Antibodies to lymphotoxin α (LTα) and LTβ recognize different glial cell types in the central nervous system

Journal of Neuroimmunology

Volumn 78, Issue 1-2, 1997, Pages 172-179

  Cannella, Barbara ^a   Dougas Sizing, Irene ^b   Benjamin, Christopher D ^b   Browning, Jeffrey L ^b   Raine, Cedric S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b BIOGEN   (United States)

Author keywords

Astrocytes; Central nervous system; Immunocytochemistry; Lymphotoxin; Multiple sclerosis; Oligodendrocytes

Indexed keywords

CYTOKINE; LYMPHOTOXIN; TUMOR NECROSIS FACTOR;

ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CELL TYPE; CENTRAL NERVOUS SYSTEM; DEMYELINATING DISEASE; EMBRYO DEVELOPMENT; GLIA CELL; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTIC INFILTRATION; MEMBRANE BINDING; MULTIPLE SCLEROSIS; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ASTROCYTES; CENTRAL NERVOUS SYSTEM; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOCYTES; LYMPHOTOXIN-ALPHA; LYMPHOTOXIN-BETA; MEMBRANE PROTEINS; MULTIPLE SCLEROSIS; NERVOUS SYSTEM DISEASES; NEUROGLIA; OLIGODENDROGLIA; REFERENCE VALUES;

EID: 0342618656     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00098-2     Document Type: Article

References (40)

1. Agarwal B.B., Natarajan K. Tumor necrosis factors: Developments during the last decade. Eur. Cytokine Netw. 7:1996;93-124.
2. Armitage R.J. Tumor necrosis factor receptor superfamily members and their ligands (Review). Currr. Opin. Immunol. 6:1994;407-413.
3. Beutler B., van Huffel C. Unraveling function in the TNF ligand and receptor families. Science. 264:1994;667-668.
4. Bonnetti, B., Raine, C.S., 1997. Multiple sclerosis: Oligodendrocytes display cell death-related molecules in situ but do not undergo apoptosis. Ann. Neurol., in press.
5. Brosnan C.F., Selmaj K., Raine C.S. Hypothesis: A role for tumor necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis. J. Neuroimmunol. 18:1988;87-94.
6. Browning J.L., Miatkowski K., Sizing I., Griffiths D., Zafari M., Benjamin C.D., Meier W., Mackay F. Signaling through the lymphotoxin beta receptor induces the death of some adenocarcinoma tumor lines. J. Exp. Med. 183:1996;867-878.
7. Browning J.L., Dougas I., Ngam-ek A., Bourdon P.R., Ehrenfels B.N., Miatkowski K., Zafari M., Yampaglia A.M., Lawton P., Meier W., Benjamin C.P., Hession C. Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors. J. Immunol. 154:1995;33-46.
8. Browning J.L., Ngam-ek A., Lawton P., DeMarinis R., Tizard R., Chow E.P., Hession C., O'Brine G.B., Foley S.F., Ware C.F. Lymphotoxin β, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell. 72:1993;847-856.
9. Chung I.Y., Benveniste E.N. Tumor necrosis factor alpha production by astrocytes: Induction by lipopolysaccharide, IFN-gamma and IL-1 beta. J. Immunol. 144:1990;2999-3007.
10. Crowe P.D., VanArsdale T.L., Walter B.N., Ware C.F., Hession C., Ehrenfels B., Browning J.L., Din W.S., Goodwin R.G., Smith C.A. A lymphotoxin-β-specific receptor. Science. 264:1994;707-710.
11. D'Souza S.D., Bonetti B., Balasingam V., Cashman N.R., Barker P.A., Troutt A.B., Raine C.S., Antel J.P. Multiple sclerosis: Fas signaling in oligodendrocyte cell death. J. Exp. Med. 184:1996;2361-2370.
12. Genain C.P., Roberts T., Davis R.L., Nguyen M.H., Uccelli A., Faulds D., Li Y., Hedgpeth J., Hauser S.L. Prevention of autoimmune demyelination in non-human primates by a c-AMP-specific phosphodiesterase inhibitor. Proc. Natl. Acad. Sci. USA. 92:1995;3601-3605.
13. Gijbels K., Galardy R.E., Steinman L. Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases. J. Clin. Invest. 94:1994;2177-2182.
14. Gogate N., Verma L., Zhou J.M., Milward E., Rusten R., O'Connor M., Kufta C., Kim J., Hudson L., Dubois-Dalcq M. Plasticity in the adult human oligodendrocyte lineage. J. Neurosci. 14:1994;4571-4587.
15. Grinspan J.B., Stern J.L., Franceschini B., Pleasure D. Trophic effects of basic fibroblast growth factor (bFGF) on differentiated oligodendroglia: A mechanism for regeneration of the oligodendroglial lineage. J. Neurosci. Res. 36:1993;672-680.
16. Hochman P.S., Majeau G.R., Mackay F., Browning J.L. Proinflammatory responses are efficiently induced by homotrimeric but not heterotrimeric lymphotoxin ligands. J. Inflamm. 46:1996;220-234.
17. Issazadeh S., Ljungdahl A., Hojeberg B., Mustafa M., Olsson T. Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: Dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor alpha and tumor necrosis factor beta. J. Neuroimmunol. 61:1995;205-212.
18. Kratz A., Campos-Neto A., Hanson M.S., Ruddle N.H. Chronic inflammation caused by lymphotoxin is lymphoid neogenesis. J. Exp. Med. 183:1996;1461-1472.
19. Lieberman A.P., Pitha P.M., Shin H.S., Shin M.L. Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc. Natl. Acad. Sci. USA. 86:1989;6348-6352.
20. Millet I., Ruddle N.H. Differential regulation of lymphotoxin (LT), lymphotoxin-beta (LT-beta) and TNF-alpha in murine T-cell clones activated through the TCR. J. Immunol. 152:1994;4336-4346.
21. McMorris F.A., McKinnon R.D. Regulation of oligodendrocyte development and CNS myelination by growth factors: Prospects for therapy of demyelinating disease. Brain Pathol. 6:1996;313-329.
22. Monastra G., Cross A., Bruni A., Raine C.S. Phosphatidylserine, a putative inhibitor of tumor necrosis factor, prevents autoimmune demyelination. Neurology. 43:1993;153-163.
23. Navikas V., He B., Link J., Haglund M., Soderstrom M., Fredrickson S., Ljungdahl A., Hojeberg B., Qiao J., Olsson T., Link H. Augmented expression of tumor necrosis factor-α and lymphotoxin in mononuclear cells in multiple sclerosis and optic neuritis. Brain. 119:1996;213-223.
24. Raine C.S. The Dale E. McFarlin memorial lecture: The immunology of the multiple sclerosis lesion. Ann. Neurol. 36:1994;561-572.
25. Rennert P.D., Browning J.L., Mebius R., Mackay F., Hochman P.S. Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs. J. Exp. Med. 184:1996;1999-2006.
26. Rieckman P., Albrecht M., Kitze B., Weber T., Tumani H., Broocks A., Luer W., Helwig A., Poser S. Tumor necrosis factor-alpha messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity. Ann. Neurol. 37:1995;82-88.
27. Robbins D.S., Shirazi Y., Drysdale B.E., Lieberman A., Shin H.S., Shin M.L. Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes. J. Immunol. 139:1987;2593-2597.
28. Ruddle N.H., Bergman C.M., McGrath M.L., Lingenheld E.G., Grunnet M.L., Padula S.J., Clark R.B. An antibody to lymphotoxin and tumor necrosis factor prevents experimental allergic encephalomyelitis. J. Exp. Med. 172:1990;1193-1200.
29. Ruddle N.H. Tumor necrosis factor (TNFα) and lymphotoxin (TNFβ) (Review). Curr. Opin. Immunol. 4:1992;327-332.
30. Selmaj K., Raine C.S. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann. Neurol. 23:1988;339-346.
31. Selmaj K., Farooq M., Norton W.T., Raine C.S., Brosnan C.F. Proliferation of astrocytes in vitro in response to cytokines. A primary role of tumor necrosis factor. J. Immunol. 144:1990;29-135.
32. Selmaj K., Raine C.S., Cannella B., Brosnan C.F. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J. Clin. Invest. 87:1991;949-954.
33. Selmaj K., Raine C.S., Cross A.H. Anti-tumor necrosis factor therapy abrogates autoimmune demyelination. Ann. Neurol. 30:1991;694-700.
34. Selmaj K., Raine C.S., Farooq M., Norton W.T., Brosnan C.F. Cytokine cytotoxicity against oligodendrocytes: Apoptosis induced by lymphotoxin. J. Immunol. 147:1991;1522-1529.
35. Sharief M.K., Hentzen R. Association between tumor necrosis factor-α and disease progression in multiple sclerosis. New Engl. J. Med. 325:1991;467-472.
36. Sommer N., Loschmann P.A., Northoff G.H., Weller M., Steinbrecher A., Steinbach J.P., Lichtenfels R., Meyermann R., Riethmuller A., Fontana A., Dichgans J., Martin R. The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis. Nature Med. 1:1995;244-248.
37. Ulvestad E., Williams K., Mork S., Antel J., Nyland H. Phenotypic differences between human monocytes/macrophages and microglial cells studied in situ and in vitro. J. Neuropathol. Exp. Neurol. 53:1994;492-501.
38. Tsukada N., Miyagi K., Matsuda M., Yanagisawa N., Yone K. Tumor necrosis factor and interleukin-1 in CSF and sera of patients with multiple sclerosis. J. Neurol. Sci. 102:1991;230-234.
39. Ware C.F., VanArsdale T.L., Crowe P.D., Browning J.L. The ligands and receptors of the lymphotoxin system (Review). Curr. Top. Microbiol. Immunol. 198:1995;175-218.
40. Wilt S.G., Milward E., Zhou J.M., Nagasato K., Patton H., Griffin D.E., O'Connor M., Dubois-Dalcq M. In vitro evidence for a dual role of tumor necrosis-α in human immunodeficiency virus type-1 encephalopathy. Ann. Neurol. 37:1995;381-394.