotein: Phosphorylation has the final say! J Physiol. 2000;524 Pt 3:629-636.
46. Laver NM, Robison WG, Jr., Calvin HI, Fu SC. Early epithelial lesions in cataracts of GSH-depleted mouse pups. Exp Eye Res. 1993;57:493-498.
47. Tumminia SJ, Qin C, Zigler JS, Jr., Russell P. The integrity of mammalian lenses in organ culture. Exp Eye Res. 1994;58:367-374.