Synthesis and pharmacological evaluation of 2,3-dihydro-3-oxo-4H- thieno[3,4-e][1,2,4]thiadiazine 1,1-dioxides as voltage-dependent calcium channel blockers

European Journal of Medicinal Chemistry

Volumn 35, Issue 7-8, 2000, Pages 751-759

  Arranz, Esther ^a   Díaz, Juan A ^a   Vega, Salvador ^a   Campos Toimil, Manuel ^b   Orallo, Francisco ^b   Cardelús, Ignasi ^c   Llenas, Jesús ^c   Fernández, Andrés G ^c  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b Univ Santiago C   (Spain)

^c C ^*  (Spain)

Author keywords

2,3 dihydro 3 oxo 4H thieno 3,4 e 1,2,4 thladiazine 1,1 dioxides; Calcium channel blockers; Cardiovascular activity

Indexed keywords

2 [4 [1 [4 (2 PYRIMIDYL) PIPERAZINYL]]BUTYL] 2,3 DIHYDRO 3 OXO 4H THIENO[3,4 E][1,2,4]THIADIAZINE 1,1 DIOXIDE DERIVATIVE; 2,3 DIHYDRO 3 OXO 4H THIENO[3,4 E][1,2,4]THIADIAZINE 1,1 DIOXIDE DERIVATIVE; ANTIHYPERTENSIVE AGENT; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; DIAZOXIDE; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PORTAL VEIN; RAT; REACTION ANALYSIS; STOMACH MOTILITY;

EID: 0343953446     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(00)00188-4     Document Type: Article

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