Signaling through the lymphotoxin β receptor induces the death of some adenocarcinoma tumor lines

Journal of Experimental Medicine

Volumn 183, Issue 3, 1996, Pages 867-878

  Browning, Jeffrey L ^a   Miatkowski, Konrad ^a   Sizing, Irene ^a   Griffiths, David ^a   Zafari, Mohammad ^a   Benjamin, Christopher D ^a   Meier, Werner ^a   Mackay, Fabienne ^a  

^a BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOTOXIN;

ADENOCARCINOMA; ARTICLE; CELL DEATH; COMPLEX FORMATION; CYTOLYSIS; GROWTH INHIBITION; IMMUNE RESPONSE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RECEPTOR BINDING; TUMOR CELL; TUMOR GROWTH;

ADENOCARCINOMA; ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; CELL DEATH; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLOW CYTOMETRY; HUMANS; INTERFERON-GAMMA, RECOMBINANT; KINETICS; LYMPHOTOXIN BETA RECEPTOR; LYMPHOTOXIN-ALPHA; MICE; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0030006198     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.3.867     Document Type: Article

References (68)

1. Smith, C.A., T. Farrah, and R.G. Goodwin. 1994. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell. 76:959-962.
2. Beyaert, R., and W. Fiers. 1994. Molecular mechanisms of tumour necrosis factor-induced cytotoxicity. FEBS (Fed. Eur. Biochem. Soc.) Lett. 340:9-16.
3. Fiers, W. 1991. Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level. FEBS (Fed. Eur. Biochem. Soc.) Lett. 285:199-212.
4. Tracey, K.J., and A. Cerami. 1993. Tumor necrosis factor, other cytokines and disease. Annu. Rev. Cell Biol. 9:317-343.
5. Tartaglia, L.A., D.V. Goeddel, C. Reynolds, I.S. Figari, R.F. Weber, B.M. Fendly, and M.A. Palladino, Jr. 1993. Stimulation of human T-cell proliferation by specific activation of the 75-kDa tumor necrosis factor receptor. J. Immunol. 151: 4637-4641.
6. Pimentel-Muinos, F.X., J. Mazana, and M. Fresno. 1995. Biphasic control of nuclear factor-kappa B activation by the T cell receptor complex: role of tumor necrosis factor alpha. Eur. J. Immunol. 25:179-186.
7. Paul, N.L., and N.H. Ruddle. 1988. Lymphotoxin. Annu. Rev. Immunol. 6:407-438.
8. Browning, J.L., A. Ngam-ek, P. Lawton, J. DeMarinis, R. Tizard, E.P. Chow, C. Hession, G.B. O'Brine, S.F. Foley, and C.F. Ware. 1993. Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell. 72:847-856.
9. Browning, J.L., I. Dougas, E.A. Ngam, P.R. Bourdon, B.N. Ehrenfels, K. Miatkowski, M. Zafari, A.M. Yampaglia, P. Lawton, W. Meier, et al. 1995. Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors. J. Immunol. 154:33-46.
10. Androlewicz, M.J., J.L. Browning, and C.F. Ware. 1992. Lymphotoxin is expressed as a heteromeric complex with a distinct 33-kDa glycoprotein on the surface of an activated human T cell hybridoma. J. Biol. Chem. 267:2542-2547.
11. Ware, C.F., P.D. Crowe, M.H. Grayson, M.J. Androlewicz, and J L Browning. 1992. Expression of surface lymphotoxin and tumor necrosis factor on activated T, B, and natural killer cells. J Immunol. 149:3881-3888.
12. Ware, C.F., T.L. VanArsdale, P.D. Crowe, and J.L. Browning. 1995. The ligands and receptors of the lymphotoxin system. Curr. Top. Microbiol. Immunol. 198:175-218.
13. Abe, Y., A. Horiuchi, Y. Osuka, S. Kimura, G.A. Granger, and T. Gatanaga. 1992. Studies of membrane-associated and soluble (secreted) lymphotoxin in human lymphokine-activated T-killer cells in vitro. Lymphokine Cytokine Res. 11:115-121.
14. Crowe, P.D., T.L. VanArsdale, B.N. Walter, C.F. Ware, C. Hession, B. Ehrenfels, J.L. Browning, W.S. Din, R.G. Goodwin, and C.A. Smith. 1994. A lymphotoxin-beta-specific receptor. Science (Wash. DC). 264:707-710.
15. De Togni, P., J. Goellner, N.H. Ruddle, P.R. Streeter, A. Fick, S Mariathasan, S.C. Smith, R. Carlson, L.P. Shornick, J. Strauss-Schoenberger, J.H. Russell, R. Karr, and D.D. Chaplin. 1993. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science (Wash. DC) 264:703-706.
16. Banks, T.A., B.T. Rouse, M.K. Kerley, P.J. Blair, V.L. Godfrey, N.A. Kuklin, D.M. Bouley, J. Thomas, S. Kanangat, and M.L Mucenski. 1995. Lymphotoxin-alpha-deficient mice: effects on secondary lymphoid development and humoral immune responsiveness. J. Immunol. 155:1685-1693.
17. Miyawaki, S., Y. Nakamura, H. Suzuka, M. Koba, R. Yasumizu, S. Ikehara, and Y. Shibata. 1994. A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur. J. Immunol. 24:429-434.
18. Pfeffer, K., T. Matsuyama, T.M. Kundig, A. Wakeham, K. Kishihara, A. Shahinian, K. Wieginann, P.S. Ohashi, M. Kronke, and T.W. Mak. 1993. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell. 73:457-467.
19. Erickson, S.L., F.J. de Sauvage, K. Kikly, K. Carver-Moore, S. Pitts-Meek, N. Gillett, K.C.F. Sheehan, R.D. Schreiber, D.V. Goeddel, and M. Moore 1994. Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature (Lond.). 372:560-563.
20. Itoh, N., S. Yonehara, A. Ishii, M. Yonehara, S. Mizushima, M. Sameshima, A. Hase, Y. Seto, and S. Nagata. 1991. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell. 66:233-243.
21. Trauth, R.C., C. Klas, A.M.J. Peters, S. Matzku, P. Moeller, W. Falk, K.-M. Debatin, and P.H. Krammer. 1989. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science (Wash. DC). 245:301-305.
22. Nagata, S., and P. Golstein. 1995. The Fas death factor. Science (Wash. DC). 267:1449-1458.
23. Sarin, A., M. Conan-Cibotti, and P.A. Henkart. 1995. Cytotoxic effect of TNF and lymphotoxin on T lymphoblasts. J. Immunol. 155:3716-3718.
24. Zheng, L., G. Fisher, R.E. Miller, J. Peschon, D.H. Lynch, and M.J. Lenardo. 1995. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature (Lond.). 377:348-351.
25. Cleveland, J.L., and J.N. Ihle. 1995. Contenders in FasL/ TNF death signaling. Cell. 81:479-482.
26. Funakoshi, S., D.L. Longo, M. Beckwith, D.K. Conley, G. Tsarfaty, I. Tsarfaty, R.J. Armitage, W.C. Fanslow, M.K. Spriggs, and W.J. Murphy. 1994. Inhibition of human B-cell lymphoma by CD40 stimulation. Blood. 83:2787-2794.
27. Smith, C.A., H.J. Gruss, T. Davis, D. Anderson, T. Farrah, E. Baker, G.R. Sutherland, C.I. Brannan, N.G. Copeland, N.A. Jenkins, et al. 1993. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell. 73:1349-1360.
28. Browning, M.J., P. Krausa, A. Rowan, D.C. Bicknell, J.G. Bodmer, and W.F. Bodmer. 1993. Tissue typing the HLA-A locus from genomic DNA by sequence specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines. Proc. Natl. Acad. Sci. USA. 90:2842-2845.
29. Miller, G.T., P.S. Hochman, W. Meier, R. Tizard, S.A. Bixler, M.D. Rosa, and B.P. Wallner. 1993. Specific interaction of lymphocyte function associated antigen-3 with CD2 can inhibit T cell responses. J. Exp. Med. 178:211-222.
30. Browning, J., and A. Ribolini. 1989. Studies on the differing effects of tumor necrosis factor and lymphotoxin on the growth of several human tumor lines. J. Immunol. 143:1859-1867.
31. Crowe, P.D., T.L. VanArsdale, B.N. Walter, K.M. Dahms, and C.F. Ware. 1994. Production of lymphotoxin (LT alpha) and a soluble dimeric form of its receptor using the baculovirus expression system. J. Immunol. Methods. 168:79-89.
32. Johne, B., M. Gadnell, and K. Hansen. 1993. Epitope mapping and binding kinetics of monoclonal antibodies studied by real time biospecific interaction analysis using surface plasmon resonance. J. Immunol. Methods. 160:191-198.
33. Lee, S.H., B.B. Aggarwal, E. Rinderknecht, F. Assisi, and H. Chiu. 1984. The synergistic anti-proliferative effect of gamma-interferon and human lymphotoxin. J. Immunol. 133:1083-1086.
34. Dealtry, G.B., M.S. Naylor, W. Fiers, and F.R. Balkwill. 1987. DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon-gamma. Eur. J. Immunol. 17:689-693.
35. Yonehara, S., A. Ishii, and M. Yonehara. 1989. A cell-killing monoclonal antibody (anti-fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J. Exp. Med. 169:1747-1756.
36. Ashkenazi, A., S.A. Marsters, D.J. Capon, S.M. Chamow, I.S. Figari, D. Pennica, D.V. Goeddel, M.A. Palladino, and D.H. Smith 1991. Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin. Proc. Natl. Acad. Sci. USA. 88:10535-10539.
37. Loetscher, H , R. Gentz, M. Zulauf, A. Lustig, H. Tabuchi, E.J. Schlaeger, M. Brockhaus, H. Gallati, M. Manneberg, and W. Lesslauer. 1991. Recombinant 55-kDa tumor necrosis factor (TNF) receptor. Stoichiometry of binding to TNF alpha and TNF beta and inhibition of TNF activity. J. Biol. Chem. 266:18324-18329.
38. Goh, C.R., C.S, Loh, and A.G. Porter. 1991. Aspartic acid 50 and tyrosine 108 are essential for receptor binding and cytotoxic activity of tumour necrosis factor beta (lymphotoxin). Protein Eng. 4:785-791.
39. Oberhammer, F., J.W. Wilson, C. Dive, I.D. Morris, J.A. Hickman, A.E. Wakeling, P.R. Walker, and M. Sikorska. 1993. Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO (Eur. Mol. Biol. Organ.) J. 12:3679-3684.
40. Dusenbury, C.E., M. A. Davis, T.S. Lawrence, and J. Maybaum. 1991. Induction of megabase DNA fragments by 5-fluorodeoxyuridine in human colorectal tumor (HT29) cells. Mol. Pharmacol. 39:285-289.
41. Bortner, C.D., N.B.E. Oldenburg, and J.A. Cidlowski. 1995. The role of DNA fragmentation in apoptosis. Trends Cell Biol. 5:21-26.
42. Ledbetter, J., L.S. Grosmaire, D. Hollenbaugh, A. Aruffo, and S.G. Nadler. 1995. Agonistic and antagonistic properties of CD40 mAb G28-5 are dependent on binding valency. Circ. Shock 44:67-72.
43. Raitano, A.B., P. Scuderi, and M. Korc. 1991. Upregulation of interferon-gamma binding by tumor necrosis factor and lymphotoxin: disparate potencies of the cytokines and modulation of their effects by phorbol ester. J. Interferon Res. 11:61-67.
44. Lynch, D. 1995. Biology of Fas. Circ. Shock. 44:63-66.
45. Crispe, I.N. 1994. Fatal interactions: Fas-induced apoptosis of mature T cells. Immunity. 1:347-349.
46. Horiuchi, A., Y. Abe, M. Miyake, K. Kimura, Y. Hitsumoto, N. Takeuchi, and S. Kimura. 1994. Role of membrane-associated lymphotoxin (mLT) in the killing activity of lymphokine-activated killer (LAK) cells towards various tumour cell lines. Clin. Exp. Immunol. 96:152-157.
47. Henkardt, P.A. 1994. Lymphocyte-mediated cytoxicity: two pathways and multiple effector molecules. Immunity. 1:343-346.
48. Banner, D.W., A. D'Arcy, W. Janes, R. Gentz, H.J. Schoenfeld, C. Broger, H. Loetscher, and W. Lesslauer. 1993. Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell. 73:431-445.
49. Engelmann, H., H. Holtmann, C. Brakebusch, Y.S. Avni, I. Sarov, Y. Nophar, O. Hadas, O. Leitner, and D. Wallach. 1990. Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity. J. Biol. Chem. 265: 14497-14504.
50. Shalaby, M.R., A. Sundan, H. Loetscher, M. Brockhaus, W. Lesslauer, and T. Espevik. 1990. Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors. J Exp. Med. 172:1517-1520.
51. Alderson, M.R., T.W. Tough, S. Braddy, T. Davis-Smith, E. Roux, K. Schooley, R.E. Miller, and D.H. Lynch. 1994. Regulation of apoptosis and T cell activation by Fas-specific mAb. Int. Immunity. 6:1799-1806.
52. + T cell subset. Eur. J. Immunol. 18:811-816.
53. Gordon, J., M.J. Millsum, G.R. Guy, and J.A. Ledbetter. 1988. Resting B lymphocytes can be triggered directly through the CDw40 (Bp50) antigen. J. Immunol. 140:1425-1430.
54. Dhein, J., P.T. Daniel, B.C. Trauth, A. Oehm, P. Moller, and P.H. Krammer. 1992. Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens. J. Immunol. 149:3166-3173.
55. Laster, S.M., J.G. Wood, and L.R. Gooding. 1988. Tumor necrosis factor can induce both apoptotic and necrotic forms of cell lysis. J. Immunol. 141:2629-2634.
56. Fady, C., A. Gardner, F. Jacoby, K. Briskin, Y. Tu, I. Schmid, and A. Lichtenstein. 1995. Atypical apoptotic cell death induced in L929 targets by exposure to tumor necrosis factor. J. Interferon Cytokine Res. 15:71-80.
57. Reid, T.R., F.M. Tortis, and G.M. Ringold. 1989. Evidence for two mechanisms by which tumor necrosis factor kills cells. J. Biol. Chem. 264:4583-4589.
58. Wong, G.H.W., and D.V. Goeddel. 1994. Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. J. Immunol. 152:1751-1755.
59. Grell, M., P.H. Krammer, and P. Scheurich. 1994. Segregation of APO-1/Fas antigen and tumor necrosis factor receptor mediated apoptosis. Eur. J. Immunol. 24:2563-2566.
60. Reid, T., P. Louie, and R.A. Heller. 1994. Mechanisms of tumor necrosis factor cytotoxicity and the cytotoxic signals transduced by the p75 tumor necrosis factor receptor. Circ. Shock. 44:84-90.
61. Peska, S., J.A. Langer, K.C. Zoon, and C.E. Samuel. 1987. Interferons and their actions. Annu. Rev. Biochem. 56:727-777.
62. Fiers, W. 1991. Tumor necrosis factor, characterization at the molecular, cellular and in vivo level. FEBS (Fed. Eur. Biochem. Soc.) Lett. 285:199-212.
63. Park, D.J., H. Nakamura, A.M. Chumakov, J.W. Said, C.M. Miller, D.L. Chen, and H.P. Koeffler. 1994. Transactivational and DNA binding activities of endogenous p53 in p53 mutant cell lines. Oncogene. 9:1899-1906.
64. Vanhaesebroeck, B., J.C. Reed, V.D. De, J. Grooten, T. Miyashita, S. Tanaka, R. Beyaert, R.F. Van, and W. Fiers. 1993. Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. Oncogene. 8:1075-1081.
65. Lowe, S.W., H.E. Ruley, T. Jacks, and D.E. Housman. 1993. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 74:957-967.
66. Lejeune, F., D. Lienard, A. Eggermont, H. Schraffordt, B. Kroon, J. Gerain, F. Rosenkaimer, and P. Schmitz. 1994. Clinical experience with high dose tumor necrosis factor alpha in regional therapy of advanced melanoma. Circ. Shock. 43:191-197.
67. Ogasawara, J., F.R. Watanabe, M. Adachi, A. Matsuzawa, T. Kasugai, Y. Kitamura, N. Itoh, T. Suda, and S. Nagata. 1993. Lethal effect of the anti-Fas antibody in mice. Nature (Lond.). 364:806-809.
68. Dighe, A.S., E. Richards, L.J. Old, and R.D. Schreiber. 1994. Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFNgamma receptors. Immunity. 1:447-456.