L-Arginine Increases Exercise-Induced Vasodilation of the Forearm in Patients with Heart Failure

Japanese Circulation Journal

Volumn 61, Issue 6, 1997, Pages 471-480

  Kubota, Toru ^a   Imaizumi, Tsutomu ^a   Oyama, Jun Ichi ^a   Ando, Shin Ichi ^a   Takeshita, Akira ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Exercise; Forearm blood flow; Heart failure; L arginine

Indexed keywords

ARGININE;

ADULT; AGED; ARTICLE; BLOOD FLOWMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; FEMALE; FOREARM BLOOD FLOW; HEART FAILURE; HUMAN; MALE; VASCULAR ENDOTHELIUM; VASODILATATION;

AGED; ARGININE; EXERCISE; FEMALE; FOREARM; HEART FAILURE, CONGESTIVE; HEMODYNAMIC PROCESSES; HUMANS; MALE; MATCHED-PAIR ANALYSIS; MIDDLE AGED; OXYGEN CONSUMPTION; REGIONAL BLOOD FLOW; VASODILATION;

EID: 0030807238     PISSN: 00471828     EISSN: None     Source Type: Journal    
DOI: 10.1253/jcj.61.471     Document Type: Article

References (34)

1. Zelis R., Mason D. T., Braunwald E: A comparison of the effects of vasodilator stimuli on peripheral resistance vessels in normal subjects and in patients with congestive heart failure. J Clin Invest 1968; 47: 960-970.
2. Zelis R., Longhurst J., Capone R. J., Mason D. T.: A comparison of regional blood flow and oxygen utilization during dynamic forearm exercise in normal subjects and patients with congestive heart failure. Circulation 1974; 50:137—143.
3. Sinoway L., Minotti J., Musch T., Goldner D., Davis D., Leaman D., Zelis R: Enhanced metabolic vasodilation secondary to diuretic therapy in decompensated congestive heart failure secondary to coronary artery disease. Am J Cardiol 1987; 60: 107-111.
4. Imaizumi T., Takeshita A., Nakamura N., Sakai K., Hirooka Y., Suzuki S., et al: Effects of captopril on forearm oxygen consumption during dynamic handgrip exercise in patients with congestive heart failure. Jpn Heart J 1990; 31: 817-828.
5. Zelis R., Flaim S. F.: Alterations in vasomotor tone in congestive heart failure. Prog Cardiovasc Dis 1982; 24: 437-459.
6. Furchgott R. F., Zawadzki J. V.: The obligatory role of the endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-376.
7. Kubo S., Rector T. S., Bank A. J., Williams R. E., Heifetz S. M.: Endothelium-dependent vasodilation is attenuated in patients with heart failure. Circulation 1991; 84: 1589-1596.
8. Hirooka Y., Imaizumi T., Harada S., Masaki H., Momohara M., Tagawa T., et al: Endothelium-dependent forearm vasodilation with acetylcholine but not that with substance P is impaired in patients with heart failure. J Cardiovasc Pharmacol 1992; 20: S221-225.
9. Drexler H., Hayoz D., Munzel T., Hornig B., Just H., Brunner H. R., Zelis R: Endothelial function in chronic congestive heart failure. Am J Cardiol 1992; 69: 1596-1601.
10. Katz S. D., Biasucci L., Sabba C., Strom J. A., Jondeau G., Galvao M., et al: Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure. J Am Coll Cardiol 1992; 19: 918-925.
11. Palmer R.M.J., Ferrige A. G., Moncada S.: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524-526.
12. Palmer R.M.J., Ashton D. S., Moncada S.: Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988; 333: 664-666.
13. Moncada S., Higgs A: The L-arginine-nitric oxide pathway. N Engl J Med 1993; 329: 2002-2012.
14. Imaizumi T., Hirooka Y., Masaki H., Harada S., Momohara M., Tagawa T., et al: Effects of L-arginine on forearm vessels and responses to acetylcholine. Hypertension 1992; 20: 511-517.
15. Panza J. A., Casino P. R., Badar D. M., Quyyumi A. A.: Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium dependent vascular relaxation in normal subjects and in patients with essential hypertension. Circulation 1993; 87: 1475-1481.
16. Hirooka Y., Imaizumi T., Tagawa T., Shiramoto M., Endo T., Ando S., et al: Effects of L-arginine on impaired acetylcholine-induced and ischemic vasodilation of the forearm in patients with heart failure. Circulation 1994; 90: 658-668.
17. Greenfied A.D.M., Whitney R. J., Mowbray J. F.: Methods for the investigation of peripheral blood flow. Br Med Bull 1963; 19: 101-109.
18. Imaizumi T., Takeshita A., Ashihara T., Nakamura M: The effects of sublingually administered nitroglycerin on forearm vascular resistance in patients with heart failure and normal subjects. Circulation 1985; 72: 747-752.
19. Tagawa T., Imaizumi T., Endo T., Shiramoto M., Harasawa Y., Takeshita A: Role of nitric oxide in reactive hyperemia in human forearm vessels. Circulation 1994; 90: 2285—2290.
20. Endo T., Imaizumi T., Tagawa T., Shiramoto M., Ando S., Takeshita A: Role of nitric oxide in exercise-induced vasodilation of the forearm. Circulation 1994; 90: 2886-2890.
21. Imaizumi T., Takeshita A., Suzuki S., Yoshida M., Ando S., Nakamura M: Age-independent forearm vasodilation by acetylcholine and adenosine 5'-triphosphate in human. Clin Sci 1985; 78: 89-93.
22. Glantz S. A., Slinker B. K.: Repeated measures. In: Primer of applied regression and analysis of variance. New York: McGraw-Hill, 1990; 381-463.
23. Vallance P., Collier J., Moncada S: Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 1989; II: 997-1000.
24. Linder L., Kiowski W., Buhler F. R., Liischer TF: Indirect evidence for release of endothelium-derived relaxing factors in human forearm circulation in vivo. Blunted response in essential hypertension. Circulation 1990; 81: 1762—1767.
25. Calfer A., Collier J., Vallance P: Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. J Clin Invest 1992; 90: 2548-2554.
26. Creager M. A., Cooke J. P., Mendelsohn M. E., Gallagher S. J., Coleman S. M., Loscalzo J., et al: Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest 1990; 86: 228-234.
27. LeJemtel T. H., Maskin C. S., Lucid D., Chadwick B. J.: Failure to augment maximal limb blood flow in response to 1-leg vs 2-leg exercise in patients with heart failure. Circulation 1986; 74: 245-251.
28. Sullivan M. J., Knight J. D., Higginbotham M. B., Cobb F. R.: Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure: Muscle blood flow is reduced with maintenance of arterial perfusion pressure. Circulation 1989; 80: 769-781.
29. Wilson J. R., Wiener D. H., Fink L. I., Ferraro N: Vasodilatory behavior of skeletal muscle arterioles in patients with nonedematous chronic heart failure. Circulation 1986; 74: 775-779.
30. Arnold J.M.O., Ribeiro J. P., Colucci W. S.: Muscle blood flow during forearm exercise in patients with severe heart failure. Circulation 1990; 82: 465-472.
31. Guyton A. C.: Muscle blood flow during exercise. In: Textbook of medical physiology, 7th edn. Philadelphia: WB Saunders, 1986; 336-338.
32. Johnson J. M.: Circulation to skeletal muscle. In: Patton H. D., Fuchs A. F., Hille B., Scher A. M., Steiner R., editors. Textbook of physiology, Vol. 2: Circulation, respiration, body fluids, metabolism and endocrinology, 21st edn. Philadelphia: WB Saunders, 1989; 887-897.
33. Gilligan D. M., Panza J. A., Kilcoyne C. M., Waclawiw M. A., Casino P. R., Quyyumi A. A.: Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation. Circulation 1994; 90: 2853-2858.
34. Wilson J. R.: Exercise intolerance in heart failure. Importance of skeletal muscle. Circulation 1995; 91: 559—561.