Activation of phosphatidylinositol 3-kinase by oxidative stress leads to the induction of microsomal epoxide hydrolase in H4IIE cells

Toxicology Letters

Volumn 121, Issue 3, 2001, Pages 191-197

  Kang, Keon Wook ^a   Ryu, Ji Hwa ^a   Kim, Sang Geon ^a  

^a Seoul National University   (South Korea)

Author keywords

Akt; Cysteine; Methionine; Microsomal epoxide hydrolase; Phosphatidylinositol 3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; EPOXIDE HYDROLASE; MESSENGER RNA; MICROSOME ENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; SULFUR AMINO ACID; WORTMANNIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; HEPATOMA CELL; INCUBATION TIME; NONHUMAN; NORTHERN BLOTTING; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACIDS, SULFUR; ANIMALS; ENZYME ACTIVATION; ENZYME INDUCTION; EPOXIDE HYDROLASES; LIVER NEOPLASMS, EXPERIMENTAL; OXIDATIVE STRESS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0343773894     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(01)00337-X     Document Type: Article

References (18)

1. Cho, M.K., Kim, S.G., 1998. Differential induction of rat hepatic microsomal epoxide and rGSTA2 by diazines: The role of cytochrome P450 2E1-mediated metabolic activation. Chem. Biol. Interact. 116, 229-245.
2. Cho, M.K., Kim, S.G., 2000. Enhanced expression of rat hepatic microsomal epoxide hydrolase by methylthiazole in conjunction with liver injury. Toxicology 146, 111-122.
3. Cho, M.K., Kim, Y.G., Lee, M.G., Kim, S.G., 2001. Prevention of c-Jun/activator protein-1 activation and microsomal epoxide hydrolase induction in the rat liver by cysteine during protein-calorie malnutrition. Biochem. Pharmacol. 61, 15-24.
4. Daniel, V., 1993. Glutathione S-transferases: gene structure and regulation of expression. Crit. Rev. Biochem. Mol. Biol. 28, 173-207.
5. B receptors. J. Biol. Chem. 274, 20657-20663.
6. Gupta, S., Campbell, D., Derijard, B., Davis, R.J., 1995. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267, 389-393.
7. Hayes, J.D., Pulford, D.J., 1995. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to chemoprotection and drug resistance. Crit. Rev. Biochem. Mol. Biol. 30, 445-600.
8. Jaiswal, A.K., 1994. Antioxidant response element. Biochem. Pharmacol. 48, 439-444.
9. Kandel, E.S., Hay, N., 1999. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp. Cell Res. 253, 210-229.
10. Kang, K.W., Ryu, J.H., Kim, S.G., 2000. The essential role of phosphatidylinositol 3-kinase and of p38 mitogen-activated protein kinase activation in the antioxidant response element-mediated rGSTA2 induction by decreased glu-tathione in H4IIE hepatoma cells. Mol. Pharmacol. 58, 1017-1025.
11. Kang, K.W., Cho, M.K., Lee, C.H., Kim, S.G., 2001. Activation of phosphatidylinositol 3-kinase and Akt by tert-butylhydroquinone (t-BHQ) is responsible for antioxidant response element-mediated rGSTA2 induction in H4IIE cells. Mol. Pharmacol. (in press).
12. Kim, S.G., Chung, H.C., Cho, J.Y., 1996. Molecular mechanism of alkyl sulfide-modulated carbon tetrachloride-induced hepatotoxicity: The role of CYP2E1, CYP2B and glutathione S-transferase expression. J. Pharmacol. Exp. Therap. 277, 1058-1066.
13. Kim, S.G., Nam, S.Y., Kim, J.H., Cho, C.K., Yoo, S.Y., 1997. Enhancement of radiation-inducible hepatic glutathione S-transferase Ya1, Yb1, Yb2, Yc1, and Yc2 expression by oltipraz: Possible role in radioprotection. Mol. Pharmacol. 51, 225-233.
14. Nam, S.Y., Kim, J.H., Cho, C.K., Yoo, S.Y., Kim, S.G., 1997. Enhancement of radiation-induced hepatic microsomal epoxide hydrolase gene expression by oltipraz in rats. Radiat. Res. 147, 613-620.
15. Tan, Y., Rouse, J., Zhang, A., Cariati, S., Cohen, P., Comb, M.J., 1996. FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J. 15, 4629-4642.
16. Ushio-Fukai, M., Alexander, R.W., Akers, M., Yin, Q., Fujio, Y., Walsh, K., Griendling, K.K., 1999. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. J. Biol. Chem. 274, 22699-22704.
17. Wang, X., McCullough, K.D., Franke, T.F., Holbrook, N.J., 2000. Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival. J. Biol. Chem. 275, 14624-14631.
18. Yu, R., Mandlekar, S., Kong, A.N.T., 2000. Molecular mechanisms of butylated hydroxyanisole-induced toxicity: Induction of apoptosis through direct release of cytochrome c. Mol. Pharmacol. 58, 431-437.