Cyclosporin A affects axons and macrophages during Wallerian degeneration

Journal of Neurotrauma

Volumn 17, Issue 5, 2000, Pages 431-440

  Taskinen, Hanna Stiina ^a   Röyttä, Matias ^a,b  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Axonal degeneration; Cyclosporin A; Macrophages; Peripheral nerve; T cells

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYCLOSPORIN A; INTERLEUKIN 2 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; IMMUNOSUPPRESSIVE TREATMENT; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; NERVE DEGENERATION; NERVE FIBER DEGENERATION; NERVE INJURY; NERVE SPROUTING; NONHUMAN; PHAGOCYTOSIS; RAT; T LYMPHOCYTE;

EID: 0343091303     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2000.17.431     Document Type: Article

References (28)

1. ANSSELIN, A.D., and POLLARD, J.D. (1990). Immunopathological factors in peripheral nerve allograft rejection: quantification of lymphocyte invasion and major histocompatibility complex expression. J. Neurosci. Sci. 96, 75-88.
2. BAIN, J.R., MACKINNON, S.E., HUDSON, A.R., FALK, R.E., FALK, J.A., and HUNTER, D.A. (1988a). The peripheral nerve allograft: an assessment of regeneration across nerve allografts in rats immunosuppressed with cyclosporin A. Plast. Reconstr. Surg. 82, 1052-1066.
3. BAIN, J.R., MACKINNON, S.E., HUDSON, A.R., FALK, R.E., FALK, J.A., and HUNTER, D.A. (1988b). The peripheral nerve allograft: a dose-response curve in the rat immunosuppressed with cyclosporin A. Plast. Reconstr. Surg. 82, 447-457.
4. BEUCHE, W., and FRIEDE, R.L. (1984). The role of non-resident cells in Wallerian degeneration. J. Neurocytol. 13, 767-796.
5. BROWN, M.C., PERRY, V.H., LUNN, E.R., GORDON, S., and HEUMANN, R. (1991). Macrophage dependence of peripheral sensory nerve regeneration: possible involvement of nerve growth factor. Neuron 6, 359-370.
6. BROWN, M.C., LUNN, E.R., and PERRY, V.H. (1992). Consequences of slow Wallerian degeneration for regenerating motor and sensory axons. J. Neurobiol. 23, 521-536.
7. BRUCK, W., BRUCK, Y., MARUSCHAK, B., and FRIEDE, R. (1994). Macrophage properties during peripheral nervous tissue rejection in vitro. J. Neuropathol. Exp. Neurol. 53, 51-60.
8. DI PADOVA, F.E. (1989). Pharmacology of cyclosporine (Sandimmune). V. Pharmacological effects on immune function: in vitro studies. Pharmacol. Rev. 41, 373-405.
9. CREANGE, A., BARLOWATZ-MEIMON, G., and GHERARDI, R.K. (1997). Cytokines and peripheral nerve disorders. Eur. Cytokine Netw. 8, 145-151.
10. GLASS, J.D., SCHRYER, B.L., and GRIFFIN, J.W. (1994). Calcium-mediated degeneration of the axonal cytoskeleton in the Ola mouse. J. Neurochem. 62, 2472-2475.
11. GOTO, S., MATSUKADO, Y., MIHARA, Y., INOUE, N., and MIYAMOTO, E. (1986). The distribution of calcineurin in rat brain by light and electron microscopic immunohistochemistry and enzyme-immunoassay. Brain Res. 397, 161-172.
12. ISHIDA, O., OCHI, M., MIYAMOTO, Y., IKUTA, Y., and AKIYAMA, M. (1989). Suppression by cyclosporine of cellular and humoral reactivity after peripheral nerve allografts in mice. Transplantation 48, 824-829.
13. LASSNER, F., SCHALLER, E., STEINHOFF, G., WONIGEIT, K., WALTER, G.F., and BERGER, A. (1989). Cellular mechanism of rejection and regeneration in peripheral nerve allografts. Transplantation 48, 386-392.
14. LOSA GARCIA, J.E., MATEOS RODRIGUEZ, F., JIMENEZ LOPEZ, A., and PEREZ ARELLANO, J.L. (1996). Action of cyclosporin A on mononuclear phagocytes. Invest. Allerg. Clin. Immunol. 6, 222-231.
15. MONACO, S., GEHRMANN, J., RAIVICH, G., and KREUTZBERG, G.W. (1992). MHC-positive, ramified macrophages in the normal and injured rat peripheral nervous system. J. Neurocytol. 21, 623-634.
16. NEMLANDER, A., AHONEN, J., WIKTOROWICZ, K., et al. (1983). Effect of cyclosporin on wound healing. Transplantation 36, 1-6.
17. OLSSON, T., KRISTENSSON, K., LJUNGDAHL, A., MAEHLEN, J., HOLMDAHL, R., and KLARESKOG, L. (1989). Gamma-interferon-like immunoreactivity in axotomized rat motor neurons. J. Neurosci. 9, 3870-3875.
18. PANT, H.C. (1988). Dephosphorylation of neurofilament protein enhances their susceptibility to degradation by calpain. Biochem. J. 256, 665-668.
19. PERRY, V.H., BROWN, M.C., and GORDON, S. (1987). The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration. J. Exp. Med. 165, 1218-1223.
20. SCHLAEPFER, W.W., LEE, C., TROJANOWSKI, J.Q., and LEE, V.M.Y. (1984). Persistence of immunoreactive neurofilament protein breakdown products in transected rat sciatic nerve. J. Neurochem. 43, 857-864.
21. STEINER, J.P., DAWSON, T.M., and FOTUHI, M., et al. (1992). High brain densities of the immunophilin FKBP colocalized with calcineurin. Nature 358, 584-586.
22. STOLL, G., GRIFFIN, J.W., LI, C.Y., and TRAPP, B.D. (1989). Wallerian degeneration in the peripheral nervous system: participation of both Schwann cells and macrophages in myelin degradation. J. Neurocytol. 18, 671-683.
23. SUNIO, A., and BITTNER, G.D. (1997). Cyclosporin A retards the Wallerian degeneration of peripheral mammalian axons. Exp. Neurol. 146, 46-56.
24. TANAKA, K., ZHANG, Q.L., and WEBSTER, H.D. (1992). Myelinated fiber regeneration after sciatic nerve crush: morphometric observations in young adult and aging mice and the effects of macrophage suppression and conditioning lesions. Exp. Neurol. 118, 53-61.
25. TASKINEN, H.S., and RÖYTTÄ, M. (1997). The dynamics of macrophage recruitment after nerve transection. Acta Neuropathol. 93, 252-259.
26. TASKINEN, H.S., OLSSON, T., BUCHT, A., KHADEMI, M., SVELANDER, L., and RÖYTTÄ, M. (2000). Peripheral nerve injury induces endoneurial expression of IFN-γ, IL-10 and TNF-α mRNA. J. Neuroimmunol. 102, 17-25.
27. THOMSON, A.W. (1992). The effects of cyclosporin A on non-T cell component of the immune system. J. Autoimmun. 5, 167-176.
28. WANG, M.S., ZELENY-POOLEY, M., and GOLD, B.G. (1997). Comparative dose-dependence study of FK 506 and cyclosporin A on the rate of axonal regeneration in rat sciatic nerve. J. Pharmacol. Exp. Ther. 282, 1084-1093.