Inhibition of proliferation and induction of differentiation of osteoblastic cells by a novel 1,25-dihydroxyvitamin D3 analog with an extensively modified side chain (CB1093)

Journal of Cellular Biochemistry

Volumn 70, Issue 3, 1998, Pages 414-424

  Ryhänen, Sanna ^a   Jääskeläinen, Tiina ^a   Saarela, Janne T A ^a   Mäenpää, Pekka H ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Analog; Bone; Differentiation; Growth inhibition; Vitamin D

Indexed keywords

20 EPI 22 ETHOXY 24A,26A,27A TRIHOMO 9,10 SECOCHOLESTA 5,7,10(19) TRIEN 23 YNE 1ALPHA,3BETA,25 TRIOL; CALCITRIOL; CALCITRIOL DERIVATIVE; MESSENGER RNA; NUCLEAR PROTEIN; OSTEOCALCIN; UNCLASSIFIED DRUG; VITAMIN D BINDING PROTEIN; VITAMIN D RECEPTOR;

ANIMAL CELL; ARTICLE; BONE GROWTH; CANCER INHIBITION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG STRUCTURE; ELECTROPHORETIC MOBILITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; OSTEOCLAST; OSTEOSARCOMA; PRIORITY JOURNAL; RAT; REPORTER GENE;

ANIMALS; BLOTTING, NORTHERN; CALCITRIOL; CELL DIFFERENTIATION; CELL DIVISION; GENE EXPRESSION REGULATION; HUMANS; MODELS, MOLECULAR; OSTEOBLASTS; OSTEOCALCIN; OSTEOSARCOMA; PROMOTER REGIONS (GENETICS); RADIOIMMUNOASSAY; RATS; RECEPTORS, CALCITRIOL; RECEPTORS, RETINOIC ACID; RECOMBINANT PROTEINS; RETINOID X RECEPTORS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 2642678407     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19980901)70:3<414::AID-JCB14>3.0.CO;2-K     Document Type: Article

References (38)

1. Allen MP, Tildesley DJ (1987): "Computer Simulation of Liquids." Clarendon Press: Oxford Science Publications.
2. 3 analogues on a glioma cell line. Cancer Lett 100:3-10.
3. Bikle DD (1992): Clinical counterpoint: vitamin D: New actions, new analogs, new therapeutic potential. Endocrinol Rev 13: 765-784.
4. 3 analogues: A novel class of potent regulators of cell growth and immune responses. Biochem Pharmacol 42:1569-1575.
5. Binderup L (1992): Immunological properties of vitamin D analogues and metabolites. Biochem Pharmacol 43:1885-1892.
6. Bouillon R, Okamura WH, Norman AW (1995): Structure-function relationships in the vitamin D endocrine system. Endocrine Rev 16:200-257.
7. Brooks BR, Bruccoleri RE, Olafson BD, States DJ, Swaminathan S, Karplus M (1983): CHARMM: A program for macromolecular energy, minimization, and dynamics calculations. J Comp Chem 4:187-217.
8. Brooks CL, Pettitt BM, Karplus M (1985): Structural and energetic effects of truncating long range interactions in ionic and polar fluids. J Chem Phys 83:5897-5908.
9. Carlberg C, Bendik I, Wyss A, Meier E, Sturzenbecker LJ, Grippo JF, Hunziker W (1993): Two nuclear signalling pathways for vitamin D. Nature 361:657-660.
10. Celeste AJ, Rosen V, Buecker JL, Kriz R, Wang EA, Wozney JM (1986): Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones. EMBO J 5:1885-1890.
11. Chomczynski P, Sacchi N (1987): Single-step method of RNA isolation by acid guanidinium thiosyanate-phenolchloroform extraction. Anal Biochem 162:156-159.
12. 3 is due to reduced catabolism and altered protein binding. Biochem Pharmacol 47:987-993.
13. 3 analogues: A novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines. Cancer Res 55:2822-2830.
14. 3 analogs and 9-cis retinoic acid. J Clin Invest 99: 349-360.
15. Ermer O (1976): Calculation of molecular properties using force fields. Applications in organic chemistry. Structure Bonding 27:161-211.
16. Hurst HC, Masson N, Jones NC, Lee KAW (1990): The cellular transcription factor CREB corresponds to activating transcription factor 47 (ATF-47) and forms complexes with a group of polypeptides related to ATF-43. Mol Cell Biol 10:6192-6203.
17. Jääskeläinen T, Pirskanen A, Ryhänen S, Palvimo JJ, DeLuca HF, and Mäenpää PH (1994): Functional interference between AP-1 and the vitamin D receptor on osteocalcin gene expression in human osteosarcoma cells. Eur J Biochem 224:11-20.
18. Kissmeyer A-M, Mathiasen IS, Latini S, Binderup L (1995): Pharmacokinetic studies of vitamin D analogues: Relationship to vitamin D binding protein (DBP). Endocrine 3:263-266.
19. Levitt M, Lifson SJ (1969): Refinement of protein conformations using a macromolecular energy minimization procedure. J Mol Biol 46:269-279.
20. 3 analogues and their 20-epi homologues with the vitamin D receptor. J Biol Chem 272:3336-3345.
21. 3-activated expression of the rat osteocalcin gene. Mol Cell Biol 13:5907-5917.
22. 3 on its receptor mRNA levels and osteocalcin synthesis in human osteosarcoma cells. Biochim Biophys Acta 1048:30-37.
23. 3 receptor-like macromolecule in rat osteogenic sarcoma cells. J Biol Chem 255:4414-4417.
24. 3-dependent interaction between the VDR AF-2 domain and SUG1. J Bone Miner Res 12(S1): S122.
25. Mørk Hansen C, Mäenpää PH (1997): EB 1089, a novel vitamin D analog with strong antiproliferative and differentiation-inducing effects on target cells. Biochem Pharmacol 53:1173-1179.
26. 3 correlates well with gene activation. J Cell Biochem 62:325-333.
27. Nordeen SK (1988): Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques 6:454-458.
28. Owen TA, Bortell R, Yocum SA, Smock SL, Zhang M, Abate C, Shalhoub V, Aronin N, Wright KL, van Wijnen AJ, Stein JL, Curran T, Lian JB, Stein GS (1990): Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription. Proc Natl Acad Sci USA 87:9990-9994.
29. Ozono K, Liao J, Kerner SA, Scott RA, Pike JW (1990): The vitamin D-responsive element in the human osteocalcin gene. Association with a nuclear proto-oncogene enhancer. J Biol Chem 265:21881-21888.
30. Pakkala I, Savli H, Knuutila S, Binderup L, Pakkala S (1997): CB 1093, a novel vitamin D analog; effects on differentiation and clonal growth on HL-60 and de novo leukemia cells. Leuk Res 21:321-326.
31. 3 are associated with enhanced activation of the vitamin D receptor. J Biol Chem 270:10551-10558.
32. 3 without increasing its affinity to the vitamin D receptor. J Cell Biochem 63:149-161.
33. 3 receptors: Structure and function in transcription. Annu Rev Nutr 11:189-216.
34. Reichel H, Koeffler HP, Norman AW (1989): The role of the vitamin D endocrine system in health and disease. N Engl J Med 320:980-991.
35. Ryhänen S, Mahonen A, Jääskeläinen T, Mäenpää PH (1996): Synthetic 20-epi analogs of calcitriol are potent inducers of target-gene activation in osteoblastic cells. Eur J Biochem 238:97-103.
36. 3 induces morphological and biochemical markers of apoptosis in MCF-7 breast cancer cells. J Steroid Biochem Mol Biol 58:367-376.
37. Suda T, Shinki T, Takahashi N (1990): The role of vitamin D in bone and intestinal cell differentiation. Annu Rev Nutr 10:195-211.
38. 3 analog KH 1060. Proc Natl Acad Sci USA 93:10685-10690.