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For previous use of azide in oligomer synthesis, see: Tornoe, C. W.; Sengelov, H.; Meldal, M. J. Pept. Sci. 2000, 6, 314. Meldal, M.; Juliano, M. A. ; Jansson, A. M. Tetrahedron Lett. 1997, 38, 2531. Kim, J.-M.; Bi, Y.; Paikoff, S. J.; Schultz, P. G. Tetrahedron Lett. 1996, 37, 5305.
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For previous use of azide in oligomer synthesis, see: Tornoe, C. W.; Sengelov, H.; Meldal, M. J. Pept. Sci. 2000, 6, 314. Meldal, M.; Juliano, M. A. ; Jansson, A. M. Tetrahedron Lett. 1997, 38, 2531. Kim, J.-M.; Bi, Y.; Paikoff, S. J.; Schultz, P. G. Tetrahedron Lett. 1996, 37, 5305.
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0345710244
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note
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Following abbreviations are used: DIC = diisopropyl carbodiimide; EDCI = 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide; HOBt = 1-hydroxybenzotriazole; NMM = W-methylmorpholine; Piv = pivaloyl; TOTU = O-[(ethoxycarbonyl) cyanomethylenamino]-N,N,N′,N′-tetramethyluronium tetrafluoroborate; TFA = trifluoroacetic acid.
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15
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0344847310
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19
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Bosch, I.; Romea, P.; Urpi, F.; Vilarrasa, J. Tetrahedron Lett. 1993, 34, 4671. Lundquist, J. T. I. V.; Pelletier, J. C. Org. Lett. 2001, 3, 781.
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21
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0344415661
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note
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Yield estimated on the basis of UV chromatogram integration.
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