Determination of liposome partitioning of ionizable drugs by titration

Journal of Pharmaceutical Sciences

Volumn 88, Issue 8, 1999, Pages 802-806

  Balon, Karsten ^a   Riebesehl, Bernd U ^a   Müller, Bernd W ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

DICLOFENAC; LIPOSOME; PHOSPHATIDYLCHOLINE; PROPRANOLOL; WATER;

ARTICLE; CONTROLLED STUDY; DRUG SCREENING; MEMBRANE; PARTITION COEFFICIENT; PH; TEMPERATURE; TITRIMETRY;

EID: 0344172182     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js9804213     Document Type: Article

References (17)

1. Barton, P.; Davis, A. M.; McCarthy, D. J.; Webborn, P. J. H. Drug-Phospholipid interactions. 2. Predicting the sites of drug distribution using n-octanol/water and membrane/water distribution coefficients. J. Pharm. Sci. 1997, 86, 1034-1039.
2. Alcorn, C. J.; Simpson, R. J.; Leahy, D.; Peters, T. H. Determination of partition and distribution coefficients with brush border membrane vesicles. Biochem. Pharmacol. 1991, 42, 2259-2264.
3. Alcorn, C. J.; Simpson, R. J.; Leahy, D. E.; Peters, T. J. Partition and distribution coefficients of solutes and drugs in brush border membrane vesicles. Biochem. Pharmacol. 1993, 45, 1775-1782.
4. Austin, R. P.; Davis, A. M.; Manners, C. N. Partitioning of ionizing molecules between aqueous buffers and phospholipid vesicles. J. Pharm. Sci. 1995, 84, 1180-1183.
5. Pauletti, G. M.; Wunderli-Allenspach, H. Partition coefficients in vitro: artificial membranes as a standardized distribution model. Eur. J. Pharm. Sci. 1994, 1, 273-282.
6. Pharmaceutical Preformulation, 1st ed.; Wells, J. I., Ed., Ellis Horwood Ltd.: London, 1988; p 25.
7. Avdeef, A.; Box, K. J.; Comer, J. E. A.; Hibbert, C.; Tam., K. Y. pH - metric logP 10: Determination of vesicle membrane - water partition coefficients of ionisable drugs. Pharm. Res. 1998, 15, 209-215.
8. Hauser, H.; Howell, K.; Dawson, R. M. C.; Bowyer, D. E. Rabbit small intestinal brush border membrane preparation and lipid composition. Biochim. Biophys. Acta 1980, 602, 567-577.
9. Small, D. M. The physical chemistry of lipids: From alkanes to phospholipids. In Handbook of Lipid Research; Plenum Press: New York, 1986; Vol. 4, p 512.
10. Avdeef, A. pH-Metric logP. Part 1: Difference plots for determining ion-pair octanol - water partition coefficients of multiprotic substances. Quant. Struct.-Act. Relat. 1992, 11, 510-517.
11. Avdeef, A. pH-metric logP - 2. Refinement of partition coefficients and ionisation constants of multiprotic substances. J. Pharm. Sci. 1993, 82, 183-190.
12. Krämer, S. D.; Wunderli-Allenspach, H. The pH dependence in the partitioning behaviour of (RS)-[3H]Propranolol between MDCK cell lipid vesicles and buffer. Pharm. Res. 1996, 13, 1851-1855.
13. Kraemer, S. D.; Jakits-Deiser, C.; Wunderli-Allenspach, H. Free fatty acids cause pH-dependent changes in drug-lipid membrane interactions around physiological pH. Pharm. Res. 1997, 14, 827-832.
14. Green, N. M. Membrane Stucture. In The Encyclopedia of Molecular Biology; Kendrew, J., Ed.; Blackwell Science Ltd.: Oxford, 1994; p 619.
15. Mason, R. P.; Rhodes D. G.; Herbette, L. G. Reevaluating Eqilibrium and Kinetic Binding Parameters for Lipophlilic Drugs Based on a Structural Model for Drug Interaction with Biological Membranes. J. Med. Chem. 1991, 34, 869-877.
16. Balon, K.; Riebesehl, B. U.; Müller, B. W. Prediction of passive intestinal drug absorption using liposome partitioning data. Presented at the 2nd World Meeting on Pharmaceutics, Biopharmaceutics, and Pharmaceutical Technology, Paris, France, May 25-28, 1998.
17. Surewicz, W. K.; Leyko, W. Interaction of propranolol with model phospholipid membranes. Biochim. Biophys. Acta, 1988, 643, 387-397.