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Volumn 15, Issue 1, 2000, Pages 25-31

Molecular analysis of 5-azacytidine-induced variants in mammalian cells

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; METHYLTRANSFERASE; PRIMER DNA; TIOGUANINE;

EID: 0343415557     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/15.1.25     Document Type: Article
Times cited : (8)

References (53)
  • 1
    • 0023114721 scopus 로고
    • The mutagenicity of 5-azacytidine and other inhibitors of replicative DNA synthesis in the L5178Y mouse lymphoma cell
    • Amacher, D. and Turner, G. (1987) The mutagenicity of 5-azacytidine and other inhibitors of replicative DNA synthesis in the L5178Y mouse lymphoma cell. Mutat. Res., 176, 123-131.
    • (1987) Mutat. Res. , vol.176 , pp. 123-131
    • Amacher, D.1    Turner, G.2
  • 2
    • 0018340479 scopus 로고
    • Production of sister chromatid exchanges by various cancer chemotherapeutic agents
    • Banerjee, A. and Benedict, W. (1979) Production of sister chromatid exchanges by various cancer chemotherapeutic agents. Cancer Res., 39, 797-799.
    • (1979) Cancer Res. , vol.39 , pp. 797-799
    • Banerjee, A.1    Benedict, W.2
  • 4
    • 0021725148 scopus 로고
    • Induction of a step in carcinogenesis that is normally associated with mutagenesis by nonmutagenic concentrations of 5-azacytidine
    • Bouck, N., Kokkinakis, D. and Ostrowsky, J. (1984) Induction of a step in carcinogenesis that is normally associated with mutagenesis by nonmutagenic concentrations of 5-azacytidine. Mol. Cell. Biol., 4, 1231-1237.
    • (1984) Mol. Cell. Biol. , vol.4 , pp. 1231-1237
    • Bouck, N.1    Kokkinakis, D.2    Ostrowsky, J.3
  • 5
    • 0022453948 scopus 로고
    • Studies of mutagenicity and clastogenicity of 5-azacytidine in human lymphoblasts and Salmonella typhimurium
    • Call, K., Jensen, J., Liber, H. and Thilly, W. (1986) Studies of mutagenicity and clastogenicity of 5-azacytidine in human lymphoblasts and Salmonella typhimurium. Mutat. Res., 160, 249-257.
    • (1986) Mutat. Res. , vol.160 , pp. 249-257
    • Call, K.1    Jensen, J.2    Liber, H.3    Thilly, W.4
  • 6
  • 7
    • 0023952030 scopus 로고
    • Carcinogenicity and haemoglobin synthesis induction by cytidine analogues
    • Carr, B.I., Rahbar, S., Asmeron, Y., Riggs, A. and Winberg, C.D. (1988) Carcinogenicity and haemoglobin synthesis induction by cytidine analogues. Br. J. Cancer, 57, 395-402.
    • (1988) Br. J. Cancer , vol.57 , pp. 395-402
    • Carr, B.I.1    Rahbar, S.2    Asmeron, Y.3    Riggs, A.4    Winberg, C.D.5
  • 8
    • 0023252235 scopus 로고
    • 5-azacytidine carcinogenesis in BALB/c mice
    • Cavaliere, A., Bufalari, A. and Vitali, R. (1987) 5-Azacytidine carcinogenesis in BALB/c mice. Cancer Lett., 37, 51-58.
    • (1987) Cancer Lett. , vol.37 , pp. 51-58
    • Cavaliere, A.1    Bufalari, A.2    Vitali, R.3
  • 9
    • 0017409254 scopus 로고
    • Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment
    • Constantinides, P.G., Jones, P.A. and Gevers, W. (1977) Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment. Nature, 267, 364-366.
    • (1977) Nature , vol.267 , pp. 364-366
    • Constantinides, P.G.1    Jones, P.A.2    Gevers, W.3
  • 10
    • 0020579397 scopus 로고
    • Eukaryotic DNA methylation
    • Cooper, D. (1983) Eukaryotic DNA methylation. Hum. Genet., 64, 315-333.
    • (1983) Hum. Genet. , vol.64 , pp. 315-333
    • Cooper, D.1
  • 11
    • 0018185292 scopus 로고
    • Molecular basis of base substitution hotspots in Escherichia coli
    • Coulondre, C., Miller, J.H., Farabaugh, P.J. and Gilbert, W. (1978) Molecular basis of base substitution hotspots in Escherichia coli. Nature, 274, 775-780.
    • (1978) Nature , vol.274 , pp. 775-780
    • Coulondre, C.1    Miller, J.H.2    Farabaugh, P.J.3    Gilbert, W.4
  • 12
    • 0014181334 scopus 로고
    • Inhibition of protein synthesis by 5-azacytidine in Escherichia coli
    • Doskocil, J., Paces, V. and Sorm, F. (1967) Inhibition of protein synthesis by 5-azacytidine in Escherichia coli. Biochim. Biophys. Acta, 145, 771-779.
    • (1967) Biochim. Biophys. Acta , vol.145 , pp. 771-779
    • Doskocil, J.1    Paces, V.2    Sorm, F.3
  • 13
    • 0342355204 scopus 로고
    • Cellular components required for mutagenesis
    • B. Friedberg, E. and Bridges, B. (eds), Wiley Liss, New York, NY
    • Elledge, S., Perry, K., Krueger, J.M.,B. and Walker, G. (1983) Cellular components required for mutagenesis. In Friedberg, E. and Bridges, B. (eds), Cellular Responses to DNA Damage. Wiley Liss, New York, NY, pp. 353-359.
    • (1983) Cellular Responses to DNA Damage , pp. 353-359
    • Elledge, S.1    Perry, K.2    Krueger, J.M.3    Walker, G.4
  • 14
    • 0018293585 scopus 로고
    • The effect of 5-azacytidine on E.Coli DNA methylase
    • Friedman, S. (1979) The effect of 5-azacytidine on E.coli DNA methylase. Biochem. Biophys. Res. Commun., 89, 1328-1333.
    • (1979) Biochem. Biophys. Res. Commun. , vol.89 , pp. 1328-1333
    • Friedman, S.1
  • 15
    • 0027261147 scopus 로고
    • The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents
    • Gorczyca, W., Gong, J., Ardelt, B., Traganos, F. and Darzynkiewicz, Z. (1993) The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res., 53, 3186-3192.
    • (1993) Cancer Res. , vol.53 , pp. 3186-3192
    • Gorczyca, W.1    Gong, J.2    Ardelt, B.3    Traganos, F.4    Darzynkiewicz, Z.5
  • 16
    • 0030055952 scopus 로고    scopus 로고
    • The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe
    • Hegde, V., McFarlane, R.J., Taylor, E.M. and Price, C. (1996) The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe. Mol. Gen. Genet., 251, 483-492.
    • (1996) Mol. Gen. Genet. , vol.251 , pp. 483-492
    • Hegde, V.1    McFarlane, R.J.2    Taylor, E.M.3    Price, C.4
  • 17
  • 18
    • 0029898837 scopus 로고    scopus 로고
    • DNA methylation errors and cancer
    • Jones, P.A. (1996) DNA methylation errors and cancer. Cancer Res., 56, 2463-2467.
    • (1996) Cancer Res. , vol.56 , pp. 2463-2467
    • Jones, P.A.1
  • 19
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogs and DNA methylation
    • Jones, P.A. and Taylor, S.M. (1980) Cellular differentiation, cytidine analogs and DNA methylation. Cell, 20, 85-93.
    • (1980) Cell , vol.20 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 20
    • 0344949234 scopus 로고
    • Cell cycle-specific reactivation of an inactive X-chromosome locus by 5-azadeoxycytidine
    • Jones, P., Taylor, S., Mohandas, T. and Shapiro, L. (1982) Cell cycle-specific reactivation of an inactive X-chromosome locus by 5-azadeoxycytidine. Proc. Natl Acad. Sci. USA, 79, 1215-1219.
    • (1982) Proc. Natl Acad. Sci. USA , vol.79 , pp. 1215-1219
    • Jones, P.1    Taylor, S.2    Mohandas, T.3    Shapiro, L.4
  • 21
    • 0015496209 scopus 로고
    • Chromatid breakage: Differential effect of inhibitors and synthesis during G2 phase
    • Karon, M. and Benedict, W.F. (1972) Chromatid breakage: differential effect of inhibitors and synthesis during G2 phase. Science, 178, 62.
    • (1972) Science , vol.178 , pp. 62
    • Karon, M.1    Benedict, W.F.2
  • 22
    • 0026685693 scopus 로고
    • 1-β-d-arabinosylcytosine and 5-azacytidine induce internucleosomal DNA fragmentation and cell death in thymocytes
    • Kizaki, H., Ohnishi, Y., Azuma, Y., Mizuno, Y. and Ohsaka, F. (1992) 1-β-D-Arabinosylcytosine and 5-azacytidine induce internucleosomal DNA fragmentation and cell death in thymocytes. Immunopharmacology, 24, 219-227.
    • (1992) Immunopharmacology , vol.24 , pp. 219-227
    • Kizaki, H.1    Ohnishi, Y.2    Azuma, Y.3    Mizuno, Y.4    Ohsaka, F.5
  • 23
    • 0028322120 scopus 로고
    • International commission for protection against environmental mutagens and carcinogens. Deoxyribonucleoside triphosphate levels: A critical factor in the maintenance of genetic stability
    • Kunz, B.A., Kohalmi, S.E., Kunkel, T.A., Mathews, C.K., McIntosh, E.M. and Reidy, J.A. (1994) International Commission for Protection Against Environmental Mutagens and Carcinogens. Deoxyribonucleoside triphosphate levels: a critical factor in the maintenance of genetic stability. Mutat. Res., 318, 1-64.
    • (1994) Mutat. Res. , vol.318 , pp. 1-64
    • Kunz, B.A.1    Kohalmi, S.E.2    Kunkel, T.A.3    Mathews, C.K.4    McIntosh, E.M.5    Reidy, J.A.6
  • 24
    • 0020027501 scopus 로고
    • Mutagenicity of 5-azacytidine and related nucleosides in C3H10T1/2 clone 8 and V79 cells
    • Landolph, J.R. and Jones, P.A. (1982) Mutagenicity of 5-azacytidine and related nucleosides in C3H10T1/2 Clone 8 and V79 cells. Cancer Res., 42, 817-823.
    • (1982) Cancer Res. , vol.42 , pp. 817-823
    • Landolph, J.R.1    Jones, P.A.2
  • 25
    • 0022001994 scopus 로고
    • Effect of 5-azacytidine (5-aza C) on the induction of chromatid aberrations (CA) and sister-chromatid exchanges (SCE)
    • Lavia, P., Ferraro, M., Micheli, A. and Olivieri, G. (1985) Effect of 5-azacytidine (5-aza C) on the induction of chromatid aberrations (CA) and sister-chromatid exchanges (SCE). Mutat. Res., 149, 463-467.
    • (1985) Mutat. Res. , vol.149 , pp. 463-467
    • Lavia, P.1    Ferraro, M.2    Micheli, A.3    Olivieri, G.4
  • 26
    • 0022648121 scopus 로고
    • Classifying mutagens as to their specificity in causing the six possible transitions and transversions: A simple analysis using the Salmonella mutagenicity assay
    • Levin, D.E. and Ames, B.N. (1986) Classifying mutagens as to their specificity in causing the six possible transitions and transversions: a simple analysis using the Salmonella mutagenicity assay. Environ. Mutagen., 8, 9-28.
    • (1986) Environ. Mutagen. , vol.8 , pp. 9-28
    • Levin, D.E.1    Ames, B.N.2
  • 27
    • 0014871518 scopus 로고
    • Phase specificity of 5-azacytidine against mammalian cells in tissue culture
    • Li, L.H., Olin, E.J., Fraser, T.J. and Bhuyan, B.K. (1970) Phase specificity of 5-azacytidine against mammalian cells in tissue culture. Cancer Res., 30, 2770-2775.
    • (1970) Cancer Res. , vol.30 , pp. 2770-2775
    • Li, L.H.1    Olin, E.J.2    Fraser, T.J.3    Bhuyan, B.K.4
  • 29
    • 0342790205 scopus 로고
    • National Cancer Institute Carcinogenesis Technical Report Series no. 42, DHHS (NIH) Publication no. 78.842. National Institutes of Health, Bethesda, MD
    • NCI (1978) Bioassav of 5-Azacytidine for Possible Carcinogenicity (CAS No. 320-67-2), National Cancer Institute Carcinogenesis Technical Report Series no. 42, DHHS (NIH) Publication no. 78.842. National Institutes of Health, Bethesda, MD.
    • (1978) Bioassav of 5-Azacytidine for Possible Carcinogenicity (CAS No. 320-67-2)
  • 30
    • 0014427526 scopus 로고
    • Incorporation of 5-azacytidine into nucleic acids of Escherichia coli
    • Paces, V., Doskocil, J. and Sorm, F. (1968) Incorporation of 5-azacytidine into nucleic acids of Escherichia coli. Biochim. Biophys. Acta, 161, 352-360.
    • (1968) Biochim. Biophys. Acta , vol.161 , pp. 352-360
    • Paces, V.1    Doskocil, J.2    Sorm, F.3
  • 31
    • 0021963928 scopus 로고
    • Involvement of DNA lesions and SOS functions in 5-bromouracil-induced mutagenesis
    • Pietrzykowska, I., Krych, M. and Shugar, D. (1985) Involvement of DNA lesions and SOS functions in 5-bromouracil-induced mutagenesis. Mutat. Res., 149, 287-296.
    • (1985) Mutat. Res. , vol.149 , pp. 287-296
    • Pietrzykowska, I.1    Krych, M.2    Shugar, D.3
  • 32
    • 0020520990 scopus 로고
    • Mutagenicity of 5-azacytidine in Salmonella typhimurium
    • Podger, D.M. (1983) Mutagenicity of 5-azacytidine in Salmonella typhimurium. Mutat. Res., 121, 1-6.
    • (1983) Mutat. Res. , vol.121 , pp. 1-6
    • Podger, D.M.1
  • 33
    • 0018838527 scopus 로고
    • 2-aminopurine
    • Ronen, A. (1980) 2-Aminopurine. Mutat. Res., 75, 1-47.
    • (1980) Mutat. Res. , vol.75 , pp. 1-47
    • Ronen, A.1
  • 34
    • 0023684737 scopus 로고
    • Characterization of a in vitro micronucleus assay with Syrian hamster embryo fibroblasts
    • Schmuck, G., Lieb, G., Wild, D., Schiffmann, D. and Henschler, D. (1988) Characterization of a in vitro micronucleus assay with Syrian hamster embryo fibroblasts. Mutat. Res., 203, 397-404.
    • (1988) Mutat. Res. , vol.203 , pp. 397-404
    • Schmuck, G.1    Lieb, G.2    Wild, D.3    Schiffmann, D.4    Henschler, D.5
  • 35
    • 0029662074 scopus 로고    scopus 로고
    • 5-azacytidine induced 6-thioguanine-resistance at the gpt locus in AS52 cells: Cellular response
    • Spencer, D.L., Caspary, W.J., Hines, K. and Tindall, K.R. (1996) 5-Azacytidine induced 6-thioguanine-resistance at the gpt locus in AS52 cells: cellular response. Environ. Mol. Mutagen., 28, 100-106.
    • (1996) Environ. Mol. Mutagen. , vol.28 , pp. 100-106
    • Spencer, D.L.1    Caspary, W.J.2    Hines, K.3    Tindall, K.R.4
  • 36
    • 0022642021 scopus 로고
    • Quantitative and moleclar analyses of radiation-induced mutation in AS52 cells
    • Stankowski, L.F. Jr, Leon F. and Hsie, A.W. (1986a) Quantitative and moleclar analyses of radiation-induced mutation in AS52 cells. Radiat. Res., 105, 37-48.
    • (1986) Radiat. Res. , vol.105 , pp. 37-48
    • Stankowski L.F., Jr.1    Leon, F.2    Hsie, A.W.3
  • 37
    • 0022646918 scopus 로고
    • Quantitative and molecular analyses of ethyl methanesulfonate- and ICR 191-induced mutation in AS52 cells
    • Stankowski, L.F. Jr, Tindall, K.R. and Hsie, A.W. (1986b) Quantitative and molecular analyses of ethyl methanesulfonate- and ICR 191-induced mutation in AS52 cells. Mutat. Res., 160, 133-147.
    • (1986) Mutat. Res. , vol.160 , pp. 133-147
    • Stankowski L.F., Jr.1    Tindall, K.R.2    Hsie, A.W.3
  • 38
    • 0026756524 scopus 로고
    • 5-azacytidine induces micronuclei in and morphological transformation of Syrian hamster embryo fibroblasts in the absence of unscheduled DNA synthesis
    • Stopper, H., Pechan, R. and Schiffmann, D. (1992) 5-Azacytidine induces micronuclei in and morphological transformation of Syrian hamster embryo fibroblasts in the absence of unscheduled DNA synthesis. Mutat. Res., 283, 21-28.
    • (1992) Mutat. Res. , vol.283 , pp. 21-28
    • Stopper, H.1    Pechan, R.2    Schiffmann, D.3
  • 39
    • 0027240007 scopus 로고
    • Cell cycle dependent micronucleus formation and mitotic disturbances in mammalian cells treated with 5-azacytidine
    • Stopper, H., Körber, C., Schiffmann, D. and Caspary, W.J. (1993) Cell cycle dependent micronucleus formation and mitotic disturbances in mammalian cells treated with 5-azacytidine. Mutat. Res., 300, 165-177.
    • (1993) Mutat. Res. , vol.300 , pp. 165-177
    • Stopper, H.1    Körber, C.2    Schiffmann, D.3    Caspary, W.J.4
  • 40
    • 0029072603 scopus 로고
    • Micronuclei induced by modulators of methylation: Analogs of 5-azacytidine
    • Stopper, H., Körber, C., Gibis, P., Spencer, D.L. and Caspary, W.J. (1995) Micronuclei induced by modulators of methylation: analogs of 5-azacytidine. Carcinogenesis, 16, 1647-1650.
    • (1995) Carcinogenesis , vol.16 , pp. 1647-1650
    • Stopper, H.1    Körber, C.2    Gibis, P.3    Spencer, D.L.4    Caspary, W.J.5
  • 41
    • 0029907663 scopus 로고    scopus 로고
    • 5-azacytidine treatment of the fission yeast leads to cytotoxicity and cell cycle arrest
    • Taylor, E.M., McFarlane, R.J. and Price, C. (1996) 5-Azacytidine treatment of the fission yeast leads to cytotoxicity and cell cycle arrest. Mol. Gen. Genet., 253, 128-137.
    • (1996) Mol. Gen. Genet. , vol.253 , pp. 128-137
    • Taylor, E.M.1    McFarlane, R.J.2    Price, C.3
  • 42
    • 0027154904 scopus 로고
    • 5-aza-2′-deoxycytidine: Cell differentiation and DNA methylation
    • Taylor, S.M. (1993) 5-Aza-2′-deoxycytidine: cell differentiation and DNA methylation. Leukemia, 1, 3-8.
    • (1993) Leukemia , vol.1 , pp. 3-8
    • Taylor, S.M.1
  • 43
    • 0020308438 scopus 로고
    • Mechanism of action of eukaryotic DNA and methyltransferase
    • Taylor, S.M. and Jones, P.A. (1982) Mechanism of action of eukaryotic DNA and methyltransferase. J. Mol. Biol., 162, 679-692.
    • (1982) J. Mol. Biol. , vol.162 , pp. 679-692
    • Taylor, S.M.1    Jones, P.A.2
  • 44
    • 0024592908 scopus 로고
    • Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells
    • Tindall, K.R. and Stankowski, L.F. Jr (1989) Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells. Mutat. Res., 220, 241-253.
    • (1989) Mutat. Res. , vol.220 , pp. 241-253
    • Tindall, K.R.1    Stankowski L.F., Jr.2
  • 47
    • 0017082530 scopus 로고
    • 5-azacytidine: A new anticancer drug with effectiveness in acute myelogenous leukemia
    • Von Hoff, D., Slavik, M. and Muggia, F. (1976) 5-Azacytidine: a new anticancer drug with effectiveness in acute myelogenous leukemia. Ann. Intern. Med., 85, 237-245.
    • (1976) Ann. Intern. Med. , vol.85 , pp. 237-245
    • Von Hoff, D.1    Slavik, M.2    Muggia, F.3
  • 48
    • 0022854396 scopus 로고
    • In vitro transformation of primary rat tracheal epithelial cells by 5-azacytidine
    • Walker, C. and Nettesheim, P. (1986) In vitro transformation of primary rat tracheal epithelial cells by 5-azacytidine. Cancer Res., 46, 6433-6437.
    • (1986) Cancer Res. , vol.46 , pp. 6433-6437
    • Walker, C.1    Nettesheim, P.2
  • 49
    • 0023258737 scopus 로고
    • Suppression of tumorigenicity mediated by 5-azacytidine and associated with increased chromosome number
    • Walker, C., Matthews, A. and Shay, J. (1987) Suppression of tumorigenicity mediated by 5-azacytidine and associated with increased chromosome number. J. Natl Cancer Inst., 78, 695-700.
    • (1987) J. Natl Cancer Inst. , vol.78 , pp. 695-700
    • Walker, C.1    Matthews, A.2    Shay, J.3
  • 50
    • 0020493818 scopus 로고
    • Heat and alkali-induced deamination of 5-methylcytosine and cytosine residues in DNA
    • Wang, R., Kuo, K., Gehrke, C., Huang, L. and Ehrlich, M. (1982) Heat and alkali-induced deamination of 5-methylcytosine and cytosine residues in DNA. Biochim. Biophys. Acta, 697, 371-377.
    • (1982) Biochim. Biophys. Acta , vol.697 , pp. 371-377
    • Wang, R.1    Kuo, K.2    Gehrke, C.3    Huang, L.4    Ehrlich, M.5
  • 51
    • 0028366407 scopus 로고
    • Effects of the umuDC, mucAB and samAB operons on the mutational specificity of chemical mutagenesis in Escherichia coli: II. Base substitution mutagenesis
    • Watanabe, M., Nohmi, T. and Ohta, T. (1994) Effects of the umuDC, mucAB and samAB operons on the mutational specificity of chemical mutagenesis in Escherichia coli: II. Base substitution mutagenesis. Mutat. Res., 314, 39-49.
    • (1994) Mutat. Res. , vol.314 , pp. 39-49
    • Watanabe, M.1    Nohmi, T.2    Ohta, T.3
  • 52
    • 0016176298 scopus 로고
    • Bromouracil mutagenesis: Mispairing or misrepair?
    • Witkin, E.M. and Parisi, E.C. (1974) Bromouracil mutagenesis: mispairing or misrepair? Mutat. Res., 25, 407-409.
    • (1974) Mutat. Res. , vol.25 , pp. 407-409
    • Witkin, E.M.1    Parisi, E.C.2
  • 53
    • 0021365731 scopus 로고
    • Genetic effects of 5-azacytidine in Saccharomycex cerevisiae
    • Zimmermann, F.K. and Scheel, I. (1984) Genetic effects of 5-azacytidine in Saccharomycex cerevisiae. Mutat. Res., 139, 21-24.
    • (1984) Mutat. Res. , vol.139 , pp. 21-24
    • Zimmermann, F.K.1    Scheel, I.2


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