In vitro metabolism of LVV-Hemorphin-7 by renal cytosol and purified prolyl endopeptidase

Peptides

Volumn 24, Issue 8, 2003, Pages 1201-1206

  Fruitier Arnaudin, I ^a   Cohen, M ^a   Coitoux, C ^b   Piot, J M ^a  

^a UNIVERSITÉ DE LA ROCHELLE   (France)

^b Inst Universitaire de Technologies   (France)

Author keywords

Hemorphin; Homogenate; Metabolism; Peptide hydrolysis; Prolyl endopeptidase; Renal cytosol; Subcellular fractions

Indexed keywords

AMINOPEPTIDASE; ANGIOTENSIN II [3-8]; CARBOXYPEPTIDASE; CATHEPSIN D; HEMOGLOBIN BETA CHAIN; LEUCYLVALYLVALINE HEMORPHIN 7; OPIATE DERIVATIVE; PEPTIDE DERIVATIVE; PROLYL ENDOPEPTIDASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; CYTOSOL; DRUG ACTIVITY; DRUG EFFECT; DRUG HALF LIFE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME PURIFICATION; HYDROLYSIS; IN VITRO STUDY; KIDNEY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0242720734     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2003.07.005     Document Type: Article

References (26)

1. Cunningham D., O'Connor B. Proline specific peptidases. Biochim. Biophys. Acta. 1343:1997;160-186.
2. Dagouassat N., Garreau I., Sannier F., Zhao Q., Piot J.M. Generation of VV-hemorphin-7 from globin by peritoneal macrophages. FEBS Lett. 382(1-2):1996;37-42.
3. Duethman D., Dewan N., Conlon J.M. Isolation of the opioid peptide Leu-Val-Val-hemorphin-7 from bronchoalveolar lavage fluid of a patient with non-small cell lung cancer. Peptides. 21:2000;137-142.
4. Erchegyi J., Kastin A.J., Zadina J.E., Qiu X.D. Isolation of a heptapeptide Val-Val-Tyr-Pro-Trp-Thr-Gln (valorphin) with some opiate activity. Int. J. Pept. Protein Res. 39:1992;477-484.
5. Fruitier I., Garreau I., Lacroix A., Cupo A., Piot J.M. Proteolytic degradation of hemoglobin by endogenous lysosomal proteases gives rise to bioactive peptides: hemorphins. FEBS Lett. 447(1):1999;81-86.
6. Fruitier I., Garreau I., Piot J.M. Cathepsin D is a good candidate for the specific release of a stable hemorphin from hemoglobin in vivo: VV-Hemorphine-7. Biochem. Biophys. Res. Commun. 246:1998;719-724.
7. Garreau I., Chansel D., Vandermeersch S., Fruitier I., Piot J.M., Ardaillou R. Hemorphins inhibit angiotensin IV binding and interact with aminopeptidase N. Peptides. 19:1998;1339-1348.
8. Glämsta E.L., Marklund A., Hellman U., Wernstedt C., Terenius L., Nyberg F. Isolation and characterization of a hemoglobin-derived opioid peptide from the human pituitary gland. Regul. Pept. 34:1991;169-179.
9. Glämsta E.L., Meyerson B., Silberring J., Terenius L., Nyberg F. Isolation of a hemoglobin-derived opioid peptide from cerebrospinal fluid of patients with cerebrovascular bleedings. Biochem. Biophys. Res. Commun. 184:1992;1060-1066.
10. Glämsta E.L., Morkrid L., Lantz I., Nyberg F. Concomitant increase in blood plasma levels of immunoreactive hemorphin-7 and beta-endorphin following long distance running. Regul. Pept. 49:1993;9-18.
11. Ivanov V.T., Karelin A.A., Philippova M.M., Nazimov I.V., Pletnev V.Z. Hemoglobin as a source of endogenous bioactive peptide: the concept of tissue-specific peptide pool. Biopolymers. 43:1997;171-188.
12. Karelin AA, Philoppova MM, Karelina EV, Ivanov V. Proteolytic degradation of hemoglobin in erythrocytes leads to active peptides. In: HLS Maia, editor. Peptides 1994. Leiden: ESCOM. p. 137-8.
13. Lantz I., Glämsta E.L., Talbäck L., Nyberg F. Hemorphins derived from hemoglobin have an inhibitory action on angiotensin converting enzyme activity. FEBS Lett. 287(12):1991;39-41.
14. Liebmann C., Schrader U., Brantl V. Opioid receptor affinities of the blood-derived tetrapeptides hemorphin and cytochrophin. Eur. J. Pharmacol. 166:1989;523-526.
15. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-276.
16. Mäkinen K.K., Sewon L., Mäkinen P. Analysis in gingival crevicular fluid of two oligopeptides derived from human hemoglobin beta-chain. J. Periodontal Res. 31:1996;43-46.
17. Moeller I., Lew R.A., Mendelsohn F.A., Smith A.I., Brennan M.E., Tetaz T.J.et al. The globin fragment LVV-hemorphin-7 is an endogenous ligand for the AT4 receptor in the brain. J. Neurochem. 68(6):1997;2530-2537.
18. Moriyama A., Nakanishi M., Sasaki M. Porcine muscle prolyl endopeptidase and its endogenous substrate. J. Biochem. 104:1988;112-117.
19. Nyberg F., Sanderson K., Glamsta E.-L. The hemorphins: A new class of opioid peptides derived from the blood protein hemoglobin. Biopolymers. 43(2):1997;147-156.
20. Piot J.M., Zhao Q., Guillochon D., Ricart G., Thomas D. Isolation and characterization of two opioid peptides from a bovine hemoglobin peptic hydrolysate. Biochem. Biophys. Res. Commun. 189:1992;101-110.
21. Sanderson K., Nyberg F., Khalil Z. Modulation of peripheral inflammation by locally administered hemorphin-7. Inflamm. Res. 47(2):1998;49-55.
22. Yatskin O.N., Philippova M.M., Blishchenko E.Y., Karelin A.A., Ivanov V.T. LVV- and VV-Hemorphins: comparative levels in rat tissues. FEBS Lett. 428(3):1998;286-290.
23. Zhao Q., Garreau I., Sannier F., Piot J.-M. Identification of hemorphins from bovine hemoglobin hydrolysate: application of UV second order derivative spectroscopy. J. Liq. Chromatogr. 18:1995;1077-1092.
24. Zhao Q., Garreau I., Sannier F., Piot J.M. Opioid peptides derived from hemoglobin: hemorphins. Biopolymers. 43:1997;75-98.
25. Zhao Q., Sannier F., Garreau I., Guillochon D., Piot J.-M. Inhibition and inhibition kinetics of angiotensin converting enzyme activity by hemorphins, isolated from a peptic bovine hemoglobin hydrolysate. Biochem. Biophys. Res. Commun. 204(1):1994;216-223.
26. Zhao Q., Sannier F., Garreau I., Lecoeur C., Piot J.-M. Reversed-phase high-performance liquid chromatography coupled with second-order derivative spectroscopy for the quantitation of aromatic amino acids in peptides: application to hemorphins. J. Chromatogr. A. 723(1):1996;35-41.