Secondary venous ischemic injury associated with neutrophil infiltration and lipid peroxidation: Amelioration of injury by cyclosporin A in a rat inguinal island flap

Annals of Plastic Surgery

Volumn 45, Issue 1, 2000, Pages 54-60

  Yücel, Akin ^a   Şenyuva, Cemal ^b   Andican, Gülnur ^b   Benlier, Erol ^b   Bolayirli, Murat ^b   Çetinkale, Oǧuz ^b   Gelişgen, Remisa ^b   Burçak, Gülden ^b  

^a NONE   (Turkey)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; MALONALDEHYDE; MYELOPEROXIDASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; GRAFT FAILURE; ISCHEMIA; ISLAND FLAP; LIPID PEROXIDATION; MALE; MICROVASCULAR SURGERY; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN FLAP SURVIVAL;

EID: 0342758481     PISSN: 01487043     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000637-200045010-00010     Document Type: Article

References (33)

1. Kerrigan CL, Daniel RK. Critical ischemia time and the failing skin flap. Plast Reconstr Surg 1982;69:986-989
2. Kerrigan CL, Zeit RG, Daniel RK. Secondary critical ischemia time of experimental skin flaps. Plast Reconstr Surg 1984;74:522-524
3. Angel MF, Narayanan K, Swartz WM, et al. The etiologic role of free radicals in hematoma induced flap necrosis. Plast Reconstr Surg 1986;77:795-803
4. Mellow CG, Knight KR, Angel MF, et al. The effect of thromboxane synthetase inhibition on tolerance of skin flaps to secondary ischemia caused by venous obstruction. Plast Reconstr Surg 1990;86:329-334
5. Angel MF, Mellow CG, Knight KR, et al. The effect of deferoxamine on tolerance to secondary ischaemia caused by venous obstruction. Br J Plast Surg 1989;42:422-424
6. Manson PN, Anthenelli RM, Im MJ, et al. The role of oxygen-free radicals in ischemic tissue injury in island skin flaps. Ann Surg 1983;198:87-90
7. Kerrigan CL, Wizman P, Hjortdal VE, et al. Global flap ischemia: a comparison of arterial versus venous etiology. Plast Reconstr Surg 1994;93:1485-1495
8. Heden P, Sollevi A. Circulatory and metabolic events in pig island skin flaps after arterial or venous occlusion. Plast Reconstr Surg 1989;84:475-481
9. Knight KR, Angel MF, Lepore DA, et al. Secondary ischaemia in rabbit skin flaps: the roles played by thromboxane and free radicals. Clin Sci 1991;80:235-240
10. May Jr JW, Chait LA, O'Brien BM, et al. The no-reflow phenomenon in experimental free flaps. Plast Reconstr Surg 1978;61:256-267
11. Zamboni WA, Roth AC, Russell RC, et al. Morphologic analysis of the microcirculation during reperfusion of ischemic skeletal muscle and the effect of hyperbaric oxygen. Plast Reconstr Surg 1993;91:1110-1123
12. Grant D, Duff J, Zhong R, et al. Successful intestinal transplantation in pigs treated with cyclosporine. Transplantation 1988;45:279-284
13. Yokota K, Takishima T, Sato K, et al. Comparative studies of FK506 and cyclosporine in canine orthotopic hepatic allograft survival. Transplant Proc 1989;21:1066-1068
14. Hayashi T, Nagasue N, Kohno H, et al. Beneficial effect of cyclosporine pre-treatment in preventing ischemic damage to the liver in dogs. Transplantation 1988;46:923-924
15. Goto S, Kim YI, Kamada N, et al. The beneficial effect of pretransplant cyclosporine therapy on recipient rats grafted with a 12-hour cold-stored liver. Transplantation 1990;49:1003-1005
16. Kawano K, Kim YI, Kaketani K, et al. The beneficial effect of cyclosporine on liver ischemia in rats. Transplantation 1989;48:759-764
17. Pigatto PD, Mozzanica N, Polenghi MM, et al. Cyclosporine A inhibits polymorphonuclear leukocyte chemotaxis in vivo. Transplant Proc 1988;20:91-94
18. Kubes P, Hunter J, Granger DN. Effects of cyclosporin A and FK506 on ischemia/reperfusion-induced neutrophil infiltration in the cat. Dig Dis Sci 1991;36:1469-1472
19. Goldin H, Keisari Y. The effect of cyclosporine on macrophage oxidative burst potential during graft-versus-host reactions in mice. Transplantation 1989;47:548-552
20. Kucukcelebi A, Ozcan M. The beneficial effect of cyclosporin-A on the no-reflow phenomenon in rat skin island flaps. Br J Plast Surg 1992;45:512-514
21. Shin MS, Angel MF, Im MJ, et al. Effects of 21-amino-steroid U74389F on skin-flap survival after secondary ischemia. Plast Reconstr Surg 1994;94:661-666
22. Lowry OH, Rosebrough NJ, Farr A, et al. Protein measurement with Folin phenol reagent. J Biol Chem 1951;193: 265-268
23. Tagesson C, Stendahl D, Magnusson KE, et al. Disintegration of single cells in suspension. Isolation of rabbit polymorphonuclear leucocyte granules. Acta Pathol Microbiol Immunol Scand (B) Microbiol Immunol 1973;81: 464-472
24. Willemart G, Knight KR, Morrison WA. Dexamethasone treatment prior to reperfusion improves the survival of skin flaps subjected to secondary venous ischaemia. Br J Plast Surg 1998;51:624-628
25. Asako H, Kubes P, Baethge BA, et al. Reduction of leukocyte adherence and emigration by cyclosporine and L683,590 (FK506) in postcapillary venules. Transplantation 1992;54:686-690
26. Vedder NB, Bucky LP, Richey NL, et al. Improved survival rates of random flaps in rabbits with a monoclonal antibody that blocks leukocyte adherence. Plast Reconstr Surg 1994;93:1035-1040
27. Çetinkale O, Ŝengul R, Bilgic L, et al. Involvement of neutrophils in ischemic injury. I. Biochemical and histopathological investigation of the effect of FK506 on dorsal skin flaps in rats. Ann Plast Surg 1997;39:505-515
28. Çetinkale O, Bilgic L, Bolayirh M, et al. Involvement of neutrophils in ischemia-reperfusion injury of inguinal island skin flaps in rats. Plast Reconstr Surg 1998;102:153-160
29. Ho VC, Griffiths CE, Ellis CN, et al. Intralesional cyclosporine in the treatment of psoriasis. A clinical, immunologic, and pharmacokinetic study. J Am Acad Dermatol 1990;22: 94-100
30. Belsito DV, Epstein SP, Schultz JM, et al. Enhancement by various cytokines or 2-beta-mercaptoethanol of Ia antigen expression on Langerhans cells in skin from normal aged and young mice. Effect of cyclosporine A. J Immunol 1989;143:1530-1536
31. Çetinkale O, Demir M, Sayman HB, et al. Effects of allopurinol, ibuprofen and cyclosporine-A on local microcirculatory disturbances due to the burn injuries. Burns 1997;23:43-49
32. Cetinkale O, Bilgic L, Ayan F, Kandilci A. Neutrophil mediated injury in ischemic skin flaps: amelioration of ischemic injury by cyclosporine in the rat. Ann Plast Surg 1996;37:66-74
33. Lundberg C, Arfors KE. Polymorphonuclear leukocyte accumulation in inflammatory dermal sites as measured by 51Cr-labeled cells and myeloperoxidase. Inflammation 1983;7:247-255