Myostatin Is a Skeletal Muscle Target of Growth Hormone Anabolic Action

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 11, 2003, Pages 5490-5496

  Liu, Wei ^a   Thomas, Scott G ^b   Asa, Sylvia L ^c   Gonzalez Cadavid, Nestor ^d   Bhasin, Shalendar ^d   Ezzat, Shereen ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HUMAN GROWTH HORMONE; MESSENGER RNA; MUSCLE PROTEIN; MYOSTATIN;

ADULT; AEROBIC CAPACITY; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BODY COMPOSITION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HORMONE ACTION; HORMONE SYNTHESIS; HUMAN; HUMAN TISSUE; HYPOPITUITARISM; MALE; MOUSE; MUSCLE BIOPSY; MUSCLE FIBRIL; MUSCLE GROWTH; NONHUMAN; OXYGEN CONSUMPTION; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; STATISTICAL SIGNIFICANCE; VASTUS LATERALIS MUSCLE;

ADULT; ANIMALS; BODY MASS INDEX; CELLS, CULTURED; EXERTION; FEMALE; GENE EXPRESSION; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MICE; MIDDLE AGED; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; RECEPTORS, SOMATOTROPIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA;

EID: 0344011124     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030497     Document Type: Article

References (27)

1. Woodhouse LJ, Asa SL, Thomas SG, Ezzat S 1999 Measures of submaximal aerobic performance evaluate and predict functional response to growth hormone (GH) treatment in GH-deficient adults. J Clin Endocrinol Metab 84: 4570-4577
2. Jones JI, Clemmons DR 1995 Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 16:3-34
3. Kambadur R, Sharma M, Smith TP, Bass JJ 1997 Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle. Genome Res 7:910-916
4. Szabo G, Dallmann G, Muller G, Patthy L, Soller M, Varga L 1998 A deletion in the myostatin gene causes the compact (Cmpt) hypermuscular mutation in mice. Mamm Genome 9:671-672
5. Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, Sinha-Hikim İ, Ma K, Ezzat S, Shen R, Lalani R, Asa S, Mamita M, Nair G, Arver S, Bhasin S 1998 Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc Natl Acad Sci USA 95:14938-14943
6. Ezzat S, Fear S, Gaillard RC, Gayle C, Landy H, Marcovitz S, Mattioni T, Nussey S, Rees A, Svanberg E 2002 Gender-specific responses of lean body composition and non-gender-specific cardiac function improvement after GH replacement in GH-deficient adults. J Clin Endocrinol Metab 87:2725-2733
7. American College of Sports Medicine 1988 Resource manual for guidelines for exercise testing and prescription. Philadelphia: Lea, Febiger; 1-436
8. Thomas SG, Woodhouse LJ, Pagura SM, Ezzat S 2002 Ventilation threshold as a measure of impaired physical performance in adults with growth hormone excess. Clin Endocrinol (Oxf) 56:351-358
9. Bassey EJ, Fentem PH, MacDonald IC, Scriven PM 1976 Self-paced walking as a method for exercise testing in elderly and young men. Clin Sci Mol Med Suppl 51:609-612
10. Van Neck JW, Dits NF, Cingel V, Hoppenbrouwers IA, Drop SL, Flyvbjerg A 2000 Dose-response effects of a new growth hormone receptor antagonist (B2036-PEG) on circulating, hepatic and renal expression of the growth hormone/insulin-like growth factor system in adult mice. J Endocrinol 167: 295-303
11. Taylor WE, Bhasin S, Artaza J, Byhower F, Azam M, Willard Jr DH, Kull Jr FC, Gonzalez-Cadavid N 2001 Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells. Am J Physiol Endocrinol Metab 280:E221-E228
12. Langley B, Thomas M, Bishop A, Sharma M, Gilmour S, Kambadur R 2002 Myostatin inhibits myoblast differentiation by down-regulating MyoD expression. J Biol Chem 277:49831-49840
13. Brill KT, Weltman AL, Gentili A, Patrie JT, Fryburg DA, Hanks JB, Urban RJ, Veldhuis JD 2002 Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men. J Clin Endocrinol Metab 87:5649-5657
14. Marcell TJ, Harman SM, Urban RJ, Metz DD, Rodgers BD, Blackman MR 2001 Comparison of GH, IGF-I, and testosterone with mRNA of receptors and myostatin in skeletal muscle in older men. Am J Physiol Endocrinol Metab 281:E1159-E1164
15. Ayling CM, Moreland BH, Zanelli JM, Schulster D 1989 Human growth hormone treatment of hypophysectomized rats increases the proportion of type-1 fibres in skeletal muscle. J Endocrinol 123:429-435
16. Cuneo RC, Salomon F, Wiles CM, Hesp R, Sonksen PH 1991 Growth hormone treatment in growth hormone-deficient adults. II. Effects on exercise performance. J Appl Physiol 70:695-700
17. Beshyah SA, Shahi M, Foale R, Johnston DG 1995 Cardiovascular effects of prolonged growth hormone replacement in adults. J Intern Med 237:35-42
18. Christ ER, Cummings MH, Westwood NB 1997 The importance of growth hormone in the regulation of erythropoiesis, red cell mass, and plasma volume in adults with growth hormone deficiency. J Clin Endocrinol Metab 82:2985-2990
19. Lombardi G, Colao A, Ferone D, Marzullo P, Orio F, Longobardi S, Merola B 1997 Effect of growth hormone on cardiac function. Horm Res 48(Suppl 4):38-42
20. Lindstedt SL, Wells DJ, Jones JH, Hoppeler H, Thronson Jr HA 1988 Limitations to aerobic performance in mammals: interaction of structure and demand. Int J Sports Med 9:210-217
21. Cuneo RC, Salomon F, Wiles CM, Sonksen PH 1990 Skeletal muscle performance in adults with growth hormone deficiency. Horm Res 33(Suppl 4):55-60
22. Jorgensen JO, Pedersen SA, Thuesen L, Jorgensen J, Ingemann-Hansen T, Skakkebaek NE, Christiansen JS 1989 Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1:1221-1225
23. Janssen YJ, Doornbos J, Roelfsema F 1999 Changes in muscle volume, strength, and bioenergetics during recombinant human growth hormone (GH) therapy in adults with GH deficiency. J Clin Endocrinol Metab 84:279-284
24. Cuneo RC, Salomon F, Wiles CM, Round JM, Jones D, Hesp R, Sonksen PH 1992 Histology of skeletal muscle in adults with GH deficiency: comparison with normal muscle and response to GH treatment. Horm Res 37:23-28
25. Grindeland RE, Roy RR, Edgerton VR, Grossman EJ, Mukku VR, Jiang B, Pierotti DJ, Rudolph I 1994 Interactive effects of growth hormone and exercise on muscle mass in suspended rats. Am J Physiol 267:R316-R322
26. Linderman JK, Gosselink KL, Booth FW, Mukku VR, Grindeland RE 1994 Resistance exercise and growth hormone as countermeasures for skeletal muscle atrophy in hindlimb-suspended rats. Am J Physiol 267:R365-R371
27. Roy RR, Tri C, Grossman EJ, Talmadge RJ, Grindeland RE, Mukku VR, Edgerton VR 1996 IGF-I, growth hormone, and/or exercise effects on non-weight-bearing soleus of hypophysectomized rats. J Appl Physiol 81:302-311