Phlebotomy increases cadmium uptake in hemochromatosis

Environmental Health Perspectives

Volumn 108, Issue 4, 2000, Pages 289-291

  Åkesson, Agneta ^a   Stål, Per ^b   Vahter, Marie ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Absorption; Cadmium; DCT1; DMT1; Hemochromatosis; HFE; Human; Iron; Lead; Nramp2

Indexed keywords

CADMIUM; CARRIER PROTEIN; DIVALENT CATION; FERRITIN; HEMOGLOBIN; IRON; LEAD; TRANSFERRIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENOTYPE; HEMOCHROMATOSIS; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INTESTINE ABSORPTION; IRON ABSORPTION; LEAD BLOOD LEVEL; MALE; NEPHROTOXICITY; PHLEBOTOMY; POLLUTANT; PRIORITY JOURNAL;

EID: 0342424288     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.00108289     Document Type: Article

References (34)

1. Järup L, Berglund M, Elinder CG, Nordberg G, Vahter M. Health effects of cadmium exposure - a review of the literature and a risk estimate. Scand J Work Environ Health 24:1-52 (1998).
2. Staessen JA, Roels HA, Emelianov D, Kuznetsova T, Thijs L, Vangronsveld J, Fagard R. Environmental exposure to cadmium, forearm bone density, and risk of fractures: prospective population study. Lancet 353:1140-1144 (1999).
3. Berglund M, Åkesson A, Nermell B, Vahter M. Intestinal absorption of dietary cadmium in women depends on body iron stores and fiber intake. Environ Health Perspect 102:1058-1066 (1994).
4. Flanagan PR, McLellan JS, Haist J, Cherian G, Chamberlain MJ, Valberg LS. Increased dietary cadmium absorption in mice and human subjects with iron deficiency. Gastroenterology 74:841-846 (1978).
5. Finch C. Regulators of iron balance in humans. Blood 84:1697-1702 (1994).
6. Fleming MD, Cameron CT, Su MA, Foernzler D, Beier DR, Dietrich WF, Andrews NC. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transport gene. Nature Genetics 16:383-386 (1997).
7. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA. Cloning and characterization of a mammalian protoncoupled metal-ion transporter. Nature 338:482-488 (1997).
8. Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, Dormishian F, Domingo R Jr, Ellis MC, Fullan A, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 13:399-408 (1996).
9. Bacon BR, Powell LW, Adams PC, Kresina TF, Hoofnagle JH. Molecular medicine and hemochromatosis: at the crossroads. Gastroenterology 116:193-207 (1999).
10. Fleming MD, Romano MA, Su MA, Garrick LM, Garrick MD, Andrews NC. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci USA 95:1148-1153 (1998).
11. Han O, Fleet JC, Wood RJ. Reciprocal regulation of HFE and Nramp2 gene expression by iron in human intestinal cells. J Nutr 129:98-104 (1999).
12. Lee PL, Gelbart T, West C, Halloran C, Beutler E. The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms. Blood Cell Mol Dis 98:199-215 (1998).
13. Su MA, Trenor CC, Fleming JC, Fleming MD, Andrews NC. The G185R mutation disrupts function of the iron transporter Nramp2. Blood 98:2157-2163 (1998).
14. Fleming RE, Migas MC, Zhou XY, Jiang JX, Britton RS, Brunt EM, Tomatsu S, Waheed A, Bacon BR, Sly WS. Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1. Proc Natl Acad Sci USA 96:3143-3148 (1999).
15. Feder JN, Penny DM, Irrinki A, Lee VK, Lebron JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci USA 95:1472-1477 (1998).
16. Gross CN, Irrinki A, Feder JN, Enns CA. Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation. J Biol Chem 273:22068-22074 (1998).
17. Lebron JA, Bennett MJ, Vaughn DE, Chirino AJ, Snow PM, Mintier GA, Feder JN, Bjorkman PJ. Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell 93:111-123 (1998).
18. Parkkila S, Waheed A, Britton RS, Feder JN, Tsuchihashi Z, Schatzman RC, Bacon BR, Sly WS. Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract. Proc Natl Acad Sci USA 94:2534-2539 (1997).
19. Parkkila S, Waheed A, Britton RS, Bacon BR, Zhou XY, Tomatsu S, Fleming RE, Sly WS. Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis. Proc Natl Acad Sci USA 94:13198-13202 (1997).
20. Roy CN, Penny DM, Feder JN, Enns CA. The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells. J Biol Chem 99:9022-9028 (1999).
21. Salter-Cid L, Brunmark A, Li YH, Leturcq D, Peterson PA, Jackson MR, Yang Y. Transferrin receptor is negatively modulated by the hemochromatosis protein HFE. Implications for cellular iron homeostasis. Proc Natl Acad Sci USA 96:5434-5439 (1999).
22. Waheed A, Parkkila S, Saarnio J, Fleming RE, Zhou XY, Tomatsu S, Britton RS, Bacon BR, Sly WS. Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proc Natl Acad Sci USA 96:1579-1584 (1999).
23. Pietrangelo A. Hemochromatosis 1998: is one gene enough? J Hepatol 29:502-509 (1998).
24. Waheed A, Parkkila S, Zhou XY, Tomatsu S, Tsuchihashi Z, Feder JN, Schatzman RC, Britton RS, Bacon BR, Sly WS. Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in CDS-7 cells. Proc Natl Acad Sci USA 94:12384-12389 (1997).
25. Barton JC, Patton MA, Edwards CQ, Griffen LM, Kushner JP, Meeks RG, Legget RW. Blood lead concentrations in hereditary hemochromatosis. J Lab Clin Med 124:193-198 (1994).
26. Cardoso EMP, Stål P, Hagen K, Cabeda JM, Esin S, Desousa M, Hultcrantz R. HFE mutations in patients with hereditary haemochromatosis in Sweden. J Intern Med 243:203-208 (1998).
27. WHO. Inorganic Lead. Environmental Health Criteria 165. Geneva:International Programme on Chemical Safety, World Health Organization, 1995.
28. WHO. Cadmium Environmental Health Criteria 134. Geneva:International Programme on Chemical Safety, World Health Organization, 1992.
29. Vahter M, Berglund M, Lind B, Jorhem L, Slorach S, Friberg L. Personal monitoring of lead and cadmium exposure - a Swedish study with special reference to methodological aspects. Scand J Work Environ Health 17:65-74 (1991).
30. Baecklund M, Pedersen NL, Björkman L, Vahter M. Variation in blood concentrations of cadmium and lead in the elderly. Environ Res 80:222-230 (1999).
31. Goyer RA. Toxic and essential metal interactions. Ann Rev Nutr 17:37-50 (1997).
32. Zoller H, Pietrangelo A, Vogel W, Weiss G. Doudenal metal-transporter (DMT1, NRAMP-2) expression in patients with hereditary haemochromatosis. Lancet 353:2120-2123 (1999).
33. Andrews NC, Levy JE. Iron is hot: an update on the pathology of hemochromatosis. Blood 92:1845-1851 (1998).
34. Raja KB, Poutney D, Bomford A, Sherman D, Simpson RJ, Williams R, Peters TJ. A duodenal mucosal abnormality in the reduction of Fe(III) in patients with genetic haemochromatosis. Gut 38:765-769 (1996).