Positive and negative outcomes of L-arginine therapy in cardiovascular diseases

Journal of Physiology and Pharmacology

Volumn 50, Issue 4, 1999, Pages 653-660

  Herbaczynska Cedro K ^a  

^a POLISH ACADEMY OF SCIENCES   (Poland)

Author keywords

Cardiovascular diseases; L arginine therapy; Nitric oxide

Indexed keywords

ARGININE; NITRIC OXIDE;

CARDIOVASCULAR DISEASE; CONFERENCE PAPER; CONGESTIVE HEART FAILURE; ESSENTIAL HYPERTENSION; HEART MUSCLE ISCHEMIA; HYPERLIPIDEMIA; PERIPHERAL OCCLUSIVE ARTERY DISEASE;

ARGININE; ARTERIAL OCCLUSIVE DISEASES; CARDIOVASCULAR DISEASES; CONTROLLED CLINICAL TRIALS; HEART FAILURE, CONGESTIVE; HUMANS; HYPERLIPIDEMIAS; MYOCARDIAL ISCHEMIA; NITRIC OXIDE; TREATMENT OUTCOME;

EID: 0343986323     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (52)

1. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-376.
2. Ludmer PL, Selwyn AP, Shook TL et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986; 315: 1046-1051.
3. Otsui S, Nakajima O, Waku S et al. Attenuation of acetylcholine - induced vasoconstriction by L-arginine is related to the progression of atherosclerosis. Am Heart J 1995; 129: 1094-1100.
4. Anderson TJ, Vehata A., Gerhard M et al. Close relation of endothelial function in the human coronary and peripheral circulation. J Am Coll Cardiol 1995; 26: 1235-1241.
5. Creager MA, Gallagher SJ, Girerd XJ et al. L-arginine improves endothelium - dependent vasodilation in hypercholesterolemic humans. J Clin Invest 1992; 90: 1248-1253.
6. Johnstone MT, Creager SJ, Scales KM et al. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation 1993; 88: 2510-2516.
7. Panza JA, Casino PR, Badar DM, Quyyumi AA. Effect of increased availability of endothelium-derved nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension. Circulation 1993; 87: 1475-1481.
8. Kubo SH, Rector TS, Bank AJ, Williams RE, Heifetz SM. Endothelium dependent vasodilation is attenuated in patients with heart failure. Circulation 1991; 84: 1589-1596.
9. Clarkson P, Adams MR, Powe AJ et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996; 97: 1989-1994.
10. Girerd XJT, Hirsch AT, Cooke JP, Creager MA. L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits. Circ Res 1990; 67: 1301-1308.
11. Drexler H, Zeiher AM, Meinzer K, Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet 1991; 338: 1546-1550.
12. Yu X, Li Y, Xiong Y. Increase of an endogenous inhibitor of nitric oxide synthesis in serum of high cholesterol fed rabbits. Life Sci 1994; 54: 753-758.
13. Boger RH, Bode-Boger SM, Szuba A et al. Asymetric dimethylarginine (ADMA): A novel risk factor for endothelial dysfunction. Its role in hypercholesterolemia. Circulation 1998; 98: 1842-1847.
14. Stroes E, Kastelein J, Cosentino F et al. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J Clin Invest 1997; 99: 41-46.
15. Pritchard KA, Groszek L, Smalley DM et al. Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Circ Res 1995; 77: 510-518.
16. Nabel E, Selwyn AP, Ganz P. Large coronary arteries in humans are responsive to changing blood flow: an endothelium-dependent mechanism that fails in patients with atherosclerosis. J Am Coll Cardiol 1990; 16: 349-356.
17. Forstermann U, Mugge A, Alheid U, Haverich A, Frolich JC. Selective attenuation of endothelium-mediated vasodilation in atherosclerotic human coronary arteries. Circ Res 1988; 62: 185-190.
18. Vita JA, Treasure CB, Nabel EG et al. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 1990; 81: 491-497.
19. Chauhan A, More RS, Mullins PA, Taylor G, Petch MC, Schofield PM. Aging-associated endothelial dysfunction in humans is reversed by L-arginine. J Am Coll Cardiol 1996; 28: 1796-1804.
20. Campisi R, Czernin J, Schoder H, Sayre JW, Schelbert HR. L-arginine normalizes coronary vasomotion in long-term smokers. Circulation 1999; 99: 491-497.
21. Lerman A, Burnett JC, Higano ST, McKinley LJ, Holmes DR. Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans. Circulation 1998; 97: 2123-2128.
22. Ceremużyński L, Chamiec T, Herbaczyńska-Cedro K. Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris. Am J Cardiol 1997; 80: 331-333.
23. Kobayashi N, Nakamura M, Hiramori K. Effects of infusion of L-arginine on exercise-induced myocardial ischemic ST-segment changes and capacity to exercise of patients with stable angina pectoris. Cor Art Dis 1999; 10: 321-326
24. Blum A, Porat R, Rosenschein U et al. Clinical and inflammatory effects of dietary L-arginine in patients with intractable angina pectoris. Am J Cardiol 1999; 83: 1488-1490.
25. Zanzinger J, Czachurski J, Seller H. Inhibition of sympathetic vasoconstriction is a major principle of vasodilation by nitric oxide in vivo. Circ Res 1994; 75: 1073-1077.
26. Vita JA, Treasure CB, Yeung AC et al. Patients with evidence of coronary endothelial dysfunction as assessed by acetylcholine infusion demonstrate marked increase in sensitivity to constrictor effects of catecholamines. Circulation 1992; 85: 1390-1397.
27. Rector T, Bank AJ, Mullen KA et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996; 93: 2135-2141.
28. Boulanger C, Luscher TF. Release of endothelin from the porcine aorta: inhibition by endothelium-derived nitric oxide. J Clin Invest 1990; 85: 587-590.
29. Boger RH, Bode-Boger SM, Thiele W, Creutzig A, Alexander K, Frolich JC. Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J Am Coll Cardiol 1998; 32: 1336-1344.
30. Bode-Boger SM, Boger RH, Alfke H et al. L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study. Circulation 1996; 93: 85-90.
31. Hirooka Y, Imaizumi T, Tagawa T et al. Effects of L-arginine on impaired acetylcholine-induced and ischemic vasodilation of the forearm in patients with heart failure. Circulation 1994; 90: 658-668.
32. Kubota T, Imaizumi T, Oyama J, Ando S, Takeshita A. L-arginine increases exercise-induced vasodilation of the forearm in patients with heart failure. Jap Circ J 1997; 62: 471-480.
33. Chin-Dusting JPF, Kaye DM, Lefkovits J, Wong J, Bergin P, Jennings GL. Dietary supplementation with L-arginine fails to restore endothelial function in forearm resistance arteries of patients with severe heart failure. J Am Coll Cardiol 1996; 27: 1207-1213.
34. Belch JJF, Bridges AB, Scott N, Chopra M. Oxygen free radicals and congestive heart failure. Br Heart J 1991; 65: 245-248.
35. Kanaya Y, Nakamura M, Kabayashi N, Hiramori K. Effects of L-arginine on lower limb vasodilator reserve and exercise capacity in patients with chronic heart failure. Heart 1999; 81: 512-517.
36. Panza JA, Quyyumi AA, Brush JE, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990; 323: 22-27.
37. Quyyumi AA, Mulcahy D, Andrews NO, Husain S, Panza JA, Cannon RO. Coronary vascular nitric oxide activity in hypertension and hypercholesterolemia. Comparison of acetylcholine and substance P. Circulation 1997; 95: 104-110.
38. Panza JA, Casino PR, Badar DM, Quyyumi AA. Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension. Circulation 1993; 87: 1475-1481.
39. Nakazano K, Watanabe N, Matsuno K, Sasak J, Sato T. Does superoxide underlie the pathogenesis of hypertension. Proc Natl Acad Sci 1991; 88: 1045-1048.
40. Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti. Cyclooxygenase Inhibition restores nitric oxide activity in essential hypertension. Hypertension 1997; 29: 74-279.
41. Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 1998; 97: 2222-2229.
42. Garcia CE, Kilcoyne CM, Cardillo C, Cannon RO, III, Quyyumi AA, Panza JA. Effect of copper-zinc superoxide dismutase on endothelium-dependent vasodilation in patients with essential hypertension. Hypertension 1995; 26: 863-868.
43. Cardillo C, Kilcoyne CM, Cannon RO, III, Quyyumi AA, Panza JA. Xanthine oxidase inhibition improves endothelium-dependent vasodilation in hypercholesterolemic but not in hypertensive patients. Hypertension 1997; 30: 57-63.
44. Taddei S, Virdis A, Mattei P, Ghiadoni L, Sudano I, Salvetti A. Defective L-arginine-nitric oxide pathway in offspring of essential hypertensive patients. Circulation 1996; 94: 1298-1303.
45. Drexler H, Fischell TA, Pinto FJ et al. Effect of L-arginine on coronary vessel wall morphology. Circulation 1994; 89: 1615-1623.
46. Schwarzbacher SP, Lim TT, Wang BY et al. Local intramural delivery of L-arginine enhances nitric oxide generation and inhibits lesion formation after ballon angioplasty. Circulation 1997; 95: 1863-1869.
47. Adams MR, Forsyth CJ, Jessup W, Robinson J, Celermajer D. Oral L-arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young men. J Am Coll Cardiol 1995; 26: 1054-61.
48. Wolf A, Zalpour C, Theilmeir G et al. Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. J Am Coll Cardiol 1997; 29: 479-485.
49. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest 1994; 94: 1172-1179
50. Giugliano D, Marfella R, Verrazzo G et al. The vascular effects of L-arginine in humans. The role of endogenous insulin. J Clin Invest 1997; 99: 433-438.
51. Wascher TC, Posch K, Wallner S, Hermetter A. Vascular effects of L-arginine: anything beyond a substrate for the NO-synthase. Biochem Biophys Res Commun 1997; 234: 35-38.
52. Nagase S, Takemura K, Ueda A et al. A novel nonenzymatic pathway for the generation of nitric oxide by the reaction of hydrogen peroxide and D-or L-arginine. Biochem Biophys Res Commun 1997; 233: 150-153.