Does the mechanism responsible for TNF-mediated insulin resistance involve the proteasome?

Medical Hypotheses

Volumn 54, Issue 4, 2000, Pages 565-569

  Pallares Trujillo J ^a   Carbo N ^a   Lopez Soriano F J ^a   Argiles J M ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLUCOSE; INSULIN; INSULIN RECEPTOR; PROTEASOME; PROTEIN TYROSINE KINASE; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN;

ADIPOCYTE; ENZYME ACTIVITY; HUMAN; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW;

EID: 0343238950     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.1999.0895     Document Type: Article

References (45)

1. Björntorp P. Metabolic implications of body fat distribution. Diabetes Care. 14:1991;1132-1143.
2. Frayn K. N., Coppack S. W. Insulin resistance, adipose tissue and coronary heart disease. Clin Sci. 82:1992;1-8.
3. Hotamisligil G. S., Shargill N. S., Spiegelman B. M. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science. 259:1993;87-91.
4. Hotamisligil G. S., Murray D. L., Choy I. N., Spiegelman B. M. Tumor necrosis factor α inhibits signaling from the insulin receptor. Proc Natl Acad Sci USA. 91:1994;4854-4858.
5. Kern P. A., Saghizadeh M., Ong J. M., Bosch R. J., Deem R., Simsolo R. B. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest. 95:1995;2111-2119.
6. Rayfield E. J., Ault M. J., Keusch G. T., Brothers M. J., Nechemias C., Smith H. Infection and diabetes: the case for glucose control. Am J Med. 72:1982;439-450.
7. Lang C. H., Dobrescu C. Sepsis-induced changes in in vivo insulin action in diabetic rats. Am J Physiol. 257:1989;E301-E308.
8. Lang C. H., Dobrescu C., Bagby G. J. Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology. 130:1992;43-52.
9. Van der Poll T., Romijnm A., Endert E., Borm J. J.J., Buller H. R., Sauerwein H. P. Tumor necrosis factor mimics the metabolic response to acute infection in healthy humans. Am J Physiol. 261:1991;E457-E465.
10. Donner C. C., Fraze E., Chen Y. D. Y., Reaven G. M. Quantitation of insulin-stimulated glucose disposal in patients with non-insulin-dependent diabetes mellitus. Diabetes. 34:1985;831-835.
11. Taylor R., Agius L. The biochemistry of diabetes. Biochem J. 250:1988;625-640.
12. Leahy J. L. Natural history of β-cell dysfunction in NIDDM. Diabetes Care. 13:1990;992-1010.
13. De Fronzo R. A., Gunnarson R., Bjorkman O., Olsson M., Wahren J. Effects of insulin on peripheral and splanchnic glucose metabolism in non-insulin-dependent (type II) diabetes mellitus. J Clin Invest. 76:1985;149-155.
14. Hotamisligil G. S., Arner P., Caro J. F., Atkinson R. L., Spiegelman B. M. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J Clin Invest. 95:1995;2409-2415.
15. Arner P. Obesity and insulin resistance in Swedish subjects. Diabet Metab. 13:1996;S85-S86.
16. Stephens J. M., Pekala P. H. Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-α J Biol Chem. 266:1991;21839-21845.
17. Pekala P., Kawakami W., Angus C. W., Lane A., Cerami A. Selective inhibition of synthesis for de novo fatty acid biosynthesis by an endotoxin-induced mediator from exudate cells. Proc Natl Acad Sci USA. 80:1983;2743-2747.
18. Spiegelman B. M., Hotamisligil G. S. Through thick and thin: wasting, obesity, and TNFα Cell. 73:1993;625-627.
19. Saghizadeh M., Ong J. M., Garvey W. T., Henry R. R., Kern P. A. The expression of TNF α by human muscle. Relationship to insulin resistance. J Clin Invest. 97:1996;1111-1116.
20. Hofmann C., Lorenz K., Braithwaite S. S. Altered gene expression for tumor necrosis factor-α and its receptors during drug and dietary modulation of insulin resistance. Endocrinology. 134:1994;264-270.
21. Hotamisligil G. S., Peraldi P., Budavari A., Ellis R., White M. F., Spiegelman B. M. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance. Science. 271:1996;665-668.
22. Dice J. F. Molecular determinants of protein half-lives in eukariotic cells. FASEB J. 1:1987;349-356.
23. Riley D. A., Bain J. L. W., Ellis S., Haas A. L. Quantitation and immunocytochemical localization of ubiquitin conjugates within rat red and white skeletal muscles. J Histochem Cytochem. 36:1988;621-632.
24. Goldstein G., Scheid M., Hammerling U., Boyse E. A., Schlesinger D. H., Niall H. D. Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells. Proc Natl Acad Sci USA. 72:1975;11-15.
25. Hershko A. Ubiquitin mediated protein degradation. J Biol Chem. 263:1988;15237-15240.
26. Orlowsky M. The multicatalytic protease complex, a major extralysosomal proteolytic system. Biochemistry. 29:1990;10289-10297.
27. Argilés J. M., López-Soriano F. J. The ubiquitin-dependent proteolytic pathway in skeletal muscle: its role in pathological states. Trends Pharmacol Sci. 17:1996;223-226.
28. Palombella V. J., Rando O. J., Goldberg A. L., Maniatis T. The ubiquitin-proteasome pathway is required for processing the NF-kappaB1 precursor protein and the activation of NK-kappaB. Cell. 78:1994;773-785.
29. Heemels M. T., Ploegh H. Generation, translocation and presentation of MHC classI-restricted peptides. Annu Rev Biochem. 64:1995;463-491.
30. Hilenski L. L., Terracio L., Haas A. L., Borg T. K. Immunolocalization of ubiquitin conjugates at Z-bands and intercalated discs of rat cardiomyocytes in vitro and in vivo. J Histochem Cytochem. 40:1992;1037-1042.
31. Costelli P., Carbó N., Tessitore L. Tumour necrosis factor-α mediates changes in muscle protein turnover in a cachectic rat tumour model. J Clin Invest. 92:1993;2783-2789.
32. 2-adrenergic agonist (clenbuterol). J Clin Invest. 95:1995;2367-2372.
33. Llovera M., López-Soriano F. J., Argilés J. M. Effects of tumor necrosis factor-α on muscle protein turnover in female Wistar rats. J Natl Cancer Inst. 85:1993;1334-1339.
34. Llovera M., García-Martínez C., Agell N., Marzábal M., López-Soriano F. J., Argilés J. M. Ubiquitin gene expression is increased in skeletal muscle of tumour-bearing rats. FEBS Lett. 338:1994;311-318.
35. Llovera M., García-Martínez C., Agell N., López-Soriano F. J., Argilés J. M. Muscle wasting associated with cancer cachexia is linked to an important activation of the ATP-dependent ubiquitin-mediated proteolysis. Int J Cancer. 61:1995;138-141.
36. García-Martínez C., Llovera M., Agell N., López-Soriano F. J., Argilés J. M. Ubiquitin gene expression in skeletal muscle is increased by tumour necrosis factor-α Biochem Biophys Res Commun. 201:1994;682-686.
37. García-Martínez C., Llovera M., Agell N., López-Soriano F. J., Argilés J. M. Ubiquitin gene expression in skeletal muscle is increased during sepsis. Involvement of TNF but not IL-1. Biochem Biophys Res Commun. 217:1996;839-844.
38. Carbó N., Llovera M., García-Martínez C. Anti-TNF treatment reverts increased muscle ubiquitin gene expression in tumour-bearing rats. Biochem Biophys Res Commun. 221:1996;653-655.
39. García-Martínez C., Agell N., Llovera M., López-Soriano F. J., Argilés J. M. Tumour necrosis factor-α increases the ubiquitinization of rat skeletal muscle proteins. FEBS Lett. 323:1993;211-214.
40. Llovera M., García-Martínez C., Agell N., López-Soriano F. J., Argilés J. M. TNF can directly induce the expression of ubiquitin-dependent proteolysis in rat soleus muscles. Biochem Biophys Res Commun. 230:1997;238-241.
41. Sharma H. S., Stahl J., Weisensee D., Low-Friedrich I. Cytoprotective mechanisms in cultured cardiomyocytes. Mol Cell Biochem. 160:1996;217-224.
42. Tsurmi C., Shimizu Y., Saeki M. cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11. Eur J Biochem. 239:1996;912-921.
43. Mori S., Claesson-Welsh L., Okuyama Y., Saito Y. Ligand-induced polyubiquitinization of receptor tyrosine kinases. Biochem Biophys Res Commun. 213:1995;32-39.
44. Uehara Y., Murakami Y., Sugimoto Y., Mizuno S. Mechanisms of reversion of Rous sarcoma virus transformation by herbimycin A: reduction of total phosphotyrosine levels due to reduced kinase activity and increased turnover of p60v-src1. Cancer Res. 49:1989;780-785.
45. Sepp-Lorenzino L., Ma Z., Lewwohl D. E., Vinitsky A., Rosen N. Herbimycin A induces the 20S proteasome- and ubiquitin-dependent degradation of receptor tyrosine kinases. J Biol Chem. 270:1995;16580-16587.