Differential effects of beta-carbolines and antidepressants on rat exploratory activity in the elevated zero-maze

Pharmacology Biochemistry and Behavior

Volumn 65, Issue 4, 2000, Pages 737-742

  Pähkla, Rein ^a   Kask, Ants ^a   Rägo, Lembit ^a  

^a UNIVERSITY OF TARTU   (Estonia)

Author keywords

Antidepressants; Beta carbolines; Elevated zero maze; Exploratory activity

Indexed keywords

6 METHOXYTRYPTOLINE; BETA CARBOLINE; DESIPRAMINE; FLUOXETINE;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG EFFECT; EXPLORATORY BEHAVIOR; LATENT PERIOD; LOCOMOTION; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT; TRANQUILIZING ACTIVITY;

ANIMALS; ANTICONVULSANTS; ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CARBOLINES; CONVULSANTS; DESIPRAMINE; EXPLORATORY BEHAVIOR; FLUOXETINE; MALE; MOTOR ACTIVITY; RATS; RATS, WISTAR;

EID: 0343294315     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(99)00265-8     Document Type: Article

References (22)

1. Airaksinen M.M., Ho B.T., An R., Taylor D. Major pharmacological effects of 6-methoxytetrahydro-β-carboline, a drug elevating the tissue 5-hydroxytryptamine level. Arzneimittelforschung/Drug Res. 28:1978;42-46.
2. Airaksinen M.M., Mikkonen E. Affinity of β-carbolines on rat brain benzodiazepine and opiate receptors. Med. Biol. 58:1980;341-344.
3. Bickerdike M.J., Marsden C.A., Dourish C.T., Fletcher A. The influence of 5-hydroxytryptamine re-uptake blockade on CCK receptor antagonist effects in the rat elevated zero-maze. Eur. J. Pharmacol. 271:1994;403-411.
4. Buckholtz N.S. Anticonvulsant effects of 6-methoxy-1,2,3,4-tetrahydro-β-carboline on audiogenic and electroconvulsive seizures in mice. Pharmacol. Biochem. Behav. 3:1975;65-68.
5. Callaway J.C., Gynther J., Poso A., Vepsalainen J., Airaksinen M.M. The Pictet-Spengler reaction and biogenic tryptamines. Formation of tetrahydro-β-carbolines at physiological pH J. Heterocyclic Chem. 31:1994;431-435.
6. Dawson G.R., Tricklebank M.D. Use of the elevated plus-maze in the search for novel anxiolytic agents. Trends Pharmacol. Sci. 16:1995;33-36.
7. Fernandez de Arriba A., Lizcano J.M., Balsa M.D., Unzeta M. Inhibition of monoamine oxidase from bovine retina by β-carbolines. J. Pharm. Pharmacol. 46:1994;809-813.
8. Handley S.L., McBlane J.W., Critchley M.A.E., Njung'e K. Multiple serotonin mechanisms in animal model of anxiety. Environmental, emotional and cognitive factors Brain Res. 58:1993;203-210.
9. Hardeland R., Reiter R.J., Poeggler B., Tan D.-X. The significance of metabolism of the neurohormone melatonin. Antioxidative protection and formation of bioactive substances Neurosci. Biobehav. Rev. 17:1993;347-357.
10. Hyttel J., Arnt J., Sánchez C. The pharmacology of citalopram. Rev. Contemp. Pharmacother. 6:1995;271-285.
11. Komulainen H., Tuomisto J., Airaksinen M.M., Kari I., Peura P., Pollari L. In vitro inhibition of serotonin, dopamine and noradrenaline uptake in rat brain synaptosomes. Acta Pharmacol. Toxicol. 46:1980;299-307.
12. 3H]imipramine recognition site. Eur. J. Pharmacol. 98:1984;153-154.
13. Matto V., Harro J., Allikmets L. The effects of cholecystokinin A and B receptor antagonists on exploratory behaviour in the elevated zero-maze in rat. Neuropharmacology. 36:1997;389-396.
14. Myers R.D. Anatomical "circuitry" in the brain mediating alcohol drinking revealed by THP-reactive sites in the limbic system. Alcohol. 7:1990;449-459.
15. Pähkla R., Harro J., Rägo L. Behavioural effects of pinoline in the rat forced swimming, open field and elevated plus-maze tests. Pharmacol. Res. 34:1996;73-78.
16. Pähkla R., Rägo L. Pinoline. Formation, distribution and effects Watson R.R. Melatonin in health promotion. 1999;163-173 CRC Press, Boca Raton, FL.
17. 3H]citalopram Pharmacol. Toxicol. 80:1997;122-126.
18. Pellow S., Chopin P., File S.E., Briley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods. 14:1985;149-167.
19. Saano V., Airaksinen M.M. Binding of β-carbolines and caffeine on benzodiazepine receptors. Correlations to convulsions and tremor Acta Pharmacol. Toxicol. 51:1982;300-308.
20. 3H]imipramine recognition sites in human platelets. J. Neurochem. 45:1985;249-256.
21. Shepherd J.K., Grewal S.S., Fletcher A., Bill D.J., Dourish C.T. Behavioural and pharmacological characterisation of the elevated "zero-maze" as an animal model of anxiety. Psychopharmacology (Berlin). 116:1994;56-64.
22. Spies C.D., Rommelspacher H., Winkler T., Muller C., Brummer G., Funk S., Specht M., Hannemann L., Schaffartzik W. Beta-carbolines in chronic alcoholics following trauma. Addict. Biol. 1:1996;93-103.