Alterations in Primary Afferent Input to Substantia Gelatinosa of Adult Rat Spinal Cord after Neonatal Capsaicin Treatment

Journal of Neuroscience Research

Volumn 74, Issue 6, 2003, Pages 928-933

  Yang, Kun ^a,b   Furue, Hidemasa ^a   Fujita, Tsugumi ^b   Kumamoto, Eiichi ^b   Yoshimura, Megumu ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b SAGA UNIVERSITY   (Japan)

Author keywords

Excitatory postsynaptic current; Nociception; Primary afferent A fiber; Primary afferent C fiber; Synaptic plasticity

Indexed keywords

CAPSAICIN;

AFFERENT NERVE GROUP 1; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TYPE; CONTROLLED STUDY; DORSAL ROOT; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; MUSCLE SPINDLE AFFERENT NERVE; NERVE CELL PLASTICITY; NERVE FIBER A BETA; NERVE FIBER A DELTA; NERVE FIBER C; NEWBORN; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL CORD DORSAL HORN; SUBSTANTIA GELATINOSA; VOLTAGE CLAMP;

ACTION POTENTIALS; AFFERENT PATHWAYS; ANIMALS; ANIMALS, NEWBORN; CAPSAICIN; EXCITATORY POSTSYNAPTIC POTENTIALS; RATS; SPINAL CORD; SUBSTANTIA GELATINOSA;

EID: 0344118159     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10818     Document Type: Article

References (32)

1. Abbadie C, Lombard M-C, Besson J-M, Trafton JA, Basbaum AI. 2002. Mu and delta opioid receptor-like immunoreactivity in the cervical spinal cord of the rat after dorsal rhizotomy or neonatal capsaicin: an analysis of pre- and postsynaptic receptor distributions. Brain Res 930:150-162.
2. Ataka T, Kumamoto E, Shimoji K, Yoshimura M. 2000. Baclofen inhibits more effectively C-afferent than Aδ-afferent glutamatergic transmission in substantia gelatinosa neurons of adult rat spinal cord slices. Pain 86:273-282.
3. Baba H, Doubell TP, Woolf CJ. 1999. Peripheral inflammation facilitates Aβ fiber-mediated synaptic input to the substantia gelatinosa of the adult rat spinal cord. J Neurosci 19:859-867.
4. Fitzgerald M, Jennings E. 1999. The postnatal development of spinal sensory processing. Proc Natl Acad Sci USA 96:7719-7722.
5. Fitzgerald M, Butcher T, Shortland P. 1994. Developmental changes in the laminar termination of A fibre cutaneous sensory afferents in the rat spinal cord dorsal horn. J Comp Neurol 348:225-233.
6. Harper AA, Lawson SN. 1985. Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones. J Physiol 359:31-46.
7. Hiura A. 2000. Neuroanatomical effects of capsaicin on the primary afferent neurons. Arch Histol Cytol 63:199-215.
8. Holzer P, Jurna I, Gamse IK, Lembeck F. 1979. Nociceptive threshold after neonatal capsaicin treatment. Eur J Pharmacol 58:511-514.
9. Inoue K, Ozaki S, Shiga T, Ito K, Masuda T, Okado N, Iseda T, Kawaguchi S, Ogawa M, Bae S-C, Yamashita N, Itohara S, Kudo N, Ito Y. 2002. Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nat Neurosci 10:946-954.
10. Jackman A, Fitzgerald M. 2000. Development of peripheral hindlimb and central spinal cord innervation by subpopulations of dorsal root ganglion cells in the embryonic rat. J Comp Neurol 418:281-298.
11. Jancsó G, Kiraly E, Jancsó-Gábor A. 1977. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature 270:741-743.
12. Kohama I, Ishikawa K, Kocsis JD. 2000. Synaptic reorganization in the substantia gelatinosa after peripheral nerve neuroma formation: aberrant innervation of lamina II neurons by Aβ afferents. J Neurosci 20:1538-1549.
13. Ma Q-P, Tian L. 2001. A-fibres sprouting from lamina I into lamina II of spinal dorsal horn after peripheral nerve injury in rats. Brain Res 904:137-140.
14. Ma Q-P, Tian L. 2002. Cholera toxin B subunit labeling in lamina II of spinal cord dorsal horn following chronic inflammation in rats. Neurosci Lett 327:161-164.
15. Nagy JI, van der Kooy D. 1983. Effects of neonatal capsaicin treatment on nociceptive thresholds in the rat. J Neurosci 3:1145-1150.
16. Nakatsuka T, Park J-S, Kumamoto E, Tamaki T, Yoshimura M. 1999. Plastic changes in sensory inputs to rat substantia gelatinosa neurons following peripheral inflammation. Pain 82:39-47.
17. Nakatsuka T, Ataka T, Kumamoto E, Tamaki T, Yoshimura M. 2000. Alteration in synaptic inputs through C-afferent fibers to substantia gelatinosa neurons of the rat spinal dorsal horn during postnatal development. Neuroscience 99:549-556.
18. Ohtori S, Chiba T, Takahashi K, Ino H, Yamagata M, Sameda H, Murata Y, Moriya H. 2000. Neonatal capsaicin treatment decreased substance P receptor immunoreactivity in lamina III neurons of the dorsal horn. Neurosci Res 38:147-154.
19. Okamoto M, Baba H, Goldstein PA, Higashi H, Shimoji K, Yoshimura M. 2001. Functional reorganization of sensory pathways in the rat spinal dorsal horn following peripheral nerve injury. J Physiol 532:241-250.
20. Park J-S, Nakatsuka T, Nagata K, Higashi H, Yoshimura M. 1999. Reorganization of the primary afferent termination in the rat spinal dorsal horn during post-natal development. Brain Res Dev Brain Res 113:29-36.
21. Ribeiro-da-Silva A, Coimbra A. 1984. Capsaicin causes selective damage to type I synaptic glomeruli in rat substantia gelatinosa. Brain Res 290:380-383.
22. Sántha P, Jancsó G. 2003. Transganglionic transport of choleragenoid by capsaicin-sensitive C-fibre afferents to the substantia gelatinosa of the spinal dorsal horn after peripheral nerve section. Neuroscience 116:621-627.
23. Sugiura Y, Lee CL, Perl ER. 1986. Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin. Science 234:358-361.
24. Tong Y-G, Wang HF, Ju G, Grant G, Hökfelt T, Zhang X. 1999. Increased uptake and transport of cholera toxin B-subunit in dorsal root ganglion neurons after peripheral axotomy: possible implications for sensory sprouting. J Comp Neurol 404:143-158.
25. Torsney C, Meredith-Middleton J, Fitzgerald M. 2000. Neonatal capsaicin treatment prevents the normal postnatal withdrawal of A fibres from lamina II without affecting Fos responses to innocuous peripheral stimulation. Brain Res Dev Brain Res 121:55-65.
26. Villière V, McLachlan EM. 1996. Electrophysiological properties of neurons in intact rat dorsal root ganglia classified by conduction velocity and action potential duration. J Neurophysiol 76:1924-1941.
27. Willis WD Jr, Coggeshall RE. 1991. Sensory mechanisms of the spinal cord, 2nd ed. New York: Plenum Press.
28. Woolf CJ, Salter MW. 2000. Neuronal plasticity: increasing the gain in pain. Science 288:1765-1768.
29. Woolf CJ, Shortland P, Coggeshall RE. 1992. Peripheral nerve injury triggers central sprouting of myelinated afferents. Nature 355:75-78.
30. Yang K, Kumamoto E, Furue H, Li Y-Q, Yoshimura M. 2000. Capsaicin induces a slow inward current which is not mediated by substance P in substantia gelatinosa neurons of the rat spinal cord. Neuropharmacology 39:2185-2194.
31. Yang K, Li Y-Q, Kumamoto E, Furue H, Yoshimura M. 2001. Voltage-clamp recordings of postsynaptic currents in substantia gelatinosa neurons in vitro and its applications to assess synaptic transmission. Brain Res Protoc 7:235-240.
32. Yoshimura M, Nishi S. 1993. Blind patch-clamp recordings from substantia gelatinosa neurons in adult rat spinal cord slices: pharmacological properties of synaptic currents. Neuroscience 53:519-526.