Defective endochondral ossification in mice with strongly compromised expression of JunB

Journal of Cell Science

Volumn 116, Issue 22, 2003, Pages 4587-4596

  Hess, Jochen ^a   Hartenstein, Bettina ^a   Teurich, Sibylle ^a   Schmidt, Dirk ^a,b   Schorpp Kistner, Marina ^a   Angel, Peter ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

AP 1; Bone; Cell cycle; Chondrocytes; Osteblasts; Osteoporosis

Indexed keywords

CYCLIN A; CYCLIN D1; PROTEIN P16; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR JUNB; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE GROWTH; BONE MARROW CELL; CARTILAGE CELL; CELL CYCLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION COEFFICIENT; EMBRYO; ENCHONDRAL OSSIFICATION; EPIPHYSIS PLATE; GENE CONTROL; GENE EXPRESSION REGULATION; GENE MUTATION; GESTATION PERIOD; GROWTH PLATE; GROWTH RETARDATION; IN VITRO STUDY; LETHALITY; LONG BONE; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOPOROSIS; PATHOGENESIS; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN FAMILY; STEM CELL; TRANSGENIC MOUSE;

ANIMALS; BONE DEVELOPMENT; CHONDROCYTES; CYCLIN A; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P16; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, KNOCKOUT; MUTATION; OSTEOBLASTS; OSTEOPOROSIS; PROTO-ONCOGENE PROTEINS C-JUN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

ANIMALIA; MUS MUSCULUS;

EID: 0344034716     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00772     Document Type: Article

References (48)

1. Andrecht, S., Kolbus, A., Hartenstein, B., Angel, P. and Schorpp-Kistner, M. (2002). Cell cycle promoting activity of JunB through cyclin A activation. J. Biol. Chem. 277, 35961-35968.
2. Angel, P. and Karin, M. (1991). The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1072, 129-157.
3. Bakiri, L., Lallemand, D., Bossy-Wetzel, E. and Yaniv, M. (2000). Cell cycle-dependent variations in c-Jun and phosphorylation: a role in the control of cyclin D1 expression. EMBO J. 19, 2056-2068.
4. Beier, F., Lee, R. J., Taylor, A. C., Pestell, R. G. and LuValle, P. (1999). Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes. Proc. Natl. Acad. Sci. USA 96, 1433-1438.
5. Beier, F., Taylor, A. C. and LuValle, P. (2000). Activating transcription factor 2 is necessary for maximal activity and serum induction of the cyclin A promoter in chondrocytes. J. Biol. Chem. 275, 12948-12953.
6. Bianco, P. and Robey, P. G. (2000). Marrow stromal stem cells. J. Clin. Invest. 105, 1663-1668.
7. Chusho, H., Tamura, N., Ogawa, Y., Yasoda, A., Suda, M., Miyazawa, T., Nakamura, K., Nakao, K., Kurihara, T., Komatsu, Y. et al. (2001). Dwarfism and early death in mice lacking C-type natriuretic peptide. Proc. Natl. Acad. Sci. USA 98, 4016-4021.
8. D'Alonzo, R. C., Selvamurugan, N., Karsenty, G. and Partridge, N. C. (2002). Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation. J. Biol. Chem. 277, 816-822.
9. Ducy, P., Schinke, T. and Karsenty, G. (2000). The osteoblast: a sophisticated fibroblast under central surveillance. Science 289, 1501-1504.
10. Enomoto, H., Enomoto-Iwamoto, M., Iwamoto, M., Nomura, S., Himeno, M., Kitamura, Y., Kishimoto, T. and Komori, T. (2000). Cbfa1 is a positive regulatory factor in chondrocyte maturation. J. Biol. Chem. 275, 8695-8702.
11. Gack, S., Vallon, R., Schmidt, J., Grigoriadis, A., Tuckermann, J., Schenkel, J., Weiher, H., Wagner, E. F. and Angel, P. (1995). Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes. Cell Growth Differ. 6, 759-767.
12. Gerber, H. P. and Ferrara, N. (2000). Angiogenesis and bone growth. Trends Cardiovasc. Med. 10, 223-228.
13. Grigoriadis, A. E., Schellander, K., Wang, Z. Q. and Wagner, E. F. (1993). Osteoblasts are target cells for transformation in c-fos transgenic mice. J. Cell Biol. 122, 685-701.
14. Grigoriadis, A. E., Wang, Z. Q., Cecchini, M. G., Hofstetter, W., Felix, R., Fleisch, H. A. and Wagner, E. F. (1994). c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266, 443-448.
15. Guo, J., Lanske, B., Liu, B. Y., Divieti, P., Kronenberg, H. M. and Bringhurst, F. R. (2001). Signal-selectivity of parathyroid hormone (PTH)/PTH-related peptide receptor-mediated regulation of differentiation in conditionally immortalized growth-plate chondrocytes. Endocrinology 142, 1260-1268.
16. Hartenstein, B., Teurich, S., Hess, J., Schenkel, J., Schorpp-Kistner, M. and Angel, P. (2002). Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB. EMBO J 21, 6321-6329.
17. Hess, J., Porte, D., Munz, C. and Angel, P. (2001). AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element. J. Biol. Chem. 276, 20029-20038.
18. Jacenko, O. (1995). c-fos and bone loss: a proto-oncogene regulates osteoclast lineage determination. BioEssays 17, 277-281.
19. Jochum, W., David, J. P., Elliott, C., Wutz, A., Plenk, H., Jr., Matsuo, K. and Wagner, E. F. (2000). Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat. Med. 6, 980-984.
20. Jochum, W., Passegue, E. and Wagner, E. F. (2001). AP-1 in mouse development and tumorigenesis. Oncogene 20, 2401-2412.
21. Kameda, T., Watanabe, H. and Iba, H. (1997). C-Jun and JunD suppress maturation of chondrocytes. Cell Growth Differ 8, 495-503.
22. Karin, M., Liu, Z. and Zandi, E. (1997). AP-1 function and regulation. Curr. Opin. Cell Biol. 9, 240-246.
23. Karsenty, G. (1999). The genetic transformation of bone biology. Genes Dev. 13, 3037-3051.
24. Karsenty, G. and Wagner, E. F. (2002). Reaching a genetic and molecular understanding of skeletal development. Dev. Cell 2, 389-406.
25. Li, B., Boast, S., de los Santos, K., Schieren, I., Quiroz, M., Teitelbaum, S. L., Tondravi, M. M. and Goff, S. P. (2000). Mice deficient in Ab1 are osteoporotic and have defects in osteoblast maturation. Nature Genet. 24, 304-308.
26. LuValle, P. and Beier, F. (2000). Cell cycle control in growth plate chondrocytes. Front. Biosci. 5, D493-503.
27. Matsuo, K., Owens, J. M., Tonko, M., Elliott, C., Chambers, T. J. and Wagner, E. F. (2000). Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation. Nat. Genet. 24, 184-187.
28. McCauley,L. K. (2001). Transgenic mouse models of metabolic bone disease. Curr. Opin. Rheumatol. 13, 316-325.
29. McLean, W. and Olsen, B. R. (2001). Mouse models of abnormal skeletal development and homeostasis. Trends Genet. 17, S38-43.
30. Mundlos, S. and Olsen, B. R. (1997a). Heritable diseases of the skeleton. Part I: Molecular insights into skeletal development-transcription factors and signaling pathways. FASEB J. 11, 125-132.
31. Mundlos, S. and Olsen, B. R. (1997b). Heritable diseases of the skeleton. Part II: Molecular insights into skeletal development-matrix components and their homeostasis. FASEB J. 11, 227-233.
32. Palcy, S., Bolivar, I. and Goltzman, D. (2000). Role of activator protein 1 transcriptional activity in the regulation of gene expression by transforming growth factor beta1 and bone morphogenetic protein 2 in ROS 17/2.8 osteoblast-like cells. J. Bone Miner. Res. 15, 2352-2361.
33. Passegue, E. and Wagner, E. F. (2000). JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression. EMBO J. 19, 2969-2979.
34. Passegue, E., Jochum, W., Schorpp-Kistner, M., Mohle-Steinlein, U. and Wagner, E. F. (2001). Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage. Cell 104, 21-32.
35. Reimold, A. M., Grusby, M. J., Kosaras, B., Fries, J. W., Mori, R., Maniwa, S., Clauss, I. M., Collins, T., Sidman, R. L., Glimcher, M. J. et al. (1996). Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice. Nature 379, 262-265.
36. Rohwedel, J., Horak, V., Hebrok, M., Fuchtbauer, E. M. and Wobus, A. M. (1995). M-twist expression inhibits mouse embryonic stem cell-derived myogenic differentiation in vitro. Exp. Cell. Res. 220, 92-100.
37. Sabatakos, G., Sims, N. A., Chen, J., Aoki, K., Kelz, M. B., Amling, M., Bouali, Y., Mukhopadhyay, K., Ford, K., Nestler, E. J. et al. (2000). Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat. Med. 6, 985-990.
38. Schiller, P. C., D'Ippolito, G., Balkan, W., Roos, B. A. and Howard, G. A. (2001). Gap-junctional communication is required for the maturation process of osteoblastic cells in culture. Bone 28, 362-369.
39. Schorpp-Kistner, M., Wang, Z. Q., Angel, P. and Wagner, E. F. (1999). JunB is essential for mammalian placentation. EMBO J. 18, 934-948.
40. Schorpp-Kistner, M., Herrlich, P. and Angel, P. (2001). The AP-1 family of transcription factors. Structure, regulation and functional analysis in mice. In Targets for cancer Chemotherapy. Totowa, NJ: Human Press Inc. 29-52.
41. St-Arnaud, R. and Quelo, I. I. (1998). Transcriptional coactivators potentiating AP-1 function in bone. Front. Biosci. 3, D838-848.
42. Stanislaus, D., Devanarayan, V. and Hock, J. M. (2000). In vivo comparison of activated protein-1 gene activation in response to human parathyroid hormone (hPTH)(1-34) and hPTH(1-84) in the distal femur metaphyses of young mice. Bone 27, 819-826.
43. Takeda, S., Bonnamy, J. P., Owen, M. J., Ducy, P. and Karsenty, G. (2001). Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev. 15, 467-481.
44. Thiriet, N., Esteve, L., Aunis, D. and Zwiller, J. (1997). Immediate early gene induction by natriuretic peptides in PC12 phaeochromocytoma and C6 glioma cells. Neuroreport 8, 399-402.
45. Thiriet, N., Jouvert, P., Gobaille, S., Solov'eva, O., Gough, B., Aunis, D., Ali, S. and Zwiller, J. (2001). C-type natriuretic peptide (CNP) regulates cocaine-induced dopamine increase and immediate early gene expression in rat brain. Eur. J. Neurosci. 14, 1702-1708.
46. Tuckermann, J. P., Pittois, K., Partridge, N. C., Merregaert, J. and Angel, P. (2000). Collagenase-3 (MMP-13) and integral membrane protein 2a (Itm2a) are marker genes of chondrogenic/osteoblastic cells in bone formation: sequential temporal, and spatial expression of Itm2a, alkaline phosphatase, MMP-13, and osteocalcin in the mouse. J. Bone Miner. Res. 15, 1257-1265.
47. Wang, Z. Q., Grigoriadis, A. E., Mohle-Steinlein, U. and Wagner, E. F. (1991). A novel target cell for c-fos-induced oncogenesis: development of chondrogenic tumours in embryonic stem cell chimeras. EMBO J. 10, 2437-2450.
48. White, A. and Wallis, G. (2001). Endochondral ossification: a delicate balance between growth and mineralisation. Curr. Biol. 11, R589-591.