Whole cell recordings from respiratory neurones in an arterially perfused in situ neonatal rat preparation

Experimental Physiology

Volumn 88, Issue 6, 2003, Pages 725-732

  Dutschmann, M ^a   Paton, Julian F R ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY PERFUSION; ARTICLE; BRAIN OXYGEN CONSUMPTION; BRAIN STEM; BREATHING PATTERN; BREATHING RATE; CELL TYPE; CONTROLLED STUDY; EXPERIMENTAL DESIGN; IN VIVO STUDY; INTRACELLULAR RECORDING; NEUROPHARMACOLOGY; NEWBORN; NONHUMAN; PONS; RAT; RESPIRATORY NERVE CELL; THALAMUS VENTRAL NUCLEUS;

EID: 0344033875     PISSN: 09580670     EISSN: None     Source Type: Journal    
DOI: 10.1113/eph8802639     Document Type: Article

References (52)

1. Berger AJ, Herbert DA & Mitchell RA (1978). Properties of apneusis produced by reversible cold block of the rostral pons. Respir Physiol 33, 323-327.
2. Bianchi AL, Denavit-Saubié M & Champagnat J (1995). Central control of breathing in mammals: neuronal circuitry, membrane properties and neurotransmitters. Physiol Rev 75, 1-45.
3. Boscan P, Kasparov S & Paton JFR (2002). Integration of baroreceptor and nociceptive afferents in the NTS; roles for substance P and GABA. Eur J Neurosci 16, 907-920.
4. Borday V, Foutz AS, Nordholm L & Denavit-Saubié M (1998). Respiratory effects of glutamate receptor antagonists in neonate and adult mammals. Eur J Pharmacol 348, 235-246.
5. Cohen MI (1968). Discharge patterns of brain-stem respiratory neurons in relation to carbon dioxide tension. J Neurophysiol 31, 142-165.
6. Cohen MI (1971). Switching of the respiratory phases and evoked phrenic responses produced by rostral pontine electrical stimulation. J Physiol 217, 133-158.
7. Del Negro CA, Morgado-Valle C & Feldman JL (2002). Respiratory rhythm: an emergent network property? Neuron 34, 821-830.
8. Dick TE, Bellingham MC & Richter DW (1994). Pontine respiratory neurons in anesthetized cats. Brain Res 636, 259-269.
9. Duffin J, Tian G & Peever JH (2000). Functional synaptic connections among respiratory neurons. Respir Physiol 122, 237-246.
10. Dutschmann M & Paton JFR (2002a). Influence of nasotrigeminal afferents on medullary respiratory neurones and the upper airway in the rat. Pflugers Arch 444, 227-235.
11. Dutschmann M & Paton JFR (2002b). Glycinergic inhibition is essential for co-ordinating cranial and spinal respiratory motor outputs in the neonatal rat. J Physiol 543, 643-653.
12. Dutschmann M, Wilson RJA & Paton JFR (2000). Respiratory activity in neonatal rats. Auton Neurosci 84, 19-29.
13. Ezure K (1990). Synaptic connections between medullary respiratory neurons and consideration on the genesis of respiratory rhythm. Prog Neurobiol 35, 429-450.
14. Ezure K, Tanaka I, Saito Y & Otake K (2002). Axonal projections of pulmonary slowly adapting receptor relay neurons in the rat. J Comp Neurol 446, 81-94.
15. Fung ML & St John WM (1994). Neuronal activities underlying inspiratory termination by pneumotaxic mechanisms. Respir Physiol 98, 267-281.
16. Fung ML & St John WM (1995). The functional expression of a Pontine pneumotaxic centre in neonatal rats. J Physiol 489, 579-591.
17. Greer JJ, Smith JC & Feldman JL (1991). Role of excitatory amino acids in the generation and transmission of respiratory drive in neonatal rat. J Physiol 437, 727-749.
18. Haji A, Okazaki M, Yamazaki H & Takeda R (2002). Physiological properties of late inspiratory neurons and their possible involvement in inspiratory off-switching in cats. J Neurophysiol 87, 1057-1067.
19. Haji A, Pierrefiche O, Takeda R, Foutz AS, Champagnat J & Denavit-Saubie M (1996). Membrane potentials of respiratory neurones during dizocilpine-induced apneusis in adult cats. J Physiol 495, 851-861.
20. Koepchen HP, Langhorst P & Seller H (1975). The problem of identification of autonomic neurons in the lower brain stem. Brain Res 87, 375-393.
21. Koshiya N & Smith JC (1999). Neuronal pacemaker for breathing visualized in vitro. Nature 400, 360-363.
22. Lumsden T (1923). Observations on the respiratory centres in the cat. J Physiol 57, 153-160.
23. Morrison SF, Cravo SL & Wilfehrt HM (1994). Pontine lesions produce apneusis in the rat. Brain Res 652, 83-86.
24. Ogilvie MD, Gottschalk A, Anders K, Richter DW & Pack AI (1992). A network model of respiratory rhythmogenesis. Am J Physiol 263, R962-975.
25. Onimaru H & Homma I (1992). Whole cell recordings from respiratory neurons in the medulla of brainstem-spinal cord preparations isolated from newborn rats. Pflugers Arch 420, 399-406.
26. Onimaru H & Homma I (2003). A novel functional neuron group for respiratory rhythm generation in the ventral medulla. J Neurosci 23, 2478-2486.
27. Paton JFR, Ramirez J-M & Richter DW (1994). Functionally intact in vitro preparation generating respiratory activity in neonatal and mature mammals. Pflugers Arch 428, 250-260.
28. Paton JFR (1996a). The respiratory network in the ventrolateral medulla of the mature mouse studied in a working heart-brainstem preparation. J Physiol 493, 819-831.
29. Paton JFR (1996b). A working heart-brainstem preparation of the mouse. J Neurosci Methods 65, 63-68.
30. Paton JFR, Boscan P, De Paula PM, Spyer KM & Machado BH (2002). Specific role of P2 receptors in the nucleus tractus solitarii for mediating cardiovascular responses to peripheral chemoreceptor activation. J Physiol 543, 995-1005.
31. Paton JFR, Li Y-W & Kasparov S (1999). Reflex response and convergence of pharyngoesophageal and peripheral chemoreceptors in the nucleus of the solitary tract. Neurosci 93, 143-154.
32. Paton JFR, Weber M, Herbert H & Dutschmann M (2003). Whole-cell patch-clamp recording from neonatal rodent ventral medullary respiratory neurones in situ. J Physiol 547.P, C3.
33. Ramirez JM, Quellmalz UJ & Richter DW (1996). Postnatal changes in the mammalian respiratory network as revealed by the transverse brainstem slice of mice. J Physiol 491, 799-812.
34. Ramirez JM, Quellmalz UJ, Wilken B & Richter DW (1998). The hypoxic response of neurones within the in vitro mammalian respiratory network. J Physiol 507, 571-582.
35. Remmers JE, Richter DW, Ballantyne D, Bainton CR & Klein JP (1986). Reflex prolongation of stage I of expiration. Pflugers Arch 407, 190-198.
36. Richter DW (1982). Generation and maintenance of the respiratory rhythm. J Exp Biol 100, 93-107.
37. Richter DW, Camerer H, Meesmann M & Rohrig N (1979). Studies on the synaptic interconnection between bulbar respiratory neurones of cats. Pflugers Arch 380, 245-257.
38. Richter DW, Heyde F & Gabriel M (1975). Intracellular recordings from different types of medullary respiratory neurons of the cat. J Neurophysiol 38, 1162-1171.
39. Richter DW & Spyer KM (2001). Studying rhythmogenesis of breathing: comparison of in vivo and in vitro models. Trends Neurosci 24, 464-472.
40. Schwarzacher SW, Wilhelm Z, Anders K & Richter DW (1991). The medullary respiratory network in the rat. J Physiol 435, 631-644.
41. Shen L & Duffin J (2002). Caudal expiratory neurons in the rat. Pflugers Archl 444, 405-410.
42. Silva-Carvalho L, Paton JFR, Goldsmith GE & Spyer KM (1991). The effects of electrical stimulation of lobule IXb of the posterior cerebellar vermis on neurones within the rostral ventrolateral medulla in the anaesthetised cat. J Auton Nerv Syst 36, 97-106.
43. Smith JC, Ballanyi K, & Richter DW (1992). Whole-cell patch-clamp recordings from respiratory neurons in neonatal rat brainstem in vitro. Neurosci Lett 134, 153-156.
44. Smith JC, Ellenberger HH, Ballanyi K, Richter DW & Feldman JL (1991). Pre-Botzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 254, 726-729.
45. Smith JC, Greer JJ, Liu GS & Feldman JL (1990). Neural mechanisms generating respiratory pattern in mammalian brain stem-spinal cord in vitro. I. Spatiotemporal patterns of motor and medullary neuron activity. J Neurophysiol 64, 1149-1169.
46. St-John WM (1998). Neurogenesis of patterns of automatic ventilatory activity. Prog Neurobiol 56, 97-117.
47. St-John WM & Paton JFR (2000). Characterizations of eupnea, apneusis and gasping in a perfused rat preparation. Respir Physiol 123, 201-213.
48. St-John WM & Zhou D (1991). Rostral pontile mechanisms regulate durations of expiratory phases. J Appl Physiol 71, 2133-2137.
49. Stuth EAE, Tonkovic-Capin M, Kampine JP, Bajic J & Zuperku EJ (1994). Dose-dependent effects of halothane on the carbon dioxide responses of expiratory and inspiratory bulbospinal neurons and the phrenic nerve activities in dogs. Anesthesiology 81, 1470-1483.
50. Takeda R & Haji A (1993). Mechanisms underlying post-inspiratory depolarization in post-inspiratory neurons of the cat. Neurosci Lett 150, 1-4.
51. Von Euler C (1977). The functional organization of the respiratory phase-switching mechanisms. Fed Proc 36, 2375-2380.
52. 2 and PH of the medulla in an arterially perfused rat preparation. Am J Physiol Regul Integr Comp Physiol 281, R528-538.