Transcriptional regulation in endoderm development: Characterization of an enhancer controlling Hnf3g expression by transgenesis and targeted mutagenesis

EMBO Journal

Volumn 16, Issue 13, 1997, Pages 3995-4006

  Hiemisch, Holger ^a   Schütz, Günther ^a   Kaestner, Klaus H ^b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

DNase I hypersensitivity; Gene expression; HNF 1; HNF 3; YAC transgenic mice

Indexed keywords

BETA GALACTOSIDASE; DEOXYRIBONUCLEASE I; HEPATIC NUCLEAR FACTOR 3G; NUCLEAR FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CHROMATIN; CONTROLLED STUDY; DNA FLANKING REGION; EMBRYO; EMBRYO DEVELOPMENT; ENDODERM; ENHANCER REGION; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCUS; GENE TARGETING; INTESTINE; LIVER; MOUSE; MULTIGENE FAMILY; MUTAGENESIS; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROTEIN DNA BINDING; REPORTER GENE; SMALL INTESTINE; STOMACH; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION; TRANSGENE; YEAST ARTIFICIAL CHROMOSOME;

ANIMALS; BASE SEQUENCE; BINDING SITES; CHROMOSOMES, ARTIFICIAL, YEAST; CLONING, MOLECULAR; DEOXYRIBONUCLEASE I; DNA-BINDING PROTEINS; ENDODERM; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; HEPATOCYTE NUCLEAR FACTOR 1; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HEPATOCYTE NUCLEAR FACTOR 1-BETA; HEPATOCYTE NUCLEAR FACTOR 3-GAMMA; INTESTINE, SMALL; LIVER; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NUCLEAR PROTEINS; PANCREAS; RATS; SEQUENCE DELETION; STOMACH; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0343051878     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.13.3995     Document Type: Article

References (50)

1. Adolph, E.A., Subramaniam, A., Cserjesi, P., Olson, E.N. and Robbins, J. (1993) Role of myocyte-specific enhancer-binding factor (MEF-2) in transcriptional regulation of the alpha-cardiac myosin heavy chain gene. J. Biol. Chem., 268, 5349-5352.
2. Ang, S.L. and Rossant, J. (1994) HNF-3 beta is essential for node and notochord formation in mouse development. Cell, 78, 561-574.
3. Ang, S.L., Wierda, A., Wong, D., Stevens, K.A., Cascio, S., Rossant, J. and Zaret, K.S. (1993) The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development, 119, 1301-1315.
4. Avraham, K.B., Prezioso, V.R., Chen, W.S., Lai, E., Sladek, F.M., Zhong, W., Darnell, J.J., Jenkins, N.A. and Copeland, N.G. (1992) Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3 alpha. HNF-3 beta. HNF-3 gamma, and HNF-4. Genomics, 13, 264-268.
5. Becker, P., Renkawitz, R. and Schütz, G. (1984) Tissue-specific DNase I hypersensitive sites in the 5′-flanking sequences of the tryptophan oxygenase and the tyrosine aminotransferase genes. EMBO J., 3, 2015-2020.
6. Bonifer, C., Yannoutsos, N., Kruger, G., Grosveld, F. and Sippel, A.E. (1994) Dissection of the locus control function located on the chicken lysozyme gene domain in transgenic mice. Nucleic Acids Res., 22, 4202-4210.
7. Boshart, M., Weih, F., Schmidt, A., Fournier, R.E. and Schutz, G. (1990) A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1. Cell, 61, 905-916.
8. Boshart, M., Klüppel, M., Schmidt, A., Schutz, G. and Luckow, B. (1992) Reporter constructs with low background activity utilizing the cat gene. Gene, 110, 129-130.
9. Cereghini, S. (1996) Liver-enriched transcription factors and hepatocyte differentiation. FASEB J., 10, 267-282.
10. Chen, C. and Okayama, H. (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol., 7, 2745-2752.
11. Chen, W.S., Manova, K., Weinstein, D.C., Duncan, S.A., Plump, A.S., Prezioso, V.R., Bachvarova, R.F. and Darnell, J.E., Jr (1994) Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes. Dev., 8, 2466-2477.
12. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation. Anal. Biochem., 162, 156-159.
13. Chouard, T., Blumenfeld, M. Bach, I., Vandekerckhove, J., Cereghini, S. and Yaniv, M. (1990) A distal dimerization domain is essential for DNA-binding by the atypical HNF1 homeodomain. Nucleic Acids Res., 18, 5853-5863.
14. Dillon, N. and Grosveld, F. (1993) Transcriptional regulation of multigene loci: multilevel control. Trends Genet., 9, 134-137.
15. Duncan, S.A., Manova, K., Chen, W.S., Hoodless, P., Weinstein, D.C., Bachvarova, R.F. and Darnell, J.E., Jr (1994) Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc. Natl Acad. Sci. USA, 91, 7598-7602.
16. Ess, K.C. Whiraker, T.L., Cost, G.J., Witte, D.P., Hutton, J.J. and Aronow, B.J. (1995) A central role for a single c-Myb binding site in a thymic locus control region. Mol. Cell. Biol., 15, 5707-5715.
17. Gualdi, R., Bossard, P., Zheng, M., Hamada, Y., Coleman, J.R. and Zaret, K.S. (1996) Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control. Genes Dev., 10, 1670-1682.
18. Guy, L.G., Kothary, R., DeRepentigny, Y., Delvoye, N., Ellis, J. and Wall, L. (1996) The β-globin locus control region enhances transcription but does not confer position-independent expression onto the lacZ gene in transgenic mice. EMBO J., 15, 3713-3721.
19. Hogan, B., Constantini, F. and Lacy, E. (1994) Manipulating the Mouse Embryo. 2nd Edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
20. Hugerat, Y., Spencer, F., Zenvirth, D. and Simchen, G. (1994) A versatile method for efficient YAC transfer between any two strains. Genomics. 22, 108-117.
21. Huxley, C. Hagino, Y., Schlessinger, D. and Olson, M.V. (1991) The human HPRT gene on a yeast artificial chromosome is functional when transferred to mouse cells by cell fusion. Genomics, 9, 742-750.
22. Jantzen, H.M., Strähle, U., Gloss, B., Stewart, F., Schmid, W., Boshart, M., Miksicek, R. and Schütz, G. (1987) Cooperatively of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene. Cell, 49, 29-38.
23. Kaestner, K.H., Hiemisch, H., Luckow, B. and Schütz, G. (1994) The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution. Genomics, 20, 377-385.
24. Killary, A.M. and Fournier, R.E. (1984) A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells. Cell, 38, 523-534.
25. Killary, A.M., Lugo, T.G. and Fournier, R.E. (1984) Isolation of thymidine kinase-deficient rat hepatoma cells by selection with bromodeoxyuridine. Hoechst 33258, and visible light, Biochem. Genet., 22, 201-213.
26. Kuo, C.J., Conley, P.B., Chen, L., Sladek, F.M., Damell, J.J. and Crabtree, G.R. (1992) A transcriptional hierarchy involved in mammalian cell-type specification. Nature, 355, 457-461.
27. Lamb, B.T. and Gearhart, J.D. (1995) YAC transgenics and the study of genetics and human disease. Cure Opin. Genet. Dev., 5, 342-348.
28. McPherson, C.E., Shim, E.Y. Friedman, D.S. and Zaret, K.S. (1993) An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array. Cell, 75, 387-398.
29. Millonig, J.H., Emerson, J.A., Levorse, J.M. and Tilghman, S.M. (1995) Molecular analysis of the distal enhancer of the mouse alpha-fetoprotein gene. Mol. Cell. Biol., 15, 3848-3856.
30. Monaghan, A.R. Kaestner, K.H., Grau, E. and Schütz, G. (1993) Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development, 119, 567-578.
31. Montoliu, L., Blendy, J.A., Cole, T.J. and Schütz, G. (1995) Analysis of perinatal gene expression: hormone response elements mediate activation of a lacZ reporter gene in liver of transgenic mice. Proc. Natl Acad. Sci. USA, 92, 4244-4248.
32. Neumann, J.R., Morency, C.A. and Russian, K.O. (1987) A novel rapid assay for chloramphenicol acetyltransferase gene expression. BioTechniques, 5, 444-447.
33. Nitsch, D., Boshart, M. and Schütz, G. (1993) Extinction of tyrosine aminotransferase gene activity in somatic cell hybrids involves modification and loss of several essential transcriptional activators. Genes Dev., 7, 308-319.
34. Ott, M.O., Rey, C.J., Cereghini, S. and Yaniv, M. (1991) vHNF1 is expressed in epithelial cells of distinct embryonic origin during development and precedes HNF1 expression. Mech. Dev., 36, 47-58.
35. Pontoglio, M., Barra, J., Hadchouel, M., Doyen, A., Kress, C., Bach, J.P., Babinet, C. and Yaniv, M. (1996) Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Cell, 84, 575-585.
36. Rey Campos, J., Chouard, T., Yaniv, M. and Cereghini, S. (1991) vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1. EMBO J., 10, 1445-1457.
37. Riley, J., Butler, R., Ogilvie, D., Finniear, R., Jenner, D., Powell, S., Anand, R., Smith, J.C. and Markham, A.F. (1990) A novel, rapid method for the isolation of terminal sequences from yeast artificial chromosome (YAC) clones. Nucleic Acids Res., 18, 2887-2890.
38. Robertson, G., Garrick, D., Wu, W., Kearns, M., Martin, D. and Whitelaw, E. (1995) Position-dependent variegation of globin transgene expression in mice. Proc. Natl Acad. Sci. USA, 92, 5371-5375.
39. Rossi, J.M., Burke, D.T. Leung, J.C. Koos, D.S., Chen, H. and Tilghman, S.M. (1992) Genomic analysis using a yeast artificial chromosome library with mouse DNA inserts. Proc. Natl Acad. Sci. USA, 89, 2456-2460.
40. Sasaki, H. and Hogan, B.L. (1993) Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development, 118, 47-59.
41. Schedl, A., Larin, Z., Montoliu, L., Thies, E., Kelsey, G., Lehrach, H. and Schütz, G. (1993) A method for the generation of YAC transgenic mice by pronuclear microinjection. Nucleic Acids Res., 21, 4783-4787.
42. Spencer, F., Hugerat, Y. Simchen, G., Hurko, O., Connelly, C. and Hieter, P. (1994) Yeast karl mutants provide an effective method for YAC transfer to new hosts. Genomics, 22, 118-126.
43. Srivastava, A.K. and Schlessinger, D. (1991) Vectors for inserting selectable markers in vector arms and human DNA inserts of yeast artificial chromosomes (YACs). Gene, 103, 53-59.
44. Taraviras, S., Monaghan, A.P. Schütz, G. and Kelsey, G. (1994) Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis. Mech. Dev., 48, 67-79.
45. Tian, J.M. and Schibler, U. (1991) Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4. Genes Dev., 5, 2225-2234.
46. Tronche, F., Bach, I., Chouard, T., David-Wattine, B., Pontoglio, M., Ringeisen, F., Sourdive, D., Thepot, D. and Yaniv, M. (1994) Hepatocyte nuclear factorl (HNF1) and liver gene expression. In Tronche, F. and Yaniv, M. (eds), Liver Gene Expression. R.G. Landes, Austin, TX, pp. 155-182.
47. Tronche, F., Ringeisen, F. Blumenfeld, M., Yaniv, M. and Pontoglio, M. (1997) Analysis of the distribution of binding sites for a tissue-specific transcription factor in the venebrate senome. J. Mol. Biol., 266, 231-245.
48. Weinstein, D.C., Ruiz, I.A.A., Chen, W.S., Hoodless, P., Prezioso, V.R., Jessell, T.M. and Darnell, J.J. (1994) The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell, 78, 575-588.
49. Winston, F. Chumley, F. and Fink, G.R. (1983) Eviction and transplacement of mutant genes in yeast. Methods Enzymol., 101, 211-228.
50. Zaret, K.S. (1996) Molecular genetics of early liver development. Annu. Rev. Physiol., 58, 231-251.