Free fatty acids cause pH-dependent changes in drug-lipid membrane interactions around physiological pH

Pharmaceutical Research

Volumn 14, Issue 6, 1997, Pages 827-832

  Krämer, Stefanie D ^a   Jakits Deiser, Christina ^a   Wunderli Allenspach, Heidi ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Drug lipid membrane interactions; Free fatty acid; Liposome; Partitioning; Phosphatidylethanolamine; Propranolol

Indexed keywords

FATTY ACID; LIPOSOME; OLEIC ACID; PHOSPHATIDYLETHANOLAMINE; PROPRANOLOL;

ARTICLE; EQUILIBRIUM DIALYSIS; IONIZATION; LIPID MEMBRANE; PARTITION COEFFICIENT; PH; PRIORITY JOURNAL; SURFACE CHARGE; ZETA POTENTIAL;

ANIMALS; BUFFERS; CHOLIC ACID; CHOLIC ACIDS; DOGS; ELECTRICITY; FATTY ACIDS, NONESTERIFIED; HYDROGEN-ION CONCENTRATION; LIPOSOMES; OLEIC ACID; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PROPRANOLOL; SURFACE PROPERTIES;

EID: 0030984681     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012175111401     Document Type: Article

References (16)

1. W. Nernst. Z. Phys. Chem. 8:110-139 (1891).
2. C. Hansch, A. Leo, and D. Hoekman. Exploring QSAR. Hydrophobic, Electronic, and Steric Constants. ACS Professional Reference Book. American Chemical Society, Washington, DC, 1995.
3. H. Miyoshi, H. Maeda, N. Tokutake, and T. Fujita. Bull. Chem. Soc. Jpn. 60:4357-4362 (1987).
4. C. J. Alcorn, R. J. Simpson, D. E. Leahy, and T. J. Peters. Biochem. Pharmacol. 45:1775-1782 (1993).
5. R. P. Austin, A. M. Davis, and C. N. Manners. J. Pharm. Sci. 84:1180-1183 (1995).
6. G. M. Pauletti and H. Wunderli-Allenspach. Eur. J. Pharm. Sci. 1:273-282 (1994).
7. C. Ottiger and H. Wunderli-Allenspach. Eur. J. Pharm. Sci., in press.
8. S. D. Krämer and H. Wunderli-Allenspach. Pharm. Res. 13:1851-1855 (1996).
9. H. Wunderli-Allenspach, M. Günthert, and S. Ott. Biochemistry 32:900-907 (1993).
10. M. J. Hope, M. B. Bally, G. Webb, and P. R. Cullis. Biochim Biophys. Acta. 812:55-65 (1985).
11. T. Teorell and E. Stenhagen. Biochem. Z. 299:416-419 (1938).
12. M. Takayama, S. Itoh, T. Nagasaki, and I. Tanimizu. Clin. Chim. Acta 79:93-98 (1977).
13. F. C. Tsui, D. M., Ojcius, and W. L. Hubbell. Biophys. J. 49:459-468 (1986).
14. R. Lieckfeldt, J. Villalaín, J. Gómez-Fernández, and G. Lee. Pharm. Res. 12:1614-1617 (1995).
15. A. Spector. J. Lipid Res. 16:165-179 (1975).
16. J. Miyazaki, K. Hideg, and D. Marsh. Biochim. Biophys. Acta 1103:62-68 (1992).