Clinical development of human polymerized hemoglobin as a blood substitute

World Journal of Surgery

Volumn 20, Issue 9, 1996, Pages 1200-1207

  Gould, Steven A ^a,b,c   Moss, Gerald S ^b  

^a MICHAEL REESE HOSPITAL   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c Northfield Laboratories Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD SUBSTITUTE; HEMOGLOBIN DERIVATIVE; PYRIDOXYLPOLYHEMOGLOBIN; TETRAMER;

BLOOD SUBSTITUTION; DRUG RESEARCH; ERYTHROCYTE; GASTROINTESTINAL SYMPTOM; HUMAN; KIDNEY DISEASE; REVIEW; VASOCONSTRICTION;

ANIMALS; BLOOD SUBSTITUTES; CLINICAL TRIALS; EXCHANGE TRANSFUSION, WHOLE BLOOD; HEMOGLOBINS; HUMANS; PYRIDOXAL PHOSPHATE; VASOCONSTRICTION;

EID: 0029998050     PISSN: 03642313     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002689900183     Document Type: Review

References (36)

1. Dodd, R.Y.: The risk of transfusion-transmitted infection. N. Engl. J. Med. 327:419, 1992
2. Gould, S.A., Rosen, A.L., Sehgal, L.R., et al.: Red cell substitutes: hemoglobin solution or fluorocarbon? J. Trauma 22:736, 1982
3. 2 carriers? Surg. Forum 32:299, 1981
4. Gould, S.A., Sehgal, L.R., Rosen, A.L., et al.: Assessment of 35% fluorocarbon emulsion. J. Trauma 23:720, 1983
5. Gould, S.A., Rosen, A.L., Sehgal, L.R., et al.: Fluosol-DA as a red cell substitute in acute anemia. N. Engl. J. Med. 315:1653, 1986
6. Gould, S.A., Sehgal, L., Sehgal, H., Moss, G.S.: The development of hemoglobin solutions as red cell substitutes. Transfus. Sci. 16(1), 1994
7. Winslow, R.M.: Hemoglobin-Based Red Cell Substitutes. Baltimore, Johns Hopkins University Press, 1992
8. Amberson, W.R., Flexner, J., Steggerda, F.R., et al.: On the use of Ringer-Locke solution containing hemoglobin as a substitute for normal blood in mammals. J. Cell. Comp. Physiol. 5:59, 1934
9. Amberson, W.R., Jennings, J.J., Rhode, C.M.: Clinical experience with hemoglobin-saline solutions. J. Appl. Physiol. 1:469, 1949
10. Brandt, J.L., Frank, R., Lichtman, H.C.: The effect of hemoglobin solutions on renal functions in man. Blood 6:1152, 1951
11. Miller, J.H., McDonald, R.K.: The effect of hemoglobin on renal function in the human. J. Clin. Invest. 30:1033, 1951
12. Savitsky, J.P., Doczi, J., Black, J., Arnold, J.D.: A clinical safety trial of stroma-free hemoglobin. Clin. Pharmacol. Ther. 23:73, 1978
13. Center for Biologies Evaluation and Research: Points to consider in the safety of hemoglobin-based oxygen carriers. Transfusion 31:369, 1991
14. Keipert, P.E., Gonzales, A., Gomez, C.L., MacDonald, V.W., Hess, J.R., Winslow, R.M.: Acute changes in systemic blood pressure and urine output of conscious rats following exchange transfusion with diaspirin-crosslinked hemoglobin solution. Transfusion 33:701, 1993
15. Martin, W., Villani, G.M., Jothianandan, D., Furchgott, R.F.: Selective blockade of endothelium-dependent and glycerol trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta. J. Pharmacol. Exp. Ther. 232:708, 1985
16. Moncada, S., Palmer, R.M.J., Higgs, E.A.: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 40:109, 1991
17. Hess, J.R., MacDonald, V.W., Brinkley, W.W.: Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. J. Appl. Physiol. 74:1769, 1993
18. Keipert, P.E., Gomez, C.L., Gonzales, A., MacDonald, V.W., Hess, J.R., Winslow, R.M.: Diaspirin-crosslinked hemoglobin: tissue distribution and long term excretion following exchange transfusion. J. Lab. Clin. Med. 123:701, 1994
19. Sehgal, L.R., Rosen, A.L., Gould, S.A., et al.: Preparation and in vitro characteristics of polymerized pyridoxylated hemoglobin. Transfusion 23:158, 1983
20. 2 capacity. Surgery 95:433, 1984
21. Gould, S.A., Sehgal, L.R., Sehgal, H.L., Moss, G.S.: Artificial blood. In Principles and Practice of Medical Intensive Care, R.W. Carlson, M.A. Geheb, editors. Philadelphia, Saunders, 1993, pp. 151-160
22. Moss, G.S., Gould, S.A., Sehgal, L.R., et al.: Hemoglobin solution: from tetramer to polymer. Surgery 95:249, 1984
23. Moss, G.S., DeWoskin, R., Rosen, A.L., et al.: Transport of oxygen and carbon dioxide by hemoglobin-saline solution in the red cell-free primate. Surg. Gynecol. Obstet. 142:357, 1976
24. 50 more important? J. Surg. Res. 33:189, 1982
25. Moss, G.S., Sehgal, L.R., Gould, S.A., et al.: Alternatives to transfusion therapy. Anesthesiol. Clin. North Am. 8:569, 1990
26. Benesch, R.E., Benesch, R., Renthal, R.D., et al.: Affinity labeling of the polyphosphate binding site of hemoglobin. Biochemistry 11:3576, 1972
27. Greenburg, A.G., Hayashi, R., Siefert, I., et al.: Intravascular persistence and oxygen delivery of pyridoxylated, stroma-free hemoglobin during gradations of hypotension. Surgery 86:13, 1979
28. 50. J. Surg. Res. 30:14, 1981
29. Gould, S.A., Rosen, A.L., Sehgal, L.R., et al.: The effect of altered hemoglobin-oxygen affinity on oxygen transport by hemoglobin solution. J. Surg. Res. 28:246, 1980
30. Gould, S.A., Sehgal, L.R., Rosen, A.L., Sehgal, H.L., Moss, G.S.: Polyhemoglobin: an improved red cell substitute. Surg. Forum 36:30, 1985
31. 2 carrier. Ann. Surg. 211:394, 1990
32. Rosen, A.L., Gould, S.A., Sehgal, L.R., et al.: Effect of hemoglobin solution on compensation to anemia in erythrocyte-free primate. J. Appl. Physiol. 68:938, 1990
33. Rosen, A.L., Gould, S.A., Sehgal, L.R., et al.: Evaluation of efficacy of stroma-free hemoglobin solutions. In Blood Substitutes, R.B. Bolin, R.P. Geyer, editors. New York, Alan R. Liss, 1983, pp. 79-88
34. Gould, S.A., Sehgal, L.R., Sehgal, H.L., Toyooka, E., Moss, G.S.: Clinical experience with human polymerized hemoglobin [abstract]. Transfusion 33(Suppl. 9S):60S, 1993
35. Gould, S.A., Moore, E.E., Moore, F.A., Haenel, J., et al.: The clinical utility of human polymerized hemoglobin as a blood substitute following trauma and emergent surgery. J Trauma 39:157, 1995
36. Center for Biologies Evaluation and Research: Points to consider on efficacy evaluation of hemoglobin- and perfluorocarbon-based oxygen carriers. Transfusion 34:712, 1994