Species differences for stereoselective hydrolysis of propranolol prodrugs in plasma and liver

Chirality

Volumn 9, Issue 7, 1997, Pages 661-666

  Yoshigae, Yasushi ^a   Imai, Teruko ^a   Horita, Akira ^a   Otagiri, Masaki ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Esterase; In vitro degradation; O acyl propranolol; Structure activity relationship; Substrate specificity

Indexed keywords

PRODRUG; PROPRANOLOL; PROPRANOLOL DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG HYDROLYSIS; ENANTIOMER; ENZYME SPECIFICITY; ISOMER; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RACEMIC MIXTURE; RAT; SPECIES DIFFERENCE; STEREOCHEMISTRY; STEREOSPECIFICITY;

ANIMALS; CYTOSOL; DOGS; HYDROLYSIS; LIVER; MALE; MICROSOMES, LIVER; PRODRUGS; PROPRANOLOL; RATS; RATS, WISTAR; SPECIES SPECIFICITY; STEREOISOMERISM;

EID: 0030694223     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1997)9:7<661::AID-CHIR4>3.0.CO;2-A     Document Type: Article

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