New strategies for combination vaccines based on the extended recombinant bacterial ghost system

Vaccine

Volumn 17, Issue 13-14, 1999, Pages 1643-1649

  Eko, F O ^a   Witte, A ^a   Huter, V ^a   Kuen, B ^a   Furst Ladani S ^a   Haslberger, A ^a   Katinger, A ^a   Hensel, A ^a   Szostak, M P ^b   Resch, S ^b   Mader, H ^b   Raza, P ^b   Brand, E ^b   Marchart, J ^b   Jechlinger, W ^b   Haidinger, W ^b   Lubitz, W ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b EVAX Technologies   (Germany)

Author keywords

Adjuvants; Bacterial ghost; Carrier system; Combination vaccines; Targeting system

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BACTERIAL VACCINE; BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; IMMUNOLOGICAL ADJUVANT;

ANIMAL MODEL; BACTERIAL INFECTION; CONFERENCE PAPER; DRUG TARGETING; ESCHERICHIA COLI; EXPERIMENTAL INFECTION; GENE EXPRESSION; GRAM NEGATIVE BACTERIUM; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; VACCINATION; VIBRIO CHOLERAE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BACTERIA; HUMANS; IMMUNIZATION; VACCINES, COMBINED; VACCINES, SYNTHETIC;

EID: 0344177532     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00423-X     Document Type: Conference Paper

References (26)

1. Witte A., Wanner G., Bläsi U., Halfmann G., Szostak M., Lubitz W. Endogenous transmembrane tunnel formation mediated by PhiX174 lysis protein E. J Bacteriol. 172:1990;4109-4114.
2. Szostak M, Lubitz W. Recombinant bacterial ghosts as multivaccine vehicles. In: Chanock RM et al., editors. Vaccines 91: Modern approaches to new vaccines including prevention of AIDS. New York: Cold Spring Harbor Laboratory Press, 1991. p. 409-414.
3. Szostak M, Auer T, Lubitz W. Immune response against recombinant bacterial ghosts carrying HIV-1 reverse transcriptase. In: Chanock RM et al., editors. Vaccines 93: Modern approaches to new vaccines including prevention of AIDS. New York: Cold Spring Harbor Laboratory Press, 1993. p. 419-425.
4. Witte A., Bläsi U., Halfmann G., Szostak M., Wanner G., Lubitz W. PhiX174 protein E mediated lysis of Escherichia coli. Biochimie. 72:1990;191-200.
5. Witte A, Brand E, Schrot G, Lubitz W. Pathway of PhiX174 protein E mediated lysis of Escherichia coli. In: dePedro MA, Höltje J-V, Löffelhardt W, editors. Bacterial growth and lysis. New York: Plenum Press, 1993. p. 277-283.
6. Witte A., Wanner G., Sulzner M., Lubitz W. Dynamics of PhiX174 protein E-mediated lysis of Escherichia coli. Arch Microbiol. 157:1992;381-388.
7. Schön P., Schrot G., Wanner G., Lubitz W., Witte A. Two-stage model for integration of the lysis protein E of PhiX174 into the cell envelope of Escherichia coli. FEMS Microbiol Rev. 17:1995;207-212.
8. Witte A., Schrot G., Schön P., Lubitz W. Proline 21, a residue within the alpha-helical domain of PhiX174 lysis protein E, is required for ist lysis function in Escherichia coli. Mol Microbiol. 26:1997;337-346.
9. Witte A, Brand E, Mayrhofer P, Narendja F, Lubitz W. Dependence of PhiX174 protein E-mediated lysis on cell division activities of Escherichia coli. Arch Microbiol 1998, in press.
10. Lubitz W., Pugsley A.P. Changes in host cell phospholipid composition of PhiX174 gene E product. FEMS Microbiol Lett. 30:1985;171-175.
11. Witte A., Wanner G., Lubitz W., Höltje J.-V. Effect of PhiX174 E-mediated lysis on murein composition of Escherichia coli. FEMS Microbiol Lett. 164:1998;149-157.
12. Szostak M.P., Hensel A., Eko F.O., Klein R., Auer T., Mader H., Haslberger A., Bunka S., Wanner G., Lubitz W. Bacterial ghosts: non-living candidate vaccines. J Biotechnol. 44:1996;17-161.
13. Jechlinger W, Szostak M, Lubitz W. Cold sensitive E-lysis systems. Gene 1998, 218:1-7.
14. Halfmann G., Götz F., Lubitz W. Expression of bacteriophage PhiX174 lysis gene E in Staphylococcus carnosus TM3000. FEMS Microbiol Lett. 108:1993;139-143.
15. Eko F.O., Szostak M.P., Wanner G., Lubitz W. Production of Vibrio cholerae ghosts (VCG) by expression of a cloned phage lysis gene: potential for vaccine development. Vaccine. 12:1994;1231-1237.
16. Eko F.O., Hensel A., Bunka S., Lubitz W. Immunogenicity of Vibrio cholerae ghosts following intra-peritoneal immunization of mice. Vaccine. 12:1994;1330-1334.
17. Hensel A., van Leengoed L.A.G., Szostak M., Windt H., Weissenböck H., Stockhofe-Zurwieden N., Katinger A., Stadler M., Ganter M., Bunka S., Pabst R., Lubitz W. Induction of protective immunity by aerosol or oral application of candidate vaccines in a dose-controlled pig aerosol infection model. J Biotechnol. 44:1996;171-181.
18. Mader H.J., Szostak M.P., Hensel A., Lubitz W., Haslberger A.G. Endotoxicity does not limit the use of bacterial ghosts as candidate vaccine. Vaccine. 15:1997;195-202.
19. Lubitz W, Szostak M. Carrier-bound recombinant proteins, process for the production and use as immunogens and vaccines. European Patent 1991, No. EP 0516655, B1.
20. Kuen B., Sleytr U.B., Lubitz W. Sequence analysis of the sbsA gene encoding the 130-kDa surface-layer protein of Bacillus stearothermophilus PV72. Gene. 145:1994;115-120.
21. Kuen B., Sára M., Lubitz W. Heterologous expression and self-assembly of the S-layer protein SbsA of Bacillus stearothermophilus in Escherichia coli. Mol Microbiol. 19:1995;495-503.
22. Kuen B., Koch A., Asenbauer W., Sára M., Lubitz W. Molecular characterization of the bacillus stearothermophilus PV72 S-layer gene sbsB induced by oxidative stress. J Bacteriol. 179:1997;1664-1670.
23. Truppe M., Howorka S., Schroll G., Lechleitner S., Kuen B., Resch S., Lubitz W. Biotechnological applications of recombinant S-layer proteins rSbsA and rSbsB from Bacillus stearothermophilus PV72. pp 88-92 in Bahl H., Scholz H., Bayan N., Chami M., Leblon G., Gulik-Krzywicki T., Shechter E., Fouet A., Mesnage S., Tosi-Couture E., Gounon P., Moch M., Conway de Macario E., Macario A.J.L., Fernández-Herrero L.A., Olabarría G., Berenguer J., Blaser M.J., Kuen B., Lubitz W., Sára M., Pouwels P.H., Kolen C.P.A.M., Boot H.J., Palva A., Truppe M., Howorka S., Schroll G., Lechleitner S., Resch S. 1997. Molecular biology of S-layers. FEMS Microbiol Rev. 20:1997;47-98.
24. Truppe M., Howorka S., Schroll G., Lechleitner S., Kuen B., Resch S., Lubitz W. Biotechnological applications of recombinant S-layer proteins rSbsA and rSbsB from Bacillus stearothermophilus PV72. pp 88-92 in Bahl H., Scholz H., Bayan N., Chami M., Leblon G., Gulik-Krzywicki T., Shechter E., Fouet A., Mesnage S., Tosi-Couture E., Gounon P., Moch M., Conway de Macario E., Macario A.J.L., Fernández-Herrero L.A., Olabarría G., Berenguer J., Blaser M.J., Kuen B., Lubitz W., Sára M., Pouwels P.H., Kolen C.P.A.M., Boot H.J., Palva A., Truppe M., Howorka S., Schroll G., Lechleitner S., Resch S. 1997. Molecular biology of S-layers. FEMS Microbiol Rev. 20:1997;47-98.
25. Truppe M., Howorka S., Schroll G., Lechleitner S., Kuen B., Resch S., Lubitz W. Biotechnological applications of recombinant S-layer proteins rSbsA and rSbsB from Bacillus stearothermophilus PV72. pp 88-92 in Bahl H., Scholz H., Bayan N., Chami M., Leblon G., Gulik-Krzywicki T., Shechter E., Fouet A., Mesnage S., Tosi-Couture E., Gounon P., Moch M., Conway de Macario E., Macario A.J.L., Fernández-Herrero L.A., Olabarría G., Berenguer J., Blaser M.J., Kuen B., Lubitz W., Sára M., Pouwels P.H., Kolen C.P.A.M., Boot H.J., Palva A., Truppe M., Howorka S., Schroll G., Lechleitner S., Resch S. 1997. Molecular biology of S-layers. FEMS Microbiol Rev. 20:1997;47-98.
26. Haslberger A.G., Mader H.J., Schmalnauer M., Kohl G., Szostak M.P., Messner P., Sleytr U.B., Wanner G., Fürst-Ladani S., Lubitz W. Bacterial cell envelopes (ghosts) and LPS but not bacterial S-layers induce synthesis of immune-mediators in mouse macrophages involving CD14. J Endotox Res. 4:1997;431-441.