Some aryl substituted 2-(4-nitrophenyl)-4-oxo-4-phenylbutanoates and 3-(4-nitrophenyl)-1-phenyl-1,4-butanediols and related compounds as inhibitors of rat liver microsomal retinoic acid metabolising enzymes

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 18, Issue 6, 2003, Pages 511-528

  Mason, Peter ^a   Greer, Valerie P ^a   Kirby, Andrew J ^a   Simons, Claire ^a   Nicholls, Paul J ^a   Smith, H John ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Inhibitors; RA; RAMBAs; Retinoic acid; Retinoic acid metabolising enzymes

Indexed keywords

2 BROMO 1 (2,4 DICHLOROPHENYL) 1 ETHANONE; 2 BROMO 1 (2,5 DICHLOROPHENYL) 1 ETHANONE; 2 BROMO 1 (3 CHLOROPHENYL) 1 ETHANONE; 2 BROMO 1 (3,4 DICHLOROPHENYL) 1 ETHANONE; 2 BROMO 1 (4 CHLOROPHENYL) 1 ETHANONE; 2 BROMO 1 (4 ETHYLPHENYL) 1 ETHANONE; 2 BROMO 1 (4 FLUOROPHENYL) 1 ETHANONE; 2 BROMO 1 (4 IODOPHENYL) 1 ETHANONE; 2 BROMO 1 (4 METHOXYPHENYL) 1 ETHANONE; 2 BROMO 1 (4 METHYLPHENYL) 1 ETHANONE; 2 BROMO 1 (CHLOROPHENYL) 1 ETHANONE; 2 BROMO 1 PHENYL 1 ETHANONE; BUTANEDIOL; BUTYRIC ACID DERIVATIVE; ENZYME INHIBITOR; KETOCONAZOLE; LACTONE DERIVATIVE; METHYL 2 (4 NITROPHENYL) 4 OXO 4 PHENYLBUTANOATE; METHYL 4 (2 CHLOROPHENYL) 2 (4 NITROPHENYL) 4 OXOBUTANOATE; METHYL 4 (2,4 DICHLOROPHENYL) 2 (4 NITROPHENYL) 4 OXOBUTANOATE; METHYL 4 (2,5 DICHLOROPHENYL) 2 (4 NITROPHENYL) 4 OXOBUTANOATE; METHYL 4 (3 CHLOROPHENYL) 2 (4 NITROPHENYL) 4 OXOBUTANOATE; METHYL 4 (4 BROMOPHENYL) 2 (4 NITROPHENYL) 4 OXOBUTANOATE; METHYL 4 (4 CHLOROPHENYL) 2 (4 NITROPHENYL) 4 OXOBUTANOATE; MICROSOME ENZYME; OXIME; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; RETINOIC ACID; TETRAHYDROFURAN DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BECKMANN REARRANGEMENT; CHEMICAL MODIFICATION; CIS ISOMER; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; TRANS ISOMER;

ANIMALS; BUTYLENE GLYCOLS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; MALE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PHENYLBUTYRATES; RATS; RATS, WISTAR; TRETINOIN;

ANIMALIA;

EID: 0344307435     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/1475636032000141881     Document Type: Article

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