Effect of αα-cross-linked hemoglobin and pyridoxalated hemoglobin polyoxyethylene conjugate solutions on gastrointestinal regional perfusion in hemorrhagic shock

Journal of Trauma - Injury, Infection and Critical Care

Volumn 45, Issue 3, 1998, Pages 457-469

  Noone, Robert B ^a   Mythen, Michael G ^b   Vaslef, Steven N ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Animal; Blood substitutes; Gastrointestinal perfusion; Hemoglobin; Hemorrhagic shock; Pigs; Regional blood flow; Resuscitation; Swine; Tonometry

Indexed keywords

BLOOD SUBSTITUTE;

ANIMAL EXPERIMENT; BLOOD SUBSTITUTION; CONFERENCE PAPER; CROSS LINKING; HEMOGLOBIN DETERMINATION; HEMORRHAGIC SHOCK; INTESTINE BLOOD FLOW; NONHUMAN; PRIORITY JOURNAL;

EID: 0344157808     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/00005373-199809000-00006     Document Type: Conference Paper

References (61)

1. Dietz NM, Joyner MJ, Warner MA. Blood substitutes: fluids, drugs, or miracle solutions? Anesth Analg. 1996; 82:390-405.
2. Freas W, Llave R, Jing M, Hart J, McQuillan P, Muldoon S. Contractile effects of diaspirin cross-linked hemoglobin (DCLHb) on isolated porcine blood vessels. J Lab Clin Med. 1995;125:762-767.
3. Alayash AI, Fratantoni JC, Bonaventura C, Bonaventura J, Cashon RE. Nitric oxide binding to human ferrihemoglobins cross-linked between either alpha or beta subunits. Arch Biochem Biophys. 1993;303:332-338.
4. Gulati A, Sharma AC. Role of nitric oxide in cardiovascular effects of diaspirin crosslinked and stroma-free hemoglobin [abstract]. FASEB J. 1994;8:A625.
5. Hess JR. Blood substitutes. Semin Hematol. 1996;33:369-378.
6. Chappell JE, McBride WJ, Shackford SR. Diaspirin cross-linked hemoglobin resuscitation improves cerebral perfusion after head injury and shock. J Trauma. 1996;41:781-788.
7. Sharma AC, Rebello S, Gulati A. Regional circulatory and systemic hemodynamic effects of diaspirin cross-linked hemoglobin in the rat. Artif Cells Blood Substit Immobil Biotechnol. 1994;22:593-602.
8. Frankel HL, Nguyen HB, Sheadonohue T, Alton LA, Ratigan J, Malcolm DS. Diaspirin cross-linked hemoglobin is efficacious in gut resuscitation as measured by a GI tract optode. J Trauma. 1996;40:231-240.
9. Marchand G, Dunlap E, Farrell L, Nigro C, Burhop K. Resuscitation with increasing doses of diaspirin crosslinked hemoglobin in swine. Artif Cells Blood Substit Immobil Biotechnol. 1996;24:469-487.
10. Schultz SC, Powell CC, Bernard E, Malcolm DS. Diaspirin crosslinked hemoglobin (DCLHb) attenuates bacterial translocation in rats. Artif Cells Blood Substit Immobil Biotechnol. 1995;23:647-664.
11. Bickell WH, Wall MJ, Pepe PE, et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med. 1994;331:1105-1109.
12. Deitch EA. The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure. Arch Surg. 1990;125:403-404.
13. Fiddian-Green RG, Haglund U, Gutierrez G, Shoemaker WC. Goals for the resuscitation of shock. Crit Care Med. 1993;21:S25-S31.
14. Haglund U, Jodal M, Lundgren O. The small bowel in arterial hypotension and shock. In: Shepherd AP, Granger DN, eds. Physiology of the Intestinal Circulation. New York, NY: Raven Press; 1984:305-319.
15. Kirton OC, Civetta JM. Splanchnic flow and resuscitation. In: Civetta JM, Taylor RW, Kirby RR, eds. Critical Care. 3rd ed. Philadelphia, Pa: Lippincott-Raven; 1997:443-455.
16. Gould SA, Moss GS. Clinical development of human polymerized hemoglobin as a blood substitute. World J Surg. 1996;20:1200-1207.
17. Przybelski RJ, Daily EK, Kisicki JC, Mattiagoldberg C, Bounds MJ, Colburn WA. Phase I study of the safety and pharmacologic effects of diaspirin cross-linked hemoglobin solution. Crit Care Med. 1996;24:1993-2000.
18. Cohn SM. Is blood obsolete? J Trauma. 1997;42:730-732.
19. de Figueiredo LFP, Mathru M, Solanki D, Macdonald VW, Hess J, Kramer GC. Pulmonary hypertension and systemic vasoconstriction may offset the benefits of acellular hemoglobin blood substitutes. J Trauma. 1997;42:847-856.
20. Ulatowski JA, Nishikawa T, Mathesonurbaitis B, Bucci E, Traystman RJ, Koehler RC. Regional blood flow alterations after bovine fumaryl beta-beta-crosslinked hemoglobin transfusion and nitric oxide synthase inhibition. Crit Care Med. 1996;24:558-565.
21. Aranow JS, Wang H, Zhuang J, Fink MP. Effect of human hemoglobin on systemic and regional hemodynamics in a porcine model of endotoxemic shock. Crit Care Med. 1996; 24:807-814.
22. Ning J, Peterson LM, Anderson PJ, Biro GP. Systemic hemodynamic and renal effects of unmodified human SFHS in dogs. Biomater Artif Cells Immobilization Biotechnol. 1992;20:723-727.
23. Fiddian-Green RG. Splanchnic ischaemia and multiple organ failure in the critically ill. Ann R Coll Surg Engl. 1988; 70:128-134.
24. Antonsson JB, Boyle CC, Kruithoff KL, et al. Validation of tonometric measurement of gut intramural pH during endotoxemia and mesenteric occlusion in pigs. Am J Physiol. 1990;259:G519-G523.
25. Gutierrez G, Bismar H, Dantzker DR, Silva N. Comparison of gastric intramucosal pH with measures of oxygen transport and consumption in critically ill patients. Crit Care Med. 1992;20:451-457.
26. Mythen MG, Webb AR. Perioperative plasma volume expansion reduces the incidence of gut mucosal hypoperfusion during cardiac surgery. Arch Surg. 1995; 130:423-429.
27. Noone RB, Yen MH, Leone BJ, Mythen MG. Gut mucosal hypoperfusion measured with an automated on-line tonometer (the Tonocap) in a canine model of hemorrhage [abstract]. Intensive Care Med. 1996;22(suppl 1):S65.
28. Noone RB, Yen MH, Leone BJ, Mythen MG. In-vivo comparison of gastrointestinal tonometry using the saline technique and a novel automated on-line air device (the Tonocap) [abstract]. Intensive Care Med. 1996;22(suppl 1):S66.
29. Noone RB, Urakubo A, Mythen MG, Vaslef SN. Comparison of gastrointestinal tonometry using the saline technique with an automated air device (the Tonocap) in swine [abstract]. Crit Care Med. 1997;25(suppl):A137.
30. Noone RB, Mythen MG, Vaslef SN. In-vitro validation of an automated on-line gastrointestinal tonometer (the Tonocap) [abstract]. Crit Care Med. 1997;25(suppl):A137.
31. 2 [abstract]. Critical Care. 1997;1(suppl):49.
32. Heymann MA, Payne BD, Hoffman JI, Rudolph AM. Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis. 1977;20:55-79.
33. Hess JR, MacDonald VW, Brinkley WW. Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. J Appl Physiol. 1993;74:1769-1778.
34. Gould SA, Moore EE, Moore FA, et al. Clinical utility of human polymerized hemoglobin as a blood substitute after acute trauma and urgent surgery. J Trauma. 1997;43:325-331.
35. Tumbleson ME, ed. Swine in Biomedical Research. New York, NY: Plenum Press; 1986;1.
36. Cohn SM, Zieg PM, Rosenfield AT, Fisher BT. Resuscitation of pulmonary contusion: effects of a red cell substitute. Crit Care Med. 1997;25:484-491.
37. Hart JL, Ledvina MA, Muldoon SM. Actions of diaspirin cross-linked hemoglobin on isolated rat and dog vessels. J Lab Clin Med. 1997;129:356-363.
38. Cohn SM, Farrell TJ. Diaspirin cross-linked hemoglobin resuscitation of hemorrhage: comparison of a blood substitute with hypertonic saline and isotonic saline. J Trauma. 1995;39:210-216.
39. 2 in anesthetized dogs. Gastroenterology. 1968;55:52-60.
40. Maxwell TM, Lim RJ, Fuchs R, Hunt TK. Continuous monitoring of tissue gas tensions and pH in hemorrhagic shock. Am J Surg. 1973;126:249-254.
41. Yee JB, McJames SW. Use of gastric intramucosal pH as a monitor during hemorrhagic shock. Circ Shock. 1994;43:44-48.
42. Schlichtig E, Lyberg T. Monitoring of tissue oxygenation in shock: an experimental study in pigs. Crit Care Med. 1995; 23:1703-1710.
43. Krafte-Jacobs B, Carver J, Wilkinson JD. Comparison of gastric intramucosal pH and standard perfusional measurements in pediatric septic shock. Chest. 1995; 108:220-225.
44. Oldner A, Goiny M, Ungerstedt U, Sollevi A. Splanchnic homeostasis during endotoxin challenge in the pig as assessed by microdialysis and tonometry. Shock. 1996; 6:188-193.
45. 2 in a porcine model of peritonitis or haemorrhage. Gut. 1995;37:791-797.
46. Revelly JP, Ayuse T, Brienza N, Fessier HE, Robotham JL. Endotoxic shock alters distribution of blood flow within the intestinal wall. Crit Care Med. 1996;24:1345-1351.
47. Bjorck M, Hedberg B. Early detection of major complications after abdominal aortic surgery: predictive value of sigmoid colon and gastric intramucosal pH monitoring. Br J Surg. 1994;81:25-30.
48. Ivatury RR, Simon RJ, Islam S, Fueg A, Rohman M, Stahl WM. A prospective randomized study of end points of resuscitation after major trauma: global oxygen transport indices versus organ-specific gastric mucosal pH. J Am Coll Surg. 1996;183:145-154.
49. Chang MC, Cheatham ML, Nelson LD, Rutherford EJ, Morris JJ. Gastric tonometry supplements information provided by systemic indicators of oxygen transport. J Trauma. 1994;37:488-494.
50. Roumen RM, Vreugde JP, Goris RJ. Gastric tonometry in multiple trauma patients. J Trauma. 1994;36:313-316.
51. Maynard N, Bihari D, Beale R, et al. Assessment of splanchnic oxygenation by gastric tonometry in patients with acute circulatory failure. JAMA. 1993;270:1203-1210.
52. Gutierrez G, Palizas F, Doglio G, et al. Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet. 1992;339:195-199.
53. Lee R, Neya K, Svizzero TA, Vlahakes GJ. Limitations of the efficacy of hemoglobin-based oxygen-carrying solutions. J Appl Physiol. 1995;79:236-242.
54. Gulati A, Sen AP, Sharma AC, Singh G. Role of ET and NO in resuscitative effect of diaspirin cross-linked hemoglobin after hemorrhage in rat. Am J Physiol. 1997; 273:H827-H836.
55. Sharma AC, Singh G, Gulati A. Role of NO mechanism in cardiovascular effects of diaspirin cross-linked hemoglobin in anesthetized rats. Am J Physiol. 1995;269:H1379-H1388.
56. Schultz SC, Grady B, Cole F, Hamilton I, Burhop K, Malcolm DS. A role for endothelin and nitric oxide in the pressor response to diaspirin cross-linked hemoglobin. J Lab Clin Med. 1993;122:301-308.
57. Matsumura S, Yamaji K, Ohki H, Kosaka K, Iwashita Y. Large scale production and characterization of lyophilized pyridoxilated hemoglobin-polyoxyethylene (PHP). Biomater Artif Cells Immobilization Biotechnol. 1992;20:435-438.
58. Malchesky PS, Takahashi T, Iwasaki K, Harasaki H, Nose Y. Conjugated human hemoglobin as a physiological oxygen carrier-pyridoxilated hemoglobin polyoxyethylene conjugate (PHP). Int J Artif Organs. 1990;13:442-450. Review.
59. Russell JA. Gastric tonometry: does it work? Intensive Care Med. 1997;23:3-6.
60. Stamler JS, Jia L, Eu JP, et al. Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science. 1997;276:2034-2037.
61. Biro GP, Ou C, Ryan MC, Anderson PJ. Oxyradical generation after resuscitation of hemorrhagic shock with blood or stroma-free hemoglobin solution. Artif Cells Blood Substit Immobil Biotechnol. 1995;23:631-645.