Biological relevance of pituitary adenylate cyclase-activating polypeptide (PACAP) in the gastrointestinal tract

Regulatory Peptides

Volumn 84, Issue 1-3, 1999, Pages 1-12

  Läuffer, Jörg M ^a,b,c   Modlin, Irvin M ^a,b   Tang, Laura H ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Gastrointestinal tract; Motility; Neuropeptides; PACAP; Proliferation; Secretion

Indexed keywords

HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; NEUROPEPTIDE;

GASTROINTESTINAL TRACT; GLUCAGON RELEASE; GUINEA PIG; NEUROSECRETORY CELL; NONHUMAN; PANCREAS SECRETION; PRIORITY JOURNAL; REVIEW; SECOND MESSENGER; SMOOTH MUSCLE;

ANIMALS; DIGESTIVE SYSTEM; HUMANS; NEUROPEPTIDES; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; RECEPTORS, PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; RECEPTORS, PITUITARY HORMONE;

EID: 0344199960     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(99)00024-5     Document Type: Review

References (139)

1. Bayliss W.M., Starling E.H. The mechanism of pancreatic secretion. J Physiol (Lond). 28:1902;325-353.
2. De Wied D. Long term effect of vasopressin on the maintenance of a conditioned avoidance response in rats. Nature. 232:1971;58-60.
3. Myers R.D. Neuroactive peptides: unique phase in research on mammalian brain over three decades. Peptides. 15:1994;367-381.
4. Staub A., Linn L., Behrens O.K. Purification and crystallization of glucagon. J Biol Chem. 214:1955;619-632.
5. Bromer W.W., Sinn L.G., Behrens O.K. The amino acid sequence of glucagon. V. Location of amide groups, acid degradation studies and summary of sequential evidence. J Am Chem Soc. 79:1957;2807-2810.
6. Bodanszky M., Ondetti M.A., Levine S.D., Williams N.J. Synthesis of secretin. II. The stepwise approach. J Am Chem Soc. 89:1967;6753-6757.
7. Said S.I., Mutt V. A peptide fraction from lung tissue with prolonged peripheral vasodilator activity. Scand J Clin Lab Invest. 24:(Suppl 107):1969;51-57.
8. Tatemoto K., Mutt V. Isolation of two novel candidate hormones using a chemical method for finding naturally occuring polypeptides. Nature. 285:1980;417-8.
9. Guillemin R., Brazeau P., Bohlen P., Esch F., Ling N., Wehrenberg W.B. Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science. 218:1982;585-587.
10. Miyata A., Arimura A., Dahl R., et al. Isolation of novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem Biophys Res Commun. 164:1989;567-574.
11. Miyata A., Jiang L., Dahl R., et al. Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP 38). Biochem Biophys Res Commun. 170:1990;643-648.
12. Harmar T., Lutz E. Multiple receptors for PACAP and VIP. Trends Pharmacol Sci. 15:1994;97-99.
13. Ohtaki T., Masuda Y., Ishibashi Y., Kitada C., Arimura A., Fujino M. Purification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide. J Biol Chem. 268:1993;26650-26657.
14. Waschek J.A. VIP and PACAP receptor-mediated actions on cell proliferation and survival. Ann NY Acad Sci. 805:1996;290-300.
15. Guo X., Wakade A.R. Differential secretion of catecholamines in response to peptidergic and cholinergic transmitters in rat adrenals. J Physiol. 475:1994;539-545.
16. Canny B.J., Rawlings S.R., Leong D.A. Pituitary adenylate cyclase-activating polypeptide specifically increases cytosolic calcium ion concentration in rat gonadotropes and somatotropes. Endocrinology. 130:1992;211-305.
17. Kawai K., Ohse C., Watanabe Y., Suzuki S., Yamashita K., Ohashi S. Pituitary adenylate cyclase activating polypeptide stimulates insulin release from the isolated perfused rat pancreas. Life Sci. 50:1991;257-261.
18. Kimura C., Ohkubo S., Ogi K., et al. A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNA's. Biochem Biophys Res Commun. 166:1990;81-89.
19. Ogi K., Miyamoto Y., Masuda Y., et al. Molecular cloning and functional expression of a cDNA encoding human pituitary adenylate cyclase activating polypeptide receptors. Biochem Biophys Res Commun. 196:1993;1511-1521.
20. Watanabe T., Masuo Y., Matsumoto H., et al. Pituitary adenylate cyclase activating polypeptide provokes cultured rat chromaffin cells to secrete adrenaline. Biochem Biophys Res Commun. 182:1992;403-411.
21. Zeng N., Bayle D.B., Walsh J.H., Kang T., Sachs G. Localization of PACAP receptors on rat fundic ECL and D cells (Abstract). Gastroenterology. 110:1996;A1136.
22. Läuffer J.M., Modlin I.M., Hinoue T., et al. Pituitary adenylate cyclase-activating polypeptide (PACAP) modulates gastric enterochromaffin-like (ECL) cell proliferation in rats. Gastroenterology. 116:1999;623-35.
23. Buscail L., Gorulet P., Cauvin A., et al. Presence of highly selective receptors for PACAP (pituitary adenylate cyclase activating peptide) in membranes from the rat pancreatic acinar cell line AR 4-2J. FEBS Lett. 262:1990;77-81.
24. Spengler D., Waeber C., Pantaloni C., et al. Differential signal transduction by five splice variants of the PACAP receptor. Nature. 365:1993;170-175.
25. Chatterjee T.K., Sharma R.V., Fisher R.A. Molecular cloning of a novel variant of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor that stimulates calcium influx by activation of L-type calcium channels. J Biol Chem. 271:1996;32226-32232.
26. Pantaloni C., Brabet P., Bilanges B., et al. Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activity. J Biol Chem. 271:1996;22146-22151.
27. Lam H.C., Takahashi K., Gathei M.A., Kanse S.M., Polak J.M., Bloom S.R. Binding sites of a novel neuropeptide pituitary adenylate cyclase activating polypeptide in the rat brain and lung. Eur J Biochem. 193:1990;725-729.
28. + channels. Br J Pharmacol. 119:1996;623-630.
29. Schworer H., Katsoulis S., Creutzfeldt W., Schmidt W.E. Pituitary adenylate cyclase activating peptide, a novel VIP-like gut-brain peptide, relaxes the guinea-pig taenia caeci via apamin-sensitive potassium channels. Naunyn-Schmiedeberg's Arch Pharmacol. 346:1992;511-514.
30. Schworer H., Clemens A., Katsoulis S., Kohier H., Creutzfeldt W., Schmidt W.E. Pituitary adenylate cyclase-activating peptide is a potent modulator of human colonic motility. Scand J Gastroenterol. 28:1993;625-632.
31. Katsoulis S., Clemens A., Schworer H., Creutzfeldt W., Schmidt W.E. Pituitary adenylate cyclase activating polypeptide (PACAP) is a potent relaxant of the rat ileum. Peptides. 14:1993;587-592.
32. Ekblad E., Sundler F. Distinct receptors mediate pituitary adenylate cyclase-activating peptide- and vasoactive intestinal peptide-induced relaxation of rat ileal longitudinal muscle. Eur J Pharmacol. 334:1997;61-66.
33. Christophe J. Type I receptors for PACAP (a neuropeptide even more important than VIP?). Biochim Biophys Acta. 1154:1993;183-199.
34. i and inositol phosphates in human neuroblastoma NB-OK-1 cells. Peptides. 14:1993;1111-1118.
35. Ny L., Larsson B., Alm P., et al. Distribution and effects of pituitary adenylate cyclase activating peptide in cat and human lower oesophageal sphincter. Br J Pharmacol. 116:1995;2873-2880.
36. Uddman R., Luts A., Absood A., et al. PACAP, a VIP-like peptide, in neurons of the esophagus. Regul Pept. 36:1991;415-422.
37. Ny L., Alm P., Ekstrom P., Hannibal J., Larsson B., Andersson K. Nitric oxide synthase-containing, peptide-containing, and acetylcholinesterase-positive nerves in the cat lower ocsophagus. Histochem J. 26:1994;721-733.
38. Hannibal J., Ekblad E., Mulder H., Sundler F., Fahrenkrug J. Pituitary adenylate cyclase activating polypeptide (PACAP) in the gastrointestinal tract of the rat: distribution and effects of capsaicin or denervation. Cell Tissue Res. 291:1998;65-79.
39. Koves K., Arimura A., Vigh S., Somogyvari-Vigh A., Miller J. Immunohistochemical localization of PACAP in the ovine digestive system. Peptides. 14:1993;449-455.
40. Sanders K.M., Ward S.M. Nitric oxide as a mediator of nonadrenergic noncholinergic transmission. Am J Physiol. 262:1992;G379-G392.
41. Katsoulis S., Schmidt W.E., Schwarzhoff R., et al. Inhibitory transmission in guinea pig stomach mediated by distinct receptors for pituitary adenylate cyclase-activating peptide. J Pharmacol Exp Ther. 278:1996;199-204.
42. Murthy K.S., Jin J.G., Grider J.R., Makhlouf G.M. Characterization of PACAP receptors and signaling pathways in rabbit gastric muscle cells. Am J Physiol. 272:1997;G1391-G1399.
43. Parkman H.P., Pagano A.P., Ryan J.P. PACAP and VIP inhibit pyloric muscle through VIP/PACAP-preferring receptors. Regul Pept. 71:1997;185-190.
44. Teng B., Murthy K.S., Kuemmerle J.F., Grider J.R., Makhlouf G.M. Expression of VIP 2/PACAP 3 receptors on dispersed and cultured rabbit and guinea pig gastric and taenia coli smooth muscle cell (Abstract). Gastroenterology. 112:1997;A1194.
45. Costa M., Furness J., Humphreys C.M.S. Apamin distinguishes two types of relaxation mediated by enteric nerves in the guinea-pig gastrointestinal tract. Naunyn-Schmiedeberg's Arch Pharmacol. 332:1986;78-88.
46. Zeng N., Kang T., Athmann C., Wen Y., Walsh J.H., Sachs G. Identification of gastric endocrine cells as the target sites of neuropeptides in regulation of gastric secretion by semi-quantitative RT-PCR and video imaging (Abstract). Gastroenterology. 114:1998;A1196.
47. Lindström E., Bjorkqvist M., Boketoft A., et al. Neurohormonal regulation of histamine and pancreastatin secretion from isolated rat stomach ECL cells. Regul Pept. 71:1997;73-86.
48. Felley C.P., Qian J.M., Mantey T., Pradhan T., Jensen R.T. Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release. Am J Physiol. 263:1992;G901-G907.
49. 14C-aminopyrine accumulation in isolated rabbit parietal cells. Peptides. 19:1998;1111-1114.
50. Ozawa M., Aono M., Mizuta K., Moriga M., Okuma M. Central administration of PACAP stimulates gastric secretion mediated through the vagal pathway in anesthetized rats. Digest Dis Sci. 42:1997;2552-2558.
51. Sundler F., Ekblad E., Absood A., Hakanson R., Koves K., Arimura A. Pituitary adenylate cyclase activating peptide: a novel vasoactive intestinal peptide-like neuropeptide in the gut. Neuroscience. 46:1992;439-454.
52. Naruse S., Nakamura T., Wei M., et al. Effects of PACAP-VIP hybrid peptides on gastric blood flow in conscious dogs. Ann NY Acad Sci. 806:1996;511-515.
53. Naruse S., Nakamura T., Nokihara K., Ando E., Wray V. The effect of PACAP on gastrointestinal blood flow in conscious dogs. Rosselin G., Rosselin Gs. Vasoactive intestinal peptide, pituitary adenylate cyclase activating polypeptide and related regulatory peptides. 1994;470-473 World Scientific, Singapore.
54. 1/PACAP receptors in postoperative ileus in rats. Br J Pharmacol. 124:1998;1181-1186.
55. Katsoulis S., Clemens A., Schworer H., Creutzfeldt W., Schmidt W.E. PACAP is a stimulator of neurogenic contraction in guinea pig ileum. Am J Physiol. 265:1993;G295-G302.
56. Onaga T., Harada Y., Okamoto K. Pituitary adenylate cyclase-activating polypeptide (PACAP) induces duodenal phasic contractions via the vagal cholinergic nerves in sheep. Regul Pept. 77:1998;69-76.
57. Cox H.M. Pituitary adenylate cyclase activating polypeptides, PACAP-27 and PACAP-38: stimulators of electrogenic ion secretion in the rat small intestine. Br J Pharmacol. 106:1992;449-455.
58. Fuchs M., Adermann K., Raab H.R., Forssmann W.G., Kuhn M. Pituitary adenylate cyclase-activating polypeptide: a potent activator of human intestinal ion transport. Ann NY Acad Sci. 806:1996;640-647.
59. Takeuchi K., Takehara K., Kato S., Yagi K. PACAPs stimulate duodenal bicarbonate secretion at PACAP receptors in the rat. Am J Physiol. 272:1997;G646-G653.
60. Racke K., Reimann A., Schworer H., Kilbinger H. Regulation of 5-HT release from enterochromaffin cells. Behav Brain Res. 73:1996;83-87.
61. Chang C.H., Chey W.Y., Braggins L., Coy D.H., Chang T. Pituitary adenylate cyclase-activating polypeptide stimulates cholecystokinin secretion in STC-1 cells. Am J Physiol. 271:1996;G516-G523.
62. Fujinuya M., Yamamoto H., Kuwahara A. Effect of VIP and PACAP on basal release of serotonin from isolated vasculary and luminally perfused rat duodenum. Am J Physiol. 275:1998;G731-G739.
63. Chang C.H., Chey W.Y., Erway B., Coy D.H., Chang T.M. Modulation of secretin release by neuropeptides in secretin-producing cells. Am J Physiol. 275:1998;G192-G202.
64. Waschek J.A., Richards M.L., Bravo D.T. Differential expression of VIP/PACAP receptor genes in breast, intestinal, and pancreatic cell lines. Cancer Lett. 92:1995;143-149.
65. Lelievre V., Meuner A.C., Caigneaux E., Falcon J., Muller J.M. Differential expression and function of PACAP and VIP receptors in four human colonic adenocarcinoma cell lines. Cell Signal. 10:1998;13-26.
66. Virgolini I., Raderer M., Kurartan A., et al. Vasoactive intestinal peptide-receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumors. New Engl J Med. 331:1994;1116-1121.
67. Portbury A.L., McConalogue K., Furness J.B., Young H.M. Distribution of pituitary adenylyl cyclase activating peptide (PACAP) immunoreactivity in neurons of the guinea-pig digestive tract and their projections in the ileum and colon. Cell Tissue Res. 279:1995;385-392.
68. Sjolund K., Fasth S., Ekman R., et al. Neuropeptides in idiopathic chronic constipation (slow transit constipation). Neurogastroenterol Motil. 9:1997;143-150.
69. Shen Z., Larsson L.T., Malmfors G., Absood A., Hakanson R., Sundler F. A novel neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP), in human intestine: evidence for reduced content in Hirschsprung's disease. Cell Tissue Res. 269:1992;369-374.
70. Larsson L.T. Hirschsprung's disease-immunohistochemical findings. Histol Histopathol. 9:1994;615-629.
71. Grider J.R., Katsoulis S., Schmidt W.E., Jin J.G. Regulation of the descending relaxation phase of intestinal peristalsis by PACAP. J Autonom Nerv Syst. 50:1994;151-159.
72. Katsoulis S., Schmidt W.E. Role of PACAP in the regulation of gastrointestinal motility. Ann NY Acad Sci. 806:1996;364-378.
73. McConalogue K., Furness J.B., Vremec M.A., Holst J.J., Tornoe K., Marley P.D. Histochemical, pharmacological, biochemical and chromatographic evidence that pituitary adenylyl cyclase activating peptide is involved in inhibitory neurotransmission in the taenia of the guinea-pig caecum. J Autonom Nerv Syst. 50:1995;311-322.
74. Nguyen T.D., Heintz G.G., Cohn J.A. Pituitary adenylate cyclase-activating polypeptide stimulates secretion in T84 cells. Gastroenterology. 103:1992;539-544.
75. Kuwahara A., Kuwahara Y., Mochizuki T., Yanaihara N. Action of pituitary adenylate cyclase-activating polypeptide on ion transport in guinea pig distal colon. Am J Physiol. 264:1993;G433-G441.
76. Rattan S., Chakder S. Excitatory and inhibitory actions of pituitary adenylate cyclase-activating peptide (PACAP) in the internal anal sphincter smooth muscle: sites of actions. J Pharmacol Exp Ther. 283:1997;722-728.
77. Rae M.G., Muir T.C. Neuronal mediators of inhibitory junction potentials and relaxation in the guinea-pig internal anal sphincter. J Physiol. 493:1996;517-527.
78. Mizumoto A., Fujimura M., Ohtawa M., et al. Pituitary adenylate cyclase activating polypeptide stimulates gallbladder motility in conscious dogs. Regul Pept. 42:1992;39-50.
79. Guijarro L.G., Rodriguez-Henche N., Garcia-Lopez E., et al. Receptors for pituitary adenylate cyclase-activating peptide in human liver. J Clin Endocrinol Metab. 80:1995;2451-2457.
80. Rodriguez-Henche N., Rodriguez-Pena M.S., Guijarro L.G., Prieto J.C. Characterization of vasoactive intestinal peptide receptors in human liver. Biochim Biophys Acta. 1221:1994;193-198.
81. Robberecht P., Gourlet P., Cauvin A., et al. PACAP and VIP receptors in rat liver membranes. Am J Physiol. 260:1991;G97-G102.
82. Yokota C., Kawai K., Ohashi S., Watanabe Y., Yamashita K. PACAP stimulates glucose output from the perfused rat liver. Peptides. 16:1995;55-60.
83. Arimura A., Somogyvari-Vigh A., Miyata A., Mizuno K., Coy D.H., Kitada C. Tissue distribution of PACAP as determined by RIA: highly abundant in the rat brain and testes. Endocrinology. 129:1991;2787-2789.
84. Parkman H.P., Pagano A.P., Ryan J.P. PACAP contracts guinea-pig gallbladder smooth muscle via a direct myogenic effect mediated through voltage dependent calcium channels (Abstract). Gastroenterology. 108:1995;A665.
85. Parkman H.P., Pagano A.P., Ryan J.P. Dual effects of PACAP on guinea pig gallbladder muscle via PACAP-preferring and VIP/PACAP-preferring receptors. Am J Physiol. 272:1997;G1433-1438.
86. Pang P.K.T., Kline L.W. Protein kinase C mediates the contractile actions of pituitary adenylate cyclase activating polypeptide in guinea pig gallbladder strips. Regul Pept. 77:1998;63-67.
87. Tornoc K., Hannibal J., Giezemann M., Schmidt P., Holst J.J. PACAP 1-27 and 1-38 in the porcine pancreas: occurrence, localization, and effects. Ann NY Acad Sci. 806:1996;521-535.
88. Fridolf T., Sundler F., Ahren B. Pituitary adenylate cyclase-activating polypeptide (PACAP): occurence in rodent pancreas and effects on insulin and glucagon secretion in the mouse. Cell Tissue Res. 269:1992;275-279.
89. Yada T., Sakurada M., Ihida K., et al. Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet B-cells. J Biol Chem. 269:1994;1290-1293.
90. Filipsson K., Sundler F., Hannibal J., Ahren B. PACAP and PACAP receptors in insulin producing tissues: localization and effects. Regul Pept. 74:1998;167-175.
91. Alonso R.M., Rodriguez A.M., Garcia U., Lopez M.A., Calvo J.J. Comparison between the effects of VIP and the novel peptide PACAP on the exocrine pancreatic secretion of the rat. Pancreas. 9:1994;123-128.
92. Schmidt W.E., Seebeck J., Hocker M., et al. PACAP and VIP stimulate enzyme secretion in rat pancreatic acini via interaction with VIP/PACAP-2 receptors: additive augmentation of CCK/carbachol-induced enzyme release. Pancreas. 8:1993;476-487.
93. Kashimura J., Shimosegawa T., Iguchi K., et al. The stimulatory effects and binding characteristics of PACAP 27 in rat dispersed pancreatic acini. Tohoku J Exp Med. 171:1993;243-254.
94. Kashimura J., Shimosegawa T., Kikuchi Y., Koizumi M., Toyota T. The stimulatory effect of PACAP 38 on amylase release in dispersed rat pancreatic acini. Tohoku J Exp Med. 164:1991;309-318.
95. Kitagawa M., Naruse S., Ishiguro H., Hayakawa T., Nokihara K. The effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on amylase secretion from guinea pig pancreatic acini. Biochem Peptides Prot Nucl Acid. 1:1995;73-76.
96. Kimball B.C., Mulholland M.W. Pituitary adenylate cyclase-activating peptide stimulates amylase release and cyclic adenosine monophosphate production in pancreatic acinar cells. Surgery. 120:1996;554-559.
97. Onaga T., Uchida M., Kimura M., et al. Effect of pituitary adenylate cyclase-activating polypeptide on exocrine and endocrine secretion in the ovine pancreas. Comp Biochem Phys C. 115:1996;185-193.
98. Zabielski R., Onaga T., Mineo H., Okine E., Kato S. Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates exocrine pancreas in conscious preruminating calves. Comp Biochem Phys C. 109:1994;93-99.
99. Mungan Z., Ertan A., Hammer R.A., Arimura A. Effect of pituitary adenylate cyclase activating polypeptide on rat pancreatic exocrine secretion. Peptides. 12:1991;559-562.
100. Lee S.T., Lee K.Y., Li P., Coy D., Chang T., Chey W.Y. Pituitary adenylate cyclase-activating peptide stimulates rat pancreatic secretion via secretin and cholecystokinin releases. Gastroenterology. 114:1998;1054-1060.
101. Wheeler S., Eardley J.E.L., McNulty K.F., Sutcliffe C.P., Morrison J.D. An investigation into the relative merits of pituitary adenylate cyclase-activating polypeptide (PACAP-27) and vasoactive intestinal polypeptide as vagal neurotransmitters in exocrine pancreas of rats. Exp Physiol. 82:1997;729-747.
102. Bertrand G., Puech R., Maisonasse Y., Bockaert J., Loubatieres-Mariani M.M. Comparative effects of PACAP and VIP on pancreatic endocrine secretions and vascular resistance in rat. Br J Pharmacol. 117:1996;764-770.
103. Carlsson P., Ostenson C., Efendic S., Langel U., Jansson L. Pituitary adenylate cyclase activating polypeptide (PACAP) redistributes the blood within the pancreas of anesthetized rats. Regul Pept. 63:1996;123-128.
104. Ito O., Naruse S., Kitagawa M., et al. The effect of VIP/PACAP family of peptides on pancreatic blood flow and secretion in conscious dogs. Regul Pept. 78:1998;105-112.
105. Filipsson K., Tornoe K., Holst J., Ahren B. Pituitary adenylate cyclase-activating polypeptide stimulates insulin and glucagon secretion in humans. J Clin Endocrinol Metab. 82:1997;3093-3098.
106. Yokota C., Kawai K., Ohashi S., Watanabe Y., Suzuki S., Yamashita K. Stimulatory effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on insulin and glucagon release from the isolated perfused rat pancreas. Acta Endocrinol. 129:1993;473-479.
107. Kulkarni R.N., Smith D.M., Ghatei M.A., Bloom S.R. A 67 kDa protein mediates pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide-stimulated insulin secretion in a hamster clonal B-cell line. J Endocrinol. 147:1995;121-130.
108. Klinteberg K., Karlsson S., Moller K., Sundler F., Ahren B. Pituitary adenylate cyclase-activating polypeptide (PACAP) and insulin secretion: effects and mechanisms. Ann NY Acad Sci. 806:1996;543-548.
109. Edwards A.V., Bloom S.R., Ghatei M.A. Pancreatic endocrine responses to the peptides VIP and PACAP in the conscious calf. Exp Physiol. 82:1997;717-727.
110. Straub S.G., Sharp G.W.G. A wortmannin-sensitive signal transduction pathway is involved in the stimulation of insuline release by vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide. J Biol Chem. 3:1996;1660-1668.
111. Filipsson K., Pacini G., Scheurink A.J.W., Ahren B. PACAP stimulates insulin secretion but inhibits insulin sensitivity in mice. Am J Physiol. 274:1998;E834-E842.
112. Fahrenkrug J., Buhl T., Hannibal J. PreproPACAP-derived peptides occur in VIP-producing tumours and co-exist with VIP. Regul Pept. 58:1995;89-98.
113. Buscail L., Cambillau C., Seva C., et al. Stimulation of rat pancreatic tumoral AR4-2J cell proliferation by pituitary adenylate cyclase-activating peptide. Gastroenterology. 103:1992;1002-1008.
114. Robberecht P., Gourlet P., De Neef P., et al. Receptor occupancy and adenylate cyclase activation in AR4-2J rat pancreatic acinar cell membranes by analogs of pituitary adenylate cyclase-activating peptides amino-terminally shortened or modified at position 1, 2, 3, 20, or 21. Mol Pharmacol. 42:1992;347-355.
115. Schäfer H., Zheng J., Gundlach F., et al. Pituitary adenylate.cyclase-activating polypeptide stimulates proto-oncogene expression and activates the AP-1 (c-Fos/c-Jun) transcription factor in AR4-2J pancreatic carcinoma cells. Eur J Biochem. 242:1996;467-476.
116. Günther R., Bauer I., Folsch U.R., Schmidt W.E. Concentration-dependent activation of different signal transduction pathways by PACAP (1-38) in the rat pancreatic tumor cell line AR42J (Abstract). Gastroenterology. 114:1998;A465.
117. Schafer H., Trauzold A., Siegel E.G., Folsch U.R., Schmidt W.E. PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line. Cancer Res. 56:1996;2641-2648.
118. Mungan Z., Arimura A., Ertan A., Rossowski W.J., Coy D.H. Pituitary adenylate cyclase-activating polypeptide relaxes rat gastrointestinal smooth muscle. Scand J Gastroenterol. 27:1992;375-380.
119. Ishihara T., Shigemoto R., Mori K., Takahashi K., Nagata S. Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron. 8:1992;811-819.
120. Pisegna J.R., Wank S.A. Molecular cloning and functional expression of the pituitary adenylate cyclase-activating polypeptide type I receptor. Proc Natl Acad Sci USA. 90:1993;6345-6349.
121. Morrow J.A., Lutz E.M., West K.M., Fink G., Harmar A.J. Molecular cloning and expression of a cDNA encoding a receptor for pituitary adenylate cyclase activating polypeptide. FEBS Lett. 329:1993;99-105.
122. Hosoya M., Onda H., Ogi K., et al. Molecular cloning and functional expression of rat cDNAs encoding the receptor for pituitary adenylate cyclase activating polypeptide. Biochem Bioph Res Commun. 194:1993;133-143.
123. Hashimoto H., Ishiliara T., Shigemoto R., Mon K., Nagata S. Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. Neuron. 11:1993;333-342.
124. Spengler D., Waeber C., Pantaloni C., et al. Differential signal transduction by five splice variants of the PACAP receptor. Nature. 365:1993;170-175.
125. Lutz E.M., Sheward W.J., West K.M., Morrow J.A., Fink G., Harmar A.J. The VIP2 receptor: molecular characterisation of a eDNA encoding a novel receptor for vasoactive intestinal peptide. FEBS Lett. 334:1993;3-8.
126. 3 receptors in rabbit and guinea pig gastric and tenia coli smooth muscle cells. Regul Pept. 77:1998;73-84.
127. Robberecht P., De Neef P., Leievre R.A. Influence of selective VIP receptors agonists in the rat gastric fundus. Eur J Phannacol. 359:1998;77-80.
128. Salomon R., Couvineau A., Rouyer-Fessard C., et al. Characterization of a common VIP-PACAP receptor in human small intestinal epithelium. Am J Physiol. 264:1993;E294-E300.
129. Mao Y.K., Wang Y.F., Moogk C., et al. Locations and molecular forms of PACAP and sites and characteristics of PACAP receptors in canine ileum. Am J Physiol. 274:1998;G217-G225.
130. Katsoulis S., Neumann R., Klomp H.J., Schmidt A., Schmidt W.E., Folsch U.R. PACAP and VIP relax colonic smooth muscle cells by no-independent pathways (Abstract). Gastroenterology. 114:1998;A775.
131. Motomura Y., Chijiiwa Y., Iwakiri Y., Ochiai T., Nawata H. Interactive mechanisms among pituitary adenylate cyclase-activating peptide, vasoactive intestinal peptide, and parathyroid hormone receptors in guinea pig cecal circular smooth muscle cells. Endocrinology. 139:1998;2869-2878.
132. McConalogue K., Lyster D.J.K., Furness L.B. Electrophysiological analysis of the actions of pituitary adenylyl cyclase activating peptide in the taenia of the guinea-pig caccum. Naunyn-Schmiedeberg's Arch Pharmacol. 352:1995;538-544.
133. Chakder S., Rattan S. Involvement of pituitary adenylate cyclase-activating peptide (PACAP) in the internal anal sphincter (IAS) smooth muscle relaxation (Abstract). Gastroenterology. 114:1998;A1134.
134. Nguyen T.D., Heintz G.G., Wolfe M.S. Structural characterization of PACAP receptors on rat liver plasma membranes. Am J Physiol. 265:1993;G811-G818.
135. Robberecht P., Woussen-Colle M.C., De Neef P., et al. The two forms of the pituitary adenylate cyclase activating polypeptide (PACAP (1-27) and PACAP (1-38)) interact with distinct receptors on rat pancreatic AR 4-2J cell membranes. FEBS Lett. 286:1991;133-136.
136. Yada T., Sakurada M., Nakata M., et al. Current status of PACAP as a regulator of insulin secretion in pancreatic islets. Ann NY Acad Sci. 806:1996;329-342.
137. Inagaki N., Kuromi H., Seino S. PACAP/VIP receptors in pancreatic B-cells: their roles in insulin secretion. Ann NY Acad Sci. 806:1996;44-53.
138. Inagaki N., Yoshida H., Mizuta M., et al. Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells. Proc Natl Acad Sci USA. 91:1994;2679-2683.
139. Svoboda M., Tastenoy M., Ciccarelli E., Stievenart M., Christofe J. Cloning of a splice variant of the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor. Biochem Biophys Res Commun. 195:1993;881-8.