Mutations in the α8 Loop of Human APE1 Alter Binding and Cleavage of DNA Containing an Abasic Site

Journal of Biological Chemistry

Volumn 278, Issue 47, 2003, Pages 46994-47001

  Shen, Jiang Cheng ^a,b   Loeb, Lawrence A ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CRYSTALLOGRAPHY; DNA; HYDROGEN BONDS; MUTAGENESIS; SUBSTITUTION REACTIONS;

BONDING POTENTIAL; MUTATIONAL ANALYSIS;

BIOCHEMISTRY;

ALKYLATING AGENT; AMINO ACID; APURINIC APYRIMIDINIC ENDODEOXYRIBONUCLEASE 1; ASPARAGINE; ASPARAGINYLPROLYLLYSYLGLYCYLASPARAGINYLLYSYLLYSYLASPARAGINE; DNA; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; MESYLIC ACID; PEPTIDE; PHOSPHATE; UNCLASSIFIED DRUG; APEX1 PROTEIN, HUMAN; APURINIC ACID; APYRIMIDINIC ACID; PEPTIDE LIBRARY; POLYNUCLEOTIDE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONTROLLED STUDY; DATA ANALYSIS; DNA BINDING; DNA CLEAVAGE; DNA DETERMINATION; DNA SEQUENCE; ESCHERICHIA COLI; GENE MUTATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; WILD TYPE; X RAY ANALYSIS; GENETICS; HYDROLYSIS; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; MUTATION; PROTEIN BINDING;

ESCHERICHIA COLI;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; APURINIC ACID; BINDING SITES; DNA; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; HUMANS; HYDROLYSIS; KINETICS; MUTATION; PEPTIDE LIBRARY; POLYNUCLEOTIDES; PROTEIN BINDING;

EID: 0344012493     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309362200     Document Type: Article

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