Intracellular iron status as a hallmark of mammalian cell susceptibility to oxidative stress: A study of L5178Y mouse lymphoma cell lines differentially sensitive to H2O2

Blood

Volumn 95, Issue 9, 2000, Pages 2960-2966

  Lipiński, Pawel ^a   Drapier, Jean Claude ^b   Oliveira, Leonor ^b   Retmańska, Hanna ^b   Sochanowicz, Barbara ^b   Kruszewski, Marcin ^b  

^a INSTITUTE OF GENETICS AND ANIMAL BREEDING   (Poland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; HYDROGEN PEROXIDE; IRON; REGULATOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL LEVEL; CONCENTRATION RESPONSE; IRON METABOLISM; LYMPHOMA CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN INTERACTION; REGULATORY MECHANISM;

EID: 0343618520     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.9.2960.009k13_2960_2966     Document Type: Article

References (48)

1. Ponka P, Beaumont C, Richardson DR. Function and regulation of transferrin and ferritin. Semin Hematol. 1998;35:35.
2. Richardson DR, Ponka P. The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochim Biophys Acta. 1997;133:1.
3. Klausner RD, Rouault TA. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell. 1993;72:19.
4. Hentze MW, Kühn LC. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci U S A. 1996;93:8175.
5. Rouault TA, Klausner RD. Post-transcriptional regulation of genes of iron metabolism in mammalian cells. J Biol Inorg Chem. 1996;1:494.
6. Guo B, Philips JD, Yu Y, Leibold EA. Iron regulates the intracellular degradation of iron regulatory proteins by the proteasome. J Biol Chem. 1995;270:21,645.
7. Breuer W, Greenberg E, Cabantchik ZI. Newly delivered transferrin iron and oxidative cell injury. FEBS Lett 1997;403:213.
8. Picard V, Epsztejn S, Santambrogio P, Cabantchik ZI, Beaumont C. Role of ferritin in the control of the labile iron pool in murine erythroleukemia cells. J Biol Chem. 1998;273:15,382.
9. Picard V, Renaudie F, Porcher C, Hentze MW, Grandchamp B, Beaumont C. Overexpression of the ferritin H subunit in cultured erythroid cells changes the intracellular iron distribution. Blood. 1996;87:2057.
10. Beer JZ, Budzicka E, Niepokójczycka E, Rosiek O, Szumiel I, Walicka M. Loss of tumorigenicity with simultaneous changes in radiosensitivity and photosensitivity during in vitro growth of L5178Y murine lymphoma cells. Cancer Res. 1983;336: 99.
11. Boużyk E, Buraczewska I, Rosiek O, Sochanowicz B, Szumiel I. Hydrogen peroxide induced reproductive and interphase death in two strains of L5178Y murine lymphoma differing in radiation sensitivity. Radiat Environ Biophys. 1991;30:105.
12. Kruszewski M, Green MHL, Lowe JE, Szumiel I. DNA strand breakage, cytotoxicity and mutagenicity of hydrogen peroxide treatment at 4 degrees C and 37 degrees C in L5178Y sublines. Mutat Res. 1994;308:233.
13. Boużyk E, Iwanenko T, Jarocewicz N, Kruszewski M, Sochanowicz B, Szumiel I. Antioxidant defense system in diferentially hydrogen peroxide sensitive L5178Y sublines. Free Radic Biol Med. 1997;22:697.
14. 2 and x-rays. Radiat Environ Biophys. 1995; 34:113.
15. Zastawny T, Kruszewski M, Oliński R. Ionizing radiation and hydrogen peroxide induced oxidative DNA base damage in two L5178Y cell lines. Free Radic Bid Med. 1998;24:1250.
16. Szumiel I. Response of two strains of L5178Y cells to cis-dichlorobis(cyclopentylamine)platinum(II). I. Cross-sensitivity to cis-PAD and UV light. Chem Biol Interact. 1979;24:51.
17. Epsztejn S, Kakhlon O, Glickstein H, Breuer W, Cabantchik ZI. Fluorescence analysis of the labile iron pool of mammalian cells. Anal Biochem. 1997;248:31.
18. Cabantchik ZI, Glickstein H, Milgram, P, Breuer W. A fluorescence assay for assessing chelation of intracellular iron in a membrane model system and mammalian cells. Anal Biochem. 1996;233: 221.
19. Leibold EA, Munro HN. Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy-and light-subunit mRNAs. Proc Natl Acad Sci U S A. 1988; 85:2171.
20. Mülner EW, Neuperl B, Kühn LC. A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA. Cell. 1989;58:373.
21. Hentze MW, Rouault TA, Harford JB, Klausner RD. Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction. Science. 1989;244:357.
22. Drapier JC, Hibbs JB Jr. Murine cytotoxic activated macrophages inhibit aconitase in tumor cells: inhibition involves the iron-sulfur prosthetic group and is reversible. J Clin Invest. 1986;78: 790.
23. Drapier JC, Hibbs JB Jr. Aconitases: a new class of metalloproteins highly sensitive to nitric oxide synthesis. Methods Enzymol. 1996;269:26.
24. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680.
25. Henderson BR, Selser C, Kühn LC. Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements. J Biol Chem. 1993;268:27,327.
26. Summers E, Worwood M, Jacobs A. Ferritin in normal erythrocytes, lymphocytes, polymorphs, and monocytes. Br J Haematol. 1974;28:19.
27. Fibach E, Konijn AM, Rachmilewitz EA. Changes in cellular ferritin content during myeloid differentiation of human leukemic cell lines. Am J Hematol. 1985;18:143.
28. Bouton C, Hirling H, Drapier JC. Redox modulation of iron regulatory proteins by peroxynitrite. J Biol Chem. 1997;272:19,969.
29. Balla G, Jacob H, Balla J, et al. Ferritin: a cytoprotective antioxidant strategem of endothelium. J Biol Chem. 1992;267:18,148.
30. Cermak J, Balla J, Jacob HS, et al. Tumor cell heme uptake induces ferritin synthesis resulting in altered oxidant sensitivity: possible role in chemotherapy efficacy. Cancer Res. 1993;53: 5308.
31. Balla J, Jacob HS, Balla G, Nath K, Eaton JW, Vercellotti GM. Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc Natl Acad Sci U S A. 1993;90:9285.
32. Ville GF, Tyrrell RM. Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin. J Biol Chem. 1993;268:14,678.
33. Cairo G, Tacchini L, Pogliaghi G, Anzon E, Tomasi A, Bernelli-Zazzera A. Induction of ferritin synthesis by oxidative stress: transcriptional and post-transcriptional regulation by expansion of the "free" iron pool. J Biol Chem. 1995;270:700.
34. Lin F, Girotti AW. Elevated ferritin production, iron containment, and oxidant resistance in hemin-treated leukemia cells. Arch Biochem Biophys. 1997;346:131.
35. Lin F, Girotti AW. Hemin-enhanced resistance of human leukemia cells to oxidative killing: antisense determination of ferritin involvement. Arch Biochem Biophys. 1998;352:51.
36. Applegate LA, Scaletta C, Panizzon R, Frenk E. Evidence that ferritin is UV inducible in human skin: part of a putative defense mechanism. J Invest Dermatol. 1998;111:159.
37. Meneghini R. Iron homeostasis, oxidative stress, and DNA damage. Free Radic Biol Med. 1997;23: 783.
38. Henle ES, Linn S. Formation, prevention, and repair of DNA damage by iron/hydrogen peroxide. J Biol Chem. 1997;272:19,095.
39. Rothman RJ, Serroni A, Farber JL. Cellular pool of transient ferric iron, chelatable by deferoxamine and distinct from ferritin, that is involved in oxidative cell injury. Mol Pharmacol. 1992;42:703.
40. Öllinger K, Roberg K. Nutrient deprivation of cultured rat hepatocytes increases the desferrioxamine-available iron pool and augments the sensitivity to hydrogen peroxide. J Biol Chem. 1997; 272:23,707.
41. Lawson DM, Treffry A, Artymiuk PJ, et al. Identification of the ferroxidase centre in ferritin. FEBS Lett 1989;254:207.
42. Lawson DM, Artymiuk PJ, Yewdall SJ, et al. Genetic engineering of crystal contacts leads to the structure solution of human H ferritin. Nature. 1991;349:541.
43. Levi S, Girelli D, Perrone F, et al. Analysis of ferritins in lymphoblastoid cell lines and in the lens of subjects with hereditary hyperferritinemia-cataract syndrome. Blood. 1998;91:4180.
44. Lipiński P, Drapier JC. Interplay between ferritin metabolism, reactive oxygen species and nitric oxide. J Biol Inorg Chem. 1997;2:559.
45. Tacchini L, Recalcati S, Bernelli-Zazzera A, Cairo G. Induction of ferritin synthesis in ischemic-reperfused rat liver: analysis of the molecular mechanisms. Gastroenterology. 1997;113:946.
46. Ouyang Q, Bommakanti M, Miskimins WK. A mitogen-responsive promoter region that is synergistically activated through multiple signalling pathways. Mol Cell Biol. 1993;13:1796.
47. Lok CN, Ponka P. Identification of a hypoxia response element in the transferrin receptor gene. J Biol Chem. 1999;274:24,147.
48. Tacchini L, Blanchi L, Bernelli-Zazzera A, Cairo G. Transferrin receptor induction by hypoxia: HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation. J Biol Chem. 1999;274:24,142.