Developmental Timing of Exposure to Elevated Levels of Phenylalanine is Associated with ADHD Symptom Expression

Journal of Abnormal Child Psychology

Volumn 31, Issue 6, 2003, Pages 565-574

  Antshell, Kevin M ^a,b   Waisbren, Susan E ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

ADHD; ADHD subtype; Development; PKU; Prenatal factors

Indexed keywords

PHENYLALANINE;

ADOLESCENT; ADULT; ARTICLE; ATTENTION DEFICIT DISORDER; BLOOD; CHILD; CONTROLLED STUDY; DEVELOPMENTAL BIOLOGY; DISEASE ASSOCIATION; DOSE RESPONSE; FEMALE; FOLLOW UP; HUMAN; HYPERACTIVITY; IMPULSIVENESS; MAJOR CLINICAL STUDY; MALE; MOTHER; PHENYLKETONURIA; POSTNATAL DEVELOPMENT; PREGNANCY; PRENATAL EXPOSURE; PROSPECTIVE STUDY; SCHOOL CHILD; SIBLING; STATISTICAL MODEL; SYMPTOMATOLOGY; TIME;

ADULT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MOTHERS; PHENYLALANINE; PHENYLKETONURIAS; PREGNANCY; PROSPECTIVE STUDIES; TIME FACTORS;

EID: 0344236350     PISSN: 00910627     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026239921561     Document Type: Article

References (68)

1. Adams, C. D., Streisand, R. M., Zawacki, T., & Joseph, K. E. (2002). Living with a chronic illness: A measure of social functioning for children and adolescents. Journal of Pediatric Psychology, 27, 593-605.
2. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
3. Arnold, G. L., Kramer, B. M., Kirby, R. S., Plumeau, P. B., Blakely, E. M., Sanger-Cregan, L. S. et al. (1998). Factors affecting cognitive, motor, behavioral and executive functioning in children with phenylketonuria. Acta Paediatrica, 87, 565-570.
4. Barkley, R. A. (1997). Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD. Psychological Bulletin, 121, 65-94.
5. Beasley, M. G., Costello, P. M., & Smith, I. (1994). Outcome of treatment in young adults with phenylketonuria detected by routine neonatal screening between 1964 and 1971. Quarterly Journal of Medicine, 87, 155-60.
6. Bellinger, D., Leviton, A., Allred, E., & Rabinowitz, M. (1994). Pre- and postnatal lead exposure and behavior problems in school-aged children. Environmental Research, 66, 12-30.
7. Brunner, R. L., & Berry, H. K. (1987). Phenylketonuria and sustained attention: The continuous performance test. International Journal of Clinical Neuropsychology, 9, 68-70.
8. Brunner, R. L., Berch, D. B., & Berry, H. (1987). Phenylketonuria and complex spatial visualization: An analysis of information processing. Developmental Medicine and Child Neurology, 4, 460-468.
9. Burlina, A. B., Bonafe, L., Ferrari, V., Suppiej, A., Zacchello, F., & Burlina, A. P. (2000). Measurement of neurotransmitter metabolites in the cerebrospinal fluid of phenylketonuric patients under dietary treatment. Journal of Inherited Metabolic Disease, 23, 313-316.
10. Carlson, C. L., & Mann, M. (2002). Sluggish cognitive tempo predicts a different pattern of impairment in the attention deficit hyperactivity disorder, predominantly inattentive type. Journal of Clinical Child and Adolescent Psychology, 31, 123-129.
11. Carlson, C. L., & Mann, M. (2000). Attention-deficit/hyperactivity disorder, predominately inattentive subtype. Child and Adolescent Psychiatric Clinics of North America, 9, 499-510.
12. Castellanos, F. X., Giedd, J. N., Marsh, W. L., Hamburger, S. D., Vaituzis, A. C., Dickstein, D. P. et al. (1996). Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder. Archives of General Psychiatry, 53, 607-616.
13. Cho, S., & McDonald, J. D. (2001). Effect of maternal blood phenylalanine level on mouse maternal phenylketonuria offspring. Molecular Genetics and Metabolism, 74, 420-425.
14. Clark, C. M., Li, D., Conry, J., Conry, R., & Loock, C. (2000). Structural and functional brain integrity of fetal alcohol syndrome in nonretarded cases. Pediatrics, 105, 1096-1099.
15. Cleary, M. A., Walter, J. H., Wraith, J. E., Jenkins, J. P. R., Alani, S. M., Tyler, K. et al. (1994). Magnetic resonance imaging of the brain in phenylketonuria. Lancet, 344, 87-90.
16. Cleary, M. A., Walter, J. H., Wraith, J. E., White, F., Tyler, K., & Jenkins, J. (1995). Magnetic resonance imaging in phenylketonuria: Reversal of cerebral white matter change. Journal of Pediatrics, 127, 251-255.
17. Demaree, H A., DeLuca, J., Gaudino, E. A., & Diamond, B. J. (1999). Speed of information processing as a key deficit in multiple sclerosis: Implications for rehabilitation. Journal of Neurology, Neurosurgery & Psychiatry, 67, 661-663.
18. Diamond, A. (1996). Evidence for the importance of dopamine for pre-frontal cortex functions early in life. Philosophical Transactions from the Royal Society, 351, 1483-1493.
19. Diamond, A., Ciaramitaro, V., Donner, E., Djali, S., & Robinson, M. B. (1994). An animal model of early treated PKU. Journal of Neuroscience. 14(5 Pt 2), 3072-3082.
20. Diamond, A., Prevor, M. B., Callender, G., & Druin, D. P. (1997). Pre-frontal cortex cognitive deficits in children treated early and continuously for PKU. Monographs of the Society for Research in Child Development, 62, 1-208.
21. DuPaul, G. J., Anastopoulos, A. D., Power, T. J., Reid, R., Ikeda, M., & McGoey, K. E. (1998). Parent ratings of attention-deficit/hyperactivity disorder: Factor structure, normative data, and psychometric properties. Journal of Psychopathology & Behavioral Assessment, 20, 83-102.
22. Dyer, C. A. (1999). Pathophysiology of phenylketonuria. Mental Retardation and Developmental Disabilities Research Reviews, 5, 104-112.
23. Frank, Y., & Ben-Nun, Y. (1988). Toward a clinical sub-grouping of hyperactive and nonhyperactive attention deficit disorder: Results of a comprehensive neurological and neuropsychological assessment. American Journal of Diseases of Children, 142, 153-155.
24. Friedman, E., Koch, R., Azen, C., Levy, H., Hanley, W., Matalon, R. et al. (1996). The international collaborative study on maternal phenylketonuria: Organization, study design and description of the sample. European Journal of Pediatrics, 155(Suppl. 1), S158-S161.
25. Gourovitch, M. L., Craft, S., Dowton, S. B., Ambrose, P., & Sparta, S. (1994). Interhemispheric transfer in children with early-treated phenylketonuria. Journal of Clinical and Experimental Neuropsychology, 16, 393-404.
26. Grodzinsky, G. M., & Diamond, R. (1992). Frontal lobe functioning in boys with attention-deficit hyperactivity disorder. Developmental Neuropsychology, 8, 427-445.
27. Gunning-Dixon, F. M., & Raz, N. (2000). The cognitive correlates of white matter abnormalities in normal aging: A quantitative review. Neuropsychology, 14, 224-232.
28. Guttler, F., & Lou, H. (1986). Dietary problems of phenylketonuria: Effect on CNS transmitters and their possible role in behaviour and neuropsychological function. Journal of Inherited Metabolic Disease, 9(Suppl. 2), 169-177.
29. Heilman, K. M., Voeller, K. K. S., & Nadeau, S. E. (1991). A possible pathophysiologic substrate of attention deficit hyperactivity disorder. Journal of Child Neurology, 6(Suppl.), S76-S81.
30. Hill, S. Y., Lowers, L., Locke-Wellman, J., & Shen, S. (2000). Maternal smoking and drinking during pregnancy and the risk for child and adolescent psychiatric disorders. Journal of Studies on Alcohol, 61, 661-668.
31. Hollingshead, A. B. (1975). Four factor index of social status. Unpublished manuscript, New Haven, CT: Yale University, Department of Sociology.
32. Hynd, G. W., Lorys, A. R., Semrud-Clikeman, M., Nieves, N., Huettner, M. I. S., & Lahey, B. B. (1991). Attention deficit disorder without hyperactivity: A distinct behavioral and neurocognitive syndrome. Journal of Child Neurology, 6, 37-43.
33. Kahn, C. A., Kelly, P. C., & Walker, W. O. (1995). Lead screening in children with attention deficit hyperactivity disorder and developmental delay. Clinical Pediatrics, 34, 498-501.
34. Kimko, H. C., Cross, J. T., & Abernethy, D. R. (1999). Pharmacokinetics and clinical effectiveness of methylphenidate. Clinical Pharmacokinetics, 37, 457-470.
35. Koch, R., Friedman, E., Azen, C., Hanley, W., Levy, H., Matalon, R. et al. (2000). The international collaborative study of maternal phenylketonuria: Status report 1998. European Journal of Pediatrics, 159(Suppl. 2), S156-S160.
36. Lahey, B. B., Carlson, C. L., & Frick, P. J. (1997). Attention deficit disorder without hyperactivity. In T. A. Widiger, A. J. Frances, H. A. Pincus, R. Ross, M. B. First, & W. Davis (Eds.), DSM-IV Source-book (Vol. 3, pp. 163-188). Washington, DC: American Psychiatric Association.
37. Lenke, R. R., & Levy, H. L. (1980). Maternal phenylketonuria and hyper-phenylalaninemia: An international survey of the outcome of untreated and treated pregnancies. New England Journal of Medicine, 303, 1202-1208.
38. Levy, H. L., & Ghavami, M. (1996). Maternal phenylketonuria: A metabolic teratogen. Teratology, 53, 176-184.
39. Levy, H. L., Lobbregt, D., Barnes, P. D., & Poussaint, T. Y. (1996). Maternal phenylketonuria: Magnetic resonance imaging of the brain in offspring. Journal of Pediatrics, 128, 770-775.
40. Lou, H. C., Guttler, F., Lykkelund, C., Bruhn, P., & Niederwieser, A. (1985). Decreased vigilance and neurotransmitter synthesis after discontinuation of dietary treatment for phenylketonuria in adolescents. European Journal of Pediatrics, 144, 17-20.
41. Lou, H. C., Toft, P. B., Andresen, J., Mikkelsen, I., Olsen, B., Guttler, F. et al. (1992). An occipito-temporal syndrome in adolescents with optimally controlled hyperphenylalaninaemia. Journal of Inherited Metabolic Disease, 15, 687-695.
42. Luciana, M., Sullivan, J., & Nelson, C. A. (2001). Associations between phenylalanine-to-tyrosine ratios and performance on tests of neuropsychological function in adolescents treated early and continuously for phenylketonuria. Child Development, 72, 1637-1652.
43. Mattson, S. N., Riley, E. P., Sowell, E. R., Jernigan, T. L., Sobel, D. F., & Jones, K. L. (1996). A decrease in the size of the basal ganglia in children with fetal alcohol syndrome. Alcoholism: Clinical and Experimental Research, 20, 1088-1093.
44. McBurnett, K., Pfiffner, L. J., & Frick, P. J. (2001). Symptom properties as a function of ADHD type: An argument for continued study of sluggish cognitive tempo. Journal of Abnormal Child Psychology, 29, 207-213.
45. Miller, M. W. (1986). Effects of alcohol on the generation and migration of cerebral cortical neurons. Science, 233, 1308-1311.
46. Miller, M. W. (1993). Cortical neurons is altered by gestational exposure to ethanol. Alcoholism: Clinical and Experimental Research, 17, 304-314.
47. National Institutes of Health. (2000). Consensus development conference. Phenylketonuria (PKU): Screening and management. NIH Consensus Statement, 17, 1-33.
48. Pearsen, K. D., Gean-Marton, A. D., Levy, H. L., & Davis, K. R. (1990). Phenylketonuria: MR imaging of the brain with clinical correlation. Radiology, 177, 437-440.
49. Piacentini, J. C., Cohen, P., & Cohen, J. (1992). Combining discrepant diagnostic information from multiple sources: Are complex algorithms better than simple ones? Journal of Abnormal Child Psychology, 20, 51-63.
50. Pietz, J., Fatkenheuer, B., Burgard, P., Armbruster, M., Esser, G., & Schmidt, H. (1997). Psychiatric disorders in adult patients with early-treated phenylketonuria. Pediatrics, 99, 345-350.
51. Pietz, J., Kreis, R., Rupp, A., Mayatepek, E., Rating, D., Boesch, C. et al. (1999). Large neutral amino acids block phenylalanine transport into brain tissue in patients with phenylketonuria. Journal of Clinical Investigation, 103, 1169-1178.
52. Ris, M. D., Williams, S. E., Hunt, M. M., Berry, H. K., & Leslie, N. (1994). Early-treated phenylketonuria: Adult neuropsychologic outcome. Journal of Pediatrics, 124, 388-392.
53. Roth, K. S. (1986). Newborn metabolic screening: A search for "natures experiments." Southern Medical Journal, 79, 47-54.
54. Sattler, J. M. (2001). Assessment of Children: Cognitive Applications (4th ed.), San Diego, CA: Jerome M. Sattler.
55. Schmidt, E., Rupp, A., Burgard, P., Pietz, J., Weglage, J., & de Sonneville, L. (1994). Sustained attention in adult phenylketonuria: the influence of the concurrent phenylalanine-blood-level. Journal of Clinical and Experimental Neuropsychology, 16, 681-688.
56. Scriver, C. R., & Kaufman, S. (2001). The hyperphenylalaninemias: Phenylalanine hydroxylase deficiency. In C. R. Scriver, A. L. Beaudet, W. S. Sly, & D. Valle (Eds.), The Metabolic and Molecular Bases of Inherited Disease (8th ed., pp. 1667-1724). New York: McGraw-Hill.
57. Smith, D. W. (1982). Recognizable patterns of human malformation: Genetic, embryologic and clinical aspects (3rd ed.). In G. L. Holmes (Ed.), Major Problems in Clinical Pediatrics (Vol. 7, pp. 1-653). Philadelphia, PA: WB Saunders Company.
58. Smith, M. L., Klim, P., Mallozzi, E., & Hanley, W. B. (1996). A test of the frontal-specificity hypothesis in the cognitive performance of adults with phenylketonuria. Developmental Neuropsychology, 12, 327-341.
59. Streissguth, A. P., O'Malley, K. (2000). Neuropsychiatric implications and long-term consequences of fetal alcohol spectrum disorders. Seminars in Clinical Neuropsychiatry, 5, 177-190.
60. Waisbren, S. E., Brown, M. J., deSonneville, L. M. J., & Levy, H. L. (1994). Review of neuropsychological functioning in treated phenylketonuria: An information processing approach. Acta Paediatr, 407 (Suppl.), 98-103.
61. Waisbren, S. E., Hanley, W., Levy, H. L., Shifrin, H., Allred, E., Azen, C. et al. (2000). Outcome at age 4 years in offspring of women with maternal phenylketonuria: The Maternal PKU Collaborative Study. Journal of the American Medical Association, 283, 756-762.
62. Wechsler, D. (1991). Wechsler Intelligence Scale for Children (3rd ed.). New York: Psychological Corporation.
63. Weglage, J., Pietsch, M., Funders, B., Koch, H. G., & Ullrich, K. (1996). Deficits in selective and sustained attention processes in early treated children with phenylketonuria-result of impaired frontal lobe functions? European Journal of Pediatrics, 155, 200-204.
64. Welsh, M. C., Pennington, B. F., Ozonoff, S., Rouse, B., & McCabe, E. R. B. (1990). Neuropsychology of early treated phenylketonuria: Specific executive function deficits. Child Development, 61, 1697-1713.
65. White, D. A., Nortz, M. J., Mandernach, T., Huntington, K., & Steiner, R. D. (2001). Deficits in memory strategy use related to prefrontal dysfunction during early development: Evidence from children with phenylketonuria. Neuropsychology, 15, 221-229.
66. White, D. A., Nortz, M. J., Mandernach, T., Huntington, K., & Steiner, R. D. (2002). Age-related working memory impairments in children with prefrontal dysfunction associated with phenylketonuria. Journal of the International Neuropsychological Society, 8, 1-11.
67. Wilcutt, E. G., Pennington, B. F., Chhabildas, N. A., Friedman, M. C., & Alexander, J. (1999). Psychiatric comorbidity associated with DSM-IV ADHD in a nonreferred sample of twins. Journal of the American Academy of Child Adolescent Psychiatry, 38, 1355-1362.
68. Yakovlev, P. I. (1962). Morphological criteria of growth and maturation of the nervous system in man. Research Publication of the Association for Research Nervous and Mental Disease, 39, 3-46.