Conversion of Homocysteine to Methionine by Methionine Synthase: A Density Functional Study

Journal of the American Chemical Society

Volumn 125, Issue 46, 2003, Pages 13970-13971

  Jensen, Kasper P ^a   Ryde, Ulf ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOCYSTEINE; METHIONINE; METHIONINE SYNTHASE;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DENSITY FUNCTIONAL THEORY; ENERGY; ENZYME ACTIVE SITE; MATHEMATICAL ANALYSIS; PROTON TRANSPORT; REACTION ANALYSIS; SOLVATION; THEORY; THERMODYNAMICS;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; HOMOCYSTEINE; METHIONINE; MODELS, MOLECULAR; THERMODYNAMICS;

EID: 0242666823     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja034697a     Document Type: Article

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14. Recently, it has been suggested that side chains must be included in modeling cobalamins, based on calculation of the electronic spectrum: Ouyang, L.; Randaccio, L.; Rulis, P.; Kurmaev, E. Z.; Moewes, A.; Ching, W. Y. J. Mol. Struct. (THEOCHEM) 2003, 622. 221. However, other investigations have found no important role of side chains, either for corrins or for porphyrins, e.g., Jensen, K. P.; Mikkelsen, K. V. Inorg. Chim. Acta 2001, 323, 5 and Sigfridsson, E.; Ryde, U. J. Biol. Inorg. Chem. 2003, 8, 273.
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